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Volume 20
Issue 13
10.3390/ijms20133324
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Article
Peer-Review Record

Scratching Counteracts IL-13 Signaling by Upregulating the Decoy Receptor IL-13Rα2 in Keratinocytes

Int. J. Mol. Sci. 2019, 20(13), 3324; https://doi.org/10.3390/ijms20133324
by Dugarmaa Ulzii 1,2, Makiko Kido-Nakahara 1,*, Takeshi Nakahara 1,3, Gaku Tsuji 1,4, Kazuhisa Furue 1, Akiko Hashimoto-Hachiya 1,4 and Masutaka Furue 1,3,4
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2019, 20(13), 3324; https://doi.org/10.3390/ijms20133324
Submission received: 26 June 2019 / Revised: 3 July 2019 / Accepted: 4 July 2019 / Published: 6 July 2019
(This article belongs to the Special Issue Therapy and Prevention of Atopic Dermatitis and Psoriasis)

Round 1

Reviewer 1 Report

very nice job

Author Response

Thank you so much for your comment. We hope the manuscript is suitable for publication in International Journal of Molecular Sciences.


Reviewer 2 Report


The itch/scratch cycle is an important, poorly understood feature of atopic eczema pathogenesis. The observation that IL13Rα2 is upregulated in response to scratch wounding supports it known protective role in skin inflammation. The observation that it is highly upregulated in lichenified AE skin implies that IL13Rα2 upregulation alone is not sufficient to ameliorate the itch/scratch cycle in AE and this limits the clinical impact of the findings.

It would be beneficial to see if the MAPK signalling pathway is also upregulated in the lichenified AE skin samples?



Author Response

We are grateful to reviewer for the useful suggestion.

 

Comment #1

It would be beneficial to see if the MAPK signalling pathway is also upregulated in the lichenified AE skin samples?

Response

Thank you for your comment. We also think that’s an important point. Actually, we are analyzing it for an ongoing project, which could be presented next time.

 

 

Thank you so much again for your important comment. We hope the manuscript is suitable for publication in International Journal of Molecular Sciences.


 


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