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Current Oncology
Volume 13
Issue 4
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..

Curr. Oncol., Volume 13, Issue 4 (August 2006) – 6 articles

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41 KiB  
Article
Targeting Transforming Growth Factor β to Enhance Cancer Immunotherapy
by T. Hahn and Emmanuel T. Akporiaye
Curr. Oncol. 2006, 13(4), 141-143; https://doi.org/10.3390/curroncol13040015 - 1 Aug 2006
Cited by 6 | Viewed by 449
Abstract
Human tumours have evolved intricate mechanisms to evade the immune system, either by avoiding recognition or by inhibiting and eliminating immune cells. [...] Full article
87 KiB  
Review
Diffusion and Dissemination of Evidence-Based Dietary Strategies for the Prevention of Cancer
by D. Ciliska, P. Robinson, T. Horsley, P. Ellis, M. Brouwers, M. Gauld, F. Baldassarre and Parminder Raina
Curr. Oncol. 2006, 13(4), 130-140; https://doi.org/10.3390/curroncol13040014 - 1 Aug 2006
Cited by 3 | Viewed by 637
Abstract
We used a systematic review to identify strategies that have been evaluated for disseminating cancer control interventions that promote the uptake of a healthy diet in adults. Studies were identified by contacting technical experts and by searching MEDLINE, PreMedline, CANCERLIT, EMBASE/Excerpta Medica, PsycINFO, [...] Read more.
We used a systematic review to identify strategies that have been evaluated for disseminating cancer control interventions that promote the uptake of a healthy diet in adults. Studies were identified by contacting technical experts and by searching MEDLINE, PreMedline, CANCERLIT, EMBASE/Excerpta Medica, PsycINFO, CINAHL, the Cochrane Database of Systematic Reviews, and reference lists. English-language primary studies were selected if they evaluated the dissemination of healthy diet interventions to individuals, health care providers, or institutions. Studies involving only children or adolescents were excluded. We retrieved 101 articles for full-text screening, and identified nine reports of seven distinct studies. Four of the studies were randomized trials, one was a cohort design, and three were descriptive studies. Six of the studies were rated methodologically weak, and one was rated moderate. Because of heterogeneity, low methodological quality, and incomplete data reporting, the studies were not pooled for meta-analysis. No beneficial dissemination strategies were found. One strategy involving the use of peer educators at the work site, which led to a shortterm increase in fruit and vegetable intake, looks promising. Overall, the quality of the evidence is not strong, and the evidence that exists is more descriptive than evaluative. No clear conclusions can be drawn from these data. Controlled studies are needed to evaluate dissemination strategies and to compare dissemination and diffusion strategies that communicate different messages and target different audiences. Full article
117 KiB  
Article
Cross-Border Referral for Early Breast Cancer: An Analysis of Radiation Fractionation Patterns
by Ian S. Dayes, T. J. Whelan, J. A. Julian, M. R. Kuettel, D. Regmi, G. S. Okawara, M. Patel, H. I. Reiter and S. Dubois
Curr. Oncol. 2006, 13(4), 124-129; https://doi.org/10.3390/curroncol13040013 - 1 Aug 2006
Cited by 8 | Viewed by 568
Abstract
Because of increasing waiting times for adjuvant radiation in the province of Ontario, patients from one Canadian centre were referred to two centres in the United States. This situation provided an opportunity to compare radiation practices. We performed a retrospective review of radiation [...] Read more.
Because of increasing waiting times for adjuvant radiation in the province of Ontario, patients from one Canadian centre were referred to two centres in the United States. This situation provided an opportunity to compare radiation practices. We performed a retrospective review of radiation prescribed to patients following breast-conserving surgery for invasive breast cancer. Patients with positive margins, 4 or more positive lymph nodes, recurrent disease, or large tumours (>5 cm) were excluded. For comparison, we reviewed a random sample of similar patients treated at the Canadian centre during the same period. A total of 120 referred and 217 non-referred patients were eligible for comparison. The analysis included 98 pairs of patients (N = 196), fully matched on age, nodal status, T stage, grade, and estrogen receptor (ER) status. Mean patient age was 60.7 years. The median total dose and number of fractions differed between centres [6040 cGy in 32 fractions (United States) vs. 4250 cGy in 16 fractions (Canadian), both p < 0.001). Boost was used more often in the United States (97% vs. 9%, p < 0.001). Variation in prescribing patterns was seen. In the United States, seven different schedules for whole-breast irradiation were used; at the Canadian centre, two schedules were prescribed. Predicted radiobiologic effects of these schedules were calculated to be similar. Differences in fractionation patterns were observed between and within U.S. and Canadian centres. Such variability is likely to affect patient convenience and resource utilization. Although patient selection, referring surgeon, and change in policies may account for some of the observed differences, further research is necessary to better understand the causes. Full article
557 KiB  
Article
Solitary Bone Metastasis beneath the Shoulder Shield: Coincidence or Cause?
by G. Fan, E. Sinclair, M. Christakis, L. Erhlich, J. Zubovits and E. Chow
Curr. Oncol. 2006, 13(4), 121-123; https://doi.org/10.3747/co.v13i4.98 - 1 Aug 2006
Viewed by 433
Abstract
Post-mastectomy radiotherapy has been demonstrated to improve locoregional control in breast cancer patients. We report a case involving a 44-year-old breast cancer patient who presented with a solitary bone metastasis in the area beneath the shoulder shield, likely from a coincidental recurrence. Full article
26 KiB  
Article
Influenza Pandemic Planning for Cancer Patients
by Peter Malcolm Battershill
Curr. Oncol. 2006, 13(4), 119-120; https://doi.org/10.3390/curroncol13040012 - 1 Aug 2006
Cited by 13 | Viewed by 633
Abstract
Given that an influenza pandemic is likely within the next few years, the World Health Organization has recommended that policymakers take action to mitigate the consequences of such a pandemic. Because of the increased risk of patients with cancer developing complications of influenza, [...] Read more.
Given that an influenza pandemic is likely within the next few years, the World Health Organization has recommended that policymakers take action to mitigate the consequences of such a pandemic. Because of the increased risk of patients with cancer developing complications of influenza, policymakers in cancer care should immediately begin planning for changes to resource allocation, clinical care, and the consent process during a pandemic. Full article
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Editorial
In This Issue of Current Oncology
by M. McLean
Curr. Oncol. 2006, 13(4), 118; https://doi.org/10.3390/curroncol13040011 - 1 Aug 2006
Viewed by 455
Abstract
Many of the newer clinical studies proposed for the management of high-risk prostate cancer include the use of chemotherapy in addition to androgen deprivation. [...] Full article
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