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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

TSLP and TSLPR Expression Levels in Peripheral Blood as Potential Biomarkers in Patients with Chronic Rhinosinusitis with Nasal Polyps

by
Emma Moreno-Jiménez
1,2,†,
Natalia Morgado
1,2,†,
Manuel Gómez-García
1,3,
Catalina Sanz
1,2,4,*,
María Gil-Melcón
5,
María Isidoro-García
1,3,4,6,
Ignacio Dávila
1,4,7,8 and
Asunción García-Sánchez
1,4,7
1
Instituto de Investigación Biomédica de Salamanca, 37007 Salamanca, Spain
2
Microbiology and Genetics Department, Universidad de Salamanca, 37007 Salamanca, Spain
3
Clinical Biochemistry Department, Hospital Universitario de Salamanca, 37007 Salamanca, Spain
4
Instituto de Salud Carlos III, Red de Enfermedades Inflamatorias—RICORS, 28029 Madrid, Spain
5
Otorhinolaryngology and Head and Neck Surgery Department, Hospital Universitario de Salamanca, 37007 Salamanca, Spain
6
Medicine Department, Universidad de Salamanca, 37007 Salamanca, Spain
7
Biomedical and Diagnostics Sciences Department, Universidad de Salamanca, 37007 Salamanca, Spain
8
Allergy Department, Hospital Universitario de Salamanca, 37007 Salamanca, Spain
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2025, 26(3), 1227; https://doi.org/10.3390/ijms26031227
Submission received: 20 December 2024 / Revised: 28 January 2025 / Accepted: 28 January 2025 / Published: 30 January 2025
(This article belongs to the Special Issue Molecular Medicine in Asthma and Allergic Diseases 2.0)
Review Reports Versions Notes

Abstract

TSLP is an alarmin released upon activation of epithelia in response to various external stimuli and is involved in type 2 cytokine-mediated pathological disorders. The formation of a high-affinity heterodimeric receptor complex, comprising the thymic stromal lymphopoietin receptor (TSLPR) chain and IL-7Rα, is required for signaling. This study investigated whether TSLP and TSLPR expression in peripheral blood or nasal polyps could provide a valuable approach for the molecular phenotyping of patients with chronic rhinosinusitis with nasal polyps (CRSwNP). The study population comprised 156 unrelated Caucasian individuals, including 45 controls and 111 patients with CRSwNP. Quantitative PCR analysis of TSLP and TSLPR was performed on the population study’s peripheral blood and nasal biopsy. The data were analyzed for potential associations, and possible use as a biomarker was studied. Significant differences were observed in TSLP and TSLPR blood expression between the control group and patients. Similarly, the expression of TSLP observed in biopsy samples was statistically significantly elevated in the polyp tissue of the patient compared with healthy controls. The combination of TSLP and TSLPR expression testing with peripheral blood eosinophils represents a more specific biomarker in patients exhibiting low eosinophil values. Further investigation of TSLP/TSLPR mRNA levels in peripheral blood may yield new minimally invasive biomarkers.
Keywords: TSLP; TSLPR; N-ERD; CRSwNP; biomarker; gene expression; nasal polyp TSLP; TSLPR; N-ERD; CRSwNP; biomarker; gene expression; nasal polyp

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MDPI and ACS Style

Moreno-Jiménez, E.; Morgado, N.; Gómez-García, M.; Sanz, C.; Gil-Melcón, M.; Isidoro-García, M.; Dávila, I.; García-Sánchez, A. TSLP and TSLPR Expression Levels in Peripheral Blood as Potential Biomarkers in Patients with Chronic Rhinosinusitis with Nasal Polyps. Int. J. Mol. Sci. 2025, 26, 1227. https://doi.org/10.3390/ijms26031227

AMA Style

Moreno-Jiménez E, Morgado N, Gómez-García M, Sanz C, Gil-Melcón M, Isidoro-García M, Dávila I, García-Sánchez A. TSLP and TSLPR Expression Levels in Peripheral Blood as Potential Biomarkers in Patients with Chronic Rhinosinusitis with Nasal Polyps. International Journal of Molecular Sciences. 2025; 26(3):1227. https://doi.org/10.3390/ijms26031227

Chicago/Turabian Style

Moreno-Jiménez, Emma, Natalia Morgado, Manuel Gómez-García, Catalina Sanz, María Gil-Melcón, María Isidoro-García, Ignacio Dávila, and Asunción García-Sánchez. 2025. "TSLP and TSLPR Expression Levels in Peripheral Blood as Potential Biomarkers in Patients with Chronic Rhinosinusitis with Nasal Polyps" International Journal of Molecular Sciences 26, no. 3: 1227. https://doi.org/10.3390/ijms26031227

APA Style

Moreno-Jiménez, E., Morgado, N., Gómez-García, M., Sanz, C., Gil-Melcón, M., Isidoro-García, M., Dávila, I., & García-Sánchez, A. (2025). TSLP and TSLPR Expression Levels in Peripheral Blood as Potential Biomarkers in Patients with Chronic Rhinosinusitis with Nasal Polyps. International Journal of Molecular Sciences, 26(3), 1227. https://doi.org/10.3390/ijms26031227

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