Fermented Houttuynia cordata Juice Exerts Cardioprotective Effects by Alleviating Cardiac Inflammation and Apoptosis in Rats with Lipopolysaccharide-Induced Sepsis

Sumneang, Natticha; Kobroob, Anongporn; Phungphong, Sukanya; Boonhoh, Worakan; Punsawad, Chuchard; Kangwan, Napapan

doi:10.3390/nu17030501

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Fermented Houttuynia cordata Juice Exerts Cardioprotective Effects by Alleviating Cardiac Inflammation and Apoptosis in Rats with Lipopolysaccharide-Induced Sepsis

by

Natticha Sumneang

^1,2

,

Anongporn Kobroob

³,

Sukanya Phungphong

^1,2

,

Worakan Boonhoh

⁴,

Chuchard Punsawad

^1,2

and

Napapan Kangwan

^3,*

¹

Department of Medical Science, School of Medicine, Walailak University, Nakhon Si Thammarat 80160, Thailand

²

Research Center in Tropical Pathobiology, Walailak University, Nakhon Si Thammarat 80160, Thailand

³

Division of Physiology, School of Medical Sciences, University of Phayao, Phayao 56000, Thailand

⁴

Akkhraratchakumari Veterinary College, Walailak University, Nakhon Si Thammarat 80160, Thailand

^*

Author to whom correspondence should be addressed.

Nutrients 2025, 17(3), 501; https://doi.org/10.3390/nu17030501

Submission received: 6 January 2025 / Revised: 27 January 2025 / Accepted: 28 January 2025 / Published: 29 January 2025

(This article belongs to the Special Issue Anti-Inflammatory, Antioxidant, and Antimicrobial Potential of Natural Products)

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Abstract

Background/Objectives: Sepsis-induced cardiac dysfunction is a major problem that often leads to severe complications and a poor prognosis. Despite the growing awareness of its impact, effective treatment options for sepsis-induced cardiac dysfunction remain limited. To date, fermented products of Houttuynia cordata (HC), known for its rich bioactive properties, have shown potential in modulating inflammatory and oxidative stress pathways. However, treatment with fermented HC juice (FHJ) in lipopolysaccharide (LPS)-induced sepsis in rats has not been investigated. Methods: Rats were pretreated with FHJ at doses of 200 mg/kg and 400 mg/kg for 2 weeks. After that, the rats were injected with a single dose of LPS (10 mg/kg), and 12 h after injection, they developed sepsis-induced cardiac dysfunction. Then, cardiac function, oxidative stress, inflammation, apoptosis, and cardiac injury markers were determined. Results: Pretreatment with FHJ at doses of 200 mg/kg and 400 mg/kg prevented LPS-induced cardiac dysfunction in rats by attenuating cardiac inflammation (IL-1β, TLR-4, and NF-κB levels), oxidative stress (MDA levels), and apoptosis (cleaved-caspase 3 and Bax/Bcl-2 expression) and reducing markers of cardiac injury (LDH and CK-MB levels). Conclusions: These results suggest that FHJ could be a potential therapeutic agent for sepsis-induced heart disease.

Keywords: fermented Houttuynia cordata juice; heart; anti-inflammation; antioxidant; apoptosis

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MDPI and ACS Style

Sumneang, N.; Kobroob, A.; Phungphong, S.; Boonhoh, W.; Punsawad, C.; Kangwan, N. Fermented Houttuynia cordata Juice Exerts Cardioprotective Effects by Alleviating Cardiac Inflammation and Apoptosis in Rats with Lipopolysaccharide-Induced Sepsis. Nutrients 2025, 17, 501. https://doi.org/10.3390/nu17030501

AMA Style

Sumneang N, Kobroob A, Phungphong S, Boonhoh W, Punsawad C, Kangwan N. Fermented Houttuynia cordata Juice Exerts Cardioprotective Effects by Alleviating Cardiac Inflammation and Apoptosis in Rats with Lipopolysaccharide-Induced Sepsis. Nutrients. 2025; 17(3):501. https://doi.org/10.3390/nu17030501

Chicago/Turabian Style

Sumneang, Natticha, Anongporn Kobroob, Sukanya Phungphong, Worakan Boonhoh, Chuchard Punsawad, and Napapan Kangwan. 2025. "Fermented Houttuynia cordata Juice Exerts Cardioprotective Effects by Alleviating Cardiac Inflammation and Apoptosis in Rats with Lipopolysaccharide-Induced Sepsis" Nutrients 17, no. 3: 501. https://doi.org/10.3390/nu17030501

APA Style

Sumneang, N., Kobroob, A., Phungphong, S., Boonhoh, W., Punsawad, C., & Kangwan, N. (2025). Fermented Houttuynia cordata Juice Exerts Cardioprotective Effects by Alleviating Cardiac Inflammation and Apoptosis in Rats with Lipopolysaccharide-Induced Sepsis. Nutrients, 17(3), 501. https://doi.org/10.3390/nu17030501

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Fermented Houttuynia cordata Juice Exerts Cardioprotective Effects by Alleviating Cardiac Inflammation and Apoptosis in Rats with Lipopolysaccharide-Induced Sepsis

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