Quantifying Actual and Perceived Inaccuracy When Estimating the Sugar, Energy Content and Portion Size of Foods
Abstract
:1. Introduction
2. Materials and Methods
2.1. Sample
2.2. Procedure
2.3. Materials and Measures
2.3.1. Food Items
2.3.2. Estimation Task
2.3.3. Expected and Perceived Accuracy
2.3.4. Experience with Food Journaling
2.3.5. Demographic and Anthropometric Variables
2.4. Statistical Analysis
3. Results
3.1. Comparison between the Four Estimation Measures: Accuracy, Frequency, and Degree of Estimation Errors
3.2. Expected and Perceived Accuracy of Estimations and Relation to Objective Accuracy
3.3. Relationships with Experience with Food Journaling, Gender and Body Mass Index (BMI)
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
- World Health Organization. Guideline: Sugars Intake for Adults and Children; World Health Organization: Geneva, Switzerland, 2015. [Google Scholar]
- Moynihan, P.; Kelly, S. Effect on caries of restricting sugars intake: Systematic review to inform WHO guidelines. J. Dent. Res. 2014, 93, 8–18. [Google Scholar] [CrossRef] [PubMed]
- Te Morenga, L.; Mallard, S.; Mann, J. Dietary sugars and body weight: Systematic review and meta-analyses of randomised controlled trials and cohort studies. BMJ 2013, 346, e7492. [Google Scholar] [CrossRef]
- Ernst, J.B.; Arens-Azevêdo, U.; Bitzer, B.; Bosy-Westphal, A.; de Zwaan, M.; Enger, S.; Fritsche, A.; Gerlach, S.; Hauner, H.; Heseker, H.; et al. Quantitative Empfehlung zur Zuckerzufuhr in Deutschland; Bonn, Germany, 2018. [Google Scholar]
- Max-Rubner-Institut. Nationale Verzehrsstudie II. Ergebnisbericht Teil 2 [National Nutrition Survey II. Results Report Part 2]; Max-Rubner Institut: Karlsruhe, Germany, 2008. [Google Scholar]
- Powell, E.S.; Smith-Taillie, L.P.; Popkin, B.M. Added sugars intake across the distribution of US children and adult consumers: 1977–2012. J. Acad. Nutr. Diet. 2016, 116, 1543–1550. [Google Scholar] [CrossRef] [PubMed]
- Hall, K.D.; Heymsfield, S.B.; Kemnitz, J.W.; Klein, S.; Schoeller, D.A.; Speakman, J.R. Energy balance and its components: Implications for body weight regulation. Am. J. Clin. Nutr. 2012, 95, 989–994. [Google Scholar] [CrossRef] [PubMed]
- Sacks, G.; Veerman, J.L.; Moodie, M.; Swinburn, B. ‘Traffic-light’nutrition labelling and ‘junk-food’tax: A modelled comparison of cost-effectiveness for obesity prevention. Int. J. Obes. 2011, 35, 1001–1009. [Google Scholar] [CrossRef] [PubMed]
- Crockett, R.A.; King, S.E.; Marteau, T.M.; Prevost, A.T.; Bignardi, G.; Roberts, N.W.; Stubbs, B.; Hollands, G.J.; Jebb, S.A. Nutritional labelling for healthier food or non‐alcoholic drink purchasing and consumption. Cochrane Databse Syst. Rev. 2018. [Google Scholar] [CrossRef] [PubMed]
- Dallacker, M.; Hertwig, R.; Mata, J. Parents’ considerable underestimation of sugar and their child’s risk of overweight. Int. J. Obes. 2018, 42, 1097–1100. [Google Scholar] [CrossRef] [PubMed]
- Block, J.P.; Condon, S.K.; Kleinman, K.; Mullen, J.; Linakis, S.; Rifas-Shiman, S.; Gillman, M.W. Consumers’ estimation of calorie content at fast food restaurants: Cross sectional observational study. BMJ 2013, 346, f2907. [Google Scholar] [CrossRef] [PubMed]
- Burton, S.; Creyer, E.H.; Kees, J.; Huggins, K. Attacking the obesity epidemic: The potential health benefits of providing nutrition information in restaurants. Am. J. Public Health 2006, 96, 1669–1675. [Google Scholar] [CrossRef] [PubMed]
- Chandon, P.; Wansink, B. Is obesity caused by calorie underestimation? A psychophysical model of meal size estimation. J. Mark. Res. 2007, 44, 84–99. [Google Scholar] [CrossRef]
- Chandon, P.; Wansink, B. The biasing health halos of fast-food restaurant health claims: Lower calorie estimates and higher side-dish consumption intentions. J. Consum. Res. 2007, 34, 301–314. [Google Scholar] [CrossRef]
- Wansink, B.; Chandon, P. Meal size, not body size, explains errors in estimating the calorie content of meals. Ann. Intern. Med. 2006, 145, 326–332. [Google Scholar] [CrossRef] [PubMed]
- Almiron-Roig, E.; Navas-Carretero, S.; Emery, P.; Martínez, J.A. Research into food portion size: Methodological aspects and applications. Food Funct. 2018, 9, 715–739. [Google Scholar] [CrossRef] [PubMed]
- Koelsch, C.; Brüggemann, I. Die Aid-Ernährungspyramide—Richtig Essen Lehren Und Lernen [the AID Nutrition Pyramid—Correcly Teaching and Learning How to Eat]; Aid Infodienst: Bonn, Germany, 2012. [Google Scholar]
- Gibson, A.A.; Hsu, M.S.; Rangan, A.M.; Seimon, R.V.; Lee, C.M.; Das, A.; Finch, C.H.; Sainsbury, A. Accuracy of hands v. household measures as portion size estimation aids. J. Nutr. Sci. 2016, 5, e29. [Google Scholar] [CrossRef] [PubMed]
- Cordeiro, F.; Epstein, D.A.; Thomaz, E.; Bales, E.; Jagannathan, A.K.; Abowd, G.D.; Fogarty, J. Barriers and negative nudges: Exploring challenges in food journaling. In Proceedings of the 33rd Annual ACM Conference on Human Factors in Computing Systems, Seoul, Korea, 18–23 April 2015; pp. 1159–1162. [Google Scholar]
- Holmstrup, M.E.; Stearns-Bruening, K.; Rozelle, J. Quantifying accurate calorie estimation using the “think aloud” method. J. Nutr. Educ. Behav. 2013, 45, 77–81. [Google Scholar] [CrossRef] [PubMed]
- Brunstrom, J.M.; Rogers, P.J.; Pothos, E.M.; Calitri, R.; Tapper, K. Estimating everyday portion size using a ‘method of constant stimuli’: In a student sample, portion size is predicted by gender, dietary behaviour, and hunger, but not BMI. Appetite 2008, 51, 296–301. [Google Scholar] [CrossRef] [PubMed]
- Carels, R.A.; Harper, J.; Konrad, K. Qualitative perceptions and caloric estimations of healthy and unhealthy foods by behavioral weight loss participants. Appetite 2006, 46, 199–206. [Google Scholar] [CrossRef] [PubMed]
- Faul, F.; Erdfelder, E.; Buchner, A.; Lang, A.-G. Statistical power analyses using G * Power 3.1: Tests for correlation and regression analyses. Behav. Res. Methods 2009, 41, 1149–1160. [Google Scholar] [CrossRef] [PubMed]
- Jungvogel, A. Lebensmittelbezogene Ernährungsempfehlungen in Deutschland [Foodrelated Dietary Guidelines in Germany]; Deutsche Gesellschaft Für Ernährung E.V. (DGE): Bonn, Germany, 2014. [Google Scholar]
- Cohen, J. A power primer. Psychol. Bull. 1992, 112, 155–159. [Google Scholar] [CrossRef]
- Page, M.C.; Braver, S.L.; MacKinnon, D.P. Two (or More) Factor Within-Subjects Analysis of Variance. In Levine’s Guide to SPSS for Analysis of Variance; Page, M.C., Braver, S.L., MacKinnon, D.P., Eds.; Lawrence Erlbaum Associates: New York, NY, USA, 2003; pp. 81–96. [Google Scholar]
- Chernev, A.; Chandon, P. Calorie estimation biases in consumer choice. In Leveraging Consumer Psychology for Effective Health Communications: The Obesity Challenge; Batra, R., Anand, K.P., Strecher, V.J., Eds.; Routledge: New York, NY, USA, 2011; pp. 104–121. [Google Scholar]
- Food Drink Europe; Euro Commerce. Guidance on the Provision of Food Information to Consumers; European Parliament, European Council, Eds.; Food Drink Europe: Brussels, Belgium, 2013. [Google Scholar]
- Deese, J.; Kaufman, R.A. Serial effects in recall of unorganized and sequentially organized verbal material. J. Exp. Psychol. 1957, 54, 180–187. [Google Scholar] [CrossRef]
- Murdock, B.B. The serial position effect of free recall. J. Exp. Psychol. 1962, 64, 482–488. [Google Scholar] [CrossRef]
- Geier, A.B.; Rozin, P.; Doros, G. Unit bias: A new heuristic that helps explain the effect of portion size on food intake. Psychol. Sci. 2006, 17, 521–525. [Google Scholar] [CrossRef] [PubMed]
- Isaac, M.S.; Schindler, R.M. The top-ten effect: Consumers’ subjective categorization of ranked lists. J. Consum. Res. 2013, 40, 1181–1202. [Google Scholar] [CrossRef]
- Keel, P.K.; Baxter, M.G.; Heatherton, T.F.; Joiner, T.E. A 20-year longitudinal study of body weight, dieting, and eating disorder symptoms. J. Abnorm. Psychol. 2007, 116, 422–432. [Google Scholar] [CrossRef]
- Block, L.G.; Grier, S.A.; Childers, T.L.; Davis, B.; Ebert, J.E.; Kumanyika, S.; Laczniak, R.N.; Machin, J.E.; Motley, C.M.; Peracchio, L.; et al. From nutrients to nurturance: A conceptual introduction to food well-being. J. Public Policy Mark. 2011, 30, 5–13. [Google Scholar] [CrossRef]
- Rozin, P. The meaning of food in our lives: A cross-cultural perspective on eating and well-being. J. Nutr. Educ. Behav. 2005, 37, 107–112. [Google Scholar] [CrossRef]
- Tiggemann, M. Dieting in moderation: The role of dietary restraint in the relationship between body dissatisfaction and psychological well-being. J. Health Psychol. 1997, 2, 501–507. [Google Scholar] [CrossRef]
- Carels, R.A.; Konrad, K.; Harper, J. Individual differences in food perceptions and calorie estimation: An examination of dieting status, weight, and gender. Appetite 2007, 49, 450–458. [Google Scholar] [CrossRef]
- Ericsson, K.A.; Krampe, R.T.; Tesch-Römer, C. The role of deliberate practice in the acquisition of expert performance. Psychol. Rev. 1993, 100, 363–406. [Google Scholar] [CrossRef]
- Beier, M.E.; Ackerman, P.L. Determinants of health knowledge: An investigation of age, gender, abilities, personality, and interests. J Personal. Soc. Psychol. 2003, 84, 439–448. [Google Scholar] [CrossRef]
- Rolls, B.J.; Fedoroff, I.C.; Guthrie, J.F. Gender differences in eating behavior and body weight regulation. Health Psychol. 1991, 10, 133–142. [Google Scholar] [CrossRef] [PubMed]
- Beardsworth, A.; Bryman, A.; Keil, T.; Goode, J.; Haslam, C.; Lancashire, E. Women, men and food: The significance of gender for nutritional attitudes and choices. Br. Food J. 2002, 104, 470–491. [Google Scholar] [CrossRef]
- Adams, J.M.; Hart, W.; Gilmer, L.; Lloyd-Richardson, E.E.; Burton, K.A. Concrete images of the sugar content in sugar-sweetened beverages reduces attraction to and selection of these beverages. Appetite 2014, 83, 10–18. [Google Scholar] [CrossRef] [PubMed]
- König, L.M.; Renner, B. Colourful = healthy? Exploring meal colour variety and its relation to food consumption. Food Qual. Prefer. 2018, 64, 66–71. [Google Scholar] [CrossRef]
- König, L.M.; Renner, B. Boosting healthy food choices by meal colour variety: Results from two experiments and a just-in-time Ecological Momentary Intervention. BMC Public Health 2019, 19, 975. [Google Scholar] [CrossRef] [PubMed]
- Parmenter, K.; Waller, J.; Wardle, J. Demographic variation in nutrition knowledge in England. Health Educ. Res. 2000, 15, 163–174. [Google Scholar] [CrossRef] [Green Version]
- Wardle, J.; Parmenter, K.; Waller, J. Nutrition knowledge and food intake. Appetite 2000, 34, 269–275. [Google Scholar] [CrossRef]
- Hendrie, G.; Cox, D.; Coveney, J. P17: Nutrition knowledge as a predictor of nutrient intake and diet quality. J. Nutr. Educ. Behav. 2008, 40, S49–S50. [Google Scholar] [CrossRef]
- Paasche‐Orlow, M.K.; Parker, R.M.; Gazmararian, J.A.; Nielsen-Bohlman, L.T.; Rudd, R.R. The prevalence of limited health literacy. J. Gen. Intern. Med. 2005, 20, 175–184. [Google Scholar] [CrossRef]
- Brogden, N.; Almiron-Roig, E. Estimated portion sizes of snacks and beverages differ from reference amounts and are affected by appetite status in non-obese men. Public Health Nutr. 2011, 14, 1743–1751. [Google Scholar] [CrossRef] [Green Version]
- McAdams, M.A.; Van Dam, R.M.; Hu, F.B. Comparison of self‐reported and measured BMI as correlates of disease markers in US adults. Obesity 2007, 15, 188–196. [Google Scholar] [CrossRef] [PubMed]
- Guerra, R.S.; Fonseca, I.; Pichel, F.; Restivo, M.T.; Amaral, T.F. Hand length as an alternative measurement of height. Eur. J. Clin. Nutr. 2014, 68, 229. [Google Scholar] [CrossRef] [PubMed]
- National Aeronautics and Space Administration. Anthropometry and biomechanics. In Man-System Integration Standards; National Aeronautics and Space Administration: Washington, DC, USA, 1995; Volume 1. [Google Scholar]
- Forouhi, N.G.; Krauss, R.M.; Taubes, G.; Willett, W. Dietary fat and cardiometabolic health: Evidence, controversies, and consensus for guidance. BMJ 2018, 361, k2139. [Google Scholar] [CrossRef] [PubMed]
Food Item | Actual Value (Ref.) | Estimated Value | |||||
---|---|---|---|---|---|---|---|
M | SD | t | df | p | Cohen’s d | ||
Quiche | |||||||
Sugar content (absolute, gram) | 1.74 | 17.86 | 16.45 | 13.68 | 194 | <0.001 | 0.98 |
Sugar content (% deviation) | 926.38 | 945.65 | |||||
Amount (hand measure) | 1 a | 1.0 | 0.37 | −0.08 | 193 | 0.939 | 0.01 |
Weight (gram) | 113 | 141.67 | 73.94 | 5.41 | 194 | <0.001 | 0.39 |
Energy content (kcal) | 372 | 269.53 | 201.63 | −7.13 | 196 | <0.001 | 0.51 |
Sandwich | |||||||
Sugar content (absolute, gram) | 1.91 | 21.84 | 28.90 | 9.68 | 196 | <0.001 | 0.70 |
Sugar content (% deviation) | 1051.72 | 1512.17 | |||||
Amount (hand measure) | 1 a | 1.13 | 0.48 | 3.79 | 193 | <0.001 | 0.27 |
Weight (gram) | 86 | 147.70 | 78.87 | 10.98 | 196 | <0.001 | 0.78 |
Energy content (kcal) | 298.6 | 238.67 | 132.45 | −6.34 | 195 | <0.001 | 0.45 |
Vegetable sticks | |||||||
Sugar content (absolute, gram) | 3.43 | 8.58 | 13.29 | 5.41 | 194 | <0.001 | 0.39 |
Sugar content (% deviation) | 150.24 | 387.58 | |||||
Amount (hand measure) | 1 a | 1.35 | 0.53 | 9.12 | 192 | <0.001 | 0.66 |
Weight (gram) | 88 | 96.71 | 65.75 | 1.86 | 196 | 0.064 | 0.13 |
Energy content (kcal) | 21.5 | 54.21 | 46.54 | 9.87 | 196 | <0.001 | 0.70 |
Creamy yogurt-herb sauce | |||||||
Sugar content (absolute, gram) | 1.14 | 9.58 | 13.62 | 8.27 | 177 | <0.001 | 0.62 |
Sugar content (% deviation) | 492.30 | 794.35 | |||||
Amount (hand measure) | 1 b | 2.13 | 1.22 | 12.70 | 188 | <0.001 | 0.95 |
Weight (gram) | 40.2 | 42.56 | 32.59 | 1.02 | 196 | 0.310 | 0.07 |
Energy content (kcal) | 75.3 | 78.27 | 83.12 | 0.50 | 194 | 0.619 | 0.04 |
Chocolate mousse | |||||||
Sugar content (absolute, gram) | 7.66 | 31.34 | 21.89 | 14.60 | 181 | <0.001 | 1.08 |
Sugar content (% deviation) | 309.15 | 285.76 | |||||
Amount (hand measure) | 0.5 a | 0.86 | 1.22 | 4.10 | 195 | <0.001 | 0.29 |
Weight (gram) | 30.5 | 57.90 | 41.86 | 9.19 | 196 | <0.001 | 0.65 |
Energy content (kcal) | 142.93 | 245.61 | 170.80 | 8.44 | 196 | <0.001 | 0.60 |
Fruit skewers | |||||||
Sugar content (absolute, gram) | 5.11 | 27.06 | 24.44 | 12.42 | 190 | <0.001 | 0.90 |
Sugar content (% deviation) | 429.61 | 478.24 | |||||
Amount (hand measure) | 1 a | 1.54 | 0.69 | 10.91 | 193 | <0.001 | 0.78 |
Weight (gram) | 60 | 84.19 | 53.03 | 6.40 | 196 | <0.001 | 0.46 |
Energy content (kcal) | 27.5 | 90.72 | 69.69 | 12.73 | 196 | <0.001 | 0.91 |
Muffin | |||||||
Sugar content (absolute, gram) | 19.4 | 44.52 | 32.65 | 10.63 | 190 | <0.001 | 0.77 |
Sugar content (% deviation) | 129.48 | 168.31 | |||||
Amount (hand measure) | 1 a | 1.09 | 0.62 | 2.04 | 195 | 0.043 | 0.15 |
Weight (gram) | 69 | 121.61 | 67.30 | 10.97 | 196 | <0.001 | 0.78 |
Energy content (kcal) | 249 | 243.86 | 150.24 | −0.48 | 196 | 0.631 | 0.03 |
Food Item | Underestimation | Correct | Overestimation | ||
---|---|---|---|---|---|
N (%) | M 1 (SD) | N (%) | N (%) | M 2 (SD) | |
Sugar content (in grams) | |||||
Quiche | 3 (1.5) | −90.42 (16.59) | 0 (0.0) | 192 (98.5) | 942.27 (944.35) |
Sandwich | 4 (2.0) | −92.15 (12.46) | 0 (0.0) | 193 (98.0) | 1075.43 (1518.71) |
Vegetable sticks | 74 (37.9) | −60.92 (31.55) | 0 (0.0) | 121 (62.1) | 279.37 (444.90) |
Creamy yogurt-herb sauce | 16 (9.0) | −37.70 (27.98) | 0 (0.0) | 162 (91.0) | 544.65 (814.22) |
Chocolate mousse | 5 (2.7) | −29.50 (7.15) | 0 (0.0) | 177 (97.3) | 318.71 (283.95) |
Fruit skewers | 18 (9.4) | −18.46 (27.06) | 0 (0.0) | 173 (90.6) | 476.23 (478.94) |
Muffin | 29 (15.2) | −33.17 (17.88) | 0 (0.0) | 162 (84.8) | 158.59 (166.60) |
Overall | 2 (1.0) | −28.24 (28.43) | 0 (0.0) | 195 (99.0) | 522.32 (528.41) |
Amount (hand measure) | |||||
Quiche | 40 (20.6) | −46.5 (10.20) | 131 (67.5) | 23 (11.9) | 79.13 (39.96) |
Sandwich | 31 (16.0) | −43.72 (16.40) | 116 (59.8) | 47 (24.2) | 82.45 (43.10) |
Vegetable sticks | 17 (8.8) | −41.71 (19.37) | 84 (43.5) | 92 (47.7) | 80.44 (38.70) |
Creamy yogurt-herb sauce | 13 (6.9) | −56.92 (16.90) | 19 (10.1) | 157 (83.1) | 140.73 (115.15) |
Chocolate mousse | 135 (68.9) | −60.94 (13.13) | 46 (23.5) | 15 (7.7) | 360 (180.48) |
Fruit skewers | 13 (6.7) | −42.95 (24.68) | 74 (38.1) | 107 (55.2) | 102.80 (54.21) |
Muffin | 35 (17.9) | −43.80 (16.68) | 129 (65.8) | 32 (16.3) | 103.28 (106.60) |
Overall | 43 (21.9) | −18.55 (11.32) | 3 (1.5) | 150 (76.5) | 45.27 (49.58) |
Weight (in grams) | |||||
Quiche | 86 (44.1) | −32.35 (19.61) | 0 (0.0) | 109 (55.9) | 70.91 (51.40) |
Sandwich | 43 (21.8) | −25.53 (21.01) | 0 (0.0) | 154 (78.2) | 98.91 (85.15) |
Vegetable sticks | 105 (53.3) | −38.69 (21.69) | 0 (0.0) | 92 (46.7) | 65.35 (75.18) |
Creamy yogurt-herb sauce | 124 (62.9) | −36.58 (28.43) | 0 (0.0) | 73 (37.1) | 77.98 (90.18) |
Chocolate mousse | 67 (34.0) | −32.84 (20.66) | 0 (0.0) | 130 (66.0) | 96.30 (111.83) |
Fruit skewers | 72 (36.5) | −33.84 (21.87) | 14 (7.1) | 111 (56.3) | 93.50 (83.38) |
Muffin | 43 (21.8) | −33.54 (22.79) | 0 (0.0) | 154 (78.2) | 106.90 (87.82) |
Overall | 57 (28.9) | −25.17 (19.45) | 0 (0.0) | 140 (71.1) | 66.92 (57.79) |
Energy content (in kcal) | |||||
Quiche | 167 (84.8) | −43.57 (21.80) | 0 (0.0) | 30 (15.2) | 61.65 (86.18) |
Sandwich | 139 (70.9) | −43.01 (18.42) | 0 (0.0) | 57 (29.1) | 35.87 (39.03) |
Vegetable sticks | 52 (26.4) | −37.03 (28.05) | 0 (0.0) | 145 (73.6) | 219.97 (214.34) |
Creamy yogurt-herb sauce | 130 (66.7) | −44.41 (21.85) | 0 (0.0) | 65 (33.3) | 100.63 (147.40) |
Chocolate mousse | 59 (29.9) | −28.38 (15.82) | 0 (0.0) | 138 (70.1) | 114.68 (118.95) |
Fruit skewers | 17 (8.6) | −33.48 (19.10) | 0 (0.0) | 180 (91.4) | 254.77 (251.17) |
Muffin | 111 (56.3) | −37.41 (20.63) | 0 (0.0) | 86 (43.7) | 43.55 (64.09) |
Overall | 45 (22.8) | −23.75 (20.05) | 0 (0.0) | 152 (77.2) | 82.77 (88.26) |
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Share and Cite
König, L.M.; Ziesemer, K.; Renner, B. Quantifying Actual and Perceived Inaccuracy When Estimating the Sugar, Energy Content and Portion Size of Foods. Nutrients 2019, 11, 2425. https://doi.org/10.3390/nu11102425
König LM, Ziesemer K, Renner B. Quantifying Actual and Perceived Inaccuracy When Estimating the Sugar, Energy Content and Portion Size of Foods. Nutrients. 2019; 11(10):2425. https://doi.org/10.3390/nu11102425
Chicago/Turabian StyleKönig, Laura M., Katrin Ziesemer, and Britta Renner. 2019. "Quantifying Actual and Perceived Inaccuracy When Estimating the Sugar, Energy Content and Portion Size of Foods" Nutrients 11, no. 10: 2425. https://doi.org/10.3390/nu11102425
APA StyleKönig, L. M., Ziesemer, K., & Renner, B. (2019). Quantifying Actual and Perceived Inaccuracy When Estimating the Sugar, Energy Content and Portion Size of Foods. Nutrients, 11(10), 2425. https://doi.org/10.3390/nu11102425