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Nutrients
Volume 17
Issue 3
10.3390/nu17030552
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Article

Improving Irritable Bowel Syndrome (IBS) Symptoms and Quality of Life with Quebracho and Chestnut Tannin-Based Supplementation: A Single-Centre, Randomised, Double-Blind, Placebo-Controlled Clinical Trial

by
Silvia Molino
1,*,†,
Lorenza Francesca De Lellis
2,
Maria Vittoria Morone
3,†,
Marcello Cordara
4,
Danaè S. Larsen
5,
Roberto Piccinocchi
6,
Gaetano Piccinocchi
7,
Alessandra Baldi
2,
Alessandro Di Minno
2,8,
Hesham R. El-Seedi
9,
Roberto Sacchi
10 and
Maria Daglia
2,11,*
1
R&D Unit, Silvateam S.p.A., 12080 San Michele Mondovì, Italy
2
Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano 49, 80131 Naples, Italy
3
Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, University of Campania “L. Vanvitelli”, 80138 Naples, Italy
4
School of Medicine, University of Milano-Bicocca, 20126 Milan, Italy
5
School of Chemical Sciences, The University of Auckland, Auckland 1010, New Zealand
6
Level 1 Medical Director Anaesthesia and Resuscitation A. U. O. Luigi Vanvitelli, Via Santa Maria di Costantinopoli, 80138 Naples, Italy
7
Comegen S.c.S., Società Cooperativa Sociale di Medici di Medicina Generale, Viale Maria Bakunin 41, 80125 Naples, Italy
8
CEINGE-Biotecnologie Avanzate, Via Gaetano Salvatore 486, 80145 Naples, Italy
9
Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah 42351, Saudi Arabia
10
Applied Statistic Unit, Department of Earth and Environmental Sciences, University of Pavia, Viale Taramelli 24, 27100 Pavia, Italy
11
International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China
 
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*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2025, 17(3), 552; https://doi.org/10.3390/nu17030552 (registering DOI)
Submission received: 23 December 2024 / Revised: 17 January 2025 / Accepted: 29 January 2025 / Published: 31 January 2025
(This article belongs to the Section Nutritional Immunology)
Review Reports Versions Notes

Abstract

Background/Objectives: Irritable Bowel Syndrome (IBS) is a disorder of the gut-brain axis for which the gastroenterologist is most often consulted. Gastrointestinal symptoms and decreased quality of life lead to a considerable burden of disease. The exact causes of IBS are not well understood, and no standard therapy has been established. The primary outcome of the study focused on the improvements of the IBS symptoms assessed through the validated questionnaire IBS-Severity Scoring System (IBS-SSS). Similarly, secondary outcomes geared towards the improvement of the quality of life (IBS-Quality of Life (IBS-QoL) and the Gastrointestinal Quality of Life Index (GIQLI)) and specific IBS symptoms (bloating, abdominal distension, feeling of heaviness, abdominal pain, and flatulence), were assessed through self-administered questionnaires. Intestinal habits (consistency and frequency of depositions) through subject stratification into diarrhoea (IBS-D), constipation (IBS-C), mixed type (IBS-M), as well as the treatment tolerability were also evaluated. Methods: A randomised, placebo-controlled, double-blind, clinical trial was conducted on 156 enrolled IBS patients (79 female and 77 male), aged 18–70 years, randomised (1:1 allocation ratio) to receive either two capsules per day of the food supplement (containing 480 mg of a complex of tannin extracts) or a placebo for 56 days. Linear random intercept mixed models (LMM) were used to analyse all experimental variables Results: Supplementation resulted in a significant improvement (p < 0.05) in the primary outcome IBSS score, with respect to the placebo group, changing the IBS condition going from mild (242.3 ± 89.8) to moderate (148.1 ± 60.6). Similarly, all indicators concerning quality of life, and specific intestinal symptoms resulted in a significant improvement (p < 0.05). Furthermore, the tannin-based treatment showed the ability to modulate the response to different symptomatology such as diarrhoea and constipation, without side effects being reported. Conclusions: The use of a supplement based on chestnut and quebracho tannins presents great application potential in the management of IBS-related disorders, with the peculiarity of resolving opposite symptoms, such as diarrhoea and constipation, indiscriminately.
Keywords: irritable bowel syndrome; tannins; quebracho; chestnut; food supplement; IBSS score; questionnaire for self-assessment of quality of life; randomised clinical trial irritable bowel syndrome; tannins; quebracho; chestnut; food supplement; IBSS score; questionnaire for self-assessment of quality of life; randomised clinical trial

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MDPI and ACS Style

Molino, S.; De Lellis, L.F.; Morone, M.V.; Cordara, M.; Larsen, D.S.; Piccinocchi, R.; Piccinocchi, G.; Baldi, A.; Di Minno, A.; El-Seedi, H.R.; et al. Improving Irritable Bowel Syndrome (IBS) Symptoms and Quality of Life with Quebracho and Chestnut Tannin-Based Supplementation: A Single-Centre, Randomised, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients 2025, 17, 552. https://doi.org/10.3390/nu17030552

AMA Style

Molino S, De Lellis LF, Morone MV, Cordara M, Larsen DS, Piccinocchi R, Piccinocchi G, Baldi A, Di Minno A, El-Seedi HR, et al. Improving Irritable Bowel Syndrome (IBS) Symptoms and Quality of Life with Quebracho and Chestnut Tannin-Based Supplementation: A Single-Centre, Randomised, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2025; 17(3):552. https://doi.org/10.3390/nu17030552

Chicago/Turabian Style

Molino, Silvia, Lorenza Francesca De Lellis, Maria Vittoria Morone, Marcello Cordara, Danaè S. Larsen, Roberto Piccinocchi, Gaetano Piccinocchi, Alessandra Baldi, Alessandro Di Minno, Hesham R. El-Seedi, and et al. 2025. "Improving Irritable Bowel Syndrome (IBS) Symptoms and Quality of Life with Quebracho and Chestnut Tannin-Based Supplementation: A Single-Centre, Randomised, Double-Blind, Placebo-Controlled Clinical Trial" Nutrients 17, no. 3: 552. https://doi.org/10.3390/nu17030552

APA Style

Molino, S., De Lellis, L. F., Morone, M. V., Cordara, M., Larsen, D. S., Piccinocchi, R., Piccinocchi, G., Baldi, A., Di Minno, A., El-Seedi, H. R., Sacchi, R., & Daglia, M. (2025). Improving Irritable Bowel Syndrome (IBS) Symptoms and Quality of Life with Quebracho and Chestnut Tannin-Based Supplementation: A Single-Centre, Randomised, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients, 17(3), 552. https://doi.org/10.3390/nu17030552

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