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Article

Structural Characterization of Multicomponent Crystals Formed from Diclofenac and Acridines

by
Artur Mirocki
* and
Artur Sikorski
*
Faculty of Chemistry, University of Gdańsk, W. Stwosza 63, 80-308 Gdańsk, Poland
*
Authors to whom correspondence should be addressed.
Materials 2022, 15(4), 1518; https://doi.org/10.3390/ma15041518
Submission received: 16 December 2021 / Revised: 4 February 2022 / Accepted: 14 February 2022 / Published: 17 February 2022
(This article belongs to the Special Issue Crystal Growth and Structure)
Browse Figures
Versions Notes

Abstract

:
Multicomponent crystals containing diclofenac and acridine (1) and diclofenac and 6,9-diamino-2-ethoxyacridine (2) were synthesized and structurally characterized. The single-crystal XRD measurements showed that compound 1 crystallizes in the triclinic P-1 space group as a salt cocrystal with one acridinium cation, one diclofenac anion, and one diclofenac molecule in the asymmetric unit, whereas compound 2 crystallizes in the triclinic P-1 space group as an ethanol solvate monohydrate salt with one 6,9-diamino-2-ethoxyacridinium cation, one diclofenac anion, one ethanol molecule, and one water molecule in the asymmetric unit. In the crystals of the title compounds, diclofenac and acridines ions and solvent molecules interact via N–H⋯O, O–H⋯O, and C–H⋯O hydrogen bonds, as well as C–H⋯π and π–π interactions, and form heterotetramer bis[⋯cation⋯anion⋯] (1) or heterohexamer bis[⋯cation⋯ethanol⋯anion⋯] (2). Moreover, in the crystal of compound 1, acridine cations and diclofenac anions interact via N–H⋯O hydrogen bond, C–H⋯π and π–π interactions to produce blocks, while diclofenac molecules interact via C–Cl⋯π interactions to form columns. In the crystal of compound 2, the ethacridine cations interact via C–H⋯π and π–π interactions building blocks, while diclofenac anions interact via π–π interactions to form columns.

1. Introduction

Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most used group of drugs due to their broad spectrum of biological activity [1,2]. They are used, inter alia, as analgesic and anti-inflammatory drugs [3,4], can reduce the risk of some cancers [5] and are used in treating Alzheimer’s disease [6,7], as well as many other applications [8,9,10]. One non-steroidal drugs is diclofenac (IUPAC: 2-(2-(2,6-dichloroanilino)phenyl)acetic acid). It is a commonly used drug for degenerative joint disease, various inflammations, such as spondylitis, and is also used after surgery and dysmenorrhea [11,12,13,14]. Moreover, diclofenac is a fast-acting drug and has analgesic and antipyretic activities, used to treat actinic keratosis and may have an antituberculosis effect [15,16,17,18,19,20,21]. Therapeutic doses of diclofenac cause fewer side effects (such as gastrointestinal damage) than aspirin and naproxen, and it is also inhibitor of cyclo-oxygenase [22]. Moreover, diclofenac is detected in water and may adversely affect organisms and thus disturb ecosystem function [23,24,25,26,27].
One of the fields dealing with the design, preparation, and research of new forms of drugs is crystal engineering. Thanks to our understanding of the nature of intermolecular interactions, such as hydrogen bonds [28,29,30], halogen bonds [31,32,33], π–π stacking interactions [34,35,36], and others [37,38,39,40], it is possible to obtain APIs as multicomponent crystals such as salts, cocrystals, salt cocrystals, or their solvates [41,42,43]. From the pharmaceutical point of view, the most interesting are the multicomponent crystals containing more than one Active Pharmaceutical Ingredients (APIs), the physicochemical and pharmacological properties of which may be better than single APIs [44,45,46,47]. A search of the Cambridge Structure Database (CSD version 5.43, update November 2021) [48] shows that there are 76 crystal structures of organic compounds containing diclofenac, including 58 structures of salts, 13 structures of cocrystals and 5 structures of salt cocrystals. However, there are only a few examples showing the possibility of formation crystalline drug–drug system involving diclofenac and aromatic nitrogenous bases [49,50,51,52,53,54,55,56,57].
In the context of obtaining a crystalline drug–drug system, acridine derivatives are very interesting. This is due to fact that acridines can intercalate into DNA which makes them exhibit anticancer, antibacterial, antiprion, and antiviral effects, among others [58,59,60,61,62]. Our previous research shows that acridine and its derivatives may interact with coformer molecules through various intermolecular interactions, such as hydrogen bonds, halogen bonds, π–π stacking interactions, and are able to form good quality crystals that are stable at room temperature [63,64,65,66]. One of the acridine derivatives represent interesting medicinal activity is ethacridine. Ethacridine (6,9-diamino-2-ethoxyacridine) is active against various infections and has antibacterial and anticancer properties, among others [67,68,69,70].
With regard to the biological activity of diclofenac and acridinium derivatives, in this article we describe the synthesis and structural characterization of two multicomponent crystals formed from diclofenac and acridine (1) and diclofenac and 6,9-diamino-2-ethoxyacridine (2) (Scheme 1).

2. Materials and Methods

All the chemical compounds were purchased from Sigma-Aldrich (St. Louis, MO, USA) (acridine, 6,9-diamino-2-ethoxyacridine-DL-lactate monohydrate) and Tokyo Chemical Industry TCI (diclofenac) and used without purification. Melting points were determined on a Büchi M-565 (Flawil, Switzerland) capillary apparatus and were uncorrected.

2.1. Synthesis of Compounds 1 and 2

(1) Acridine (0.020 g, 0.111 mmol) and diclofenac (0.030 g, 0.111 mmol) were dissolved in 4 mL of an ethanol/water mixture (1:1 v/v) and heated for 20 min in order to dissolve the sample. The solution was allowed to evaporate for a few days to give yellow crystals of 1 (m.p. = 158.0 °C).
(2) 6,9-Diamino-2-ethoxyacridine-DL-lactate monohydrate (0.020 g, 0.0552 mmol) and diclofenac (0.016 g, 0.0552 mmol) were dissolved in 4 mL of an ethanol/water mixture (1:1 v/v) and heated for 20 min in order to dissolve the sample and evaporate the lactic acid. The solution was allowed to evaporate for a few days to give yellow crystals of 2 (m.p. = 138.9 °C).

2.2. X-ray Measurements and Refinements

Good-quality single-crystal specimens of compounds 1 and 2 were selected for X-ray diffraction experiments at T = 295(2) K (Table 1). Diffraction data were collected on an Oxford Diffraction Gemini R ULTRA Ruby CCD diffractometer (Oxfordshire, United Kingdom) with MoKα (λ = 0.71073 Å) radiation. The lattice parameters were obtained by least-squares fit to the optimized setting angles of the reflections collected by means of CrysAlis CCD (ver. 1.171.41.16a) [71]. Data were reduced using CrysAlis RED software (ver. 1.171.41.16a) [71] and applying multi-scan absorption corrections. The structures were solved with direct methods that carried out refinements by full-matrix least-squares on F2 using the SHELXL-2017/1 program (ver. 2017/1) [72].
All H atoms bound to N/O-atoms were located on a difference Fourier map and refined freely. All H atoms bound to aromatic C atoms were placed geometrically and refined using a riding model with d(C–H) = 0.93 Å and Uiso(H) = 1.2Ueq(C). All H atoms from the methyl group were positioned geometrically and refined using a riding model, with d(C–H) = 0.96 Å and Uiso(H) = 1.5Ueq(C). All H atoms from the water molecules were positioned geometrically and refined using a riding model, with d(O–H) = 0.85 Å and Uiso(H) = 1.5Ueq(O) (DFIX command). All interactions and the Kitaigorodskii type of packing index were calculated using the PLATON program (ver. 181115) [73]. The following programs were used to prepare the molecular graphics: ORTEPII [74], PLUTO-78 [75], and Mercury (ver. 2020.2.0) [76]. Full crystallographic details for title compound have been deposited in the Cambridge Crystallographic Data Center (deposition No. CCDC 2,128,053 and 2,128,054) and they may be obtained from http://www.ccdc.cam.ac.uk, (accessed on 25 January 2022) email: [email protected], or The Director, CCDC, 12 Union Road, Cambridge, CB2 1EZ, UK.

3. Results

3.1. Crystal Structure of Compound 1

The single-crystal X-ray diffraction measurements show that compound 1 crystallizes in the triclinic P-1 space group with one acridinium cation, one diclofenac anion and one diclofenac molecule in the asymmetric unit (Figure 1).
The lengths of C–O bonds from carboxylic group in diclofenac anion (1.249 Å and 1.260 Å) indicating a proton transfer occurring between the carboxylic group of diclofenac and acridine. An acridine skeleton is nearly planar, whereas the angle between the planes of aromatic rings is 87.2° and 60.6°, and the angle –C–N–C– are 118.9° and 123.5° in diclofenac anion and molecule, respectively. We also observe intramolecular N–H⋯O hydrogen bonds [d(H23⋯O33) = 2.39(2) Å, and ∠(N23–H23⋯O33) = 130 (2)°, and d(H42⋯O52) = 2.36 (2) Å, and ∠(N42–H42⋯O52) = 142 (2)°] in both diclofenac anion and molecule (Table 2, Figure 1). In the crystal of 1, diclofenac anion and molecule are linked via O(carboxy)-H⋯O(carboxy) hydrogen bond [d(H51⋯O32) = 1.69 (3) Å, and ∠(O51–H51⋯O32) = 164 (3)°] to form a monoanionic dimer (Figure 1). The acridinium cation interact with diclofenac anion through the N(acridine)–H⋯O(carboxy) hydrogen bond [d(H10⋯O33) = 1.79 (2) Å, and ∠(N10–H10⋯O33) = 170 (2)°], and C(acridine)–H⋯π intermolecular interaction [d(H1⋯Cg4) = 2.79 Å, and ∠(C1–H1⋯Cg4) = 165°] to form a cyclic heterotetramer stabilized by the weak C(acridine)–H⋯O(carboxy) hydrogen bonds between C-4 atom of acridinium cation and an O-atom from carboxylate group of diclofenac anion [d(H4⋯O32) = 2.40 Å, and ∠(C4–H4⋯O32) = 160°] (Table 2 and Table 3, Figure 2). In this heterotetramer, the adjacent acridinium cations interact via π–π stacking with centroid⋯centroid distances [d(Cg⋯Cg)] ranging from 3.737 (1) Å to 3.841 (1) Å and separation 3.483 Å between the mean planes of the acridine skeleton (Table 4, Figure 2).
Moreover, the neighboring heterotetramers interact via π–π interactions between the acridine skeleton and the aromatic ring of the diclofenac anion (Cg4) with centroid⋯centroid distances ranging from 3.662 (1) Å to 3.917 (1) Å and separation 3.257 Å, to form blocks along the a-axis (Table 4, Figure 3—highlighted in blue). The adjacent diclofenac molecules are connected by C–Cl⋯π intermolecular interaction [d(Cl40⋯Cg6) = 3.725 (1) Å, and ∠(C35–Cl40⋯Cg6) = 95.86 (8)°] to form columns (Table 3, Figure 3—highlighted in orange). The adjacent blocks are connected to each other through columns by C–Cl⋯π interaction [d(Cl21⋯Cg7) = 3.885(1) Å, and ∠(C16–Cl21⋯Cg7) = 127.92 (2)°], and the weak C–H⋯O(carboxy) hydrogen bond [d(H45⋯O32) = 2.71 (1) Å, and ∠(C45–H45⋯O32) = 160 (1)°], between the diclofenac anion and molecule, and C(acridine)–H⋯π intermolecular interaction [d(H7⋯Cg7) = 2.90 Å, and ∠(C7–H7⋯Cg7) = 156°] between the acridine cation and the diclofenac molecule (Table 3, Figure 3).
They are stabilized by the weak C(acridine)–H⋯O(carboxy) hydrogen bonds between the C-8 atom of the acridinium cation and an O-atom from the carboxyl group of the diclofenac molecule [d(H8⋯O52) = 2.50 Å, and ∠(C8–H8⋯O52) = 150°] to form a 3D framework structure (Figure 3).

3.2. Crystal Structure of Compound 2

The single-crystal X-ray diffraction measurements show that compound 2 crystallizes in the triclinic P-1 space group with one 6,9-diamino-2-ethoxyacridinium cation, one diclofenac anion, one ethanol molecule and one water molecule in the asymmetric unit (Figure 4).
The lengths of C–O bonds from carboxylic group ranging from 1.248 Å to 1.255 Å indicating a proton transfer occurring between the carboxylic group of diclofenac and 6,9-diamino-2-ethoxyacridine. An ethacridine skeleton is nearly planar, while in the diclofenac anion the angle between the planes of aromatic rings is 71.6°, and the angle –C–N–C– is 122°. In the diclofenac anion, there is an intramolecular N–H⋯O hydrogen bond [d(H28⋯O38) = 2.43(6) Å, and ∠(N28–H28⋯O38) = 141(6)°]. In the crystal of compound 2, the 6,9-diamino-2-ethoxyacridine cation is linked with the diclofenac anion by N(acridine)–H⋯O(carboxy) hydrogen bond [d(H10⋯O38) = 2.01(6) Å and ∠(N10–H10⋯O38) = 157(6)°], and with the ethanol molecule by N(9-amino)–H⋯O(ethanol) hydrogen bond [d(H15B⋯O41) = 2.00(6) Å and ∠(N15–H15B⋯O41) = 173(6)°], while the ethanol molecule interact with the diclofenac anion via O(ethanol)–H⋯O(carboxy) hydrogen bond [d(H41⋯O38) = 2.04 Å and ∠(O41–H41⋯O38) = 176°], and form a cyclic heterohexamer (Table 2, Figure 5). This heterohexamer is stabilized by the weak C(acridine)–H⋯O(carboxy) hydrogen bonds between the C-4 atom of the acridinium cation and the O-atom from the carboxylate group of the diclofenac anion [d(H4⋯O37) = 2.59 Å, and ∠(C4–H4⋯O37) = 151°] and N(6-amino)–H⋯Cl hydrogen bond between the amino group and a Cl-atom from the diclofenac anion [d(H16A⋯Cl26) = 2.91(9) Å, and ∠(N16–H16A⋯Cl26) = 133(7)°] (Table 2, Figure 5).
Adjacent 6,9-diamino-2-ethoxyacridine cations engaged in the formation of heterohexamer interact with each other via π–π interactions with the distance between centroids ranging from 3.835 (3) Å to 3.917 (4) Å and separation 3.545 Å between the mean planes of the 6,9-diamino-2-ethoxyacridine skeleton (Table 4, Figure 5). Moreover, the adjacent heterohexamers are linked by C–H⋯π interaction [d(H18A⋯Cg3) = 2.80 Å, and ∠(C18–H18⋯Cg3) = 150°] to form blocks (Table 3, Figure 6—highlighted in blue). In turn, the adjacent diclofenac anions interact via π–π intermolecular interaction with distance between centroids 3.553 (4) Å and separation 3.432 Å, to form columns along the a-axis (Table 4, Figure 6—highlighted in orange), which connect adjacent blocks of acridines.
The adjacent blocks are also connected through a water molecule by N(9-amino)–H⋯O(water) hydrogen bond [d(H15A⋯O42) = 1.91 (8) Å, and ∠(N15–H15A⋯O42) = 163 (7)°] between the amino group of the acridinium cation and water molecule, the O(water)–H⋯O(ethoxy) hydrogen bond [d(H42B⋯O17) = 2.17 (7) Å, and ∠(O42–H42B⋯O17) = 154 (6)°] between the water molecule and ethoxy group from the acridinium cation, the O(water)–H⋯O(carboxy) hydrogen bond [d(H42A⋯O37) = 1.95 (6) Å, and ∠(O42–H42A⋯O37) = 158 (8)°] between the water molecule and an O-atom from the carboxylate group of the diclofenac anion and the weak C(acridine)–H⋯O(water) hydrogen bonds between the C-8 atom of the acridinium cation and the water molecule [d(H8⋯O42) = 2.45 Å, and ∠(C8–H8⋯O42) = 165°]. Alternately arranged blocks and columns are connected by N(6-amino)–H⋯O(carboxy) hydrogen bond [d(H16B⋯O37) = 2.19 (7) Å, and ∠(N16–H16B⋯O37) = 171 (7)°], to form a 3D framework structure (Figure 6).

4. Discussion

The title compounds crystallize in the triclinic P-1 space group, but they are not isostructural. Compound 1 crystallizes as salt cocrystal with one acridinium cation, one diclofenac anion and one diclofenac molecule in the asymmetric unit. In CSD, there are only five structures of salt cocrystal (REFCODES: XUVYAP01, WABHOA, WABHUG, WABJAO, XUVQEL) [49,52,77]. In the structures deposited in the CSD, the angle between the planes of aromatic rings is from 59.6° to 78.3° and the angle –C–N–C– is in the range 116.3–125.2° in diclofenac molecule which corresponds to the angle between the plane of aromatic rings (60.6°) and angle –C–N–C– (123.5°) observed in the diclofenac molecule in the crystal of compound 1. Simultaneously, in the structures deposited in the CSD-containing diclofenac anion, the angle between the planes of aromatic rings is from 58.2° to 80.4° and the angles –C–N–C– is in the range 120.3° to 125.2°, while the angles between the plane of aromatic rings is 87.2° and the angles –C–N–C– is 118.9° in compound 1. In this crystal structure, we observed specific cyclic heterotetramer bis[⋯cation⋯anion⋯], containing N(acridine)–H⋯O(diclofenac) and C(acridine)–H⋯π(diclofenac) intermolecular interactions, which is not observed in the crystal structures in our previous studies (about acridine) [64]. Additionally, acridinium cations do not form π–stacked columns, whereas the neighboring heterotetramers are connected by columns made of diclofenac molecules, which interact by C–Cl⋯π intermolecular interaction with each other. Compound 2 was obtained as an ethanol solvate monohydrate salt, and crystallizes with one acridinium cation, one diclofenac anion, one ethanol molecule and one water molecule in the asymmetric unit. Moreover, there is only one structure containing a diclofenac anion and an ethanol molecule, and there are not any structures containing an ethanol molecule and a water molecule in CSD. In the crystal of 2, the angle between the plane of aromatic rings is 71.6° and the angle –C–N–C– is 122° in the diclofenac anion, which corresponds to the data obtained from CSD. It means that the angles between the plane of aromatic rings is bigger in compound 1, but the angle –C–N–C– is smaller than observed in the structure of compound 2. In this crystal structure we observed cyclic heterohexamer bis[⋯cation⋯ethanol⋯anion⋯]. The similar heterohexamer we observed in the crystal structures of ethacridinium phthalate isobutanol solvate [66], where instead of the ethanol molecule there is an isobutanol molecule, but the distance between mean planes of ethacridinium is longer in the crystal of compound 2 (3.431 Å and 3.545 Å in the crystal of ethacridinium phthalate isobutanol solvate and compound 2, respectively). In the crystal structure of compound 2, neighboring heterohexamers are linked via π–π interactions and π–stacked columns of ethacridine are formed, whereas inversely oriented diclofenac anions interact through π–π interactions each other and linked these columns. The differences in the crystal packing of the title compounds influence the Kitaigorodskii type of packing index —the percentage of filled space are equal to 67.9% and 68.5% for compound 1 and 2, respectively (the Kitaigorodskii type of packing index).

5. Conclusions

Structural investigations of compounds obtained from the crystallization of diclofenac with acridines show that salt cocrystal (1) or solvate monohydrate salt (2) are formed. The title compounds crystallize in the triclinic P-1 space group, but they are not isostructural. Moreover, the crystal packing of both compounds is differed. In the crystals of title compounds, diclofenac and acridines ions and solvent molecules interact via N–H⋯O, O–H⋯O, and C–H⋯O hydrogen bonds, as well as C–H⋯π and π–π interactions, and form heterotetramer bis[⋯cation⋯anion⋯] or heterohexamer bis[⋯cation⋯ethanol⋯anion⋯] in compound 1 and 2, respectively. In the crystal of compound 1, the acridine cations and the diclofenac anions interact via N–H⋯O hydrogen bond, C–H⋯π and π–π interactions to form blocks, whereas the diclofenac molecules interact via C–Cl⋯π interactions to form columns. In the crystal of compound 2, the ethacridine cations interact via C–H⋯π and π–π interactions building blocks, while diclofenac anions interact via π–π interactions to form columns. The results of our research provide new insight into the unique crystal structure containing diclofenac and acridine/6,9-diamino-2-ethoxyacridine (ethacridine) and can be used to obtain and design new forms of drugs involving these APIs.

Author Contributions

Conceptualization, A.M. and A.S.; methodology, A.M. and A.S.; software, A.M. and A.S.; formal analysis, A.M. and A.S.; investigation, A.M. and A.S.; writing—original draft preparation, A.M. and A.S.; visualization, A.M. and A.S.; project administration, A.M. and A.S. All authors have read and agreed to the published version of the manuscript.

Funding

Research of Young Scientists grant (BMN) no. 539-T080-B898-21 (University of Gdańsk) and DS 531-T080-D738-22 (University of Gdańsk).

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Data are contained within the article.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Jones, R. Nonsteroidal anti-inflammatory drug prescribing: Past, present, and future. Am. J. Med. 2001, 110, S4–S7. [Google Scholar] [CrossRef]
  2. Sostres, C.; Gargallo, C.J.; Arroyo, M.T.; Lanas, A. Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on uppergastrointestinal tract. Best Pract. Res. Clin. Gastroenterol. 2010, 24, 121–132. [Google Scholar] [CrossRef] [PubMed]
  3. Heyneman, C.A.; Lawless-Liday, C.; Wall, G.C. Oral versus topical NSAIDs in rheumatic diseases: A comparison. Drugs 2000, 60, 555–574. [Google Scholar] [CrossRef] [PubMed]
  4. Parolini, M. Toxicity of the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) acetylsalicylic acid, paracetamol, diclofenac, ibuprofen and naproxen towards freshwater invertebrates: A review. Sci. Total Environ. 2020, 740, 140043. [Google Scholar] [CrossRef] [PubMed]
  5. Khuder, S.A.; Mutgi, A.B. Breast cancer and NSAID use: A meta-analysis. Br. J. Cancer 2001, 84, 1188–1192. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  6. Stewart, W.F.; Kawas, C.; Corrada, M.; Metter, E.J. Risk of Alzheimer’s disease and duration of NSAID use. Neurology 1997, 48, 626–632. [Google Scholar] [CrossRef] [PubMed]
  7. Gasparini, L.; Ongini, E.; Wenk, G. Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer’s disease: Old and new mechanisms ofaction. J. Neurochem. 2004, 91, 521–536. [Google Scholar] [CrossRef]
  8. Gierse, J.K.; Hauser, S.D.; Creely, D.P.; Koboldt, C.; Rangwala, S.H.; Isakson, P.C.; Seibert, K. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem. J. 1995, 305, 479–484. [Google Scholar] [CrossRef] [Green Version]
  9. O’Connor, J.P.; Lysz, T. Celecoxib, NSAIDs and the skeleton. Drugs Today 2008, 44, 693–709. [Google Scholar] [CrossRef]
  10. Gartenmann, S.; Schmidlin, P.; Maier, N.; Wiedemeier, D.B.; Attin, T. Effect of adjuvant use of nsaid in reducing probing pocket depth in the context of conventional periodontal therapy: A systematic review of randomized trials. Appl. Sci. 2020, 10, 7657. [Google Scholar] [CrossRef]
  11. Singh, G.; Fort, J.G.; Goldstein, J.L.; Levy, R.A.; Hanrahan, P.S.; Bello, A.E.; Andrade-Ortega, L.; Wallemark, C.; Agrawal, N.M.; Eisen, G.M.; et al. Celecoxib versus naproxen and diclofenac in osteoarthritis patients: SUCCESS-I study. Am. J. Med. 2006, 119, 255–266. [Google Scholar] [CrossRef]
  12. Brogden, R.N.; Heel, R.C.; Pakes, G.E.; Speight, T.M.; Avery, G.S. Diclofenac sodium: A review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. Drugs 1980, 20, 24–48. [Google Scholar] [CrossRef]
  13. Goa, K.L.; Chrisp, P. Ocular Diclofenac: A Review of Its Pharmacology and Clinical Use in Cataract Surgery, and Potentialin Other Inflammatory Ocular Conditions. Drugs Aging 1992, 2, 473–486. [Google Scholar] [CrossRef]
  14. Menassé, R.; Hedwall, P.R.; Kraetz, J.; Pericin, C.; Riesterer, L.; Sallmann, A.; Ziel, R.; Jaques, R. Pharmacological properties of diclofenac sodium and its metabolites. Scand. J. Rheum. 1978, 7, 5–16. [Google Scholar] [CrossRef]
  15. Small, R.E. Diclofenac sodium. Clin. Pharm. 1989, 8, 545–558. [Google Scholar]
  16. Goh, C.F.; Lane, M.E. Formulation of diclofenac for dermal delivery. Int. J. Pharm. 2014, 473, 607–616. [Google Scholar] [CrossRef]
  17. Dutta, N.K.; Dastidar, S.G.; Kumar, A.; Mazumdar, K.; Ray, R.; Chakrabarty, A.N. Antimycobacterial activity of the antiinflammatory agent diclofenac sodium, and its synergism with streptomycin. Braz. J. Microbiol. 2004, 35, 316–323. [Google Scholar] [CrossRef] [Green Version]
  18. Mazumdar, K.; Dastidar, S.G.; Park, J.H.; Dutta, N.K. The anti-inflammatory non-antibiotic helper compound diclofenac: An antibacterial drug target. Eur. J. Clin. Microbiol. Infect. Dis. 2009, 28, 881–891. [Google Scholar] [CrossRef]
  19. Maitra, A.; Bates, S.; Shaik, M.; Evangelopoulos, D.; Abubakar, I.; McHugh, T.D.; Lipman, M.; Bhakta, S. Repurposing drugs for treatment of tuberculosis: A role for non-steroidal anti-inflammatory drugs. Br. Med. Bull. 2016, 118, 138. [Google Scholar] [CrossRef] [Green Version]
  20. Kroesen, V.M.; Gröschel, M.I.; Martinson, N.; Zumla, A.; Maeurer, M.; van der Werf, T.S.; Vilaplana, C. Non-steroidal anti-inflammatory drugs as host-directed therapy for tuberculosis: A systematic review. Front. Immunol. 2017, 8, 772. [Google Scholar] [CrossRef]
  21. Ivanyi, J.; Zumla, A. Nonsteroidal antiinflammatory drugs for adjunctive tuberculosis treatment. J. Infect. Dis. 2013, 208, 185–188. [Google Scholar] [CrossRef]
  22. Todd, P.A.; Sorkin, E.M. Diclofenac Sodium: A Reappraisal of Its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Efficacy. Drugs 1988, 35, 244–285. [Google Scholar] [CrossRef] [PubMed]
  23. Vieno, N.; Sillanpää, M. Fate of diclofenac in municipal wastewater treatment plant—A review. Environ. Int. 2014, 69, 28–39. [Google Scholar] [CrossRef] [PubMed]
  24. Acuña, V.; Ginebreda, A.; Mor, J.R.; Petrovic, M.; Sabater, S.; Sumpter, J.; Barceló, D. Balancing the health benefits and environmental risks of pharmaceuticals: Diclofenac as an example. Environ. Int. 2015, 85, 327–333. [Google Scholar] [CrossRef] [PubMed]
  25. Vishnu Priyan, V.; Shahnaz, T.; Suganya, E.; Sivaprakasam, S.; Narayanasamy, S. Ecotoxicological assessment of micropollutant Diclofenac biosorption on magnetic sawdust: Phyto, Microbial and Fish toxicity studies. J. Hazard. Mater. 2021, 403, 123532. [Google Scholar] [CrossRef]
  26. Harshkova, D.; Majewska, M.; Pokora, W.; Baścik-Remisiewicz, A.; Tułodziecki, S.; Aksmann, A. Diclofenac and atrazine restrict the growth of a synchronous Chlamydomonas reinhardtii population via various mechanisms. Aquat. Toxicol. 2021, 230, 105698. [Google Scholar] [CrossRef]
  27. Lv, Y.; Liang, Z.; Li, Y.; Chen, Y.; Liu, K.; Yang, G.; Liu, Y.; Lin, C.; Ye, X.; Shi, Y.; et al. Efficient adsorption of diclofenac sodium in water by a novel functionalized cellulose aerogel. Environ. Res. 2021, 194, 11065. [Google Scholar] [CrossRef]
  28. Desiraju, G.R. C–H⋯O and other weak hydrogen bonds. From crystal engineering to virtual screening. Chem. Commun. 2005, 24, 2995–3001. [Google Scholar] [CrossRef]
  29. Steiner, T. C–H⋯O hydrogen bonding in crystals. Crystallogr. Rev. 2003, 9, 177–228. [Google Scholar] [CrossRef]
  30. Saha, B.K.; Nangia, A.; Jaskólski, M. Crystal engineering with hydrogen bonds and halogen bonds. CrystEngComm 2005, 7, 355–358. [Google Scholar] [CrossRef]
  31. Aakeröy, C.B.; Chopade, P.D.; Desper, J. Establishing a hierarchy of halogen bonding by engineering crystals without disorder. Cryst. Growth Des. 2013, 13, 4145–4150. [Google Scholar] [CrossRef]
  32. Mukherjee, A.; Tothadi, S.; Desiraju, G.R. Halogen bonds in crystal engineering: Like hydrogen bonds yet different. Acc. Chem. Res. 2014, 47, 2514–2524. [Google Scholar] [CrossRef]
  33. Alizadeh, V.; Mahmoudi, G.; Vinokurova, M.A.; Pokazeev, K.M.; Alekseeva, K.A.; Miroslaw, B.; Khandar, A.A.; Frontera, A.; Safin, D.A. Spodium bonds and metal-halogen⋯halogen-metal interactions in propagation of monomeric units to dimeric or polymeric architectures. J. Mol. Struct. 2022, 1252, 132144. [Google Scholar] [CrossRef]
  34. Soltani, B.; Nabipour, H.; Engle, J.T.; Ziegler, C.J. π⋯π and hydrogen bonding interactions in the crystal structure of trans-dichloro-tetrakis (1H-indazole-N2)-nickel (II). Mater. Today Proc. 2018, 5, 15845–15851. [Google Scholar] [CrossRef]
  35. Prohens, R.; Portell, A.; Vallcorba, O.; Font-Bardia, M.; Bauzá, A.; Frontera, A. Polymorphism in secondary squaramides: On the importance of π-interactions involving the four membered ring. CrystEngComm 2018, 20, 237–244. [Google Scholar] [CrossRef]
  36. Pal, P.; Das, K.; Hossain, A.; Gomila, R.M.; Frontera, A.; Mukhopadhyay, S. Synthesis and crystal structure of the simultaneous binding of Ni (ii) cation and chloride by the protonated 2, 4, 6 tris-(2-pyridyl)-1, 3, 5 triazine ligand: Theoretical investigations of anion⋯π, π⋯π and hydrogen bonding interactions. New J. Chem. 2021, 45, 11689–11696. [Google Scholar] [CrossRef]
  37. Basak, T.; Frontera, A.; Chattopadhyay, S. Existence of stronger CH⋯π (chelate ring) interaction compared to CH⋯ π (arene) interactions in the supramolecular assembly of dinuclear iron (III) Schiff base complexes: A theoretical insight. Inorg. Chim. Acta 2021, 516, 120081. [Google Scholar] [CrossRef]
  38. Frontera, A.; Gamez, P.; Mascal, M.; Mooibroek, T.J.; Reedijk, J. Putting anion–π interactions into perspective. Angew. Chem. Int. Ed. 2011, 50, 9564–9583. [Google Scholar] [CrossRef]
  39. Yamada, S. Cation–π interactions in organic crystals. Coord. Chem. Rev. 2020, 415, 213301. [Google Scholar] [CrossRef]
  40. Bhowal, R.; Biswas, S.; Thumbarathil, A.; Koner, A.L.; Chopra, D. Exploring the relationship between intermolecular interactions and solid-state photophysical properties of organic co-crystals. J. Phys. Chem. C 2018, 123, 9311–9322. [Google Scholar] [CrossRef]
  41. Aitipamula, S.; Banerjee, R.; Bansal, A.K.; Biradha, K.; Cheney, M.L.; Choudhury, A.R.; Zaworotko, M.J. Polymorphs, salts, and cocrystals: What’s in a name? Cryst. Growth Des. 2012, 12, 2147–2152. [Google Scholar] [CrossRef]
  42. Aakeröy, C.B.; Fasulo, M.E.; Desper, J. Cocrystal or salt: Does it really matter? Mol. Pharm. 2007, 4, 317–322. [Google Scholar] [CrossRef]
  43. Qiao, N.; Li, M.; Schlindwein, W.; Malek, N.; Davies, A.; Trappitt, G. Pharmaceutical cocrystals: An overview. Int. J. Pharm. 2011, 419, 1–11. [Google Scholar] [CrossRef]
  44. Desiraju, G.R. Crystal engineering: A holistic view. Angew. Chem. 2007, 46, 8342–8356. [Google Scholar] [CrossRef]
  45. Aakeröy, C.B.; Champness, N.R.; Janiak, C. Recent advances in crystal engineering. CrystEngComm 2010, 12, 22–43. [Google Scholar] [CrossRef]
  46. Barbas, R.; Bofill, L.; De Sande, D.; Font-Bardia, M.; Prohens, R. Crystal engineering of nutraceutical phytosterols: New cocrystal solid solutions. CrystEngComm 2020, 22, 4210–4214. [Google Scholar] [CrossRef]
  47. Zaworotko, M. Crystal engineering of the composition of API’s: Understanding polymorphs and designing pharmaceutical co-crystals. Am. Pharm. Outsourc. 2004, 5, 16–23. [Google Scholar]
  48. Groom, C.R.; Bruno, I.J.; Lightfoot, M.P.; Ward, S.C. The Cambridge Structural Database. Acta Cryst. 2016, 2016. B72, 171–179. [Google Scholar] [CrossRef]
  49. Goswami, P.K.; Kumar, V.; Ramanan, A. Multicomponent solids of diclofenac with pyridine based coformers. J. Mol. Struct. 2020, 1210, 128066. [Google Scholar] [CrossRef]
  50. Zheng, Q.; Rood, S.L.; Unruh, D.K.; Hutchins, K.M. Unique supramolecular complex of diclofenac: Structural robustness, crystal-to-crystal solvent exchange, and mechanochemical synthesis. Chem. Commun. 2019, 55, 7639–7642. [Google Scholar] [CrossRef]
  51. Aakeröy, C.B.; Grommet, A.B.; Desper, J. Co-crystal screening of diclofenac. Pharmaceutics 2011, 3, 601–614. [Google Scholar] [CrossRef] [PubMed]
  52. Bodart, L.; Prinzo, M.; Derlet, A.; Tumanov, N.; Wouters, J. Taking advantage of solvate formation to modulate drug–drug ratio in clofaziminium diclofenac salts. CrystEngComm 2021, 23, 185–201. [Google Scholar] [CrossRef]
  53. Bhattacharya, B.; Mondal, A.; Soni, S.R.; Das, S.; Bhunia, S.; Raju, K.B.; Ghosh, A.; Reddy, C.M. Multidrug salt forms of norfloxacin with non-steroidal anti-inflammatory drugs: Solubility and membrane permeability studies. CrystEngComm 2018, 20, 6420–6429. [Google Scholar] [CrossRef]
  54. Surov, A.O.; Voronin, A.P.; Vener, M.V.; Churakov, A.V.; Perlovich, G.L. Specific features of supramolecular organisation and hydrogen bonding in proline cocrystals: A case study of fenamates and diclofenac. CrystEngComm 2018, 20, 6970–6981. [Google Scholar] [CrossRef]
  55. Goud, N.R.; Suresh, K.; Nangia, A. Solubility and stability advantage of aceclofenac salts. Cryst. Growth Des. 2013, 13, 1590–1601. [Google Scholar] [CrossRef]
  56. Nugrahani, I.; Kumalasari, R.A.; Auli, W.N.; Horikawa, A.; Uekusa, H. Salt cocrystal of diclofenac sodium-l-proline: Structural, pseudo polymorphism, and pharmaceutics performance study. Pharmaceutics 2020, 12, 690. [Google Scholar] [CrossRef]
  57. Wang, R.; Yuan, P.; Yang, D.; Zhang, B.; Zhang, L.; Lu, Y.; Du, G. Structural features and interactions of new sulfamethazine salt and cocrystal. J. Mol. Struct. 2020, 1229, 129596. [Google Scholar] [CrossRef]
  58. Belmont, P.; Bosson, J.; Godet, T.; Tiano, M. Acridine and acridone derivatives, anticancer properties and synthetic methods: Where are we now? Anti-Cancer Agents Med. Chem. 2007, 7, 139–169. [Google Scholar] [CrossRef]
  59. Stanslas, J.; Hagan, D.J.; Ellis, M.J.; Turner, C.; Carmichael, J.; Ward, W.; Hammonds, T.R.; Stevens, M.F.G. Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA affinic tetra- and pentacyclic acridines. J. Med. Chem. 2000, 43, 1563–1572. [Google Scholar] [CrossRef]
  60. Ferreira, R.; Aviñó, A.; Mazzini, S.; Eritja, R. Synthesis, DNA-binding and antiproliferative properties of acridine and 5-methylacridine derivatives. Molecules 2012, 17, 7067–7082. [Google Scholar] [CrossRef] [Green Version]
  61. Guendel, I.; Carpio, L.; Easley, R.; Van Duyne, R.; Coley, W.; Agbottah, E.; Dowd, C.; Kashanchi, F.; Kehn-Hall, K. 9-Aminoacridine inhibition of HIV-1 Tat dependent transcription. Virol. J. 2009, 6, 1–14. [Google Scholar] [CrossRef] [Green Version]
  62. Bongarzone, S.; Bolognesi, M.L. The concept of privileged structures in rational drug design: Focus on acridine and quinoline scaffolds in neurodegenerative and protozoan diseases. Expert Opin. Drug Discov. 2011, 6, 251–268. [Google Scholar] [CrossRef]
  63. Sikorski, A.; Trzybiński, D. Synthesis and structural characterization of a cocrystal salt containing acriflavine and 3,5-dinitrobenzoic acid. Tetrahedron Lett. 2014, 55, 2253–2255. [Google Scholar] [CrossRef]
  64. Kowalska, K.; Trzybiński, D.; Sikorski, A. Influence of the halogen substituent on the formation of halogen and hydrogen bonding in co-crystals formed from acridine and benzoic acids. CrystEngComm 2015, 17, 7199–7212. [Google Scholar] [CrossRef]
  65. Mirocki, A.; Sikorski, A. Influence of Halogen Substituent on the Self-Assembly and Crystal Packing of Multicomponent Crystals Formed from Ethacridine and Meta-Halobenzoic Acids. Crystals 2020, 10, 79. [Google Scholar] [CrossRef] [Green Version]
  66. Mirocki, A.; Sikorski, A. The Influence of Solvent on the Crystal Packing of Ethacridinium Phthalate Solvates. Materials 2020, 13, 5073. [Google Scholar] [CrossRef]
  67. Huang, T.S.; Lee, J.J.; Li, Y.S.; Cheng, S.P. Ethacridine Induces Apoptosis and Differentiation in Thyroid Cancer Cells In Vitro. Anticancer Res. 2019, 39, 4095–4100. [Google Scholar] [CrossRef]
  68. Koelzer, S.C.; Held, H.; Toennes, S.W.; Verhoff, M.A.; Wunder, C. Self-induced illegal abortion with Rivanol®: A medicolegal–toxicological case report. Forensic Sci. Int. 2016, 268, e18–e22. [Google Scholar] [CrossRef]
  69. Oie, S.; Kamiya, A. Bacterial contamination of commercially available ethacridine lactate (acrinol) product. J. Hosp. Infect. 1996, 34, 51–58. [Google Scholar] [CrossRef]
  70. Li, X.; Lidsky, P.V.; Xiao, Y.; Wu, C.T.; Garcia-Knight, M.; Yang, J.; Nakayama, T.; Nayak, J.V.; Jackson, P.K.; Andino, R.; et al. Ethacridine inhibits SARS-CoV-2 by inactivating viral particles. PLoS Pathog. 2021, 17, e1009898. [Google Scholar] [CrossRef]
  71. CrysAlis CCD and CrysAlis RED; Version 1.171.36.24; Oxford Diffraction Ltd.: Yarnton, UK, 2012.
  72. Sheldrick, G.M. Crystal structure refinement with SHELXL. Acta Cryst. C 2015, 71, 3–8. [Google Scholar] [CrossRef] [PubMed]
  73. Spek, A.L. Structure validation in chemical crystallography. Acta Cryst. 2009, D65, 148–155. [Google Scholar] [CrossRef] [PubMed]
  74. Johnson, C.K. ORTEP II, Report ORNL-5138; Oak Ridge National Laboratory: Oak Ridge, TN, USA, 1976. [Google Scholar]
  75. Motherwell, S.; Clegg, S. PLUTO-78, Program for Drawing and Molecular Structure; University of Cambridge: Cambridge, UK, 1978. [Google Scholar]
  76. Macrae, C.F.; Bruno, I.J.; Chisholm, J.A.; Edgington, P.R.; McCabe, P.; Pidcock, E.; Rodriguez-Monge, L.; Taylor, R.; van de Streek, J.; Wood, P.A. Mercury CSD 2.0—New Features for the Visualization and Investigation of Crystal Structures. J. Appl. Crystallogr. 2008, 41, 466–470. [Google Scholar] [CrossRef]
  77. Lynch, D.E.; Coventry University, Coventry CV1 5FB, West Midlands, UK. Personal communication, (CSD Communication). 2009.
Materials 15 01518 sch001 550
Scheme 1. Chemical structures reported in this paper.
Scheme 1. Chemical structures reported in this paper.
Materials 15 01518 sch001
Materials 15 01518 g001 550
Figure 1. Molecular structure of compound 1 showing the atom-labelling scheme (Cg1, Cg2, Cg3, Cg4, Cg5, Cg6, and Cg7 denote the ring centroids; hydrogen bonds are represented by dashed lines).
Figure 1. Molecular structure of compound 1 showing the atom-labelling scheme (Cg1, Cg2, Cg3, Cg4, Cg5, Cg6, and Cg7 denote the ring centroids; hydrogen bonds are represented by dashed lines).
Materials 15 01518 g001
Materials 15 01518 g002 550
Figure 2. Heterotetramer formed by acridinium and diclofenac ions in compound 1 (hydrogen bonds are represented by dashed lines, whereas C–H⋯π interactions are represented by dotted lines).
Figure 2. Heterotetramer formed by acridinium and diclofenac ions in compound 1 (hydrogen bonds are represented by dashed lines, whereas C–H⋯π interactions are represented by dotted lines).
Materials 15 01518 g002
Materials 15 01518 g003 550
Figure 3. Crystal packing of compound 1 viewed along the a-axis (hydrogen bonds are represented by dashed lines, whereas C–Cl⋯π interactions are represented by dotted lines).
Figure 3. Crystal packing of compound 1 viewed along the a-axis (hydrogen bonds are represented by dashed lines, whereas C–Cl⋯π interactions are represented by dotted lines).
Materials 15 01518 g003
Materials 15 01518 g004 550
Figure 4. Molecular structure of compound 2 showing the atom-labelling scheme (Cg1, Cg2, Cg3, Cg4, and Cg5 denote the ring centroids; hydrogen bonds are represented by dashed lines).
Figure 4. Molecular structure of compound 2 showing the atom-labelling scheme (Cg1, Cg2, Cg3, Cg4, and Cg5 denote the ring centroids; hydrogen bonds are represented by dashed lines).
Materials 15 01518 g004
Materials 15 01518 g005 550
Figure 5. Heterohexamer formed by ethoxyacridinium and diclofenac ions and ethanol molecule in compound 2 (hydrogen bonds are represented by dashed lines, whereas C–H⋯π interactions are represented by dotted lines).
Figure 5. Heterohexamer formed by ethoxyacridinium and diclofenac ions and ethanol molecule in compound 2 (hydrogen bonds are represented by dashed lines, whereas C–H⋯π interactions are represented by dotted lines).
Materials 15 01518 g005
Materials 15 01518 g006 550
Figure 6. Crystal packing of compound 2 viewed along the b-axis (hydrogen bonds are represented by dashed lines, whereas π–π interactions are represented by dotted lines).
Figure 6. Crystal packing of compound 2 viewed along the b-axis (hydrogen bonds are represented by dashed lines, whereas π–π interactions are represented by dotted lines).
Materials 15 01518 g006
Table
Table 1. Crystal data and structure refinement for compounds 1 and 2.
Table 1. Crystal data and structure refinement for compounds 1 and 2.
Compound12
Chemical formulaC41H31Cl4N3O4C31H34Cl2N4O5
Formula weight/g·mol−1771.49613.52
Crystal systemtriclinictriclinic
Space groupP-1P-1
a/Å10.1582(4)7.6339(10)
b/Å12.3057(6)10.2331(17)
c/Å14.8978(7)19.250(3)
α/°91.050(4)84.860(12)
β/°99.988(3)89.009(11)
γ/°99.111(4)88.337(13)
V/Å31808.9(1)1497.0(4)
Z22
T/K295(2)295(2)
λMo/Å0.710730.71073
ρcalc/g·cm−31.4161.361
F(000)796644
µ/mm−10.3750.264
θ range/°3.31–25.003.29–25.00
Completeness θ/%99.799.8
Reflections collected127849800
Reflections63535246
unique[Rint = 0.0297][Rint = 0.0883]
Data/restraints/parameters6353/0/4855246/3/411
Goodness of fit on F21.0211.007
Final R1 value (I > 2σ(I))0.04450.0891
Final wR2 value (I > 2σ(I))0.08440.1855
Final R1 value (all data)0.07030.2190
Final wR2 value (all data)0.09450.2559
CCDC number21280542128053
Table
Table 2. Hydrogen bonds geometry for compounds 1 and 2.
Table 2. Hydrogen bonds geometry for compounds 1 and 2.
CompoundD–H⋯Ad(D–H)
[Å]		d(H⋯A)
[Å]		d(D⋯A)
[Å]		∠D–H⋯A [°]
N23–H23⋯O330.81 (2)2.39 (2)2.977 (2)130 (2)
N42–H42⋯O520.82 (2)2.36 (2)3.044 (3)142 (2)
N10–H10⋯O330.87 (2)1.79 (2)2.648 (2)170 (2)
1O51–H51⋯O320.90 (4)1.69 (3)2.560 (3)164 (3)
C45–H45⋯O32 i0.932.71 (1)3.603160 (1)
C4–H4⋯O320.932.403.292 (3)160
C8–H8⋯O52 ii0.932.503.342 (3)150
Symmetry code: (i) 1 − x, −y, 1 − z; (ii) 1 − x, 1 − y, 1 − z.
N28–H28⋯O380.91 (6)2.43 (6)3.188 (7)141 (6)
N10–H10⋯O380.94 (6)2.01 (6)2.898 (7)157 (6)
2N15–H15B⋯O410.95 (6)2.00 (6)2.945 (8)173 (6)
N15–H15A⋯O420.95 (8)1.91 (8)2.832 (9)163 (7)
N16–H16B⋯O37 i0.84 (7)2.19 (7)3.015 (1)171 (7)
N16–H16A⋯Cl260.932.91 (9)3.603133 (7)
O41–H41⋯O38 ii0.822.042.864 (7)176
O42–H42A⋯O37 ii0.85 (4)1.95 (6)2.753 (6)158 (8)
O42–H42B⋯O17 i0.83 (7)2.17 (7)2.941 (7)154 (6)
C4–H4⋯O370.932.593.438 (8)151
C8–H8⋯O420.932.453.353 (9)165
Symmetry code: (i) x, 1 + y, z; (ii) 1 − x, 1 − y, 1 − z.
Table
Table 3. C–X⋯π interactions geometry for compounds 1 and 2 (X = H/Cl).
Table 3. C–X⋯π interactions geometry for compounds 1 and 2 (X = H/Cl).
CompoundC–X⋯Cgd(X⋯Cg) [Å]d(C⋯Cg) [Å]∠C–X⋯Cg [°]
C1–H1⋯Cg4 ii2.793.697 (3)165
C7–H7⋯Cg7 ii2.903.769 (3)156
1C16–Cl21⋯Cg7 iii3.885 (1)5.138 (2)127.92 (8)
C35–Cl40⋯Cg6 iv3.725 (1)4.267 (2)95.89 (8)
Symmetry code: (ii) 1 − x, 1 − y, 1 − z; (iii) 1 + x, 1 + y, z; (iv) 1 − x, −y, 2 − z.
2C18–H18A⋯Cg3 iii2.803.666 (7)150
Symmetry code: (iii) 2 − x, 1 − y, 1 − z.
Table
Table 4. π–π interactions geometry for compounds 1 and 2.
Table 4. π–π interactions geometry for compounds 1 and 2.
CompoundCgI aCgJ aCgI⋯CgJ b
[Å]		Dihedral Angle c [°]Interplanar Distance d [Å]Offset e
[Å]
11 ii3.737 (1)0.0 (1)3.409 (9)1.533
12 ii3.841 (1)2.2 (1)3.404 (9)1.672
123 ii3.796 (2)3.8 (1)3.464 (1)1.388
14 v3.662 (1)3.9 (1)3.345 (9)1.293
34 v3.917 (1)2.4 (1)3.459 (1)1.883
Symmetry code: (ii) 1 − x, 1 − y, 1 − z; (v) 2 − x, 1 − y, 1 − z.
11 ii3.835 (3)0.0 (3)3.517 (2)1.528
223 ii3.917 (4)2.1 (3)3.530 (3)1.596
44 iv3.553 (4)0.0 (3)3.432 (3)0.919
Symmetry code: (ii) 1 − x, 1 − y, 1 − z; (iv) 1 − x, 1 − y, 2 − z.
(a) Cg represents the center of gravity of the rings. (b) Cg⋯Cg is the distance between ring centroids. (c) The dihedral angle is that between the mean planes of CgI and CgJ. (d) The interplanar distance is the perpendicular distance from CgI to ring J. (e) The offset is the perpendicular distance from ring I to ring J.
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Mirocki, A.; Sikorski, A. Structural Characterization of Multicomponent Crystals Formed from Diclofenac and Acridines. Materials 2022, 15, 1518. https://doi.org/10.3390/ma15041518

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Mirocki A, Sikorski A. Structural Characterization of Multicomponent Crystals Formed from Diclofenac and Acridines. Materials. 2022; 15(4):1518. https://doi.org/10.3390/ma15041518

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Mirocki, Artur, and Artur Sikorski. 2022. "Structural Characterization of Multicomponent Crystals Formed from Diclofenac and Acridines" Materials 15, no. 4: 1518. https://doi.org/10.3390/ma15041518

APA Style

Mirocki, A., & Sikorski, A. (2022). Structural Characterization of Multicomponent Crystals Formed from Diclofenac and Acridines. Materials, 15(4), 1518. https://doi.org/10.3390/ma15041518

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