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Nutritional Therapy of Intestinal Diseases and Intestinal Microecology

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: 25 June 2025 | Viewed by 514

Special Issue Editor

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
Interests: gut inflammation; precision nutrition; host-diet-gut microbiome interaction; immune response; pre/probiotics; nutritional epigenomics; intestinal microecology

Special Issue Information

Dear Colleagues,

Recent research has highlighted the critical role that dietary nutrients play in shaping the composition and function of our gut microbiota, as well as maintaining intestinal balance, which in turn influences health outcomes. Dietary bioactive compounds have been shown to target enzymes involved in epigenetic gene regulation, thereby having a profound impact on gut health. Moreover, the gut microbiome—often referred to as our "second genome"—and its metabolites act as key players in the intricate dance between diet and gene expression. They influence the release, metabolism, and bioavailability of various dietary agents, shedding light on the variability observed in how individuals respond to dietary interventions in human studies. Thus, understanding the dynamic interplay between nutrition and gut microbiota is essential for unraveling the ways in which different dietary components affect the host–microbe axis and gastrointestinal health. Advancements in this exciting field are crucial for developing personalized, evidence-based dietary interventions aimed at preventing and mitigating intestinal diseases.

Dr. Qi Su
Guest Editor

Manuscript Submission Information

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Keywords

  • gut inflammation
  • precision nutrition
  • host–diet–gut microbiome interaction
  • immune response
  • pre/probiotics
  • nutritional epigenomics
  • intestinal microecology

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Published Papers (1 paper)

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Review

18 pages, 677 KiB  
Review
Low-FODMAP Diet for Irritable Bowel Syndrome: Insights from Microbiome
by Haoshuai Zhang and Qi Su
Nutrients 2025, 17(3), 544; https://doi.org/10.3390/nu17030544 - 31 Jan 2025
Viewed by 346
Abstract
Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder characterized by chronic abdominal pain, bloating, and altered bowel habits. Low-FODMAP diets, which involve restricting fermentable oligosaccharides, disaccharides, monosaccharides, and polyols, have emerged as an effective dietary intervention for alleviating IBS symptoms. This review [...] Read more.
Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder characterized by chronic abdominal pain, bloating, and altered bowel habits. Low-FODMAP diets, which involve restricting fermentable oligosaccharides, disaccharides, monosaccharides, and polyols, have emerged as an effective dietary intervention for alleviating IBS symptoms. This review paper aims to synthesize current insights into the impact of a low-FODMAP diet on the gut microbiome and its mechanisms of action in managing IBS. We explore the alterations in microbial composition and function associated with a low-FODMAP diet and discuss the implications of these changes for gut health and symptom relief. Additionally, we examine the balance between symptom improvement and potential negative effects on microbial diversity and long-term gut health. Emerging evidence suggests that while a low-FODMAP diet can significantly reduce IBS symptoms, it may also lead to reductions in beneficial microbial populations. Strategies to mitigate these effects, such as the reintroduction phase and the use of probiotics, are evaluated. This review highlights the importance of a personalized approach to dietary management in IBS, considering individual variations in microbiome responses. Understanding the intricate relationship between diet, the gut microbiome, and IBS symptomatology will guide the development of more effective, sustainable dietary strategies for IBS patients. Full article
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