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Separations
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Isolation of Natural Products and Their Application in Pharmaceuticals
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Isolation of Natural Products and Their Application in Pharmaceuticals

A special issue of Separations (ISSN 2297-8739). This special issue belongs to the section "Analysis of Natural Products and Pharmaceuticals".

Deadline for manuscript submissions: closed (24 January 2024) | Viewed by 4993

Special Issue Editor

Dr. Changshan Niu

E-Mail Website
Guest Editor
College of Pharmacy, University of Utah, Salt Lake City, UT 84112, USA
Interests: natural product chemistry; biosynthetic biology; marine animal; marine microbes; medicinal plants; bioactivity; terpenes

Special Issue Information

Dear Colleagues,

Natural products are chemical compounds produced by living organisms, such as plants, animals, and microorganisms. These compounds have evolved over millions of years to serve various biological functions, and they often exhibit unique and diverse chemical structures with significant pharmacological activities. The process of isolating natural products involves extracting active compounds from natural sources and purifying them to obtain a highly concentrated and chemically pure form. Once natural products are isolated and their structures are identified, they can be evaluated for their potential pharmaceutical applications.

The purpose of this special issue is to collect and share new findings or reviews focusing on, but not limited to, new compounds isolated from different natural sources, novel isolation or detection techniques, interesting bioactivity of natural products, and new applications in Pharmaceuticals of the bioactive molecules.

We encourage and welcome you to share your research findings or new ideas highlighting Isolation of Natural Products and Their Application in Pharmaceuticals.

Dr. Changshan Niu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • drug discovery
  • medicinal plants
  • marine animals
  • microbes
  • activity
  • bioactive molecules
  • natural product extraction

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Published Papers (2 papers)

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Research

14 pages, 2600 KiB  
Article
Pharmaceutical Screening of Bat Feces and Their Applications and Risks in Traditional Chinese Medicine
by Kou-Toung Chung, Ching-Lung Lin, Wu-Chang Chuang, Ming-Chung Lee, Li-Wen Chen and Chung-Hsin Wu
Separations 2024, 11(3), 76; https://doi.org/10.3390/separations11030076 - 29 Feb 2024
Viewed by 1940
Abstract
Bat feces have been reported in traditional Chinese medicine (TCM) books to have the effect of reducing fever and improving eyesight, but the mechanism of vision improvement still needs further research. To this end, we used 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and liquid [...] Read more.
Bat feces have been reported in traditional Chinese medicine (TCM) books to have the effect of reducing fever and improving eyesight, but the mechanism of vision improvement still needs further research. To this end, we used 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and liquid chromatography/tandem mass spectrometry (LC/MS/MS) to analyze the antioxidant capacity of and the types of vitamins in bat feces. We hoped to screen the pharmacological components of bat feces and to explain the role that these components may play in treating visual deterioration. Our results found that bat feces had a good antioxidant capacity and mainly contained vitamins B1 (thiamine), B2 (riboflavin), B3 (nicotinamide), B3 (nicotinic acid), and B5 (pantothenic acid). Although these vitamins may help to maintain the health of the optic nerve and cornea, the vitamin content of bat feces is low, but the heavy metal content is high, as shown using inductively coupled plasma–mass spectrometry (ICP-MS) analysis. Therefore, we suggest that the use of bat feces as TCM to improve vision should be strictly restricted. Full article
(This article belongs to the Special Issue Isolation of Natural Products and Their Application in Pharmaceuticals)
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17 pages, 1778 KiB  
Article
Optimization of the Vacuum Fractional Distillation Process for Enhancing the α-Guaiene of Patchouli Oil with Response Surface Methodology
by Asri Widyasanti, Sarifah Nurjanah, Bambang Nurhadi and Che Puteh Osman
Separations 2023, 10(9), 469; https://doi.org/10.3390/separations10090469 - 25 Aug 2023
Viewed by 2603
Abstract
α-guaiene is one of the primary sesquiterpene compounds used as a flavor and fragrance agent in patchouli oil. The fraction of patchouli oil that is rich in α-guaiene has been successfully isolated. In the present work, α-guaiene was isolated from crude patchouli oil [...] Read more.
α-guaiene is one of the primary sesquiterpene compounds used as a flavor and fragrance agent in patchouli oil. The fraction of patchouli oil that is rich in α-guaiene has been successfully isolated. In the present work, α-guaiene was isolated from crude patchouli oil through vacuum fractional distillation followed by GC-MS identification. Three important process parameters—feed volume, reflux ratio, and applied run pressure—were investigated and optimized using Box–Behnken design. The research methodology was an experimental laboratory using response surface methodology (RSM) with a feed volume level from 75 mL to 125 mL, a reflux ratio from 10:1 to 30:1, and an applied run pressure from 5 mmHg to 15 mmHg. The α-guaiene-enriched fraction was found in the first distillate fraction patchouli. The optimum condition that generated α-guaiene fraction at 44.70% purity was the treatment with a feed volume of 75 mL, a reflux ratio of 24:1, and applied run pressure of 14.80 mmHg. Results indicated that feed volume did not significantly affect the α-guaiene content, while the applied run pressure and reflux ratio used had a significant effect. A quadratic mathematical model with R2 0.861 and validation 96.14% was suitable for predicting the optimum α-guaiene fraction content during the vacuum fractional distillation process. Full article
(This article belongs to the Special Issue Isolation of Natural Products and Their Application in Pharmaceuticals)
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