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Veterinary Sciences
Special Issues
Canine and Feline Mammary Tumors
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Canine and Feline Mammary Tumors

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Veterinary Biomedical Sciences".

Deadline for manuscript submissions: closed (20 November 2022) | Viewed by 9609

Special Issue Editors

Dr. Barbara Brunetti

E-Mail Website
Guest Editor
Department of Veterinary Medical Sciences, University of Bologna Via Tolara di sopra, 50, Ozzano dell’Emilia, 40064 Bologna, Italy
Interests: veterinary oncology; canine and feline mammary carcinomas; HER2 oncogene; pulmonary carcinoma
Special Issues, Collections and Topics in MDPI journals
Dr. Barbara Bacci

E-Mail Website
Guest Editor
Department of Veterinary Medical Sciences, University of Bologna Via Tolara di sopra, 50, Ozzano dell’Emilia, 40064 Bologna, Italy
Interests: canine and feline pathology; equine pathology; oncology; immunohistochemistry; digital pathology
Special Issues, Collections and Topics in MDPI journals
Dr. Luisa Vera Muscatello

E-Mail Website
Guest Editor
Department of Veterinary Medical Sciences, University of Bologna Via Tolara di sopra, 50, Ozzano dell’Emilia, 40064 Bologna, Italy
Interests: cancer cytogenetics; mammary tumors; liver pathology

Special Issue Information

Dear Colleagues,

The purpose of this Special Issue is to investigate canine and feline mammary tumors. The incidence of these neoplasms is strongly influenced by cultural and socio-economic factors and it would be very interesting to have an overview with scientific papers from a range of different countries. In Western countries, early spaying is increasingly common and this greatly influences the occurrence and appearance of mammary tumors; pets are subjected to high standards of veterinary care and even very small lesions are immediately excised; hence, it would be interesting to evaluate how this has influenced the proportion between benign and malignant neoplasms over the years and how this information can improve the development of new therapies for our pets.

The types of carcinomas that can arise from the canine and feline mammary gland are extremely heterogeneous. In fact, the number of entities included in classification of mammary tumors in dogs and cats has significantly increased from the older WHO classification to the more recently published classification of the Davis–Thompson Foundation. Feline and canine mammary carcinomas also have many similarities to breast cancers in women, which could be of potential interest for the development of animal models for human diseases. The purpose of this Special Issue is to collect scientific works on feline and canine mammary tumors from all points of view: clinical, surgical, pathological, comparative and therapeutic.

You are invited to submit either an original article or a review summarizing different aspects of canine and feline mammary tumors. Articles highlighting and documenting any aspect of canine and feline mammary tumors are welcome and will be taken into consideration for publication.

Dr. Barbara Brunetti
Dr. Barbara Bacci
Dr. Luisa Vera Muscatello
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mammary tumors
  • feline
  • canine
  • molecular profile
  • prognostic markers
  • therapy

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Published Papers (3 papers)

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Research

11 pages, 3268 KiB  
Article
Antitumor Effects of Esculetin, a Natural Coumarin Derivative, against Canine Mammary Gland Tumor Cells by Inducing Cell Cycle Arrest and Apoptosis
by Jawun Choi, Min-Jae Yoo, Sang-Youel Park and Jae-Won Seol
Vet. Sci. 2023, 10(2), 84; https://doi.org/10.3390/vetsci10020084 - 22 Jan 2023
Cited by 12 | Viewed by 2928
Abstract
Mammary gland tumors are the most common neoplasms in female dogs, of which 50% are malignant. Esculetin, a coumarin derivative, reportedly induces death in different types of cancer cells. In this study, we explore the anticancer effects of esculetin against CMT-U27 and CF41.mg [...] Read more.
Mammary gland tumors are the most common neoplasms in female dogs, of which 50% are malignant. Esculetin, a coumarin derivative, reportedly induces death in different types of cancer cells. In this study, we explore the anticancer effects of esculetin against CMT-U27 and CF41.mg canine mammary gland tumor cells. Esculetin significantly inhibited the viability and migration of both CMT-U27 and CF41.mg cells in a dose- and time-dependent manner. Flow cytometric analysis and terminal deoxynucleotidyl transferase dUTP nick-end labeling assay revealed increased numbers of annexin-V-positive cells and DNA fragmentation. Furthermore, a cell cycle analysis demonstrated that esculetin blocked the cell progression at the G0/G1 phase and the S phase in CMT-U27 and CF41.mg cells. These results were supported by a Western blot analysis, which revealed upregulated protein expression of cleaved caspase-3, a marker of apoptosis, and downregulated cyclin-dependent kinase 4 and cyclin D1 protein, the cell cycle regulators. In conclusion, this novel study proves that esculetin exerts in vitro antitumor effects by inducing apoptosis and cell cycle arrest in canine mammary gland tumors. Full article
(This article belongs to the Special Issue Canine and Feline Mammary Tumors)
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14 pages, 1829 KiB  
Article
HER2 Overexpression and Cytogenetical Patterns in Canine Mammary Carcinomas
by L. V. Muscatello, F. Gobbo, E. Di Oto, G. Sarli, R. De Maria, A. De Leo, G. Tallini and B. Brunetti
Vet. Sci. 2022, 9(11), 583; https://doi.org/10.3390/vetsci9110583 - 22 Oct 2022
Cited by 9 | Viewed by 2159
Abstract
Human epidermal growth factor receptor 2 (HER2) is a tyrosine kinase receptor that promotes tumor cell growth and is implicated in the pathogenesis of human breast cancer. The role of HER2 in canine mammary carcinomas (CMCs) is not clear. Therefore, this study aimed [...] Read more.
Human epidermal growth factor receptor 2 (HER2) is a tyrosine kinase receptor that promotes tumor cell growth and is implicated in the pathogenesis of human breast cancer. The role of HER2 in canine mammary carcinomas (CMCs) is not clear. Therefore, this study aimed to examine the protein expression and cytogenetic changes of HER2 and their correlation with other clinical–pathological parameters in CMC. We retrospectively selected 112 CMCs. HER2, ER, and Ki67 were assessed by immunohistochemistry. HER2 antibody validation was investigated by immunoblot on mammary tumor cell lines. Fluorescence in situ hybridization (FISH) was performed with probes for HER2 and CRYBA1 (control gene present on CFA9). HER2 protein overexpression was detected in 15 carcinomas (13.5%). A total of 90 carcinomas were considered technically adequate by FISH, and 8 out of 90 CMC (10%) were HER2 amplified, 3 of which showed a cluster-type pattern. HER2 overexpression was correlated with an increased number of HER2 gene copies (p = 0.01; R = 0.24) and overall survival (p = 0.03), but no correlation with ER, Ki67, grade, metastases, and tumor-specific survival was found. Surprisingly, co-amplification or polysomy was identified in three tumors, characterized by an increased copy number of both HER2 and CRYBA1. A morphological translocation-fusion pattern was recognized in 20 carcinomas (22%), with a co-localized signal of HER2 and CRYBA1. HER2 is not associated with clinical–pathological parameters of increased malignancy in canine mammary tumors, but it is suitable for studying different amplification patterns. Full article
(This article belongs to the Special Issue Canine and Feline Mammary Tumors)
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14 pages, 5915 KiB  
Article
LncRNA Expression Profiles in Canine Mammary Tumors Identify lnc34977 as a Promoter of Proliferation, Migration and Invasion of Canine Mammary Tumor Cells
by Baochun Lu, Juye Wu, Hebi Chen, Shoujun Li and Kun Jia
Vet. Sci. 2022, 9(2), 82; https://doi.org/10.3390/vetsci9020082 - 15 Feb 2022
Cited by 7 | Viewed by 2976
Abstract
Canine mammary tumor (CMT) is the most common tumor in canines after skin tumors. Long noncoding RNAs (lncRNAs) have crucial roles in human breast tumor initiation and progression, but the role of lncRNAs in canine mammary tumors is unclear. We analyzed the expression [...] Read more.
Canine mammary tumor (CMT) is the most common tumor in canines after skin tumors. Long noncoding RNAs (lncRNAs) have crucial roles in human breast tumor initiation and progression, but the role of lncRNAs in canine mammary tumors is unclear. We analyzed the expression profiles of canine mammary tumors and their adjacent non-neoplastic tissue to explore abnormally expressed lncRNAs. LncRNA expression was detected by qRT–PCR. After overexpression of lnc40589 and knockdown of lnc34977 in CMT cells, CCK-8, colony formation, wound healing and Transwell assays were used to assess the proliferation, migration and invasive ability of canine mammary tumor cells. We also established a mammary tumor-bearing nude mouse model. GO analysis and KEGG pathway analysis demonstrated that the differentially expressed lncRNAs were closely related to the mammary tumor. lnc40589 was significantly upregulated and lnc34977 was significantly downregulated in CMTs. In addition, lnc40589 inhibits cell proliferation, migration and invasion, while lnc34977 promotes cell proliferation, migration and invasion. In addition, lnc34977 promotes the development of mammary tumors in animals. Taken together, our study results reveal the lncRNA expression profiles in CMTs and indicate that lnc34977 promotes the development of CMT both in cell culture and in vivo. Full article
(This article belongs to the Special Issue Canine and Feline Mammary Tumors)
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