Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.9
5.2
Journals
Vaccines
Special Issues
Humoral and Cellular Response after Vaccination
share announcement

Humoral and Cellular Response after Vaccination

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Cellular/Molecular Immunology".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 3153

Special Issue Editors

Dr. Adrian Onu

E-Mail Website
Guest Editor
1. “Cantacuzino” Institute, 050096 Bucharest, Romania
2. Faculty of Pharmacy, Titu Maiorescu University, 040317 Bucharest, Romania
Interests: vaccine technology; biotechnology; immune response; proteomics; protein biophysics
Dr. Iuliana Caras

E-Mail Website
Guest Editor
Cantacuzino, National Medical-Military Institute for Research and Development, 050096 Bucharest, Romania
Interests: immune response; innate immunity; dendritic cells; toll-like receptors

Special Issue Information

Dear Colleagues,

Efficient vaccination relies on inducing a robust adaptive immune response, both cellular and humoral, each playing a specific role in preventing or controlling infection. The challenge in developing an effective vaccine lies in finding the right balance between the different types of immune response required. To evaluate a vaccine, a range of methods have been developed. Immunization markers are constantly evolving, and sometimes newer markers from large data sets, identified through principal component analysis, replace traditional ones. In addition to the polarization of the immune response, the impact of immunization on innate immunity (trained immunity) calls for the use of additional instruments and concepts to assess vaccine effectiveness.

This special issue seeks to provide an overview of the current methodology for evaluating vaccines, from the design phase to clinical trials. The proposed articles aim to offer relevant insights into these concepts in the field of modern vaccination.

Dr. Adrian Onu
Dr. Iuliana Caras
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vaccine
  • infectious disease
  • humoral immunity
  • cellular immunity
  • innate immunity
  • trained immunity
  • pathogen
  • virus

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

28 pages, 4868 KiB  
Article
A Serum Multi-Parametric Analysis Identifies an Early Innate Immune Signature Associated to Increased Vaccine-Specific Antibody Production and Seroconversion in Simultaneous COVID-19 mRNA and Cell-Based Quadrivalent Influenza Vaccination
by Martina Severa, Daniela Ricci, Marilena Paola Etna, Marzia Facchini, Simona Puzelli, Giorgio Fedele, Egidio Iorio, Giada Cairo, Sara Castrechini, Valentina Ungari, Marco Iannetta, Pasqualina Leone, Mattea Chirico, Maria Elena Pisanu, Barbara Bottazzi, Livia Benedetti, Michela Sali, Remo Bartolomucci, Stefano Balducci, Cecilia Garlanda, Paola Stefanelli, Antonietta Spadea, Anna Teresa Palamara and Eliana Marina Cocciaadd Show full author list remove Hide full author list
Vaccines 2024, 12(9), 1050; https://doi.org/10.3390/vaccines12091050 - 13 Sep 2024
Viewed by 1058
Abstract
In this pilot study, a multi-parametric analysis comparing immune responses in sera of adult healthy subjects (HS) or people with type 2 diabetes mellitus (T2D) undergoing the single or simultaneous administration of mRNA-based COVID-19 and cellular quadrivalent inactivated influenza vaccines was conducted. While [...] Read more.
In this pilot study, a multi-parametric analysis comparing immune responses in sera of adult healthy subjects (HS) or people with type 2 diabetes mellitus (T2D) undergoing the single or simultaneous administration of mRNA-based COVID-19 and cellular quadrivalent inactivated influenza vaccines was conducted. While SARS-CoV-2 antibodies remains comparable, influenza antibody titers and seroconversion were significantly higher upon simultaneous vaccination. Magnitude of anti-influenza humoral response closely correlated with an early innate immune signature, previously described for the COVID-19 vaccine, composed of IL-15, IL-6, TNF-α, IFN-γ, CXCL-10 and here extended also to acute-phase protein Pentraxin 3. People with T2D receiving simultaneous vaccination showed a protective response comparable to HS correlating with the early induction of IFN-γ/CXCL10 and a significant reduction of the circulating glucose level due to increased oxidation of glucose digestion and consumption. These data, although preliminary and in-need of validation in larger cohorts, might be exploited to optimize future vaccination in people with chronic disorders, including diabetes. Full article
(This article belongs to the Special Issue Humoral and Cellular Response after Vaccination)
►▼ Show Figures

Figure 1

14 pages, 2178 KiB  
Article
Local Immune Activation and Age Impact on Humoral Immunity in Mice, with a Focus on IgG Sialylation
by Priti Gupta, Tibor Sághy, Miriam Bollmann, Tao Jin, Claes Ohlsson, Hans Carlsten, Carmen Corciulo and Cecilia Engdahl
Vaccines 2024, 12(5), 479; https://doi.org/10.3390/vaccines12050479 - 29 Apr 2024
Viewed by 1199
Abstract
Age alters the host’s susceptibility to immune induction. Humoral immunity with circulating antibodies, particularly immunoglobulin G (IgG), plays an essential role in immune response. IgG glycosylation in the fragment crystallizable (Fc) region, including sialylation, is important in regulating the effector function by interacting [...] Read more.
Age alters the host’s susceptibility to immune induction. Humoral immunity with circulating antibodies, particularly immunoglobulin G (IgG), plays an essential role in immune response. IgG glycosylation in the fragment crystallizable (Fc) region, including sialylation, is important in regulating the effector function by interacting with Fc gamma receptors (FcγRs). Glycosylation is fundamentally changed with age and inflammatory responses. We aimed to explore the regulation of humoral immunity by comparing responses to antigen-induced immune challenges in young and adult mice using a local antigen-induced arthritis mouse model. This study examines the differences in immune response between healthy and immune-challenged states across these groups. Our initial assessment of the arthritis model indicated that adult mice presented more severe knee swelling than their younger counterparts. In contrast, we found that neither histological assessment, bone mineral density, nor the number of osteoclasts differs. Our data revealed an age-associated but not immune challenge increase in total IgG; the only subtype affected by immune challenge was IgG1 and partially IgG3. Interestingly, the sialylation of IgG2b and IgG3 is affected by age and immune challenges but not stimulated further by immune challenges in adult mice. This suggests a shift in IgG towards a pro-inflammatory and potentially pathogenic state with age and inflammation. Full article
(This article belongs to the Special Issue Humoral and Cellular Response after Vaccination)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop