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Veterinary Sciences
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Advanced Therapy in Companion Animals
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Advanced Therapy in Companion Animals

A special issue of Veterinary Sciences (ISSN 2306-7381).

Deadline for manuscript submissions: 1 March 2025 | Viewed by 4554

Special Issue Editors

Dr. Ziyao Zhou

E-Mail Website
Guest Editor
Department of Veterinary Surgery, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Interests: veterinary dentistry; computer-aid design personalized medicine
Prof. Dr. Zhijun Zhong

E-Mail Website
Guest Editor
Department of Veterinary Surgery, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Interests: microbiology; antibiotic resistance

Special Issue Information

Dear Colleagues,

The Special Issue on "Advanced Therapy in Companion Animals" focuses on the latest innovations and techniques in veterinary medicine aimed at improving the health and well-being of pets. This edition explores cutting-edge therapies, including regenerative medicine, gene therapy, immunotherapy, and precision medicine, which are revolutionizing the treatment of chronic and acute conditions in companion animals. By highlighting breakthroughs in diagnostics, personalized treatment plans, and minimally invasive surgical procedures, the issue underscores the growing role of advanced technology in extending and enhancing the quality of life for pets. The special edition also emphasizes the importance of interdisciplinary collaboration between veterinarians, researchers, and biotechnologists to drive further progress in the field. With a combination of case studies, clinical trials, and expert reviews, this issue serves as a comprehensive resource for veterinary professionals seeking to stay at the forefront of advanced therapeutic approaches.

Dr. Ziyao Zhou
Prof. Dr. Zhijun Zhong
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • regenerative medicine
  • gene therapy
  • immunotherapy
  • precision medicine
  • companion animals
  • veterinary innovation
  • chronic conditions
  • personalized treatment
  • minimally invasive surgery
  • interdisciplinary collaboration

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Published Papers (5 papers)

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Research

13 pages, 2080 KiB  
Article
Changes in Biomarkers of Inflammation and Oxidative Status in Dogs Subjected to Celiotomy or Video-Assisted Ovariohysterectomy
by Fabíola Dalmolin, Camila Peres Rubio, Carla Sordi Furlanetto, Rafael Steffens, Najla Ibrahim Isa Abdel Hadi, Adriellen de Lima da Silva, Paloma Tomazi, Bernardo Nascimento Antunes, Fabiana Elias, Elizabeth Moreira dos Santos Schmidt and Maurício Veloso Brun
Vet. Sci. 2024, 11(11), 583; https://doi.org/10.3390/vetsci11110583 - 19 Nov 2024
Viewed by 366
Abstract
We evaluated the surgical stress response of dogs undergoing three ovariohysterectomy (OVH) techniques. Twenty-nine healthy females were allocated into groups: celiotomy and ligature (CelioSut), celiotomy and bipolar energy (CelioBip), and a video-assisted technique using two portals and bipolar energy (VidBip). Clinical evaluation was [...] Read more.
We evaluated the surgical stress response of dogs undergoing three ovariohysterectomy (OVH) techniques. Twenty-nine healthy females were allocated into groups: celiotomy and ligature (CelioSut), celiotomy and bipolar energy (CelioBip), and a video-assisted technique using two portals and bipolar energy (VidBip). Clinical evaluation was performed, and the following blood analyses were determined: acute phase proteins (C-reactive protein and haptoglobin), white blood cell counting (WBC), and biomarkers of oxidative status. The VidBip required more time despite a smaller incision, lower heart rate, and earlier feeding and urination. All groups had high white blood cells counts; the C-reactive protein (CRP) levels peaked at 6 and 12 h in all groups and was higher in the CelioBip and VidBip groups compared to CelioSut; haptoglobin concentrations peaked at 48 h in all groups and increased in dogs of the CelioSut group. Trolox equivalent antioxidant capacity, ferric reducing ability of plasma, cupric reducing antioxidant capacity, and advanced oxidation protein were not significantly different among the groups or time points. Total thiol concentrations were lower in CelioBip and CelioSut groups. All surgical techniques induced an inflammatory and oxidative stress response, but the video-assisted technique produced early clinical recovery. The bipolar device produces fewer disturbances than suspensory ligament rupture and ligature. Full article
(This article belongs to the Special Issue Advanced Therapy in Companion Animals)
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19 pages, 1874 KiB  
Article
Evaluation of Haematological Ratios at: Different Stages of Canine Periodontal Disease
by Carolina Silva, Ana Carolina Abrantes, Ana Carolina Fontes, Isabel Dias, Rosário Domingues, Francisco Peixoto and Carlos Viegas
Vet. Sci. 2024, 11(11), 581; https://doi.org/10.3390/vetsci11110581 - 19 Nov 2024
Viewed by 315
Abstract
This is a retrospective study about haematological ratios in different stages of canine periodontal disease in one single breed, more specifically the Portuguese Podengo. The aim of the study was to assess the clinical significance of five haematological ratios, namely neutrophil-to-lymphocyte ratio (NLR), [...] Read more.
This is a retrospective study about haematological ratios in different stages of canine periodontal disease in one single breed, more specifically the Portuguese Podengo. The aim of the study was to assess the clinical significance of five haematological ratios, namely neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume-to-platelet count ratio (MPV/PLT), monocyte-to-lymphocyte ratio (MLR), and platelet-to-neutrophil ratio (PNR), easily obtained through the parameters provided by the complete blood count, in the stages of gingivitis and periodontitis, compared to clinical healthy individuals. Receiver operating characteristic curves were generated to identify ideal sensitivity and specificity cut-offs for cases of gingivitis or periodontitis. Our study included 80 dogs, which comprised 24 healthy dogs, 26 diagnosed with gingivitis, and 30 with periodontitis. The median NLR was significantly lower in periodontitis than in clinical healthy dogs (p = 0.040) and in dogs with gingivitis (p = 0.037). The median PLR was significantly lower in cases of gingivitis (p = 0.020) and periodontitis (p = 0.024) than in healthy dogs. MPV/PLT and MLR did not demonstrate significant differences between any of the three groups. The median PNR was significantly lower in gingivitis than in control dogs (p = 0.019). PNR had the highest accurate results, in distinguishing between healthy individuals and those with gingivitis, with an area under the curve of 0.692 (95% CI [0.539–0.845], p = 0.020). However, even this index had weak discriminatory power between the groups in the analysis. The impact of systemic inflammation generated by canine periodontal disease can thus be seen through some of these indices. However, the results obtained here demonstrate the need for complementarity with other methods to diagnose canine periodontal disease and reinforce the need for additional studies with more markers of systemic inflammatory response. Full article
(This article belongs to the Special Issue Advanced Therapy in Companion Animals)
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10 pages, 2232 KiB  
Article
Extensive Epidural Hemorrhage Associated with Thoracolumbar Disc Extrusion in French Bulldogs
by Julius Underberg, Arianna Maiolini, Maja Waschk and Daniela Schweizer
Vet. Sci. 2024, 11(11), 573; https://doi.org/10.3390/vetsci11110573 - 16 Nov 2024
Viewed by 394
Abstract
(1) Background: Intervertebral disc extrusion may be accompanied by extensive epidural hemorrhage (EEH) and result in spinal cord compression. EEH is more commonly seen in French Bulldogs compared to other breeds. The majority of French Bulldogs have lumbar intervertebral disc extrusion, but it [...] Read more.
(1) Background: Intervertebral disc extrusion may be accompanied by extensive epidural hemorrhage (EEH) and result in spinal cord compression. EEH is more commonly seen in French Bulldogs compared to other breeds. The majority of French Bulldogs have lumbar intervertebral disc extrusion, but it is unclear if there is an association between the site of thoracolumbar disc extrusion and EEH. This retrospective study’s aim was to investigate the association and prevalence between the site of thoracolumbar intervertebral disc extrusion and EEH in French Bulldogs. (2) Methods: Thoracolumbar MRI of French Bulldogs was examined for the site of intervertebral disc extrusion and the presence, distribution, and extent of EEH. (3) Results: In 148 French Bulldogs with thoracolumbar intervertebral disc extrusion, the most common location was L4/L5 (22%), followed by L3/L4 (20%) and T13/L1 (15%), and 70.3% had EEH. The highest incidence of EEH across all thoracolumbar sites was seen at L1/L2 (84.2%), followed by L5/L6 (81.3%) and L2/L3 (72.2%). The incidence of EEH was 70.5% across all lumbar sites and 66.9% for all thoracic sites. (4) Conclusion: In this population of French Bulldogs, the prevalence of lumbar disc extrusion was high, and 70.3% had EEH. There was no significant difference between the site of thoracolumbar intervertebral disc extrusion and EEH. Full article
(This article belongs to the Special Issue Advanced Therapy in Companion Animals)
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25 pages, 5177 KiB  
Article
Feline Infectious Peritonitis Effusion Index: A Novel Diagnostic Method and Validation of Flow Cytometry-Based Delta Total Nucleated Cells Analysis on the Sysmex XN-1000V®
by Ricardo Lopes, Filipe Sampaio, Hugo Lima de Carvalho, Andreia Garcês, Cátia Fernandes, Carolina Vitória Neves, Alexandre Sardinha de Brito, Tiago Marques, Carlos Sousa, Ana Rita Silva, Ângela Martins, Luís Cardoso, Ana Cláudia Coelho and Elsa Leclerc Duarte
Vet. Sci. 2024, 11(11), 563; https://doi.org/10.3390/vetsci11110563 - 13 Nov 2024
Viewed by 903
Abstract
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led the medical and scientific community to explore the pathogenesis and clinical manifestations of coronaviruses. In felines, a widespread coronavirus known as feline coronavirus (FCoV) can lead to feline infectious peritonitis (FIP), [...] Read more.
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led the medical and scientific community to explore the pathogenesis and clinical manifestations of coronaviruses. In felines, a widespread coronavirus known as feline coronavirus (FCoV) can lead to feline infectious peritonitis (FIP), a highly fatal disease characterised by severe systemic inflammation. Diagnosing FCoV remains challenging due to the limited accuracy of the available methods. The present study introduces the FIP Effusion Index, a novel diagnostic method that combines the albumin-to-globulin (ALB/GLOB) ratio with the delta total nucleated cell (∆TNC) count obtained via flow cytometry using the Sysmex XN-1000V® analyser in effusions. Samples from cats (n = 50) with suspected FIP were analysed for ∆TNC, with findings showing that a ∆TNC ≥ 2.1 is highly indicative of FIP and a ∆TNC ≥ 4.9 can be considered diagnostic. The FIP Effusion Index enhanced diagnostic precision in our group of samples, achieving 96.3% sensitivity and 95.7% specificity for values ≥ 5.06, and reaching perfect specificity (100%) with 96.3% sensitivity for values ≥ 7.54. This combined approach surpasses the accuracy of individual parameters, establishing the FIP Effusion Index as a superior diagnostic tool for FIP, with potential applications in both veterinary and human medicine for related coronavirus diseases. Full article
(This article belongs to the Special Issue Advanced Therapy in Companion Animals)
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11 pages, 451 KiB  
Article
Treatment with Leflunomide in Conjunction with Glucocorticoids for Dogs with Immune-Mediated Polyarthritis Is Not Associated with Improved Outcomes: A Retrospective Cohort Study of 93 Dogs from Australia (2017–2024)
by Remon Wilson, Inar Swift, Mikaela Groth-Semple, Sabrina Lee, Tamara Dann, Ahmed Arafa, Curtis Poyton and Mary Thompson
Vet. Sci. 2024, 11(11), 537; https://doi.org/10.3390/vetsci11110537 - 1 Nov 2024
Viewed by 1954
Abstract
Immune-mediated polyarthritis (IMPA) has a relatively high relapse rate compared to other immune-mediated diseases. Leflunomide is frequently used to treat dogs with IMPA in conjunction with prednisolone. This retrospective cohort study aimed to evaluate the therapeutic efficacy of leflunomide as an adjunctive therapy [...] Read more.
Immune-mediated polyarthritis (IMPA) has a relatively high relapse rate compared to other immune-mediated diseases. Leflunomide is frequently used to treat dogs with IMPA in conjunction with prednisolone. This retrospective cohort study aimed to evaluate the therapeutic efficacy of leflunomide as an adjunctive therapy to prednisolone in reducing relapse and mortality rates in dogs diagnosed with IMPA in Australia. The medical records of client-owned dogs diagnosed with IMPA at a specialist referral hospital in Southeast Queensland from 2017 to 2024 were reviewed. A total of 93 dogs were included in this study, divided into two groups based on the treatment received: Group PRED, consisting of 53 dogs treated with prednisolone as the sole immunosuppressive agent, and Group L+PRED, consisting of 40 dogs that received leflunomide as adjunctive therapy alongside prednisolone. Data collected included breed, age, weight, sex, serum C-reactive protein concentration, results of synovial fluid analysis and microbial culture, treatment protocol, relapse rates and time to relapse, and mortality rates. There was no difference in relapse or mortality rates, time to relapse, nor time to discontinue prednisolone between the PRED and L+PRED groups. The L+PRED group had higher body weights and lower prednisolone dose rate at discharge compared to those in the PRED group. This study demonstrated that the use of leflunomide as an adjunctive therapy to prednisolone for the treatment of dogs with IMPA had no improved outcomes, reduced relapse rates, or shortening in the duration of prednisolone therapy when compared to dogs receiving prednisolone monotherapy. Full article
(This article belongs to the Special Issue Advanced Therapy in Companion Animals)
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