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New Diagnostic and Therapeutic Approaches in Food Allergy

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 2455

Special Issue Editors


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Guest Editor
Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD), 28040 Madrid, Spain
Interests: asthma; drug allergy; dendritic cell; basophil activation test

Special Issue Information

Dear Colleagues,

Food allergy is an adverse reaction of the immune system triggered by harmless food-derived allergens. In recent years, the incidence of these allergic disorders has increased, becoming a serious social and economic burden worldwide. Although various studies and guidelines have emphasized that food allergies are more common in children than in adults, they can cause mild to severe symptoms in both groups and can sometimes be life-threatening. Therefore, diagnosis and treatment are crucial in order to avoid food allergy reactions.

This Special Issue welcomes submissions of Original Research Articles, Clinical Case Reports and Reviews on novel studies performed in the diagnosis and treatment of food allergies. Specific subject areas of interest include, but are not limited to, the following:

  • Specific mechanisms of food allergy (cellular and molecular).
  • Current clinical tips on food allergy diagnosis.
  • Novel methods on food allergy diagnosis.
  • Cellular and molecular biomarkers of food allergy.
  • The role in food tolerance acquisition.
  • Involvement of dendritic cells, T regulatory cells and innate lymphoid cells in food allergy mechanisms.
  • New perspectives of allergen immunotherapy.
  • New approaches to desensitization in food allergy.
  • Monoclonal antibody therapies in food allergy treatment.
  • Clinical implications of food–pollen crossreactivity.
  • Genetic and epigenetic in food allergy.

Dr. José Antonio Canas
Dr. Blanca Cárdaba
Dr. Rubén Fernández-Santamaría
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • food allergy
  • T2 response
  • IgE-mediated mechanisms
  • basophil activation test
  • immunotherapy

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Published Papers (2 papers)

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17 pages, 1730 KiB  
Article
Fenugreek: New Therapeutic Resource or Emerging Allergen?
by Clara Alessandrello, Serena Sanfilippo, Sebastiano Gangemi, Giovanni Pioggia and Paola Lucia Minciullo
Appl. Sci. 2024, 14(20), 9195; https://doi.org/10.3390/app14209195 - 10 Oct 2024
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Abstract
Background: Fenugreek, or Trigonella foenum greacum, is an ancient medicinal plant native to the eastern Mediterranean that later spread to Asia; it is used as a medicinal herb, spice, or food. It is a component of spice mixes, such as curry, and [...] Read more.
Background: Fenugreek, or Trigonella foenum greacum, is an ancient medicinal plant native to the eastern Mediterranean that later spread to Asia; it is used as a medicinal herb, spice, or food. It is a component of spice mixes, such as curry, and it is also used as a supplement in wheat and corn flour for bread making. Fenugreek appears to have many health benefits and potential medicinal properties; for this reason, it is increasingly being used in nutraceutical formulations. This study aimed to describe patients who visited our operative unit for a suspected adverse reaction after ingestion of fenugreek and to highlight possible cross-reactivity between fenugreek and other legumes or other foods. Methods: A total of 13 patients (5 males and 8 females; mean age: 30.6; range: 20–42 years) visited our outpatient clinic with a clinical history suggestive of an allergic reaction to spices or legumes. They underwent a skin prick test for fenugreek, fresh foods, and food extracts. Results: A total of 6 out of 13 patients positive for fenugreek had experienced allergic symptoms after ingesting foods containing spices, and 10 patients presented polysensitization with other legumes, of which 8 also presented sensitization to pistachios. Conclusions: Given the increasing use of novel spices in Mediterranean cuisine and the possible spread of fenugreek-based nutraceuticals, it is relevant to draw attention to possible allergic reactions. Further studies are also needed to be able to establish its cross-reactivity pattern. Full article
(This article belongs to the Special Issue New Diagnostic and Therapeutic Approaches in Food Allergy)
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21 pages, 356 KiB  
Systematic Review
Impact of Childhood Food Allergy on Quality of Life: A Systematic Review
by Selene Valero-Moreno, Rocío Torres-Llanos and Marián Pérez-Marín
Appl. Sci. 2024, 14(23), 10989; https://doi.org/10.3390/app142310989 - 26 Nov 2024
Abstract
Background: Food allergy is the third most commonly diagnosed allergic disorder in children, particularly during infancy and preschool years. Its prevalence has been rising rapidly in recent years, making it a significant public health concern. This study aims to conduct a systematic review [...] Read more.
Background: Food allergy is the third most commonly diagnosed allergic disorder in children, particularly during infancy and preschool years. Its prevalence has been rising rapidly in recent years, making it a significant public health concern. This study aims to conduct a systematic review of the impact of childhood food allergies on quality of life. Methods: A comprehensive search of databases from the last five years was conducted following the PRISMA guidelines, resulting in the selection of 21 relevant articles. Results: The findings indicate that food allergies significantly reduce children’s quality of life, with age, the number of allergens, and allergy severity being key determinants. Affected children experience higher levels of anxiety, depression, and reduced psychosocial functioning. Caregivers also face substantial burdens, including constant concerns over accidental exposure, limitations in social activities, financial strain, and increased work absences. In school settings, these children are more prone to teasing or bullying, highlighting the need for increased education and social awareness. Conclusions: Food allergies significantly impact the quality of life for both patients and their families, especially mothers, with worsening effects as children age, including heightened risks of bullying and social limitations, highlighting the need for education, psychological support, and resource allocation. Full article
(This article belongs to the Special Issue New Diagnostic and Therapeutic Approaches in Food Allergy)
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