Targeting Uremic Toxins in Chronic Kidney Disease: Novel Therapeutic Approaches
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Uremic Toxins".
Deadline for manuscript submissions: 21 May 2025 | Viewed by 757
Special Issue Editors
Interests: uremic toxin; uremia; chronic kidney disease; metabolic complications
Special Issues, Collections and Topics in MDPI journals
Interests: uremic toxin; uremia; chronic kidney disease; cardiovascular complications
Special Issue Information
Dear Colleagues,
Chronic kidney disease (CKD) is a progressive condition marked by the gradual loss of kidney function, leading to the accumulation of harmful substances often referred to as uremic toxins. As kidney function deteriorates, the body accumulates these harmful substances that would normally be excreted in the urine. These uremic toxins contribute to a wide range of complications, including cardiovascular diseases, low-grade inflammation, and further kidney damage, thereby accelerating CKD progression. Traditional treatments primarily focus on controlling blood pressure, blood sugar, and other risk factors to slow kidney function decline. However, these approaches often fail to adequately address the buildup of uremic toxins, leaving patients vulnerable to their deleterious effects. Recent advancements in our understanding of CKD pathophysiology have spurred the development of novel therapeutic approaches specifically aimed at targeting uremic toxins. These include strategies such as the use of adsorbents that bind and neutralize toxins in the gastrointestinal tract, probiotics and prebiotics that alter gut microbiota to reduce toxin production, innovative pharmacological agents that enhance toxin removal or inhibit their harmful effects, and new technologies of dialysis. By focusing directly on reducing the burden of uremic toxins, these emerging therapies offer the potential to improve outcomes for CKD patients, providing a new frontier in the management of this chronic and debilitating disease.
This Special Issue of Toxins will focus on novel and emerging technologies, drugs, or nutritional approaches that have been studied and developed to decrease production, enhance removal, or prevent the toxicity of uremic toxins. Original research articles, reviews, and methodological papers are welcome.
Prof. Dr. Christophe O. Soulage
Prof. Dr. Fitsum Guebre-Egziabher
Dr. Laetitia Koppe
Guest Editors
Manuscript Submission Information
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Keywords
- uremic toxins
- dialysis
- hemodialysis
- gut microbiota
- prebiotics
- probiotics
- adsorbents
- protein-bound uremic toxins
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