MRI and Clinical Biomarkers Overlap between Glaucoma and Alzheimer’s Disease
, Francesca Di Giuliano 2,†, Silvia Minosse 3, Giulio Pocobelli 1, Carlo Nucci 1,* and Francesco Garaci 3,4
Round 1
Reviewer 1 Report
The review paper by Martucci et al. provides a compelling exploration of the overlapping clinical biomarkers between Glaucoma and Alzheimer's disease, as identified through fMRI. It specifically zeroes in on the structural alterations in the optic nerve, retinal nerve fiber layer, and regions of the brain implicated in visual information processing. By conducting a meticulous review that amalgamates a range of scholarly sources, the authors offer valuable insights into the neural structural changes associated with both Glaucoma and Alzheimer's disease. The paper is well-crafted, featuring appropriate citations of pertinent literature, and is thus fitting for publication in IJMS.
Reviewer 2 Report
The aim of this manuscript is to summarize the current state of the art on the use of advanced neuroimaging techniques in glaucoma and Alzheimer’s Diseases highlighting emerging biomarkers shared by both diseases.
This manuscript shows rich content, providing a deep insight for some works: the study is within the journal’s scope, and I found it to be well-written, providing sufficient information. The manuscript provides an organic overview, with a densely organized structure and based on well-synthetized evidence.
The main topic is interesting, and certainly of great clinical impact. As regards the originality and strengths of this manuscript, this is a significant contribute to the ongoing research on this topic, as it extends the research field on the use of advanced neuroimaging techniques in glaucoma and Alzheimer’s Diseases highlighting emerging biomarkers shared by both diseases. Overall, the contents are rich, and the authors also give their deep insight for some works.
Furthermore, there is a specific and detailed explanation for the scientific evidence mentioned in this manuscript : this is particularly significant, since the manuscript relies on a multitude of data, to derive its conclusions.
The conclusion of this manuscript is perfectly in line with the main purpose of the paper: the authors have designed and conducted the study properly. As regards the conclusions, they are well written and present an adequate balance between the description of previous findings and the results presented by the authors.
Finally, this manuscript also shows a basic structure, properly divided and looks like very informative on this topic.
In conclusion, this manuscript is densely presented and well organized, based on well-synthetized evidence. The authors were lucid in their style of writing, making it easy to read and understand the message, portrayed in the manuscript. However, many of the topics are very concisely covered. This manuscript provided a comprehensive analysis of current knowledge in this field. Moreover, this research has futuristic importance and could be potential for future research. The article is accurate, provides relevant information on the topic and I accept it for publication in present form.
