Viral Hepatitis and Hepatocellular Carcinoma
A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Hepatitis Virus Vaccines".
Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 5206
Special Issue Editor
Special Issue Information
Dear Colleagues,
As we know, ‘viral hepatitis’ is a broad term to describe liver damage due to hepatitis virus (A, B, C, D and E) infection. While hepatitis A and E viruses cause acute hepatitis; hepatitis B, C and D viruses can cause both acute and chronic infections. Chronic hepatitis can lead to complications such as cirrhosis, liver failure and liver cancer, especially hepatocellular carcinoma (HCC).
Hepatitis B and C virus (HBV and HCV) infections are leading cause of HCC worldwide. According to world health organisation (WHO) statistics, 500 million people are estimated to be infected with HBV or HCV worldwide. These viruses kill 1.5 million people a year; 1 in every 3 people has been exposed to either or both viruses and most infected people do not know about it due to dormant symptoms.
A safe and effective vaccine against HBV is now available and universal vaccination programs are being run aiming to eliminate HBV-related viral hepatitis as a public health threat by 2030. There is no vaccine for HCV however, a major advance in the liver field in last 5 years has been the introduction of direct acting antivirals (DAAs) targeting HCV infection. Although these agents are costly, it is now clear that the majority of patients can be cured of HCV infection thus reducing further complications and associated death rates. What is also increasingly clear, however, is that while this reduces HCC risk in infected individuals, the risk is not eliminated – in either the global population treated with antivirals, or in those with HCV receiving curative treatments for HCC. Why this risk persists is not presently known.
HCC is a stepwise process and involves a combination of genetic and epigenetic alterations. Hence, in this special issue I invite you to submit original articles, case reports or review articles to advance our existing knowledgebase regarding (i) viral hepatitis prevention or treatment, (ii) screening of chronic hepatitis patients to assess HCC development, (iii) molecular pathogenesis of viral hepatitis-related HCC development and (iv) novel treatment strategies for viral hepatitis-related HCC.
Dr. Ruchi Shukla
Guest Editor
Manuscript Submission Information
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Keywords
- Viral Hepatitis
- Liver Cancer
- Hepatocellular Carcinoma
- HCC Risk
- Cancer Prevention
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