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Nutrients, Volume 17, Issue 3 (February-1 2025) – 202 articles

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57 pages, 1810 KiB  
Review
Impact of Olive Oil Components on the Expression of Genes Related to Type 2 Diabetes Mellitus
by Camelia Munteanu, Polina Kotova and Betty Schwartz
Nutrients 2025, 17(3), 570; https://doi.org/10.3390/nu17030570 - 3 Feb 2025
Viewed by 18
Abstract
Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder characterized by insulin resistance and beta cell dysfunction, resulting in hyperglycemia. Olive oil, a cornerstone of the Mediterranean diet, has attracted considerable attention due to its potential health benefits, including reducing the risk [...] Read more.
Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder characterized by insulin resistance and beta cell dysfunction, resulting in hyperglycemia. Olive oil, a cornerstone of the Mediterranean diet, has attracted considerable attention due to its potential health benefits, including reducing the risk of developing T2DM. This literature review aims to critically examine and synthesize existing research regarding the impact of olive oil on the expression of genes relevant to T2DM. This paper also seeks to provide an immunological and genetic perspective on the signaling pathways of the main components of extra virgin olive oil. Key bioactive components of olive oil, such as oleic acid and phenolic compounds, were identified as modulators of insulin signaling. These compounds enhanced the insulin signaling pathway, improved lipid metabolism, and reduced oxidative stress by decreasing reactive oxygen species (ROS) production. Additionally, they were shown to alleviate inflammation by inhibiting the NF-κB pathway and downregulating pro-inflammatory cytokines and enzymes. Furthermore, these bioactive compounds were observed to mitigate endoplasmic reticulum (ER) stress by downregulating stress markers, thereby protecting beta cells from apoptosis and preserving their function. In summary, olive oil, particularly its bioactive constituents, has been demonstrated to enhance insulin sensitivity, protect beta cell function, and reduce inflammation and oxidative stress by modulating key genes involved in these processes. These findings underscore olive oil’s therapeutic potential in managing T2DM. However, further research, including well-designed human clinical trials, is required to fully elucidate the role of olive oil in personalized nutrition strategies for the prevention and treatment of T2DM. Full article
(This article belongs to the Section Lipids)
13 pages, 1354 KiB  
Review
Targeting Helicobacter pylori Through the “Muco-Microbiotic Layer” Lens: The Challenge of Probiotics and Microbiota Nanovesicles
by Olga Maria Manna, Celeste Caruso Bavisotto, Melania Ionelia Gratie, Provvidenza Damiani, Giuseppe Bonaventura, Francesco Cappello, Giovanni Tomasello and Vito D’Andrea
Nutrients 2025, 17(3), 569; https://doi.org/10.3390/nu17030569 - 3 Feb 2025
Viewed by 183
Abstract
The muco-microbiotic layer represents a critical biological frontier in gastroenterology, emphasizing the intricate interplay between the protective mucus, its resident microbiota, and extracellular vesicles. This review explores the functional morphology of the gastric mucosa, focusing on the gastric muco-microbiotic layer, its role as [...] Read more.
The muco-microbiotic layer represents a critical biological frontier in gastroenterology, emphasizing the intricate interplay between the protective mucus, its resident microbiota, and extracellular vesicles. This review explores the functional morphology of the gastric mucosa, focusing on the gastric muco-microbiotic layer, its role as a protective barrier, and its dynamic interaction with some of the most insidious pathogens such as Helicobacter pylori (H. pylori). Highlighting the multifaceted mechanisms of H. pylori pathogenesis, we have delved into bacterial virulence factors, host immune responses, and the microbiota’s regulatory effects. Novel therapeutic strategies for H. pylori eradication, including traditional antibiotic therapies and emerging adjuvant treatments like probiotics and probiotic-derived extracellular vesicles, are critically examined. These findings underscore the potential of targeting nanovesicular interactions in the gastric mucosa, proposing a paradigm shift in the management of H. pylori infections to improve patient outcomes while mitigating antibiotic resistance. Full article
(This article belongs to the Special Issue Dietary Nutrition on Gastrointestinal Health)
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17 pages, 1796 KiB  
Article
Role of Ginseng and L-Carnitine in Modulating Exercise Endurance and Oxidative Stress in Rats
by Kakanang Posridee, Sajeera Kupittayanant, Pornthep Rachnavy, Anant Oonsivilai and Ratchadaporn Oonsivilai
Nutrients 2025, 17(3), 568; https://doi.org/10.3390/nu17030568 - 3 Feb 2025
Viewed by 201
Abstract
Ginseng and L-carnitine are natural compounds often used as dietary supplements to enhance athletic performance. However, their combined effects on exercise endurance remain unclear. Objectives: This study aimed to investigate the effects of ginseng extract and L-carnitine supplementation on exercise endurance in [...] Read more.
Ginseng and L-carnitine are natural compounds often used as dietary supplements to enhance athletic performance. However, their combined effects on exercise endurance remain unclear. Objectives: This study aimed to investigate the effects of ginseng extract and L-carnitine supplementation on exercise endurance in a rat model. Methods: Male Wistar rats were divided into 10 groups (n = 5 per group): control, ginseng extract (250 and 500 mg/kg/day), L-carnitine (250 and 500 mg/kg/day), and combined treatment. Half of the groups underwent a 16-day exercise training program of swimming without loading. Exercise endurance was assessed using a tail-suspended forced swimming test. Relative organ weight, glycogen content, blood biochemistry, and gene expression were analyzed. Results: Both ginseng extract and L-carnitine supplementation significantly increased exercise endurance, particularly in the exercise group. Ginseng extract and L-carnitine also increased liver glycogen content and upregulated the expression of AMPKα1 and PGC-1α genes in the liver and muscle. In addition, both supplements reduced oxidative stress by decreasing MDA levels and increasing SOD activity. Conclusions: Ginseng extract and L-carnitine supplementation may enhance exercise endurance by improving energy metabolism, reducing oxidative stress, and upregulating key genes involved in mitochondrial biogenesis. Full article
(This article belongs to the Special Issue Dietary Supplements in Exercise and Sports Activities)
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15 pages, 2004 KiB  
Article
Dairy Consumption and the Colonic Mucosa-Associated Gut Microbiota in Humans—A Preliminary Investigation
by Ellie Chen, Nadim J. Ajami, Donna L. White, Yanhong Liu, Shawn Gurwara, Kristi Hoffman, David Y. Graham, Hashem B. El-Serag, Joseph F. Petrosino and Li Jiao
Nutrients 2025, 17(3), 567; https://doi.org/10.3390/nu17030567 - 2 Feb 2025
Viewed by 448
Abstract
Background: Dairy consumption has been associated with various health outcomes that may be mediated by changes in gut microbiota. Methods: This cross-sectional study investigated the association between the colonic mucosa-associated gut microbiota and the self-reported intake of total dairy, milk, cheese, and yogurt. [...] Read more.
Background: Dairy consumption has been associated with various health outcomes that may be mediated by changes in gut microbiota. Methods: This cross-sectional study investigated the association between the colonic mucosa-associated gut microbiota and the self-reported intake of total dairy, milk, cheese, and yogurt. A total of 97 colonic mucosal biopsies collected from 34 polyp-free individuals were analyzed. Dairy consumption in the past year was assessed using a food frequency questionnaire. The 16S rRNA gene V4 region was amplified and sequenced. Operational taxonomic unit (OTU) classification was performed using the UPARSE and SILVA databases. OTU diversity and relative abundance were compared between lower vs. higher dairy consumption groups. Multivariable negative binomial regression models for panel data were used to estimate the incidence rate ratio and 95% confidence interval for bacterial counts and dairy consumption. False discovery rate-adjusted p values (q value) < 0.05 indicated statistical significance. Results: Higher total dairy and milk consumption and lower cheese consumption were associated with higher alpha microbial diversity (adjusted p values < 0.05). Higher total dairy and milk consumption was also associated with higher relative abundance of Faecalibacterium. Higher milk consumption was associated with higher relative abundance of Akkermansia. Higher total dairy and cheese consumption was associated with lower relative abundance of Bacteroides. Conclusions: Dairy consumption may influence host health by modulating the structure and composition of the colonic adherent gut microbiota. Full article
(This article belongs to the Section Nutritional Epidemiology)
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23 pages, 1343 KiB  
Review
Preoperative Nutrition in Bariatric Surgery: A Narrative Review on Enhancing Surgical Success and Patient Outcomes
by Daniel Simancas-Racines, Evelyn Frias-Toral, Martín Campuzano-Donoso, Daniel Ramos-Sarmiento, Raynier Zambrano-Villacres, Claudia Reytor-González and Luigi Schiavo
Nutrients 2025, 17(3), 566; https://doi.org/10.3390/nu17030566 - 2 Feb 2025
Viewed by 336
Abstract
Bariatric surgery has become the preferred treatment for individuals with morbid obesity. Nutrition is key in optimizing surgical outcomes by reducing risks and enhancing recovery. Preoperative strategies, such as reducing body fat, decreasing liver size, and improving metabolic profiles, have been shown to [...] Read more.
Bariatric surgery has become the preferred treatment for individuals with morbid obesity. Nutrition is key in optimizing surgical outcomes by reducing risks and enhancing recovery. Preoperative strategies, such as reducing body fat, decreasing liver size, and improving metabolic profiles, have been shown to facilitate safer surgical procedures with fewer complications. This narrative review aims to provide an analysis of the fundamental role of preoperative nutritional management in improving bariatric surgery outcomes, emphasizing the importance of addressing specific nutritional challenges to enhance surgical safety, recovery, and overall health. Preoperative nutritional interventions focus on correcting comorbidities and nutritional deficiencies, particularly hypovitaminosis and micronutrient imbalances, through a multidisciplinary approach involving nutritionists and other healthcare professionals. These interventions not only prepare patients for the physiological demands of surgery but also initiate a period of adaptation to new dietary habits, aiming to improve long-term compliance and mitigate risks such as postoperative weight regain and dumping syndrome. Adopting dietary changes, such as very low-calorie or ketogenic diets 6–12 weeks before surgery, enhances adherence to postoperative restrictions and overall surgical success. Future research should focus on developing comprehensive guidelines for preoperative nutritional care to improve patient outcomes globally. Full article
(This article belongs to the Section Nutrition and Obesity)
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14 pages, 877 KiB  
Article
Impact of Vitamin D Deficiency on Gestational Diabetes and Pregnancy Outcomes Across Diverse Ethnic Groups: A Retrospective Cohort Study
by Sushant Saluja, Navin Sugathan, Roopa Krishnamurthy and Edward B. Jude
Nutrients 2025, 17(3), 565; https://doi.org/10.3390/nu17030565 - 2 Feb 2025
Viewed by 296
Abstract
Background: Vitamin D deficiency is linked to adverse pregnancy outcomes like gestational diabetes mellitus (GDM), but its effects across ethnic groups are unclear. This study examines the relationship among vitamin D levels, glucose tolerance, GDM prevalence, and neonatal outcomes in a multi-ethnic cohort [...] Read more.
Background: Vitamin D deficiency is linked to adverse pregnancy outcomes like gestational diabetes mellitus (GDM), but its effects across ethnic groups are unclear. This study examines the relationship among vitamin D levels, glucose tolerance, GDM prevalence, and neonatal outcomes in a multi-ethnic cohort of pregnant women. Methods: We conducted a retrospective analysis of 252 pregnant women from antenatal clinics between 2018 and 2022. Participants were divided into four groups based on serum vitamin D levels: severely deficient (<25 nmol/L), deficient (25–50 nmol/L), insufficient (51–75 nmol/L), and sufficient (>75 nmol/L). The analysis included multivariate linear regression models adjusted for age, ethnicity, BMI, gestational diabetes status, and seasonality. An area under the receiver operating characteristic (AUROC) analysis identified the vitamin D threshold linked to an increased GDM risk. Results: Women classified as severely deficient had higher fasting glucose levels (5.73 ± 1.24 mmol/L) than those in other groups (p = 0.003, adjusted). The AUROC analysis identified a vitamin D threshold of 45 nmol/L associated with an elevated GDM risk (AUROC = 0.78, CI: 0.70–0.85). South Asian women had lower vitamin D levels (41.17 ± 18.03 nmol/L vs. 45.15 ± 16.75 nmol/L) and higher glucose tolerance test (GTT) levels than Caucasian women, despite having lower BMIs. Moreover, vitamin D levels positively correlated with neonatal birth weight (p = 0.02). Conclusions: There is a strong link between vitamin D deficiency and increased GDM risk, especially among South Asian women. These findings underscore the need for targeted interventions to improve vitamin D levels in high-risk ethnic groups. Full article
(This article belongs to the Special Issue Nutrition Strategy for Maternal and Infant Wellbeing)
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18 pages, 1233 KiB  
Article
The Effect of Flavonoids and Topiramate on Glucose Carbon Metabolism in a HepG2 Steatosis Cell Culture Model: A Stable Isotope Study
by Li Ma, Qing-Yi Lu, Shu Lim, Guang Han, Laszlo G. Boros, Mina Desai and Jennifer K. Yee
Nutrients 2025, 17(3), 564; https://doi.org/10.3390/nu17030564 - 31 Jan 2025
Viewed by 612
Abstract
Background: Insufficient treatment options are available for metabolic dysfunction-associated steatotic liver disease (MASLD). Flavonoids and topiramate have been studied for weight loss but need investigation into their effects on liver metabolism. This study’s aim was to examine the effects of flavonoids or [...] Read more.
Background: Insufficient treatment options are available for metabolic dysfunction-associated steatotic liver disease (MASLD). Flavonoids and topiramate have been studied for weight loss but need investigation into their effects on liver metabolism. This study’s aim was to examine the effects of flavonoids or topiramate on glucose metabolic carbon flux in a cell culture model of steatosis. Methods: Steatosis was induced in HepG2 cells through exposure to oleic acid (OA, 0.5 mml/L) conjugated to bovine serum albumin (2:1). Additionally, 50% U13C-glucose was supplied in the medium as a stable isotope tracer. Cells were treated with DMSO, 10 μM of naringenin, morin, silibinin, or topiramate (44 μM) for 72 h. A non-steatotic, untreated HepG2 cell control was included. Cell extracts were analyzed by gas chromatography/mass spectrometry and mass isotopomer distribution analysis for glycogen synthesis, de novo fatty acid synthesis, tricarboxylic acid (TCA) cycle activity, and ribose synthesis. Groups were compared by ANOVA with Tukey’s pair-wise testing. Results: Compared to untreated HepG2 controls, OA-exposed steatotic cells exhibited increased lipid accumulation by ORO staining (1.6-fold), enhanced palmitate de novo synthesis, reduced pyruvate carboxylase/pyruvate dehydrogenase (PC/PDH) ratio, and reduced ribose synthesis. Treatment with topiramate or silibinin ameliorated the lipid accumulation (1.3-fold) and mitigated enhancement of de novo synthesis. Morin-treated cells exhibited enhanced de novo synthesis but suppressed ribose synthesis. Conclusions: Potential mechanisms of reduced lipid accumulation by topiramate and silibinin may include suppression of palmitate de novo synthesis and a relative decrease in carbon flux through the PDH pathway. Further studies are needed on potential utility in MASLD based on their specific metabolic effects. Full article
(This article belongs to the Special Issue The Role of Bioactive Compounds in Human Health and Diseases (2nd Edition))
22 pages, 3255 KiB  
Systematic Review
Effect of Different Dietary Patterns on Patients with Depressive Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
by Rahele Tavakoly, Alina Moosburner, Dennis Anheyer and Holger Cramer
Nutrients 2025, 17(3), 563; https://doi.org/10.3390/nu17030563 - 31 Jan 2025
Viewed by 358
Abstract
Objectives: This study aimed to investigate the effects of different dietary patterns on depressive disorders. Methods: PubMed/MEDLINE, Cochrane CENTRAL, Embase, PsycINFO, Scopus, and ProQuest databases were systematically searched until 30 April 2024 for randomized controlled trials (RCTs) assessing the effects of [...] Read more.
Objectives: This study aimed to investigate the effects of different dietary patterns on depressive disorders. Methods: PubMed/MEDLINE, Cochrane CENTRAL, Embase, PsycINFO, Scopus, and ProQuest databases were systematically searched until 30 April 2024 for randomized controlled trials (RCTs) assessing the effects of different dietary patterns on depressive symptoms in adults with depressive disorders. Secondary outcomes included remission rates, quality of life, and safety. Standardized mean difference (SMD) and 95% confidence intervals (CIs) were aggregated using a random-effects model. Study quality was assessed with the Cochrane Risk of Bias (RoB)-2 tool, and certainty of evidence was determined using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. Results: Five RCTs (n = 952) were included, all investigating the Mediterranean diet (MD) in individuals with major depressive disorder or elevated depression levels. The analysis found no significant effect of short-term MD intervention on depression severity compared to active (SMD = −1.25 [95%CI: −5.11 to 2.61]) or passive (SMD = −0.22 [95%CI: −0.74 to 0.29]) controls. There was no effect on quality of life compared to active controls (SMD = 0.71 [95%CI = −3.38 to 4.79]). Intermediate and long-term results were similar. The overall risk of bias was “some concerns”, and the certainty of evidence was “very low” for most of the results. Conclusions: The MD appears to have no potential influence on major depressive disorder. However, this finding should be interpreted cautiously due to the limited number of RCTs. Further studies on dietary patterns and depressive disorders are needed for more robust conclusions. Systematic Review Registration: PROSPERO registration no. CRD42024541885. Full article
(This article belongs to the Section Nutrition and Public Health)
26 pages, 724 KiB  
Review
Health Effects and Therapeutic Potential of the Gut Microbe Akkermansia muciniphila
by Ezinne Aja, Amber Zeng, Weston Gray, Kaden Connelley, Anil Chaganti and Jonathan P. Jacobs
Nutrients 2025, 17(3), 562; https://doi.org/10.3390/nu17030562 - 31 Jan 2025
Viewed by 392
Abstract
Akkermansia muciniphila is a bacterium commonly found in the human gastrointestinal tract that has received considerable interest as a potential probiotic for the improvement of gut health and overall metabolic function. A. muciniphila is enriched in the mucus layer of the intestinal lining, [...] Read more.
Akkermansia muciniphila is a bacterium commonly found in the human gastrointestinal tract that has received considerable interest as a potential probiotic for the improvement of gut health and overall metabolic function. A. muciniphila is enriched in the mucus layer of the intestinal lining, where it degrades mucin and plays a significant role in gut barrier maintenance and immune regulation. A higher abundance of A. muciniphila has been observed in the gut of healthy individuals relative to those with metabolic disorders, and multiple metabolic benefits, including improved glucose management, reduced body fat, and reduced inflammation have been linked to A. muciniphila. Current research on A. muciniphila primarily relies on mouse models, with limited human interventional studies available. While these animal studies offer valuable insights into the potential roles of A. muciniphila in health and disease, further clinical investigations in humans are needed to fully understand its impact. Here, we explore the current scope of A. muciniphila research and its potential as a therapeutic agent to improve gut and metabolic health while also emphasizing the need to optimize techniques to further improve studies of this organism. Full article
(This article belongs to the Section Prebiotics and Probiotics)
27 pages, 1321 KiB  
Article
Impact of Different Low-Volume Concurrent Training Regimens on Cardiometabolic Health, Inflammation, and Fitness in Obese Metabolic Syndrome Patients
by Dejan Reljic, Hans Joachim Herrmann, Markus Friedrich Neurath and Yurdagül Zopf
Nutrients 2025, 17(3), 561; https://doi.org/10.3390/nu17030561 - 31 Jan 2025
Viewed by 330
Abstract
Background/Objectives: Evidence supports the benefits of concurrent training (CT), which combines endurance and resistance exercises, for enhancing health and physical fitness. Recently, low-volume, time-efficient exercise approaches such as low-volume high-intensity interval training (LOW-HIIT), whole-body electromyostimulation (WB-EMS), and single-set resistance training (1-RT) have gained [...] Read more.
Background/Objectives: Evidence supports the benefits of concurrent training (CT), which combines endurance and resistance exercises, for enhancing health and physical fitness. Recently, low-volume, time-efficient exercise approaches such as low-volume high-intensity interval training (LOW-HIIT), whole-body electromyostimulation (WB-EMS), and single-set resistance training (1-RT) have gained popularity for their feasibility and efficacy in improving various health outcomes. This study investigated the effects of low-volume CT, focusing on (1) whether exercise order affects cardiometabolic health, inflammation, and fitness adaptations and (2) which combination, LOW-HIIT plus WB-EMS or LOW-HIIT plus 1-RT, yields better results. Methods: Ninety-three obese metabolic syndrome (MetS) patients undergoing caloric restriction were randomly assigned to four groups performing the different low-volume CT protocols over 12 weeks. Outcomes included cardiometabolic, inflammatory, and fitness parameters. Results: In both combinations, no significant differences were found regarding exercise order. However, the pooled LOW-HIIT and 1-RT group achieved superior improvements in blood pressure, blood lipids, inflammation markers (CRP, hsCRP), the MetS severity score, and overall fitness compared to the LOW-HIIT and WB-EMS combination. Compared to previous studies using these modalities individually, LOW-HIIT plus 1-RT appeared to further reduce inflammation, whereas LOW-HIIT combined with WB-EMS was less effective for cardiometabolic health, potentially due to interference effects between modalities. Conclusions: While LOW-HIIT plus WB-EMS appears to be a viable option for individuals unable to perform traditional resistance training, the findings suggest prioritizing LOW-HIIT plus 1-RT to maximize health outcomes. These findings highlight the importance of tailored exercise prescriptions and the need for further research into optimizing CT protocols for diverse populations. Full article
(This article belongs to the Special Issue Ameliorating Low-Grade Inflammation through Nutrition Interventions and Exercises)
17 pages, 332 KiB  
Article
Dynamic Nutrition Strategies for Anorexia Nervosa: Marker-Based Integration of Calories and Proteins
by Eugenia Dozio, Martina Alonge, Gianluca Tori, Andrea Caumo, Rina Giuseppa Russo, Edoardo Scuttari, Leonardo Fringuelli and Ileana Terruzzi
Nutrients 2025, 17(3), 560; https://doi.org/10.3390/nu17030560 - 31 Jan 2025
Viewed by 343
Abstract
Background/Objectives: Anorexia nervosa (AN) is a severe psychiatric disorder characterized by profound nutritional deficits and significant alterations in body composition, cellular integrity, and hydration. Nutritional rehabilitation is critical not only for weight restoration but also for improving body composition and metabolic functions. However, [...] Read more.
Background/Objectives: Anorexia nervosa (AN) is a severe psychiatric disorder characterized by profound nutritional deficits and significant alterations in body composition, cellular integrity, and hydration. Nutritional rehabilitation is critical not only for weight restoration but also for improving body composition and metabolic functions. However, optimal strategies for integrating caloric and protein intake to achieve balanced recovery remain underexplored. This study aims to evaluate the interactions between caloric/protein intake and time on quantitative (weight and BMI) and qualitative (body composition and cellular health) outcomes, and to identify markers that predict recovery trajectories and guide personalized nutritional interventions. Methods: This retrospective observational study analyzed 79 patients with AN admitted to Villa Miralago for six months of nutritional rehabilitation. Anthropometric and body composition parameters—including body weight (BW), body mass index (BMI), fat mass (FM), fat-free mass (FFM), body cell mass (BCM), phase angle (PA), and hydration markers (TBW and ECW)—were assessed at baseline (T0), 3 months (T1), and 6 months (T2). Generalized Estimating Equations (GEEs) were used to evaluate the effects of caloric and protein intake over time. Results: Significant increases in BW (+6.54 kg, p < 0.0001) and BMI (+2.47 kg/m2, p < 0.0001) were observed, alongside improvements in FM, FFM, and BCM. PA increased significantly (+0.47°, p < 0.0001), indicating enhanced cellular health. TBW increased (+1.58 L, p < 0.0001), while ECW% decreased, reflecting improved fluid distribution. Caloric intake predominantly influenced early fat mass recovery, while protein intake was crucial for preserving lean tissues and promoting cellular regeneration. Interaction effects between caloric/protein intake and time revealed dynamic changes in body composition, underscoring the need for adaptive strategies. Conclusions: This study highlights the importance of a dynamic, marker-based approach to nutritional rehabilitation in AN. Integrating caloric and protein intake with advanced body composition and hydration markers enables personalized interventions and balanced recovery, shifting AN treatment toward a focus on qualitative improvements overweight restoration alone. Full article
(This article belongs to the Special Issue Disordered Eating and Lifestyle Studies—2nd Edition)
16 pages, 393 KiB  
Review
Nutritional Habits in Crohn’s Disease Onset and Management
by Konstantinos Papadimitriou, Georgia-Eirini Deligiannidou, Gavriela Voulgaridou, Constantinos Giaginis and Sousana K. Papadopoulou
Nutrients 2025, 17(3), 559; https://doi.org/10.3390/nu17030559 - 31 Jan 2025
Viewed by 309
Abstract
Crohn’s disease (CD)’s activation factors are still unclear. However, they are reported to involve an interaction between genetic susceptibility and unhealthy lifestyle factors like smoking, alcohol consumption, low physical activity, low BMI (<18.5 kg/m2), and probably unbalanced nutritional habits. Therefore, the [...] Read more.
Crohn’s disease (CD)’s activation factors are still unclear. However, they are reported to involve an interaction between genetic susceptibility and unhealthy lifestyle factors like smoking, alcohol consumption, low physical activity, low BMI (<18.5 kg/m2), and probably unbalanced nutritional habits. Therefore, the aim of the present narrative review is to demonstrate the possible effects of different nutritional habits, before the occurrence of the disease, as crucial factors for the inception of CD activation. The structure of the present narrative review was conducted following the instructions of the “Narrative Review Academy of Nutrition and Dietetics Checklist”. It is well established that the consumption of specific foods and drinks, such as spicy and fatty foods, raw vegetables and fruits, dairy products, carbonated beverages, and coffee or tea, can provoke the exacerbation of CD symptoms. On the other hand, Mediterranean-oriented diets seem to provide an inverse association with the incidence of CD. Moreover, patients seem to have the knowledge to select foods that contribute to the remission of their symptoms. However, it is not clearly reported whether the inception of CD activation is due to lifelong unbalanced nutritional habits and their subsequent effect on gut microbiota secretion, which seems to be the gold standard for CD’s investigation. Therefore, more future studies should record, examine, and compare the nutritional habits between patients with CD (immediately after the disease’s diagnosis) and healthy populations in a lifelong manner, in order to reveal the possible influence of foods on CD inception. Full article
(This article belongs to the Special Issue Impact of Different Nutritional, Supplementation and Physical Activity Strategies on Patients with Inflammatory Bowel Disease—Second Edition)
29 pages, 929 KiB  
Review
Protective Effects of Bifidobacterium Breve MCC1274 as a Novel Therapy for Alzheimer’s Disease
by Mona Abdelhamid, Scott E. Counts, Chunyu Zhou, Hideki Hida, Jae-Il Kim, Makoto Michikawa and Cha-Gyun Jung
Nutrients 2025, 17(3), 558; https://doi.org/10.3390/nu17030558 - 31 Jan 2025
Viewed by 448
Abstract
Alzheimer’s disease (AD) is the most common form of dementia and is characterized by memory impairment that significantly interferes with daily life. Therapeutic options for AD that substantively modify disease progression remain a critical unmet need. In this regard, the gut microbiota is [...] Read more.
Alzheimer’s disease (AD) is the most common form of dementia and is characterized by memory impairment that significantly interferes with daily life. Therapeutic options for AD that substantively modify disease progression remain a critical unmet need. In this regard, the gut microbiota is crucial in maintaining human health by regulating metabolism and immune responses, and increasing evidence suggests that probiotics, particularly beneficial bacteria, can enhance memory and cognitive functions. Recent studies have highlighted the positive effects of Bifidobacterium breve MCC1274 (B. breve MCC1274) on individuals with mild cognitive impairment (MCI) and schizophrenia. Additionally, oral supplementation with B. breve MCC1274 has been shown to effectively prevent memory decline in AppNL–G–F mice. In relation to Alzheimer’s pathology, oral supplementation with B. breve MCC1274 has been found to reduce amyloid-β (Aβ) accumulation and tau phosphorylation in both AppNL–G–F and wild-type (WT) mice. It also decreases microglial activation and increases levels of synaptic proteins. In this review, we examine the beneficial effects of B. breve MCC1274 on AD, exploring potential mechanisms of action and how this probiotic strain may aid in preventing or treating the disease. Furthermore, we discuss the broader implications of B. breve MCC1274 for improving overall host health and provide insights into future research directions for this promising probiotic therapy. Full article
(This article belongs to the Section Prebiotics and Probiotics)
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14 pages, 727 KiB  
Article
An Online Nutrition Education Program Targeting Intentions and Related Determinants Towards Dietary Supplement Use: An Application of the Theory of Planned Behavior
by  Jana Daher, Margo Mountjoy and Dalia El Khoury
Nutrients 2025, 17(3), 557; https://doi.org/10.3390/nu17030557 - 31 Jan 2025
Viewed by 342
Abstract
Background/Objectives: Dietary supplement use among varsity athletes is influenced by various psychological and social factors, yet there is limited evidence on the effectiveness of educational interventions in influencing these determinants. The aim of this study was to determine the effects of an online [...] Read more.
Background/Objectives: Dietary supplement use among varsity athletes is influenced by various psychological and social factors, yet there is limited evidence on the effectiveness of educational interventions in influencing these determinants. The aim of this study was to determine the effects of an online nutrition education program on improvements in intentions and related determinants towards the use of dietary supplements in varsity athletes at the University of Guelph in Canada. The theory of planned behavior served as the theoretical framework for examining these determinants as predictors of behavior change. Methods: A randomized wait-list controlled trial was conducted on a total of 30 varsity athletes, randomized into experimental (n = 18) and control (n = 12) groups. The experimental group received access to an online nutrition education program focused on sports nutrition and dietary supplements, while the control group did not have access during the study. Results: There was a significant (p < 0.05) intervention effect on varsity athletes’ attitudes (Mean1(control) = 13.17; Mean1(experimental) = 13.56; Mean2(control) = 13.92; Mean2(experimental) = 12.11), perceived behavioral control (Mean1(control) = 15.92; Mean1(experimental) = 16.11; Mean2(control) = 16.33; Mean2(experimental) = 18.39), and intentions (Mean1(control) = 12.5; Mean1(experimental) = 12.89; Mean2(control) = 11.58; Mean2(experimental) = 9.44) towards dietary supplement use. No significant changes were made to descriptive and injunctive norms. Conclusions: These findings suggest that this nutrition education program significantly improved intentions and related determinants towards dietary supplement use in varsity athletes. The absence of a successful change in subjective norm should be a focus for similar future interventions. Full article
(This article belongs to the Special Issue Nutrition and Supplements for Athletic Training and Racing)
14 pages, 742 KiB  
Article
Possible Prognostic Role of BMI Before Chemotherapy in the Outcomes of Women with Ovarian Cancer
by Stavroula A. Paschou, Angeliki Andrikopoulou, Nikoletta Mili, Anna Svarna, Maria Kaparelou, Katerina Stefanaki, Nikolaos Dedes, Efstathia Liatsou, Nikolaos Thomakos, Dimitrios Haidopoulos, Theodora Psaltopoulou, Efstathios Kastritis, Flora Zagouri, Meletios-Athanasios Dimopoulos and Michalis Liontos
Nutrients 2025, 17(3), 556; https://doi.org/10.3390/nu17030556 - 31 Jan 2025
Viewed by 340
Abstract
Background/Objectives: Survival rates for ovarian cancer remain distressingly low. Despite established prognostic factors, the need to identify modifiable parameters to influence survival outcomes is imperative. Overweight and obesity, both prevalent conditions, have been implicated in cancer development and potentially poor survival. However, conflicting [...] Read more.
Background/Objectives: Survival rates for ovarian cancer remain distressingly low. Despite established prognostic factors, the need to identify modifiable parameters to influence survival outcomes is imperative. Overweight and obesity, both prevalent conditions, have been implicated in cancer development and potentially poor survival. However, conflicting data on the associations of body mass index (BMI) with progression-free survival (PFS) and overall survival (OS) in ovarian cancer patients necessitate further exploration. This study aims to investigate the prognostic role of BMI before chemotherapy in women with ovarian cancer, specifically focusing on PFS and OS. Methods: A retrospective analysis encompassed 1,136 patients diagnosed with ovarian carcinomas between 1995 and 2018. Patients were categorized based on BMI at presentation, and a comprehensive examination of clinicopathological, treatment, and survival data was conducted. Results: In the patient population, normal weight patients (BMI <25 kg/m2) demonstrated a median PFS of 12.8 months (95% CI 11.7–13.9 months), while overweight/obese patients (BMI ≥25 kg/m2) exhibited a significantly longer median PFS of 14.9 months (95% CI 13.6–16.4 months, p = 0.006). No statistically significant difference was noted in median OS between the two BMI groups. Subgroup analysis for different histological subtypes revealed a statistically significant benefit for overweight and obese patients with serous and endometrioid histology (mPFS 12.9 months, 95% CI 11.7–14.0 vs 15.6 months, 95% CI 13.9–17.3, p = 0.012 and 14.6 months 95%CI 13.7–15.5 vs 25.6 months, 95%CI 9.5–41.7, p = 0.031, respectively). Additionally, BMI ≥25 kg/m2 demonstrated a significant advantage in advanced-stage disease. Conclusions: The study underscores the intricate association between BMI and ovarian cancer prognosis. While a statistically significant difference in progression-free survival was noted between normal weight and overweight/obese patients, with the latter group experiencing a survival benefit, no such difference was observed in overall survival. Full article
(This article belongs to the Special Issue Dietary Patterns and Cancer: Risks and Survival Outcomes)
17 pages, 621 KiB  
Review
Fetal Growth Restriction and Its Metabolism-Related Long-Term Outcomes—Underlying Mechanisms and Clinical Implications
by Anca Adam-Raileanu, Ingrith Miron, Ancuta Lupu, Laura Bozomitu, Maria Oana Sasaran, Ruxandra Russu, Solange Tamara Rosu, Alin Horatiu Nedelcu, Delia Lidia Salaru, Ginel Baciu, Cristina Maria Mihai, Tatiana Chisnoiu, Omer Faruk Beser and Vasile Valeriu Lupu
Nutrients 2025, 17(3), 555; https://doi.org/10.3390/nu17030555 - 31 Jan 2025
Viewed by 313
Abstract
The developmental origins of adult disease theory support the concept that undernourished fetuses are at risk of developing metabolic syndrome due to the energy-saving ‘Thrifty Phenotype’. This metabolic plasticity represents an evolutionary adaptation that allows individuals to resist the intense pressure caused by [...] Read more.
The developmental origins of adult disease theory support the concept that undernourished fetuses are at risk of developing metabolic syndrome due to the energy-saving ‘Thrifty Phenotype’. This metabolic plasticity represents an evolutionary adaptation that allows individuals to resist the intense pressure caused by cyclically recurring periods of nutritional deprivation. A comprehensive review was conducted following an extensive literature search in the PubMed/Medline and EMBASE databases concerning reports on fetal/intrauterine growth restriction and its metabolic-related long-term outcomes. We only included articles written in English that were published before July 1, 2024. There are several underlying mechanisms and metabolic and endocrine adjustments shaped by the perinatal environment, and they all contribute to progression towards adult disease. From in utero malnutrition or other insults during the fetal period to fetal programing and postnatal catch-up growth, it is difficult to identify the exact moment when this adaptative phenomenon meant to assure fetal survival and to set children on their own physiological growth curves lose its beneficial effect, establishing the trajectory to obesity, insulin resistance, and other hallmarks of metabolic syndrome. With clinical correspondence to an altered body mass, composition, and eating behaviors, it is evident that the metabolic complications linked to FGR are intricate and arise from disturbances in several pathways and organs, but the underlying processes responsible for the long-term consequences are just starting to be understood. The lack of continuity in perinatal-to-pediatric FGR research sets the challenge of exploring new directions in future scientific opportunities. These will hopefully represent a cornerstone in the management of FGR-related metabolic disorders in children, preventing these disorders from evolving into adult disease. Full article
(This article belongs to the Topic Metabolic Syndrome, Biomarkers and Lifestyles)
16 pages, 629 KiB  
Article
Antioxidant Intake and Ovarian Reserve in Women Attending a Fertility Center
by Ana B. Maldonado-Cárceles, Irene Souter, Ming-Chieh Li, Makiko Mitsunami, Irene Dimitriadis, Jennifer B. Ford, Lidia Mínguez-Alarcón and Jorge E. Chavarro
Nutrients 2025, 17(3), 554; https://doi.org/10.3390/nu17030554 - 31 Jan 2025
Viewed by 466
Abstract
Background/Objectives: The aim of this study was to investigate the association between antioxidant intake and antral follicle count (AFC), a marker of ovarian reserve, in women attending a fertility clinic. Methods: We conducted an observational study with 567 women undergoing infertility evaluation at [...] Read more.
Background/Objectives: The aim of this study was to investigate the association between antioxidant intake and antral follicle count (AFC), a marker of ovarian reserve, in women attending a fertility clinic. Methods: We conducted an observational study with 567 women undergoing infertility evaluation at the Massachusetts General Hospital Fertility Center, who were enrolled in the Environment and Reproductive Health (EARTH) study. Participants filled out the lifestyle and health questionnaires and a validated food frequency questionnaire (FFQ) for assessing habitual dietary intake and underwent a transvaginal ultrasound to measure AFC. Intake of nutrients with direct antioxidant capacity (vitamin A, C, and E and carotenoids) and intake of antioxidant food sources were estimated from the FFQ. Adjusted Poisson regression models were fitted to assess the relationships between antioxidants and AFC while adjusting for potential confounders. Non-linearity was assessed with restricted cubic splines. Results: The median (interquartile range) age and AFC of participants were 35.0 (32.0–38.0) years and 13 (9–18), respectively. Our findings revealed a non-linear association between lycopene intake and AFC. There was a positive linear association with the highest AFC among women consuming approximately 6000 mcg/day of lycopene (P for non-linearity = 0.003). An inverse association was observed between retinol intake, predominantly from dairy foods, and AFC among women aged under 35 years (P-trend < 0.001 and 0.01, respectively). Conclusions: Our findings suggest that lycopene intake might influence the ovarian reserve in fertility patients. The observed inverse association with retinol, if confirmed, may reflect biological mechanisms different from oxidative stress. The underlying mechanisms of these associations remain to be elucidated and warrant further investigation. Full article
(This article belongs to the Special Issue Impact of Diet, Nutrition and Lifestyle on Reproductive Health)
21 pages, 2621 KiB  
Article
Sunflower Oil Fortified with Vitamins D and A and Sunflower Lecithin Ameliorated Scopolamine-Induced Cognitive Dysfunction in Mice and Exploration of the Underlying Protective Pathways
by Xue Tang, Chengkai Zhu, Tristan C. Liu, Rongxiang Zhu, Guoliang Deng, Peng Zhou and Dasong Liu
Nutrients 2025, 17(3), 553; https://doi.org/10.3390/nu17030553 - 31 Jan 2025
Viewed by 287
Abstract
The incidence of cognitive disorders is increasing globally, with a reported prevalence of over 50 million individuals affected, and current interventions offer limited efficacy. This study investigates the effects of sunflower oil fortified with sunflower lecithin, vitamin D, and vitamin A on scopolamine-induced [...] Read more.
The incidence of cognitive disorders is increasing globally, with a reported prevalence of over 50 million individuals affected, and current interventions offer limited efficacy. This study investigates the effects of sunflower oil fortified with sunflower lecithin, vitamin D, and vitamin A on scopolamine-induced cognitive dysfunction in mice and explores the underlying mechanisms. The incidence of cognitive disorders, such as Alzheimer’s disease, is increasing yearly, and current interventions offer limited efficacy. Therefore, this research aims to evaluate the cognitive improvement effects of the three added functional factors on mice with learning and memory impairments, along with the associated molecular mechanisms. Behavioral tests, biochemical assays, and real-time quantitative polymerase chain reaction (RT-qPCR) were utilized to examine the intervention effects of these functional factors on scopolamine-induced cognitive impairment in mice. The results revealed that the groups treated with sunflower lecithin and vitamin D significantly enhanced the mice’s exploratory behavior, working memory, and spatial memory, with increases of 1.6 times and 4.5 times, respectively, in the open field and novel object recognition tests (VD group). Additionally, these treatments reduced levels of inflammatory markers and IL-6, increased antioxidant GSH levels, and decreased oxidative stress marker MDA levels, with all effects showing significant differences (p < 0.01). The effects were further enhanced when vitamin A was combined with these treatments. Transcriptomic analysis demonstrated that the intervention groups had markedly improved learning and memory abilities through upregulation of key gene expression levels in the PI3K-AKT signaling pathway, cholinergic pathway, and folate biosynthesis pathway. These findings provide a theoretical basis for the development of nutritionally fortified edible oils with added sunflower lecithin, vitamin D, and vitamin A, which may help prevent and ameliorate cognitive disorders. Full article
(This article belongs to the Section Nutrition and Public Health)
19 pages, 1341 KiB  
Article
Improving Irritable Bowel Syndrome (IBS) Symptoms and Quality of Life with Quebracho and Chestnut Tannin-Based Supplementation: A Single-Centre, Randomised, Double-Blind, Placebo-Controlled Clinical Trial
by Silvia Molino, Lorenza Francesca De Lellis, Maria Vittoria Morone, Marcello Cordara, Danaè S. Larsen, Roberto Piccinocchi, Gaetano Piccinocchi, Alessandra Baldi, Alessandro Di Minno, Hesham R. El-Seedi, Roberto Sacchi and Maria Daglia
Nutrients 2025, 17(3), 552; https://doi.org/10.3390/nu17030552 - 31 Jan 2025
Viewed by 304
Abstract
Background/Objectives: Irritable Bowel Syndrome (IBS) is a disorder of the gut-brain axis for which the gastroenterologist is most often consulted. Gastrointestinal symptoms and decreased quality of life lead to a considerable burden of disease. The exact causes of IBS are not well [...] Read more.
Background/Objectives: Irritable Bowel Syndrome (IBS) is a disorder of the gut-brain axis for which the gastroenterologist is most often consulted. Gastrointestinal symptoms and decreased quality of life lead to a considerable burden of disease. The exact causes of IBS are not well understood, and no standard therapy has been established. The primary outcome of the study focused on the improvements of the IBS symptoms assessed through the validated questionnaire IBS-Severity Scoring System (IBS-SSS). Similarly, secondary outcomes geared towards the improvement of the quality of life (IBS-Quality of Life (IBS-QoL) and the Gastrointestinal Quality of Life Index (GIQLI)) and specific IBS symptoms (bloating, abdominal distension, feeling of heaviness, abdominal pain, and flatulence), were assessed through self-administered questionnaires. Intestinal habits (consistency and frequency of depositions) through subject stratification into diarrhoea (IBS-D), constipation (IBS-C), mixed type (IBS-M), as well as the treatment tolerability were also evaluated. Methods: A randomised, placebo-controlled, double-blind, clinical trial was conducted on 156 enrolled IBS patients (79 female and 77 male), aged 18–70 years, randomised (1:1 allocation ratio) to receive either two capsules per day of the food supplement (containing 480 mg of a complex of tannin extracts) or a placebo for 56 days. Linear random intercept mixed models (LMM) were used to analyse all experimental variables Results: Supplementation resulted in a significant improvement (p < 0.05) in the primary outcome IBSS score, with respect to the placebo group, changing the IBS condition going from mild (242.3 ± 89.8) to moderate (148.1 ± 60.6). Similarly, all indicators concerning quality of life, and specific intestinal symptoms resulted in a significant improvement (p < 0.05). Furthermore, the tannin-based treatment showed the ability to modulate the response to different symptomatology such as diarrhoea and constipation, without side effects being reported. Conclusions: The use of a supplement based on chestnut and quebracho tannins presents great application potential in the management of IBS-related disorders, with the peculiarity of resolving opposite symptoms, such as diarrhoea and constipation, indiscriminately. Full article
(This article belongs to the Section Nutritional Immunology)
19 pages, 1508 KiB  
Article
Isolated White Lupin Proteins Beneficially Modulate the Intestinal Microbiota Composition in Rats
by Luis A. Rubio and Giulia Chiesa
Nutrients 2025, 17(3), 551; https://doi.org/10.3390/nu17030551 - 31 Jan 2025
Viewed by 305
Abstract
Background: Previous work has shown that the mostly beneficial modulation of intestinal microbiota generally found with legume-based diets is likely to be due, at least in part, to their constituent protein components. Objectives: The faecal microbiota composition was studied in rats fed diets [...] Read more.
Background: Previous work has shown that the mostly beneficial modulation of intestinal microbiota generally found with legume-based diets is likely to be due, at least in part, to their constituent protein components. Objectives: The faecal microbiota composition was studied in rats fed diets differing only in their constituent proteins. Methods: Rats (n = 10/group) were fed for 28 days diets based in milk [(lactalbumin (LA), casein (CAS)], or white lupin (Lupinus albus) protein isolate (LPI). Results: Significant differences among the three groups in bacteria composition and functionality were found by both qPCR and Illumina sequencing analysis. Significant (p < 0.01) differences were found by ANOSIM and Discriminant Analysis among groups at the family, genus and species levels in both microbiota composition and functionality. A number of groups able to explain the differences between animal (casein, lactalbumin) and lupin proteins were revealed by LEfSe and PCA analysis. Specifically, feeding the CAS diet resulted in lower Bifidobacteria and Lactobacilli compared to the other diets, and the LPI diet gave place to lower Enterobacteria than CAS, and lower Escherichia/Shigella than LA and CAS. Differences in the LA group were attributable to Bifidobacterium spp., Collinsella spp. (in particular C. stercoris), Bacteroides spp., Eubacterium spp. (in particular E. dolichum), Roseburia spp. (in particular R. faecis), and Oscillospira spp. In the case of the CAS group, the organisms were Parabacteroides spp., Blautia spp., Enterobacteriaceae spp., Turicibacter spp., species from Christenellaceae, species from Alphaproteobacteria and Mogibacteriaceae, Coprobacillus spp. and Dorea spp. In the case of the LPI group, the organisms were Lactobacillus spp. (Lactobacillus spp. and L. reuteri), species from Clostridiaceae, species from Peptostreptococcaceae, species from Erysipelotrichaceae, and Adlercreutzia spp. Conclusions: Based on the results obtained, LPI is likely to beneficially modulate the intestinal microbiota composition in rats. Additionally, LA-based diet was associated to a healthier microbiota composition than CAS, although the CAS diet also modulated the intestinal microbiota to a composition compatible with improved bowel movement frequency and lipid metabolism. Full article
(This article belongs to the Special Issue Protein Intake and Metabolism in Sports Performance)
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16 pages, 252 KiB  
Article
Dietary Micronutrient Intake During Pregnancy Is Suboptimal in a Group of Healthy Scottish Women, Irrespective of Maternal Body Mass Index
by Eleanor M. Jarvie, Julie A. Lovegrove, Michelle Weech, Dilys J. Freeman and Barbara J. Meyer
Nutrients 2025, 17(3), 550; https://doi.org/10.3390/nu17030550 - 31 Jan 2025
Viewed by 322
Abstract
Background/Objectives: A balanced nutritious diet is vital during pregnancy for both the mother and the baby. The aims of this longitudinal study were to (1) determine any differences in macro- and micronutrient intakes in a group of UK women during pregnancy (and [...] Read more.
Background/Objectives: A balanced nutritious diet is vital during pregnancy for both the mother and the baby. The aims of this longitudinal study were to (1) determine any differences in macro- and micronutrient intakes in a group of UK women during pregnancy (and in the post-partum period) who were overweight or obese (BMI mean (SD) 31.1 (2.9)) at antenatal booking appointment compared with women who were within the ideal BMI range (BMI mean (SD) 22.1 (1.9)) and (2) determine the proportion of women who met the Harmonized Average Requirements (H-AR) during pregnancy. Methods: Forty-two participants attended four clinic visits: three during pregnancy, one in each trimester (V1, V2, and V3), and one 12 weeks post-partum (V4). Dietary intake was assessed by 24 h diet recall and analysed using DietPlan6. Results: There were no differences in energy and macronutrient intakes between overweight/obese and lean women. During pregnancy, the overweight/obese women consumed a mean (SD) of 3238 (941) sodium (mg per day), which was approximately 10% higher compared to 2934 (732) sodium (mg per day) in the lean group (p = 0.015). Dietary and supplemental intakes of the sodium to potassium ratio was 21% higher in overweight/obese women compared to the lean women, p = 0.0031 (mean (SD) of 1.17 (0.35) versus 0.93 (0.28), respectively). Virtually all women did not meet the H-AR for niacin, folate, and vitamin D through dietary intake alone. Conclusions: The ‘eat better and not more’ message during pregnancy is supported. Full article
(This article belongs to the Section Nutrition in Women)
15 pages, 2037 KiB  
Article
Effects of Fish Oil with Heat Treatment on Obesity, Inflammation, and Gut Microbiota in Ovariectomized Mice
by Rong Fan, Judy Kim, Young-Cheul Kim and Soonkyu Chung
Nutrients 2025, 17(3), 549; https://doi.org/10.3390/nu17030549 - 31 Jan 2025
Viewed by 275
Abstract
Background/Objectives: Menopause induces substantial metabolic changes, including a reduction in metabolic rate and an elevated risk of developing metabolic diseases. Fish oil (FO) supplementation has been shown to ameliorate menopause-associated metabolic risks. Hyperthermia treatment (HT) has recently gained attention for its potential to [...] Read more.
Background/Objectives: Menopause induces substantial metabolic changes, including a reduction in metabolic rate and an elevated risk of developing metabolic diseases. Fish oil (FO) supplementation has been shown to ameliorate menopause-associated metabolic risks. Hyperthermia treatment (HT) has recently gained attention for its potential to improve metabolic and immune health. However, it remains to be determined whether HT can confer metabolic benefits comparable to those of FO supplementation or enhance the metabolic benefits of FO supplementation. This study aims to delineate the distinctive and collaborative effects of HT and FO supplementation in mitigating menopause-associated metabolic dysfunction. Methods: Female C57BL/6 ovariectomized (OVX) mice were randomly assigned to four groups (n = 12/group) to evaluate the individual and combined effects of FO supplementation (5% w/w) and HT treatment. For HT, whole-body heat exposure was conducted at 40–41 °C for 30 min, 5 days per week. After 12 weeks, animals were used to evaluate the changes in glucose and lipid metabolism, obesity outcome, and inflammatory markers. The gut microbiome analysis was conducted from cecal content by 16S rRNA sequencing. Acute inflammation was induced by lipopolysaccharide (LPS) injection to evaluate inflammatory responses. Results: HT alone distinctively reduced weight gain, lowered core body temperature, and attenuated insulin resistance comparable to FO supplement in OVX mice. The collaborative effect of FO and HT was not evident in metabolic parameters but more prominent in attenuating proinflammatory responses and microbiota modulation. Conclusions: Our findings suggest that the combined treatment of FO supplementation and HT may serve as an effective strategy to mitigate menopause-associated immune susceptibility and metabolic dysfunction. These benefits are likely mediated, at least in part, through the reduction in inflammation and modulation of the gut microbiota. Full article
(This article belongs to the Section Nutrition in Women)
27 pages, 4544 KiB  
Systematic Review
Dietary Patterns, Oxidative Stress, and Early Inflammation: A Systematic Review and Meta-Analysis Comparing Mediterranean, Vegan, and Vegetarian Diets
by Sara Ilari, Stefania Proietti, Francesca Milani, Laura Vitiello, Carolina Muscoli, Patrizia Russo and Stefano Bonassi
Nutrients 2025, 17(3), 548; https://doi.org/10.3390/nu17030548 - 31 Jan 2025
Viewed by 355
Abstract
Background: Dietary habits influenced by lifestyle and cultural factors play a critical role in health by modulating oxidative stress and inflammation. While diets offer significant benefits, they may also pose risks, such as nutrient deficiencies, emphasizing the need for a balanced approach. Exploring [...] Read more.
Background: Dietary habits influenced by lifestyle and cultural factors play a critical role in health by modulating oxidative stress and inflammation. While diets offer significant benefits, they may also pose risks, such as nutrient deficiencies, emphasizing the need for a balanced approach. Exploring Mediterranean and plant-based diet effects on oxidative stress and inflammation biomarkers may help improve health outcomes and disease prevention strategies. Methods: This study analyzed 65 studies following PRISMA guidelines to evaluate the effects of Mediterranean and plant-based diets on biomarkers of oxidative stress and inflammation in healthy individuals. Results: The Mediterranean diet was weakly associated with reductions in oxidative stress markers, including MDA (ROM: 0.80; 95% CI: 0.57–1.13; p = 0.2092) and 8OHdG (ROM: 0.81; 95% CI: 0.59–1.11; p = 0.1847), as well as inflammation markers such as CRP (ROM: 0.72; 95% CI: 0.42–1.23; p = 0.1545) and IL-6 (ROM: 1.23; 95% CI: 0.97–1.55; p = 0.08). The vegetarian diet significantly reduced CRP (ROM: 0.82; 95% CI: 0.69–0.98; p = 0.0297), while the vegan diet showed a borderline reduction (ROM: 0.81; 95% CI: 0.56–1.17; p = 0.2544), suggesting lower systemic inflammation compared to omnivorous diets. Conclusions: Although all three diets demonstrate potential in reducing oxidative stress and inflammation, the antioxidant effects—especially for the Mediterranean diet—are lower than anticipated, indicating alternative mechanisms. Further research is essential to confirm these findings and clarify the underlying mechanisms to enhance preventive health strategies. Full article
(This article belongs to the Section Nutritional Epidemiology)
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16 pages, 2563 KiB  
Article
EGCG Alleviates DSS-Induced Colitis by Inhibiting Ferroptosis Through the Activation of the Nrf2-GPX4 Pathway and Enhancing Iron Metabolism
by Junzhou Chen, Conghui Yin, Yilong Zhang, Xin Lai, Chen Liu, Yuheng Luo, Junqiu Luo, Jun He, Bing Yu, Quyuan Wang, Huifen Wang, Daiwen Chen and Aimin Wu
Nutrients 2025, 17(3), 547; https://doi.org/10.3390/nu17030547 - 31 Jan 2025
Viewed by 289
Abstract
Background: Ferroptosis is a regulated cell death process linked to various diseases. This study explored whether Epigallocatechin-3-gallate (EGCG), a tea-derived antioxidant, could regulate ferroptosis to alleviate dextran sulfate sodium (DSS)-induced colitis. Methods: A DSS-induced colitis model was used to assess EGCG’s effects. Ferroptosis [...] Read more.
Background: Ferroptosis is a regulated cell death process linked to various diseases. This study explored whether Epigallocatechin-3-gallate (EGCG), a tea-derived antioxidant, could regulate ferroptosis to alleviate dextran sulfate sodium (DSS)-induced colitis. Methods: A DSS-induced colitis model was used to assess EGCG’s effects. Ferroptosis markers, oxidative stress, and iron metabolism were evaluated, alongside Nrf2-GPX4 pathway activation and ferritin (FTH/L) expression. Results: Iron dysregulation and oxidative stress contributed to DSS-induced colitis by activating ferroptosis in colonic epithelial cells. EGCG supplementation inhibited ferroptosis, reducing oxidative damage. Mechanistically, EGCG activated the Nrf2-GPX4 pathway, enhancing antioxidant defense, and improved iron metabolism by upregulating ferritin expression. Conclusions: EGCG effectively suppressed DSS-induced ferroptosis and colitis, highlighting its potential as a ferroptosis inhibitor and therapeutic agent. Full article
(This article belongs to the Special Issue Metabolic Features and Nutritional Interventions in Chronic Diseases)
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13 pages, 3158 KiB  
Article
Comparison of the Acute Effects of Carbohydrate Mouth Rinse and Coach Encouragement on Kinematic Profiles During Small-Sided Games in Young Male Soccer Players
by Yakup Zühtü Birinci, Serkan Pancar and Yusuf Soylu
Nutrients 2025, 17(3), 546; https://doi.org/10.3390/nu17030546 - 31 Jan 2025
Viewed by 360
Abstract
Background: Carbohydrate mouth rinsing (CHOmr), a nutritional intervention for delaying fatigue and meeting the energy demands of soccer, and the motivational strategy of coach encouragement (CE) are widely recognized as effective approaches for enhancing athletic performance in soccer. Objectives: This study aimed [...] Read more.
Background: Carbohydrate mouth rinsing (CHOmr), a nutritional intervention for delaying fatigue and meeting the energy demands of soccer, and the motivational strategy of coach encouragement (CE) are widely recognized as effective approaches for enhancing athletic performance in soccer. Objectives: This study aimed to compare the effects of CHOmr + CE, CHOmr, and CE on heart rate (HR) and kinematic profiles during four-a-side small-sided soccer games (SSGs). Methods: Twenty-four young soccer players (age: 17.2 ± 0.8 years) played six bouts of four-a-side SSGs with CHOmr + CE, CHOmr, or CE at 3-day intervals in a randomized, single-blinded, placebo-controlled, or crossover study design. The HR and kinematic responses were continuously recorded during all games. Results: There were no statistically significant differences between the groups in peak heart rate (HRpeak) (p ≥ 0.05, F = 0.326, p = 0.723, η2 = 0.014) and mean heart rate (HRmean) (p ≥ 0.05, F = 0.845, p = 0.436, η2 = 0.035). No significant differences were found for distances in Zone 1 (p ≥ 0.05, F = 1.21, p = 0.306, η2 = 0.050), Zone 4 (p ≥ 0.05, F = 0.310, p = 0.735, η2 = 0.013), Zone 5 (p ≥ 0.05, F = 1.02, p = 0.368, η2 = 0.042), or Zone 6 (p ≥ 0.05, F = 0.161, p = 0.211, η2 = 0.055), nor acceleration (p ≥ 0.05, F = 0.208, p = 0.137, η2 = 0.083) and deceleration (p ≥ 0.05, F = 0.790, p = 0.460, η2 = 0.033). Similarly, although no significant differences were observed in the distance in Zone 3 (p ≥ 0.05, F = 3.12, p = 0.054, η2 = 0.119) or repeated sprint distance (p ≥ 0.05, F = 2.96, p = 0.062, η2 = 0.114), the CHOmr +CE group exhibited higher average values for these variables. However, a statistically significant difference was observed in the distance covered in Zone 2 (p ≤ 0.05, F = 3.89, p = 0.028, η2 = 0.145), with the CHOmr +CE group performing better, as confirmed by the post-hoc analyses. Conclusions: Although our findings indicate that CE alone may influence kinematic profiles during SSGs, similar to CHOmr or its combination with CE, further research should explore the underlying mechanisms and potential contextual factors influencing these outcomes. Therefore, we suggest that coaches prefer CE because it is easy to implement. Full article
(This article belongs to the Special Issue The Role of Protein and Carbohydrate Supplementation in Improving Athletic Performance)
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14 pages, 416 KiB  
Article
Unlocking the Predictive Power of Nutritional Scores in Septic Patients
by Arianna Toscano, Federica Bellone, Noemi Maggio, Maria Cinquegrani, Francesca Spadaro, Francesca Maria Bueti, Giuseppe Lorello, Herbert Ryan Marini, Alberto Lo Gullo, Giorgio Basile, Giovanni Squadrito, Giuseppe Mandraffino and Carmela Morace
Nutrients 2025, 17(3), 545; https://doi.org/10.3390/nu17030545 - 31 Jan 2025
Viewed by 312
Abstract
Background: Sepsis is a critical condition characterized by severe immune dysregulation, ranking among the leading causes of morbidity and mortality in intensive care and internal medicine units. Nutritional status plays a pivotal role in modulating these responses, as when inadequate it can [...] Read more.
Background: Sepsis is a critical condition characterized by severe immune dysregulation, ranking among the leading causes of morbidity and mortality in intensive care and internal medicine units. Nutritional status plays a pivotal role in modulating these responses, as when inadequate it can compromise immune defenses, the body’s ability to handle stress and inflammation, and the clinical course. Malnutrition is frequently observed in septic patients and is strongly associated with worse clinical outcomes, including increased mortality, prolonged hospital stays, and greater complication rates. In this context, nutritional scoring systems have emerged as valuable tools to evaluate patients’ nutritional status and predict clinical trajectories. Objectives: Given the absence of a direct comparison of their performance in an internal medicine setting, this study aimed to assess the effectiveness of various nutritional scores as predictive tools for clinical outcomes in septic patients, emphasizing their application within the field of internal medicine. Methods and Results: A retrospective analysis was conducted on 143 patients diagnosed with sepsis or septic shock who were admitted to an internal medicine unit. Key variables included clinical and laboratory parameters, comorbidities, and nutritional scores at the time of diagnosis. The modified Glasgow Prognostic Score (mGPS), the Prognostic Nutritional Index (PNI), the Controlling Nutritional Status (CONUT) score, the modified Nutrition Risk in Critically Ill (mNUTRIC) score, and the blood urea nitrogen-to-albumin ratio (BAR) were evaluated in forecasting mortality and clinical outcomes in patients with sepsis. Among them, the mNUTRIC score emerged as the strongest independent predictor of in-hospital mortality, with a good performance and a reasonable threshold for risk stratification. Conclusions: The study highlights the mNUTRIC score’s practicality and reliability in assessing nutritional and inflammatory risks in septic patients, particularly in non-ICU settings. These findings suggest its potential utility in guiding nutritional interventions and improving clinical outcomes, emphasizing the importance of integrating nutritional assessment into sepsis management. Full article
(This article belongs to the Section Clinical Nutrition)
18 pages, 677 KiB  
Review
Low-FODMAP Diet for Irritable Bowel Syndrome: Insights from Microbiome
by Haoshuai Zhang and Qi Su
Nutrients 2025, 17(3), 544; https://doi.org/10.3390/nu17030544 - 31 Jan 2025
Viewed by 346
Abstract
Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder characterized by chronic abdominal pain, bloating, and altered bowel habits. Low-FODMAP diets, which involve restricting fermentable oligosaccharides, disaccharides, monosaccharides, and polyols, have emerged as an effective dietary intervention for alleviating IBS symptoms. This review [...] Read more.
Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder characterized by chronic abdominal pain, bloating, and altered bowel habits. Low-FODMAP diets, which involve restricting fermentable oligosaccharides, disaccharides, monosaccharides, and polyols, have emerged as an effective dietary intervention for alleviating IBS symptoms. This review paper aims to synthesize current insights into the impact of a low-FODMAP diet on the gut microbiome and its mechanisms of action in managing IBS. We explore the alterations in microbial composition and function associated with a low-FODMAP diet and discuss the implications of these changes for gut health and symptom relief. Additionally, we examine the balance between symptom improvement and potential negative effects on microbial diversity and long-term gut health. Emerging evidence suggests that while a low-FODMAP diet can significantly reduce IBS symptoms, it may also lead to reductions in beneficial microbial populations. Strategies to mitigate these effects, such as the reintroduction phase and the use of probiotics, are evaluated. This review highlights the importance of a personalized approach to dietary management in IBS, considering individual variations in microbiome responses. Understanding the intricate relationship between diet, the gut microbiome, and IBS symptomatology will guide the development of more effective, sustainable dietary strategies for IBS patients. Full article
(This article belongs to the Special Issue Nutritional Therapy of Intestinal Diseases and Intestinal Microecology)
12 pages, 263 KiB  
Article
Dental Caries, Tooth Erosion and Nutritional Habits in a Cohort of Athletes: A Cross-Sectional Study
by Baptiste Mielle, André Júdice, Luís Proença, Vanessa Machado, Ana M. Vieira, José João Mendes, Cristina Manso, Cecília Rozan and João Botelho
Nutrients 2025, 17(3), 543; https://doi.org/10.3390/nu17030543 - 31 Jan 2025
Viewed by 297
Abstract
Background/Objectives: this study aimed to study the association of dental caries and erosion in athletes with dietary and oral health habits. Methods: An observational cross-sectional study was conducted at the Sports Dentistry department of a university clinic. Intraoral examination included the International Caries [...] Read more.
Background/Objectives: this study aimed to study the association of dental caries and erosion in athletes with dietary and oral health habits. Methods: An observational cross-sectional study was conducted at the Sports Dentistry department of a university clinic. Intraoral examination included the International Caries Detection and Assessment System (ICDAS II) index and the Basic Erosive Wear Examination (BEWE). A questionnaire was completed with sociodemographic data, and dietary and oral hygiene habits. An inferential and multivariable regression analysis was performed to study the association of dental caries and erosion with confounding variables. Results: A total of 80 athletes were included. The prevalence of dental caries and erosion was 50.0% and 40%, respectively. Significant associations were observed between self-perceived oral health and caries lesions, with “Good” (−5.01, p < 0.001) and “Very good” (−5.46, p < 0.001) perceptions linked to fewer lesions. BEWE scores revealed significant associations with meal frequency uncertainty (−12.56, p = 0.014) and uncertainty about the last dental visit (8.82, p = 0.014). Self-perceived oral health as “Good” or “Very good” was associated with lower dental erosion (p < 0.010). Other demographic and behavioral factors were not significantly associated with caries or erosion. Conclusions: this cohort of athletes exhibited a high prevalence of dental caries and erosion, with associated dietary and oral hygiene habits. These results highlight the need for targeted dietary counseling and oral health education for athletes, whose nutritional needs may lead to increased consumption of sugar-rich diets. Full article
(This article belongs to the Special Issue Sports Nutrition: Current and Novel Insights—2nd Edition)
11 pages, 910 KiB  
Article
Women with Autoimmune Thyroiditis Taking Levothyroxine During Pregnancy: Is Iodine Supplementation Needed?
by Simona Censi, Giulia Messina, Emma Feligiotti, Cristina Clausi, Ilaria Piva, Daniela Basso, Isabella Merante Boschin, Loris Bertazza, Fiammetta Battheu, Susi Barollo, Marta Camilot and Caterina Mian
Nutrients 2025, 17(3), 542; https://doi.org/10.3390/nu17030542 - 31 Jan 2025
Viewed by 254
Abstract
Background: Iodine is fundamental for the synthesis of thyroid hormones, which play a central role in foetal neurological development. The need for an iodine-containing supplement (ICS) in L-T4-treated women during pregnancy is still a subject of debate. Aim of the Study: The aim [...] Read more.
Background: Iodine is fundamental for the synthesis of thyroid hormones, which play a central role in foetal neurological development. The need for an iodine-containing supplement (ICS) in L-T4-treated women during pregnancy is still a subject of debate. Aim of the Study: The aim of the study is to investigate the iodine status in women with autoimmune thyroiditis (AT) who have or have not been treated with L-T4. Methods: This was a cross-sectional, observational study involving pregnant women with AT, treated with/without L-T4. Upon enrolment, women provided a urine sample (to measure the urinary iodine concentration (UIC), which was normalised to urinary creatinine values (UI/Creat)), and completed a questionnaire. TSH, FT4, and neonatal TSH were also obtained. Results: Among women taking an ICS, 74.1% had a UI/Creat level ≥ 150 μg/g, compared with only 46.2% of those not taking an ICS (p = 0.03). Among L-T4 users only, a UI/Creat level ≥ 150 μg/g was more frequent in ICS users than in non-ICS users (72.8% vs. 41.7%) (p = 0.03). In the multivariate analysis, ICS use was the only independent variable for UI/Creat ≥ 150 μg/g (OR: 3.4; CI: 1.1–10.9) (p = 0.04). There was a tendency towards higher UI/Creat levels as the L-T4 (µg/Kg) dosage increased, although no correlation was found. Newborns of women taking an ICS were found to have elevated neonatal TSH (2.8 mIU/L vs. 1.7 mIU/L) (p = 0.04). All newborns with a TSH >5 mUI/L were those of women taking supplements. Conclusions: Women with AT taking L-T4 still need iodine supplementation, although the amount should be regulated on the basis of their L-T4 dosage. Full article
(This article belongs to the Special Issue Iodine Fortification in Food Production and Human Health)
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11 pages, 204 KiB  
Article
An Active Learning Model for Promoting Healthy Cooking and Dietary Strategies Among South Asian Children: A Proof-of-Concept Study
by Tricia S. Tang, Simran Gill and Inderpreet Basra
Nutrients 2025, 17(3), 541; https://doi.org/10.3390/nu17030541 - 31 Jan 2025
Viewed by 297
Abstract
Background/Objectives: South Asian children living in Canada have a higher prevalence of cardiovascular disease risk factors compared to their non-South Asian counterparts, and poor dietary habits may contribute to this health disparity. Methods: This study uses a pre–post intervention design to [...] Read more.
Background/Objectives: South Asian children living in Canada have a higher prevalence of cardiovascular disease risk factors compared to their non-South Asian counterparts, and poor dietary habits may contribute to this health disparity. Methods: This study uses a pre–post intervention design to examine the impact of a family-focused, “hands-on” cooking workshop on improving three cooking and dietary strategies: (1) using healthy cooking techniques, (2) practicing portion control, and (3) making healthy substitutions. We recruited 70 South Asian parent–child dyads (n = 140) across four elementary schools in Surrey, British Columbia. The 90 min workshop includes a didactic segment on healthy food preparation and dietary strategies, followed by an interactive cooking session where participants make a healthier version of a traditional Punjabi dish. Results: Among the three dietary strategies measured, both children and parents increased their frequency of using healthy cooking techniques (child p = 0.02; parent p < 0.001) and practicing portion control (child p < 0.001; parent p = 0.02). No changes were reported by either group for making healthy substitutions. Conclusions: Findings suggest that educational approaches that engage the family as a unit and encourage active participation are associated with improvements in cooking and dietary strategies in the South Asian community. Full article
(This article belongs to the Section Pediatric Nutrition)
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