How to Deal with Skin Biopsy in an Infant with Blisters?

Round 1

Reviewer 1 Report

well written review, good idea to summarize these entities in one paper

Author Response

I would like to thank very strongly reviewer 1 for the kind comments on the manuscipt.

Reviewer 2 Report

I enjoyed very much reading this paper on blistering disorders in infants. The approach of the authors to this difficult topic includes clinical and histopathological features.  They discuss all the major diseases causing blisters in young patients. Nice tables and good pictures illustrate the manuscript.

I have some minor comments for the authors:

1. Page 3, line 87. I think you should add that the blister is subepidermal in TEN.
2. Page 3, line 101. "Skin" instead  of "Skib"
3. Figure 3b. This image is not representative of bullous impetigo, as a subepidermal blister is not shown, consider replacing it.
4. Pag 6, line 153. You probably mean a "fresh lesion" not a "fresh biopsy".
5. Table 2. It is not completely clear, I think you should include the location of the staining for laminin and collagen VII (roof or floor).
6. Page 6, line 176. "If necessary, other specialized antibodies are performed to study the other proteins 176 of the DEJ". Could you please specify these antibodies?
7. Page 16, line 311. Other AIBDs. Although very rare, some cases of IgA lineal bullous dermatosis have been reported in neonates.

Author Response

I would like to thank very strongly reviewer 2 for the kind comments on the manuscript, tables and pictures, and also for the corrections and suggestions.

1-the item was added

2-correction done

3-unfortunately I Don't have any other picture, as impetigo is not often biopsied. If you find the picture not suitable for publication, it can be removed.

4-you are perfectly right, this was corrected.

5-Table 2 was completed as requested.

6-Antibodies were specified

7-Thanks for the suggestion, this was Added.

Reviewer 3 Report

The manuscript gives an excellent review on the value of skin biopsies in infants with blisters. It is well written, has instructive tables and good pictures.

 

Before the section 2, etiology, add a table that summaries the diseases causing blisters in infants

Spelling errors,

p1, line 33 suction blister

p2, line 60, lesional skin

p2, line 64, immunoperoxidase

p3, line 97, …peeling is helpful…

line 101, Skin …

p11, line 221 ….Galler et al (14) ….

P12, line 230 Palmo-plantar …

P13 line 262, Blaschko-linear

P14, after line 278, leave more space to the picture

P15, after line 293, leave more space to the picture

 

 

Author Response

I would like to thank very strongly reviewer 3 for the kind comments on the manuscript, tables and pictures, and also for the corrections and suggestions.

 

A table was added with the main causes before section 2 as suggested.

The spelling errors p1, 2, 3, 11, 12 and 13 were corrected.

p14 and 15: Thanks for the sugestions, I will ask the editor to leave more space before the pictures.