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Symmetry
Special Issues
Biochemistry, Gene Symmetry and Molecular Biology
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Biochemistry, Gene Symmetry and Molecular Biology

A special issue of Symmetry (ISSN 2073-8994). This special issue belongs to the section "Life Sciences".

Deadline for manuscript submissions: closed (15 December 2021) | Viewed by 10100

Special Issue Editor

Prof. Dr. Laura Pop

E-Mail Website
Guest Editor
University of Medicine and Pharmacy ‘Iuliu Hatieganu” , Victor Babes nr.8, Cluj-Napoca, Romania
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue highlights recent work related to biochemistry, genetics, symmetry in genes and genomes, and molecular biology in different diseases related to screening, diagnosis, and prognosis. We would like to correlate specific biological and biochemical processes to genes and genotypes of the disease. 

We are soliciting contributions (research and review articles) covering a broad range of topics in biochemistry, genetics, and molecular biology, including (though not limited to) the following:

  • Biochemical processes related to diseases;
  • Molecular biology processes related to diseases;
  • Genetic profiles of different diseases;
  • Correlations between biochemical, genetic, and molecular biological processes;
  • Specific molecular biology techniques applied in diagnosis and prognosis of different diseases;
  • Symmetry and asymmetry in genomes and genes.

Please note that all submitted papers should be within the scope of the journal.

Prof. Laura Ancuţa Pop
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Symmetry is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biochemical processes
  • molecular biology processes
  • molecular biology techniques
  • genes

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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Research

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19 pages, 2584 KiB  
Article
Mathematical Algorithm for Identification of Eukaryotic Promoter Sequences
by Eugene V. Korotkov, Yulia. M. Suvorova, Anna V. Nezhdanova, Sofia E. Gaidukova, Irina V. Yakovleva, Anastasia M. Kamionskaya and Maria A. Korotkova
Symmetry 2021, 13(6), 917; https://doi.org/10.3390/sym13060917 - 21 May 2021
Cited by 7 | Viewed by 3116
Abstract
Identification of promoter sequences in the eukaryotic genome, by computer methods, is an important task of bioinformatics. However, this problem has not been solved since the best algorithms have a false positive probability of 10−3–10−4 per nucleotide. As a result [...] Read more.
Identification of promoter sequences in the eukaryotic genome, by computer methods, is an important task of bioinformatics. However, this problem has not been solved since the best algorithms have a false positive probability of 10−3–10−4 per nucleotide. As a result of full genome analysis, there may be more false positives than annotated gene promoters. The probability of a false positive should be reduced to 10−6–10−8 to reduce the number of false positives and increase the reliability of the prediction. The method for multi alignment of the promoter sequences was developed. Then, mathematical methods were developed for calculation of the statistically important classes of the promoter sequences. Five promoter classes, from the rice genome, were created. We developed promoter classes to search for potential promoter sequences in the rice genome with a false positive number less than 10−8 per nucleotide. Five classes of promoter sequences contain 1740, 222, 199, 167 and 130 promoters, respectively. A total of 145,277 potential promoter sequences (PPSs) were identified. Of these, 18,563 are promoters of known genes, 87,233 PPSs intersect with transposable elements, and 37,390 PPSs were found in previously unannotated sequences. The number of false positives for a randomly mixed rice genome is less than 10−8 per nucleotide. The method developed for detecting PPSs was compared with some previously used approaches. The developed mathematical method can be used to search for genes, transposable elements, and transcript start sites in eukaryotic genomes. Full article
(This article belongs to the Special Issue Biochemistry, Gene Symmetry and Molecular Biology)
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Review

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21 pages, 1316 KiB  
Review
Non-Coding RNAs and Reactive Oxygen Species–Symmetric Players of the Pathogenesis Associated with Bacterial and Viral Infections
by Zaki Milhem, Paul Chiroi, Andreea Nutu, Maximilian Ilea, Mihaela Lupse, Oana Zanoaga and Ioana Berindan-Neagoe
Symmetry 2021, 13(7), 1307; https://doi.org/10.3390/sym13071307 - 20 Jul 2021
Cited by 2 | Viewed by 6211
Abstract
Infections can be triggered by a wide range of pathogens. However, there are few strains of bacteria that cause illness, but some are quite life-threatening. Likewise, viral infections are responsible for many human diseases, usually characterized by high contagiousness. Hence, as bacterial and [...] Read more.
Infections can be triggered by a wide range of pathogens. However, there are few strains of bacteria that cause illness, but some are quite life-threatening. Likewise, viral infections are responsible for many human diseases, usually characterized by high contagiousness. Hence, as bacterial and viral infections can both cause similar symptoms, it can be difficult to determine the exact cause of a specific infection, and this limitation is critical. However, recent scientific advances have geared us up with the proper tools required for better diagnoses. Recent discoveries have confirmed the involvement of non-coding RNAs (ncRNAs) in regulating the pathogenesis of certain bacterial or viral infections. Moreover, the presence of reactive oxygen species (ROS) is also known as a common infection trait that can be used to achieve a more complete description of such pathogen-driven conditions. Thus, this opens further research opportunities, allowing scientists to explore infection-associated genetic patterns and develop better diagnosis and treatment methods. Therefore, the aim of this review is to summarize the current knowledge of the implication of ncRNAs and ROS in bacterial and viral infections, with great emphasis on their symmetry but, also, on their main differences. Full article
(This article belongs to the Special Issue Biochemistry, Gene Symmetry and Molecular Biology)
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