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Molecular Medicine in Asthma and Allergic Diseases 2.0
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Molecular Medicine in Asthma and Allergic Diseases 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 4214

Special Issue Editors

Dr. Blanca Cárdaba

E-Mail Website
Guest Editor
Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD), 28040 Madrid, Spain
Interests: asthma; system biology; allergic biomarkers
Special Issues, Collections and Topics in MDPI journals
Dr. Jose Antonio Cañas Mañas

E-Mail Website
Guest Editor
Allergy Research Group, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Málaga, Spain
Interests: asthma; allergy; eosinophils; microRNAs; food allergy; dendritic cells; regulatory T cells; basophils; flow cytometry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Allergic diseases and asthma are common, complex, heterogeneous diseases with a wide spectrum of clinical symptoms, essentially due to their multifactorial nature. However, despite the multiple advances on allergen characterization and molecular and cellular bases that underlie these diseases, there are many essential aspects that should be improved at different levels. For example, with the exception of allergen-specific immunotherapy (SIT) in the case of diagnosis with known allergens, most treatments are indicated to control the disease and not to cure it. Sometimes, the diagnosis and the specific treatments, e.g., for patients who are polyallergic, are not easy; additionally, there are no clear biomarkers to predict or prevent what patients will develop as the most severe, clinical form of the disease.

Advances in molecular and cellular biology and genetic engineering, driven by the new techniques of studies at the genomic, proteomic, transcriptomic, epigenomic, metabolomic, etc., levels aided by complex computer analysis systems are allowing for the study of this type of disease to be approached from other perspectives, providing new key tools that could drive new molecular medicine in the future.

In this Special Issue, we invite original articles or reviews that address allergic diseases and asthma, preferably from a molecular perspective, providing new knowledge on diagnostic, prevention, or novelty treatments supported by future molecular medicine applicable to these complex diseases.

Dr. Blanca Cárdaba
Dr. Jose Antonio Cañas Mañas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • allergy
  • asthma
  • biologic treatments
  • molecular biomarkers
  • molecular diagnosis
  • endotypes
  • immunomodulation
  • vaccines

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Related Special Issue

Published Papers (3 papers)

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Research

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17 pages, 965 KiB  
Article
The Sensitization Profile for Selected Food Allergens in Polish Children Assessed with the Use of a Precision Allergy Molecular Diagnostic Technique
by Izabela Knyziak-Mędrzycka, Emilia Majsiak, Weronika Gromek, Danuta Kozłowska, Jakub Swadźba, Joanna Beata Bierła, Ryszard Kurzawa and Bożena Cukrowska
Int. J. Mol. Sci. 2024, 25(2), 825; https://doi.org/10.3390/ijms25020825 - 9 Jan 2024
Cited by 2 | Viewed by 1733
Abstract
Individual populations show a variety of sensitization patterns, which may be associated with the geographic region, climate, dietary habits, or ways of preparing food. The purpose of this study was to comprehensively assess the food allergy sensitization profile in Polish children, particularly to [...] Read more.
Individual populations show a variety of sensitization patterns, which may be associated with the geographic region, climate, dietary habits, or ways of preparing food. The purpose of this study was to comprehensively assess the food allergy sensitization profile in Polish children, particularly to eight food allergens (so-called “the Big 8”): cow milk, eggs, wheat, soybeans, fish, crustacean shellfish, tree nuts, and peanuts. To assess the prevalence and serum levels of specific immunoglobulins E (sIgE), we analyzed the results obtained from selected laboratories located in all regions of Poland that used the multiplex ALEX® test in the period from 2019 to 2022. Results from 3715 children were obtained. The mean age of the study population was 7.0 years. The results were stratified by age: <12 months (3.63%), 1–5 years (39.54%), 6–13 years (46.32%), and 14–18 years (10.0%). The final analysis included the sIgE results obtained with 95 food extracts and 77 food allergen molecules. The highest rates of sIgE to food allergen extracts were found for peanut (29.20%), hazel (28.20%), and apple (23.60%), and those to allergenic molecules were found for the PR-10 family of molecules (Cor a 1.0401 (23.77%), Mal d 1 (22.37%), Ara h 8 (16.93%), and globulin 7/8S (Ara h 1; 15.59%)). The lowest rates of sIgE reactivity to extracts were found for strawberry (0.40%), oregano (0.30%), and thornback ray (0.16%), and those to allergenic molecules were found for Mal d 2 (0.27%) (thaumatin-like protein, TLP), Ani s 1 (0.30%) (Kunitz-type serine protease inhibitor), and Che a 1 (0.43%) (Ole e 1 family). The rates of sensitization to storage proteins of the analyzed “the Big 8” molecules decreased significantly (p < 0.05) with age. Conversely, the rates of sensitization to PR-10 family proteins increased significantly with age. The three most common allergens in Poland, regardless of whether IgE was assayed against extracts or molecules of food allergens, were peanut, hazel, and apple (in different order depending on the ranking). A detailed analysis of sensitization to the extracts and molecules of main food allergens based on the results of a multiplex ALEX® test demonstrated the sensitization profile in Polish children (including molecular sensitization, particularly the “the Big 8” food allergen molecules), which shows considerable differences in comparison with those in other countries. Serum sIgE analysis of children from all regions of Poland revealed a food allergen molecular sensitization profile that changes with age. Full article
(This article belongs to the Special Issue Molecular Medicine in Asthma and Allergic Diseases 2.0)
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Review

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16 pages, 1982 KiB  
Review
Single-Cell Analysis: A Method for In-Depth Phenotyping of Cells Involved in Asthma
by Daniel Rodríguez-González, Gema Guillén-Sánchez, Victoria del Pozo and José Antonio Cañas
Int. J. Mol. Sci. 2024, 25(23), 12633; https://doi.org/10.3390/ijms252312633 - 25 Nov 2024
Viewed by 334
Abstract
Asthma is a chronic inflammatory lung disease with high prevalence, making it one of the most common chronic conditions worldwide. Its pathophysiology is influenced by a range of genetic and environmental factors, resulting in a complex and heterogeneous disease profile. Asthma is primarily [...] Read more.
Asthma is a chronic inflammatory lung disease with high prevalence, making it one of the most common chronic conditions worldwide. Its pathophysiology is influenced by a range of genetic and environmental factors, resulting in a complex and heterogeneous disease profile. Asthma is primarily associated with a type 2 (T2) immune response, though non-T2 endotypes also contribute to disease pathology. Generally, asthma is characterized by the infiltration and activation of various cell types, including dendritic cells, eosinophils, innate lymphoid cells, lymphocytes, mast cells, and neutrophils, which participate in T1, T2, and T17 immune responses. Despite advances in understanding, many questions remain unresolved. Therefore, emerging omic techniques, such as single-cell RNA sequencing (scRNA-seq), offer novel insights into the underlying mechanisms of asthma and the roles of these immune cells. Recent scRNA-seq studies in asthma have identified multiple novel immune cell subtypes and clusters, suggesting their potential functions in disease pathology. The rapid advancement of scRNA-seq technology now enables in-depth investigation of individual cells within tissues, allowing for precise cell-type classification and detailed molecular profiling. Nonetheless, certain limitations persist, which require further refinement in future studies. Full article
(This article belongs to the Special Issue Molecular Medicine in Asthma and Allergic Diseases 2.0)
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18 pages, 662 KiB  
Review
Treatment of Allergies to Fur Animals
by Tomasz Rosada, Zbigniew Bartuzi, Magdalena Grześk-Kaczyńska, Magdalena Rydzyńska and Natalia Ukleja-Sokołowska
Int. J. Mol. Sci. 2024, 25(13), 7218; https://doi.org/10.3390/ijms25137218 - 29 Jun 2024
Viewed by 1209
Abstract
Allergy to fur animals is becoming an increasingly common clinical problem in everyday medical practice. Depending on the route of exposure to the allergen, patients present with many, often non-specific symptoms. The most common illnesses among people with allergies to the above-mentioned allergens [...] Read more.
Allergy to fur animals is becoming an increasingly common clinical problem in everyday medical practice. Depending on the route of exposure to the allergen, patients present with many, often non-specific symptoms. The most common illnesses among people with allergies to the above-mentioned allergens are as follows: allergic rhinitis, allergic conjunctivitis, atopic bronchial asthma, food allergy, allergic contact dermatitis, and sometimes anaphylactic shock. In recent years, there has been a change in the holistic approach to the treatment of allergy patients. The method of treatment should be tailored to a specific patient, taking into account his or her predispositions, economic possibilities, and therapeutic goals. The article describes the main methods of treating allergies, focusing primarily on allergies to fur animals. Allergy treatment always requires great care, and qualification for specific types of therapy should be preceded by a thorough and accurate diagnosis. Full article
(This article belongs to the Special Issue Molecular Medicine in Asthma and Allergic Diseases 2.0)
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