Immune Responses in Patients with Inflammatory Bowel Disease After Vaccination

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Clinical Immunology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1708

Special Issue Editors


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Guest Editor
Department of Medicine B for Gastroenterology, Hepatology, Endocrinology and Clincial Infectiology, University Hospital Muenster, 48149 Muenster, Germany
Interests: clinical infectiology (opportunistic infections, HIV, viral hepatitis, mycobacterioses, gastrointestinal infections); chronic inflammatory bowel diseases

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Guest Editor
1. Department for Gastroenterology, Diabetology and Palliative Care, Bonifatius Hospital Lingen, 49808 Lingen, Germany
2. Department for Gastroenterology, Hepatology and Transplant Medicine, University Hospital Essen, 45147 Essen, Germany
Interests: inflammatory bowel disease; opportunistic infections

Special Issue Information

Dear Colleagues,

We are pleased to invite you to publish your work in this Special Issue, ‘Immune Responses in Patients with Inflammatory Bowel Disease after Vaccination’. Patients with inflammatory bowel disease often require immunomodulatory therapies to control their symptoms and intestinal inflammation. To date, numerous drugs from different drug classes have been approved. Combination therapies are being increasingly discussed for refractory IBD courses. Immunomodulation potentially leads to a restricted immune response after application of vaccines in these patients. As a result, the protective effect of vaccines against infections and severe disease progression may be reduced. In addition, the risk of opportunistic infections and severe courses of conventional infections increases, particularly with combined immunomodulatory therapy.

This Special Issue aims to gather important insights into the immune response to vaccination in patients with inflammatory bowel disease. Both original research articles and reviews are welcome. Research areas may include (but not limited to) basic scientific findings on vaccination from the fields of virology, bacteriology and immunology, innovative approaches to vaccine development and clinical studies on vaccine response and disease progression in IBD patients. Of particular interest are the approaches to prevent opportunistic infections such as cytomegalovirus reactivation.

We look forward to receiving your contributions.

Dr. Phil-Robin Tepasse
Dr. Arne Bokemeyer
Guest Editors

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Keywords

  • inflammatory bowel disease
  • vaccination
  • opportunistic infections
  • immune response
  • immunomodulatory therapy

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Published Papers (1 paper)

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Review

16 pages, 1091 KiB  
Review
Beyond Suppression: Peripheral T Cell Responses to Vaccination in Inflammatory Bowel Disease Patients Undergoing Anti-Tumor-Necrosis-Factor Therapy
by Martin Qui and Ennaliza Salazar
Vaccines 2024, 12(11), 1280; https://doi.org/10.3390/vaccines12111280 - 14 Nov 2024
Viewed by 1118
Abstract
Alimentary tract inflammation in inflammatory bowel disease (IBD) is treated by systemically administered drugs that alter fundamental host immune responses. Biologics that target tumor necrosis factor (TNF) are first-line biologics in IBD, used widely for their effectiveness, steroid-sparing quality, and lower cost. While [...] Read more.
Alimentary tract inflammation in inflammatory bowel disease (IBD) is treated by systemically administered drugs that alter fundamental host immune responses. Biologics that target tumor necrosis factor (TNF) are first-line biologics in IBD, used widely for their effectiveness, steroid-sparing quality, and lower cost. While they enable a significant proportion of patients to achieve clinical remission, they carry an increased risk of infection and poor serological responses to vaccination. Conversely, our understanding of adaptive T cell responses in anti-TNF-treated IBD patients remains limited. The introduction of COVID-19 vaccines has prompted research that both challenges and refines our view on immunomodulatory therapy and its potential implications for immunity and protection. Here, we review these emergent findings, evaluate how they shape our understanding of vaccine-induced T cell responses in the context of anti-TNF therapy in IBD, and provide a perspective highlighting the need for a holistic evaluation of both cellular and humoral immunity in this population. Full article
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