Diagnosis, Epidemiology, and Control of Lymphatic Filariasis

A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366). This special issue belongs to the section "Neglected and Emerging Tropical Diseases".

Deadline for manuscript submissions: closed (28 August 2023) | Viewed by 2951

Special Issue Editors


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Guest Editor
Division of Infectious Diseases, Washington University School of Medicine in St. Louis, St. Louis, MO, USA
Interests: redox balance; drug development; biomarker; antioxidants; inflammation; epidemiology; diagnostics of filariasis

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Guest Editor
Department of Zoology, Visva-Bharati, Santiniketan, India
Interests: antifilarial drug development; immunology of lymphatic filariasis; apoptosis; epidemiology

Special Issue Information

Dear Colleagues,

This Special Issue entitled “Diagnosis, Epidemiology, and Control of Lymphatic Filariasis” has been framed to assemble up-to-date information related to this neglected tropical disease. Despite widespread drug administration (mass drug administration), this disease is still prevalent in certain geographical areas. Therefore, updated epidemiological understanding is necessary for therapeutic intervention. On the other hand, efficient diagnostic strategies are lacking. The only detection kits available are not potent enough to diagnose co-infection if any is present. This failure of detection can be a major cause behind the adverse effects of drug administration. However, the specific aim of this issue is not only diagnosis and the epidemiological study of this parasitic disease, but also identification of controlling measures. Presently available therapeutics are not promising enough when it comes to killing the adult parasites inside the host. Thus, there is an urgent need for potent adulticidal drugs as well. In addition to these, we will also be interested in including preliminary overviews of the clinical trials going on, vaccine development, and studies on host–parasite interactions. Prominent understanding of those aspects will help to control this disease or at least to eradicate it to some extent.

Dr. Nikhilesh Joardar
Prof. Dr. Santi Prasad Sinha Babu
Guest Editors

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Keywords

  • antifilarial compounds
  • redox homeostasis
  • filarial-parasite-induced inflammation
  • diagnostic marker
  • epidemiology

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Published Papers (1 paper)

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Review

11 pages, 263 KiB  
Review
Zambia: A Narrative Review of Success and Challenges in Lymphatic Filariasis Elimination
by Kingford Chimfwembe, Hugh Shirley, Natalie Baker and Richard Wamai
Trop. Med. Infect. Dis. 2024, 9(1), 21; https://doi.org/10.3390/tropicalmed9010021 - 15 Jan 2024
Cited by 2 | Viewed by 2623
Abstract
The establishment of the Global Programme to Eliminate Lymphatic Filariasis (GPELF) to stop the transmission of infection has significantly reduced the incidence of lymphatic filariasis, a debilitating mosquito-borne neglected tropical disease. The primary strategies that have been employed include mass drug administration (MDA) [...] Read more.
The establishment of the Global Programme to Eliminate Lymphatic Filariasis (GPELF) to stop the transmission of infection has significantly reduced the incidence of lymphatic filariasis, a debilitating mosquito-borne neglected tropical disease. The primary strategies that have been employed include mass drug administration (MDA) of anthelminthics and morbidity management and disability prevention (MMDP). While some countries have been able to reach elimination status in Africa, there is still active transmission of LF in Zambia. The nematode responsible for the disease is Wuchereria bancrofti, which is transmitted by Anopheles mosquitoes. To alleviate the suffering of those infected by the disease, the Zambian Ministry of Health launched a program to eliminate LF as a public health problem in 2003. This project reviewed the efforts to achieve the elimination of LF in Zambia, past and present government policies, and the anticipated challenges. MDAs have been conducted since 2014 and coverage has been between 87% and 92%. Zambia has now moved towards pre-transmission assessment surveys (PRETAS) and transmission assessment surveys (TAS). MMDP is a major priority and planned to be conducted between 2022 and 2026. COVID-19 presented a new challenge in the control of LF, while climate change, immigration, co-infections, and funding limitations will complicate further progress. Full article
(This article belongs to the Special Issue Diagnosis, Epidemiology, and Control of Lymphatic Filariasis)
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