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Volume 13
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Systematic Review

The Role of the Endometrial Microbiota in Endometrial Cancer: A Systematic Review of the Literature

by
Guglielmo Stabile
1,
Alessandra Doria
1,
Matteo Bruno
2,
Marco D’Indinosante
2,*,
Valerio Gallotta
2,
Francesco Fanfani
2,3,
Giovanni Scambia
2,3,
Stefano Restaino
4,
Giuseppe Vizzielli
5,
Stefania Carlucci
1 and
Luigi Nappi
1
1
Department of Medical and Surgical Sciences, Institute of Obstetrics and Gynecology, University of Foggia, 71121 Foggia, Italy
2
UOC Ginecologia Oncologica, Dipartimento per le Scienze della Salute della Donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy
3
Università Cattolica del Sacro Cuore, 00168 Rome, Italy
4
Department of Medicinal Area (DAME) Clinic of Obstetrics and Gynecology, Santa Maria della Misericordia Hospital, Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, Italy
5
Obstetrics and Gynecology Clinic, Department of Medicine, University of Udine, 33100 Udine, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(23), 7135; https://doi.org/10.3390/jcm13237135
Submission received: 29 September 2024 / Revised: 17 November 2024 / Accepted: 23 November 2024 / Published: 25 November 2024
(This article belongs to the Section Obstetrics & Gynecology)
Versions Notes

Abstract

Background: Endometrial cancer is currently the sixth most frequent cancer in women, and scientific research is focusing on the search for particular features of the endometrium that may explain a further predisposition to the onset of endometrial cancer, aimed at improving knowledge of the pathogenetic factors of this disease. The aim of our review is to analyze in detail the results of the literature on the endometrial microbiota in patients with endometrial cancer and to investigate its role. Methods: We performed our research on the Pubmed, Web of Science, and Scopus databases. We searched up to December 2023 and considered manuscripts published from 2000. Only articles in English were included in the search. We excluded studies in which the endometrial microbiota were collected through the vagina or cervical canal. Results: We included in our review a total of five manuscripts at the end of the screening process, and the total number of patients involved was 190. Four studies considered only post-menopausal patients, while one study considered both pre- and post-menopausal patients. In all studies, the microbiota analysis was derived from a post-hysterectomy biopsy. From our review, it emerged that Bacteroidetes, Actinobacteria, Firmicutes, and Proteobacteria are the most represented bacteria in patients with endometrial cancer. These are both Gram-positive and Gram-negative, but predominantly anaerobic bacteria. Conclusions: The reduced microbial diversity and the presence of specific bacteria is often associated with endometrial cancer. Further work on larger population samples, and on healthy women and those affected by endometrial carcinoma, is needed to understand how the endometrial microbiota changes and influences the development of the tumor and whether intervening in the changes in the microbiota will have a therapeutic impact on endometrial carcinoma
Keywords: endometrial cancer; endometrial microbiota; microbiome; oncology; uterus endometrial cancer; endometrial microbiota; microbiome; oncology; uterus

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MDPI and ACS Style

Stabile, G.; Doria, A.; Bruno, M.; D’Indinosante, M.; Gallotta, V.; Fanfani, F.; Scambia, G.; Restaino, S.; Vizzielli, G.; Carlucci, S.; et al. The Role of the Endometrial Microbiota in Endometrial Cancer: A Systematic Review of the Literature. J. Clin. Med. 2024, 13, 7135. https://doi.org/10.3390/jcm13237135

AMA Style

Stabile G, Doria A, Bruno M, D’Indinosante M, Gallotta V, Fanfani F, Scambia G, Restaino S, Vizzielli G, Carlucci S, et al. The Role of the Endometrial Microbiota in Endometrial Cancer: A Systematic Review of the Literature. Journal of Clinical Medicine. 2024; 13(23):7135. https://doi.org/10.3390/jcm13237135

Chicago/Turabian Style

Stabile, Guglielmo, Alessandra Doria, Matteo Bruno, Marco D’Indinosante, Valerio Gallotta, Francesco Fanfani, Giovanni Scambia, Stefano Restaino, Giuseppe Vizzielli, Stefania Carlucci, and et al. 2024. "The Role of the Endometrial Microbiota in Endometrial Cancer: A Systematic Review of the Literature" Journal of Clinical Medicine 13, no. 23: 7135. https://doi.org/10.3390/jcm13237135

APA Style

Stabile, G., Doria, A., Bruno, M., D’Indinosante, M., Gallotta, V., Fanfani, F., Scambia, G., Restaino, S., Vizzielli, G., Carlucci, S., & Nappi, L. (2024). The Role of the Endometrial Microbiota in Endometrial Cancer: A Systematic Review of the Literature. Journal of Clinical Medicine, 13(23), 7135. https://doi.org/10.3390/jcm13237135

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