Bacterial Porins and Their Implication in Pathophysiology of Septic Complications In Vitro and In Vivo

Topic Information

Dear Colleagues,

Bacterial porins control cellular interactions with host proteins and other circulating substances, such as drugs and nutrients. They may act as toxins, damaging different systems and organs in the host. For this reason, they play a fundamental role in the processes involved in drug resistance and bacterial-induced complications, such as thrombosis, bleeding, and septic shock. Our in vitro experience in the early 2000s showed that bacterial porin from salmonella is able to activate the clotting cascade with the direct activation of thrombin, explaining its frequent association with thrombosis and disseminated intravascular coagulation. Furthermore, resistance towards drugs other than antibiotics may also explain other types of complications, such as kidney or liver failure. Therefore, this multidisciplinary topic of Toxins is directed to scholars that are experts not only in the field of bacterial porins, but also in the clinical spectrum of their induced complications, such as septic shock, disseminated intravascular coagulation, thrombosis of small or large vessels, and kidney or liver failure.

Dr. Pierpaolo Di Micco
Dr. Alessandro Perrella
Dr. Olga Scudiero
Topic Editors

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Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Antibiotics antibiotics	4.3	7.3	2012	14.7 Days	CHF 2900	Submit
Applied Microbiology applmicrobiol	-	-	2021	16.3 Days	CHF 1000	Submit
Immuno immuno	2.1	2.6	2021	28.1 Days	CHF 1000	Submit
Medicina medicina	2.4	3.3	1920	17.8 Days	CHF 2200	Submit
Toxins toxins	3.9	7.5	2009	18.9 Days	CHF 2700	Submit

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All Antibiotics Applied Microbiology Immuno Medicina Toxins

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Open AccessReview

Bacterial Porins and Their Procoagulant Role: Implication in the Pathophysiology of Several Thrombotic Complications during Sepsis

by Carmine Siniscalchi, Alessandro Perrella, Ugo Trama, Francesca Futura Bernardi, Egidio Imbalzano, Giuseppe Camporese, Vincenzo Russo, Olga Scudiero, Tiziana Meschi and Pierpaolo Di Micco

Toxins 2024, 16(8), 368; https://doi.org/10.3390/toxins16080368 - 20 Aug 2024

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Abstract

The association between sepsis and thrombotic complications is still not well known. Different mechanisms have been shown to be involved in the sepsis-induced prothrombotic state, but clinical scenarios may differ. In this review, we have summarized the role that bacterial products such as [...] Read more.

The association between sepsis and thrombotic complications is still not well known. Different mechanisms have been shown to be involved in the sepsis-induced prothrombotic state, but clinical scenarios may differ. In this review, we have summarized the role that bacterial products such as porins and toxins can have in the induction of the prothrombotic state during sepsis and the interaction that they can have with each other. Furthermore, the above-mentioned mechanisms might be involved in the pattern of the clinical presentation of thrombotic events during bacterial sepsis, which would secondarily explain the association between sepsis and venous thromboembolism, the association between sepsis and disseminated intravascular coagulation, and the association between sepsis and microangiopathic venous thromboembolism. Full article

(This article belongs to the Topic Bacterial Porins and Their Implication in Pathophysiology of Septic Complications In Vitro and In Vivo)

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