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Separations
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Extraction and Analysis of Active Ingredients from Natural Products
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Extraction and Analysis of Active Ingredients from Natural Products

A special issue of Separations (ISSN 2297-8739). This special issue belongs to the section "Analysis of Natural Products and Pharmaceuticals".

Deadline for manuscript submissions: closed (20 July 2023) | Viewed by 4320

Special Issue Editors

Dr. Zeyu Wu

E-Mail Website
Guest Editor
1. School of Food and Biological Engineering, Hefei University of Technology, Hefei, China
2. Engineering Research Center of Bio-Process of Ministry of Education, Hefei University of Technology, Hefei, China
Interests: food processing; functional foods; food safety; analytical methods development
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. An Zhou

E-Mail Website
Guest Editor
1. The Experimental Research Center, Anhui University of Chinese Medicine, Hefei 230038, China
2. Anhui Province Key Laboratory of Research and Development of Chinese Medicine, Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei 230038, China
Interests: quality evaluation of Chinese medicines; metabolomics study on Chinese medicines; bioactive components from Chinese medicines
Dr. Shudong He

E-Mail Website
Guest Editor
School of Food Science and Biological Engineering, Hefei University of Technology, Hefei, China
Interests: food protein; food peptide; food allergy; food characteristics; food flavor; beverage development; edible film
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Active ingredients in natural products are receiving increasing attention around the world, mainly as a result of their close relationship with human wellness. Extraction and analysis are considered to be two important aspects for improving the quality and application of active ingredients in natural products. This Special Issue focuses on the methods employed in the extraction, separation and analysis of active ingredients in natural products. Manuscripts should focus on—but are not limited to—the following topics:

  • Extraction methods, such as ultrasound-assisted extraction, microwave assisted extraction, high pressure assisted extraction, and supercritical fluid extraction.
  • Separation methods, including membrane separation, column chromatography, molecular imprinting technique and crystallization.
  • Chromatographic based analysis, such as HPLC, GC, LC-MS, and GC-MS.
  • Non-chromatographic methods, including chemiluminescence and Raman spectroscopic techniques.
  • Computational modelling of separations.

Original research papers, reviews and short communications are welcome.

Dr. Zeyu Wu
Prof. Dr. An Zhou
Dr. Shudong He
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • extraction methods
  • separation techniques
  • chromatography technologies
  • active ingredients
  • computational modeling

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Published Papers (2 papers)

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Research

13 pages, 1578 KiB  
Article
Chemometric Approach of Different Extraction Conditions on Scavenging Activity of Helichrisym italicum (Roth) G. Don Extracts
by Branislava Teofilović, Filip Balaž, Milica Karadžić Banjac, Nevena Grujić-Letić, Emilia Gligorić, Strahinja Kovačević, Sanja Podunavac-Kuzmanović and Srđan Stojanović
Separations 2023, 10(8), 436; https://doi.org/10.3390/separations10080436 - 2 Aug 2023
Cited by 1 | Viewed by 1180
Abstract
Helichrysum italicum (Roth) G. Don is widely used as a liver stimulant and diuretic, as well as an antioxidant, antiallergenic, antimicrobial, antiviral, choleric, and antihypertensive agent. Therefore, the purpose of this study was to analyze the different extracts of H. italicum and to [...] Read more.
Helichrysum italicum (Roth) G. Don is widely used as a liver stimulant and diuretic, as well as an antioxidant, antiallergenic, antimicrobial, antiviral, choleric, and antihypertensive agent. Therefore, the purpose of this study was to analyze the different extracts of H. italicum and to determine the relationship between total phenolic/flavonoid content and antioxidant activity. Plant material was pulverized to be 0.3 and 2 mm, and the extraction was obtained with 5 mL of different ethanol concentrations (30, 40, 50, 60, 96%, v/v) and water during different periods (10, 30, 60 min and 24 h) and with concentrated methanol (95%, v/v), dichloromethane, acetone, chloroform, ethyl acetate, and hexane during 10 and 30 min due to solvents volatility. Extracts were evaporated on the rotary evaporator. Total phenolic and flavonoid content were determined via spectrophotometric measurement, and antioxidant capacity was investigated by the inhibitory activity of DPPH radicals. The group of 92 extracts described through their TPC, flavonoids, yield, and IC50 values were subjected to PCA and HCA analysis. PCA and HCA were performed using Statistica v 10.0 software. The number of phenolic compounds ranged from 2.58 ± 0.1 to 43.60 ± 0.3 mg GAE/g of dry extract, and total flavonoids content ranged from 0.25 ± 0.01 to 23.96 ± 0.19 mg QE/g of dry extract. All extracts showed good antioxidant activity with an IC50 value in the range from 4.92 ± 0.2 to 231.12 ± 1.9 μg/mL. PCA and HCA analysis were performed on the whole data set comprising 92 extracts for both particle sizes (s0.3 and s2) as well as heat map analysis. It was found that the increased time of extraction, concentration of ethanol, and degree of fragmentation enhances the quality of the extracts in terms of phenolic component content and antioxidant effects. Applied chemometric analysis contributed to the extraction conditions grouping, overview, and selection in order to distinguish the extracts with the promising TPC, flavonoids, yield, and IC50 values. Full article
(This article belongs to the Special Issue Extraction and Analysis of Active Ingredients from Natural Products)
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14 pages, 1799 KiB  
Article
Optimization of Gallic Acid-Rich Extract from Mango (Mangifera indica) Seed Kernels through Ultrasound-Assisted Extraction
by Zafar Hayat, Tuba Riaz, Kinza Saleem, Kashif Akram, Hafeez Ur Rehman and Muhammad Azam
Separations 2023, 10(7), 376; https://doi.org/10.3390/separations10070376 - 26 Jun 2023
Cited by 9 | Viewed by 2626
Abstract
Different types of agro-waste provide potential substrates for the extraction of bioactive compounds. Mango waste (e.g., peels and seeds) is one such example and may serve as a source of gallic acid, a well-known bioactive compound classified as a secondary polyphenolic metabolite. Here, [...] Read more.
Different types of agro-waste provide potential substrates for the extraction of bioactive compounds. Mango waste (e.g., peels and seeds) is one such example and may serve as a source of gallic acid, a well-known bioactive compound classified as a secondary polyphenolic metabolite. Here, we explored the efficacy of ultrasound-assisted extraction (UAE) in extracting gallic acid from mango seed kernels using different solvent concentrations (0–60%), solvent-to-sample ratios (10–50 mL/g), temperatures (30–60 °C), and times (10–30 min). The maximum yield of gallic acid (6.1 ± 0.09 mg/g) was obtained when using a 19.4% solvent concentration, a 29.32 mL/g solvent-to-sample ratio, and the extraction was conducted at 38.47 °C for 21.4 min, similar to the values predicted by the model equation. As compared to the conventional extraction procedure, the extract obtained by the optimized method was found to be significantly different in total phenolic content, total flavonoid content, and radical scavenging activity. Non-significant differences were observed in antimicrobial activity. The results indicate that mango seed kernels may be a good source of phenolics, and those phenolics can be effectively obtained through an optimized UAE method. Hence, mango seed kernels may be utilized as a suitable source of extracting phenolics in nutraceutical and food applications. Full article
(This article belongs to the Special Issue Extraction and Analysis of Active Ingredients from Natural Products)
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