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Article

Half-Sandwich Nickelacarboranes Derived from [7-(MeO(CH2)2S)-7,8-C2B9H11]−

by
Dmitriy K. Semyonov
1,2,
Marina Yu. Stogniy
1,2,*,
Kyrill Yu. Suponitsky
3 and
Igor B. Sivaev
1,4
1
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov Str., 119334 Moscow, Russia
2
M. V. Lomonosov Institute of Fine Chemical Technology, MIREA—Russian Technological University, 86 Vernadsky Av., 119571 Moscow, Russia
3
N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninskii Av., 119991 Moscow, Russia
4
Basic Department of Chemistry of Innovative Materials and Technologies, G.V. Plekhanov Russian University of Economics, 36 Stremyannyi Line, 117997 Moscow, Russia
*
Author to whom correspondence should be addressed.
Inorganics 2023, 11(3), 127; https://doi.org/10.3390/inorganics11030127
Submission received: 28 February 2023 / Revised: 14 March 2023 / Accepted: 15 March 2023 / Published: 17 March 2023
(This article belongs to the Special Issue Bioactivity of Transition Metal-Based Complexes)
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Abstract

:
New carboranyl thioethers 1-MeO(CH2)nS-1,2-C2B10H11 (n = 2, 3) were prepared by the alkylation of the trimethylammonium salt of 1-mercapto-ortho-carborane with 1-bromo- 2-methoxyethane and 1-bromo-3-methoxypropane, respectively. Their deboronation with cesium fluoride in ethanol gave the corresponding nido-carboranes Cs[7-MeO(CH2)nS-7,8-C2B9H11] (n = 2, 3). The reactions of Cs[7-MeO(CH2)2S-7,8-C2B9H11] with various nickel(II) phosphine complexes [(dppe)NiCl2] and [(R’R2P)2NiCl2] (R = R’ = Ph, Bu; R = Me, R’ = Ph; R = Ph, R’ = Me, Et) were studied and a series of nickelacarboranes 3,3-dppe-1-MeO(CH2)2S-closo-3,1,2-NiC2B9H10 and 3,3- (R’R2P)2-1-MeO(CH2)2S-closo-3,1,2-NiC2B9H10 (R = R’ = Bu; R = Me, R’ = Ph; R = Ph, R’ = Me, Et) was prepared. The molecular crystal structure of 3,3-dppe-1-MeO(CH2)2S-closo-3,1,2-NiC2B9H10 was determined by single-crystal X-ray diffraction.

Graphical Abstract

1. Introduction

The discovery of the deboronation reaction of closo-carborane to nido-carborane under the action of nucleophiles became the starting point for the development of metallacarborane chemistry [1,2]. This was facilitated by the unusual chemical and physical properties of the open-face dicarbollide ligand [nido-7,8-C2B9H11]2− as well as its similarity to the cyclopentadienyl anion [C5H5]− [3,4,5,6]. To date, a huge variety of sandwich and half-sandwich complexes of transition metals with dicarbollide ligands have been synthesized [7,8,9,10,11,12]. Many of them have shown excellent prospects for use in a wide variety of fields, from which catalysis [13,14,15,16] and medicine [17,18,19,20,21,22,23,24,25,26,27,28] stand out. At the same time, it should be noted that the degree of knowledge of metallacarboranes varies greatly depending on the complexing metal. The most studied are sandwiched cobalt bis(dicarbollide) complexes [29,30,31]. The synthesis and properties of half-sandwich complexes of ruthenium, rhodium, and iridium, which are intensively used in catalysis, has also been widely investigated [13,15,16,32,33,34,35,36]. At the same time, the chemistry of nickelacarboranes remains poorly studied and is mainly associated with nickel bis(dicarbollide) complexes [37].
The few examples of half-sandwich nickelacarboranes are represented by nickel(II) complexes both with the parent dicarbollide ligand [7,38,39,40,41,42,43] and with its C- or B-substituted derivatives [44,45,46,47,48,49,50,51,52]. In this contribution, we describe the synthesis of nickel phosphine complexes based on novel carboranyl thioether ligand nido-[7- MeO(CH2)2S-7,8-C2B9H11]−

2. Results and Discussion

It is well known that the introduction of a substituent into the nido-carborane cage can significantly affect the structure and properties of the resulting complexes thereof. For example, the use of nido-carborane ligands with the charge-compensating substituent [53] makes it possible to reduce the total charge of the system and stabilize the metal atom in a lower oxidation state [54]. The introduction of substituent(s) with additional donor groups can lead to the formation of complexes in which the metal is coordinated not with the open pentagonal face of nido-carborane (classical η5-coordination), but with the side substituent (so-called exo-complexes) [55,56,57]. There are also several examples of complexes where nido-carborane acts as a η5:κ1- or η5:κ2-ligand with a side substituent participating in the coordination of the metal center along with the open pentagonal face of the nido-carborane basket [47,51,52,58,59,60,61,62,63,64,65,66,67]. In addition, the presence of a substituent can cause steric hindrances in the mutual rotation of ligands or even prevent the formation of a complex [68,69,70].
In our previous work, we began studying the effect of a substituent at the carbon atom in the nido-carborane ligand on its ability to form nickel(II) half-sandwich phosphine complexes. The complexation of dicarbollide ligands containing methyl, phenyl, and N,N′-dicyclohexylamidine substituents with the participation of nickel phosphine complexes [(Ph3P)2NiCl2], [(MePh2P)2NiCl2], and [(dppe)NiCl2] was studied [71].
In the present study, we prepared two new C-substituted nido-carboranes with a methoxy group as an additional donor group in the side substituent. For this purpose, the previously developed method of the alkylation of trimethylammonium salt of mercapto-closo-carborane [72,73] was applied using 1-bromo-2-methoxyethane and 1-bromo-3- methoxypropane as alkylating agents (Scheme 1). The use of this method made it possible to avoid substitution at the second carbon atom of the ortho-carborane cage and led to the preparation of carboranyl thioethers 1 and 2 in two steps with moderate (compound 1) and good (compound 2) yields. The deboronation of ortho-carborane derivatives 1 and 2 with cesium fluoride gave the corresponding anionic nido-carboranes 3 and 4 (Scheme 1).
The preparation of compounds 1–4 was confirmed by NMR spectroscopy data. For example, the conversion of closo-compounds 1 and 2 into nido-species 3 and 4 is clearly evidenced by a change in the spectral pattern (both the range of signals and their number) in the 11B NMR spectra. Thus, the 11B NMR spectrum of 1 consists of five groups of doublets with an integral ratio 1:1:4:2:2 in the range of −(2.1–12.5) ppm, which corresponds to the range of closo-carborane derivatives and indicates the presence of a plane of symmetry in the compound. On the contrary, the 11B NMR spectrum of nido-carborane derivative 3 consists of seven groups of signals with the integral ratio 1:1:1:3:1:1:1 in the range of −(9.8–36.6) ppm and this spectral pattern corresponds to the region of nido-carborane derivatives and indicates the loss of the symmetry plane by the molecule.
Compound 3 was chosen for studying reactions with nickel(II) phosphine complexes. The reaction of 3 with [(dppe)NiCl2] in dry THF using potassium tert-butoxide as a base for the deprotonation of nido-carborane does not require heating and proceeds completely within 30 min at room temperature under argon atmosphere (Scheme 2). The resulting half-sandwich complex 3,3-dppe-1-MeO(CH2)2S-closo-3,1,2-NiC2B9H10 (5) was isolated by column chromatography on silica (eluent CH2Cl2) as dark green crystals with the yield of 68%.
The formation of nickelacarborane 5 is well monitored by 11B NMR spectroscopy. Figure 1 shows that the signals of the nickel(II) half-sandwich complex 5 are shifted to a lower field relative to the signals of nido-carborane 3. They are in the range from 5.5 to −20.8 ppm and represent a series of six broadened doublets with the integral ratio 1:2:1:2:2:1. The 1H NMR spectrum of 5 contains typical multiplets from phosphine ligands in the aromatic region as well as the signals from the dicarbollide side substituent. The methylene protons of the dppe ligand appear as a broad multiplet at 2.87–2.81 ppm. The signal of the unsubstituted CH hydrogen of the dicarbollide ligand appears as a broadened singlet at 1.90 ppm. The 13C NMR spectrum of complex 5 contains a series of doublets from aromatic carbons in the region of 135–128 ppm as a result of their splitting on phosphorus atoms. The CHcarb signal appears as a singlet at 52.1 ppm, while the methylene groups of the dppe ligand appear as a doublet at 29.3 ppm with the C–P splitting constant of 23.5 Hz. The 31P NMR spectrum of 5 contains one singlet at 59.3 ppm.
The solid state structure of complex 5 was determined by single-crystal X-ray diffraction. An asymmetric unit cell contains two molecules of nickelacarborane 3,3-dppe-1-MeO(CH2)2S-closo-3,1,2-NiC2B9H10 and one molecule of acetone solvent. A general view of the nickelacarborane molecule is given in Figure 2. The orientation of the dicarbollide ligand in complex 5, determined by the dihedral angle between the P1−Ni1−P2 plane and the B8−Ni1−Center(C1−C2) plane, which is 78.9(2)° and 74.5(2)° for two independent molecules, slightly deviates from the nearly ideal electronically controlled orientation found in the structure of 3,3-dppe-closo-3,1,2-NiC2B9H11 (the similar dihedral angle of ~89°) [43] and is close to that found in 3,3-dppe-1-Ph-closo-3,1,2-NiC2B9H10 (the dihedral angle of ~83°) [71].
The two independent molecules in structure 5 adopt a slightly different structure due to the differences in the conformation of the dppe ligand, as shown in Figure 3 and Figure S1.
More pronounced differences are observed for the orientation of the SCH2CH2OMe substituent (see Figure 3 and Figure S1), which can be explained by the influence of the crystal packing. This means that symmetry-independent molecules have a somewhat different environment in the unit cell which is clearly represented by their interaction with the solvent acetone. In both molecules, the CH fragment of the phenyl ring of the dppe ligand is involved in H-bonding with the solvent molecule. However, the interaction of acetone with molecule A (C25-H25A∙∙∙O1S: C-H, 0.95 Å; O∙∙∙H, 2.57 Å; C∙∙∙O, 3.312(3) Å; <CHO, 136°) is weaker than that with A’ (C27-H27B∙∙∙O1S: C-H, 0.95 Å; O∙∙∙H, 2.40 Å; C∙∙∙O, 3.268(3) Å; <CHO, 152°) (Figure 4).
Next, we studied the metalation of nido-carborane 3 with different phosphine complexes of nickel(II) [(R’R2P)2NiCl2] (R = R’ = Ph, Bu; R = Me, R’ = Ph; R = Ph, R’ = Me, Et). It was expected that the methoxy group of the side substituent with a pair of electrons on an oxygen atom could participate in the complexation with the metal, as observed earlier [58,60,62], along with the displacement of one phosphine ligand. The reaction conditions were the same as those for the synthesis of complex 5. However, as a result, a series of half-sandwich nickel(II) complexes with two phosphine ligands (which is without the direct participation of side substituent in the formation of complex) 6–9 was obtained (Scheme 3). The reaction of 3 with [(Ph3P)2NiCl2] did not lead to the formation of any nickelacarborane and only the starting nido-carborane was isolated from the reaction mixture.
We assume that the absence of metallacarborane product in the reaction of 3 with [(Ph3P)2NiCl2] is due to steric hindrances caused by the presence of bulky triphenylphosphine ligands (the Tolman cone angle θ is 145°) along with the substituent at carbon atom in the open pentagonal face of nido-carborane. We observed a similar result earlier in an attempt to metalate C-substituted nido-carboranes with the [(Ph3P)2NiCl2] complex, even in the case of a such small substituent as the methyl group in 7-methyl-nido-carborane [71]. However, the replacement of at least one phenyl group by alkyl one (the Tolman cone angles are 140, 136, and 112° for PPh2Et, PPh2Me, and PPhMe2, respectively), as well as the use of a PBu3 ligand (the Tolman cone angle is 132°), leads to the formation of half-sandwich nickelacarboranes as it was supported by the 11B NMR spectroscopy data. The signals of complexes 6–9 in the 11B NMR spectra appear as a set of five to eight broadened doublets in the characteristic range of −(3.0–23.0) ppm (see Supplementary Materials).
The most clear evidence of the presence of steric hindrance in complexes 6–9 is their 31P NMR spectra, each of which contains doublets of two nonequivalent phosphine ligands with the J(P–P) splitting constants of ~0 Hz. The 1H and 13C NMR spectra of 6–9 also indicate the absence of the free rotation of ligands due to steric hindrances. In the 1H NMR spectra, the signals of the CHcarb groups of the dicarbollide ligand are the most indicative. For example, in the 1H NMR spectra of complexes 6 and 7, these signals appear as high-field doublets with 4J(P-H) splitting constants of 10.8 and 14.3 Hz, respectively. The signals of CHcarb groups also appear as doublets in the 13C NMR spectra of 6–9. For example, for complex 9, it is observed at 41.0 ppm with the 3J(P-C) splitting constant of 15.0 Hz. It should be noted that such a spectral pattern is quite characteristic of the complexes with restricted rotation of the dicarbollide ligand [68,69,71].
There is also other spectral evidence of the absence of the free rotation of ligands in complexes 6–9 due to steric hindrances. In particular, in the 1H NMR spectrum of complex 7, the signals of the methyl groups of the PPh2Me ligands appear as doublets at 1.93 ppm (J = 9.8 Hz) and 1.55 ppm (J = 8.1 Hz) (Figure 5), while in the 13C NMR spectrum, the corresponding doublets are located at 20.2 ppm (J = 39.5 Hz) and 10.0 ppm (J = 33.6 Hz).

3. Conclusions

In this work, the reactions of C-substituted nido-carboranyl thioether [7-(MeO(CH2)2S)-7,8-C2B9H11]− (3) with various nickel(II) phosphine complexes were studied. The reaction of ligand 3 with (dppe)NiCl2 was found to result in the formation of half-sandwich complex 3,3-dppe-1-MeO(CH2)2S-closo-3,1,2-NiC2B9H10 (5), the structure of which was determined by single crystal X-ray diffraction. The metallation of 3 with diphosphine nickel complexes [(R’R2P)2NiCl2] (R = R’ = Bu; R = Me, R’ = Ph; R = Ph, R’ = Me, Et) led to the corresponding nickelacarboranes 3,3-(R’R2P)2-1-MeO(CH2)2S-closo- 3,1,2-NiC2B9H10 (R = R’ = Bu; R = Me, R’ = Ph; R = Ph, R’ = Me, Et) (6–9) containing two phosphine ligands. The donor methoxy group in the side chain of the dicarbollide ligand does not participate in the complexation with metal. However, the presence of the side substituent causes steric hindrances that prevent the free rotation of the ligands, which is clearly reflected by the NMR spectroscopy data. The synthesized nickelacarboranes are of interest as potential catalysts for selective carbene-transfer reactions. Their biological activity will also be investigated.

4. Experimental Section

4.1. Materials and Methods

Trimethylammonium salt of 1-mercapto-ortho-carborane [73], dichloro(1,2-bis(diphenylphosphino)ethane)nickel(II) [(dppe)NiCl2], dichlorobis(triphenylphosphine)nickel(II) [(Ph3P)2NiCl2], dichlorobis(dimethylphenylphosphine)nickel(II) [(Me2PhP)2NiCl2], dichlorobis(methyldiphenylphosphine)nickel(II) [(MePh2P)2NiCl2], dichlorobis(ethyldiphenylphosphine)nickel(II) [(EtPh2P)2NiCl2], and dichlorobis(tributhylphosphine)nickel(II) [(Bu3P)2NiCl2] [74] were synthesized according to methods described in the literature. Tetrahydrofuran was dried using the standard procedure [75]. 1-Bromo-2-methoxyethane and 1-bromo-3-methoxypropane were purchased from Acros Organics and ABCR, correspondingly, and used without purification. The reaction progress was monitored by thin-layer chromatography (Merck F254 silica gel on aluminum plates) and visualized using 0.5% PdCl2 in 1% HCl in aq. MeOH (1:10). Acros Organics silica gel (0.060–0.200 mm) was used for column chromatography. The instruments used to characterize the synthesized compounds is given in the Supplementary Materials.

4.2. Synthesis of 1-(MeO(CH2)2S)-1,2-C2B10H11 (1)

1-Bromo-2-methoxyethane (0.40 mL, 4.25 mmol) was added to a solution of the trimethylammonium salt of 1-mercapto-ortho-carborane (1.00 g, 4.25 mmol) in ethanol (40 mL) and the mixture was heated under reflux for approximately 5 h. The reaction mixture was allowed to cool to room temperature and evaporated to dryness in vacuum. The obtained product was isolated by column chromatography on silica with dichloromethane as an eluent to give a yellowish oil of 1 (0.39 g, 40% yield). 1H NMR (acetone-d6, ppm): δ 4.78 (1H, s, CHcarb), 3.58 (2H, t, J = 6.0 Hz, SCH2CH2OCH3), 3.28 (3H, s, OCH3), 3.20 (2H, t, J = 6.0 Hz, SCH2CH2OCH3), and 3.0 ÷ 1.5 (10H, m, BH). 13C NMR (acetone-d6, ppm): δ 77.9 (CScarb), 70.0 (SCH2CH2OCH3), 68.7 (CHcarb), 57.8 (OCH3), 36.9 (SCH2CH2OCH3). 11B NMR (acetone-d6, ppm): δ −2.1 (1B, d, J = 150 Hz), −5.6 (1B, d, J = 150 Hz), −9.5 (4B, d, J = 138 Hz), −12.1 (2B, d, J = 180 Hz), and −12.5 (2B, d, J = 165 Hz). IR (film, cm−1): 3048 (νC-H), 2940 (νC-H), 2838 (νC-H), 2610 (br, νB-H), 2588 (br, νB-H), 1479, 1455, 1423, 1385, 1291. ESI HRMS: m/z for C5H18B10OS: calcd. 258.2763 [M+Na]+, obsd. 258.2776 [M+Na]+.

4.3. Synthesis of 1-(MeO(CH2)3S)-1,2-C2B10H11 (2)

The procedure was similar to that described for 1, using the trimethylammonium salt of 1-mercapto-ortho-carborane (0.10 g, 0.43 mmol) in ethanol (10 mL) and 1-bromo-3-methoxypropane (0.05 mL, 0.43 mmol) to give a yellowish oil of 2 (0.08 g, 71% yield). 1H NMR (acetone-d6, ppm): δ 4.77 (1H, s, CHcarb), 3.39 (2H, t, J = 5.9 Hz, SCH2CH2CH2OCH3), 3.25 (3H, s, OCH3), 3.06 (2H, t, J = 7.4 Hz, SCH2CH2CH2OCH3), 1.82 (2H, m, J = 6.7 Hz, SCH2CH2CH2OCH3), 2.9 ÷ 1.3 (10H, m, BH). 13C NMR (acetone-d6, ppm): δ 75.7 (CScarb), 70.1 (SCH2CH2CH2OCH3), 68.6 (CHcarb), 57.7 (OCH3), 34.0 (SCH2CH2CH2OCH3), 28.5 (SCH2CH2CH2OCH3). 11B NMR (acetone-d6, ppm): δ −2.1 (1B, d, J = 149 Hz), −5.5 (1B, d, J = 148 Hz), −9.5 (4B, d, J = 145 Hz), −12.1 (2B, d, J = 175 Hz), −12.5 (2B, d, J = 159 Hz). IR (film, cm−1): 3070 (νC-H), 2992 (νC-H), 2933 (νC-H), 2884 (νC-H), 2838 (νC-H), 2599 (br, νB-H), 1478, 1449, 1386, 1295. ESI HRMS: m/z for C6H20B10OS: calcd. 249.2198 [M+H]+, obsd. 249.2197 [M+H]+.

4.4. Synthesis of Cs[7-(MeO(CH2)2S)-7,8-C2B9H11] (3)

Cesium fluoride (0.51 g, 3.36 mmol) was added to a solution of 1 (0.39 g, 1.68 mmol) in ethanol (30 mL) and the reaction mixture was heated under reflux for approximately 16 h (the end of the reaction was determined by TLC in CHCl3) during which a white precipitate formed. The mixture was cooled to room temperature, the solid was filtered off, and the filtrate was evaporated under reduced pressure. Acetone (20 mL) was added to the residue and the excess of cesium fluoride was filtered off. The solution was evaporated to dryness to give a white crystalline product 3 (0.57 g, 95% yield). 1H NMR (acetone-d6, ppm): δ 3.49 (2H, m, SCH2CH2OCH3), 3.29 (3H, s, OCH3), 3.00 (1H, m, SCH2CH2OCH3), 2.61 (1H, m, SCH2CH2OCH3), 1.94 (1H, s, CHcarb), 3.0 ÷ (−0.4) (9H, m, BH), −2.7 (1H, br m, BHB). 13C NMR (acetone-d6, ppm): δ 72.6 (SCH2CH2OCH3), 57.5 (OCH3), 53.0 (CHcarb), 35.5 (SCH2CH2OCH3). 11B NMR (acetone-d6, ppm): δ −9.8 (1B, d, J = 115 Hz), −10.5 (1B, d, J = 116 Hz), −14.8 (1B, d, J = 161 Hz), −17.0 (3B, d, J = 133 Hz), −22.2 (1B, d, J = 149 Hz), −32.9 (1B, dd, J = 139, 32 Hz), −36.6 (1B, d, J = 139 Hz). IR (film, cm−1): 2987 (νC-H), 2937 (νC-H), 2900 (νC-H), 2838 (νC-H), 2539 (br, νB-H), 1476, 1464, 1447, 1383, 1258. ESI HRMS: m/z for C5H18B9OS: calcd. m/z 224.1962 [M]−, obsd. m/z 224.1976 [M]−. UV (acetone, nm): λ 313.

4.5. Synthesis of Cs[7-(MeO(CH2)3S)-7,8-C2B9H11] (4)

The procedure was similar to that described for 3, using 2 (0.07 g, 0.29 mmol) in ethanol (10 mL) and cesium fluoride (0.09 g, 0.58 mmol) to give a white crystalline product 4 (0.13 g, 98% yield). 1H NMR (acetone-d6, ppm): δ 3.40 (2H, m, SCH2CH2CH2OCH3), 3.24 (3H, s, OCH3), 2.86 (1H, m, SCH2CH2CH2OCH3), 2.52 (1H, m, SCH2CH2CH2OCH3), 1.95 (1H, s, CHcarb), 1.84 (1H, m, SCH2CH2CH2OCH3), 1.73 (1H, m, SCH2CH2CH2OCH3), 3.1 ÷ (−0.4) (9H, m, BH), −2.7 (1H, br m, BHB). 13C NMR (acetone-d6, ppm): δ 71.0 (SCH2CH2CH2OCH3), 57.6 (OCH3), 53.0 (CHcarb), 33.1 (SCH2CH2CH2OCH3), 30.7 (SCH2CH2CH2OCH3). 11B NMR (acetone-d6, ppm): δ −9.9 (1B, d, J = 140 Hz), −10.5 (1B, d, J = 140 Hz), −14.9 (1B, d, J = 158 Hz), −16.9 (2B, d, J = 137 Hz), −17.8 (1B, d, J = 121 Hz), −22.3 (1B, d, J = 150 Hz). −33.0 (1B, dd, J = 132, 53 Hz), −36.7 (1B, d, J = 140 Hz). IR (film, cm−1): 2936 (νC-H), 2897 (νC-H), 2885 (νC-H), 2837 (νC-H), 2537 (br, νB-H), 1444, 1419, 1364, 1229. ESI HRMS: m/z for C6H20B9OS: calcd. m/z 238.2119 [M]−, obsd. m/z 238.2123 [M]−.

4.6. General Procedure for the Synthesis of Complexes 5–9

To a solution of 3 in the dry THF under argon atmosphere, the 3-fold excess of potassium tert-butoxide was added. The mixture was stirred for 15 min at ambient temperature and ~10 mol.% excess of nickel(II) phosphine complex was added. The reaction mixture immediately changed its color to different shades of green. The reaction mixture was stirred for 30 min at ambient temperature and the solution was evaporated under reduced pressure. The purification of crude product was carried out by column chromatography in dichloromethane as an eluent.
3,3-dppe-1-MeO(CH2)2S-closo-3,1,2-NiC2B9H10 (5). The synthesis was carried out using 3 (0.17 g, 0.48 mmol), t-BuOK (0.16 g, 1.43 mmol), and [(dppe)NiCl2] (0.28 g, 0.53 mmol) in THF (20 mL) to give green solid of 5 (0.22 g, 68% yield). 1H NMR (acetone-d6, ppm): δ 7.92 (4H, m, PPh2), 7.85 (4H, m, PPh2), 7.54 ÷ 7.41 (12H, br m, PPh2), 3.14 (3H, s, OCH3), 3.01 (1H, m, SCH2CH2OCH3), 2.89 (1H, m, SCH2CH2OCH3), 2.87 ÷ 2.81 (4H, br m, -PCH2CH2P-), 2.57 ÷ 2.39 (2H, br m, SCH2CH2OCH3), 1.90 (1H, s, CHcarb), 4.4 ÷ 0.6 (9H, m, BH). 13C NMR (acetone-d6, ppm): δ 134.19 (d, J = 4.7 Hz, Ph), 134.14 (d, J = 4.7 Hz, Ph), 132.98 (d, J = 4.7 Hz, Ph), 132.93 (d, J = 4.7 Hz, Ph), 131.0 (p-Ph), 130.9 (p-Ph), 128.72 (d, J = 5.1 Hz, Ph), 128.67 (d, J = 5.1 Hz, Ph), 128.24 (d, J = 5.1 Hz, Ph), 128.19 (d, J = 5.1 Hz, Ph), 71.1 (SCH2CH2OCH3), 57.6 (OCH3), 56.4 (CScarb), 52.1 (CHcarb), 36.1 (SCH2CH2OCH3), 29.3 (d, J = 23.5 Hz, -PCH2CH2P-). 11B NMR (acetone-d6, ppm): δ 5.5 (1B, d, J = 119 Hz), −7.2 (2B, d, J = 140 Hz), −11.3 (1B, d, J = 162 Hz), −12.8 (2B, d, J = 184 Hz), −16.8 (2B, d, J = 150 Hz), −20.8 (1B, d, J = 128 Hz). 31P NMR (acetone-d6, ppm): δ 59.3 (dppe). IR (film, cm−1): 3064 (νC-H), 2989 (νC-H), 2932 (νC-H), 2898 (νC-H), 2830 (νC-H), 2561 (br, νB-H), 2539 (br, νB-H), 1591, 1572, 1488, 1439, 1416, 1382, 1314, 1251. ESI HRMS: m/z for C31H41B9NiOP2S: calcd. m/z 718.2237 [M+K]+, obsd. m/z 718.2238 [M+K]+. UV (acetone, nm): λ 339, 431, 589, 711.
3,3-(Me2PhP)2-1-MeO(CH2)2S-closo-3,1,2-NiC2B9H10 (6). The synthesis was carried out using 3 (0.17 g, 0.48 mmol), t-BuOK (0.16 g, 1.43 mmol), and [(Me2PhP)2NiCl2] (0.22 g, 0.53 mmol) in THF (20 mL) to give a green solid of 6 (0.16 g, 59% yield). 1H NMR (acetone-d6, ppm): δ 7.68 (2H, m, PPh), 7.48 (8H, m, PPh), 3.56 ÷ 3.48 (2H, br m, SCH2CH2OCH3), 3.32 (3H, m, OCH3), 3.07 ÷ 2.98 (2H, br m, SCH2CH2OCH3), 1.70 (3H, d, J = 8.1 Hz, PCH3), 1.61 (1H, d, J = 10.8 Hz, CHcarb), 1.51 (3H, d, J = 8.1 Hz, PCH3), 1.36 (3H, d, J = 4.4 Hz, PCH3), 1.29 (3H, d, J = 8.9 Hz, PCH3), 3.1 ÷ 0.6 (9H, m, BH). 13C NMR (acetone-d6, ppm): δ 130.7 (Ph), 130.4 (Ph), 129.9 (Ph), 128.4 (Ph), 71.3 (SCH2CH2OCH3), 57.5 (OCH3), 53.8 (CScarb), 44.1 (d, J = 19.1Hz, CHcarb), 35.9 (SCH2CH2OCH3), 17.5 (d, J = 35.9 Hz, PCH3), 15.3 (d, J = 23.8 Hz, PCH3), 13.4 (d, J = 22.7 Hz, PCH3), 12.9 (d, J = 24.8 Hz, PCH3). 11B NMR (acetone-d6, ppm): δ −5.0 (2B, d, J = 130 Hz), −8.7 (1B, d, J = 142 Hz), −11.2 (1B, d, J = 167 Hz), −12.8 (1B, d, J = 168 Hz), −15.4 (2B, d, J = 132 Hz), −20.4 (1B, d, J = 152 Hz) −22.4, (1B, d, J = 156 Hz). 31P NMR (acetone-d6, ppm): δ 6.9 (d, JPP = 48.5 Hz), −11.8 (d, JPP = 48.5 Hz). IR (film, cm−1): 3094 (νC-H), 3067 (νC-H), 2988 (νC-H), 2927 (νC-H), 2834 (νC-H), 2547 (br, νB-H), 1482, 1438, 1421, 1379, 1302, 1284, 1249. ESI HRMS: m/z for C21H39B9NiOP2S: calcd. m/z 596.2075 [M+K]+, obsd. m/z 596.2077 [M+K]+. UV (acetone, nm): λ 342, 433, 589, 705.
3,3-(MePh2P)2-1-MeO(CH2)2S-closo-3,1,2-NiC2B9H10 (7). The synthesis was carried out using 3 (0.25 g, 0.70 mmol), t-BuOK (0.24 g, 2.10 mmol), and [(MePh2P)2NiCl2] (0.41 g, 0.77 mmol) in THF (20 mL) to give a green solid of 7 (0.30 g, 63% yield). 1H NMR (acetone-d6, ppm): δ 7.81 ÷ 7.70 (6H, br m, PPh), 7.46 ÷ 7.23 (14H, br m, PPh), 3.57 ÷ 3.49 (1H, br m, SCH2CH2OCH3), 3.49 ÷ 3.42 (1H, br m, SCH2CH2OCH3), 3.34 (3H, m, OCH3), 2.96 (2H, t, J = 6.7 Hz, SCH2CH2OCH3), 1.93 (3H, d, J = 9.8 Hz, PCH3), 1.55 (3H, d, J = 8.1 Hz, PCH3), 0.82 (1H, d, J = 14.3 Hz, CHcarb), 3.6 ÷ 0.5 (9H, m, BH). 13C NMR (acetone-d6, ppm): δ 133.5 (d, J = 8.5 Hz, Ph), 133.4 (d, J = 47.5 Hz, ipso-Ph), 133.2 (d, J = 7.1 Hz, Ph), 132.9 (d, J = 9.7 Hz, Ph), 132.1 (d, J = 8.9 Hz, Ph), 132.0 (d, J = 46.2 Hz, ipso-Ph), 130.6 (d, J = 8.6 Hz, Ph), 130.5 (d, J = 8.6 Hz, Ph), 130.0 (Ph), 128.4 (Ph), 128.3 (d, J = 9.7 Hz, Ph), 128.1 (d, J = 9.3 Hz, Ph), 71.6 (SCH2CH2OCH3), 57.8 (OCH3), 51.8 (CScarb), 47.2 (d, J = 23.6 Hz, CHcarb), 36.2 (SCH2CH2OCH3), 20.2 (d, J = 39.5 Hz, PCH3), 10.0 (d, J = 33.6 Hz, PCH3). 11B NMR (acetone-d6, ppm): δ −3.8 (2B, d, J = 130 Hz), −7.5 (1B, d, J = 142 Hz), −10.5 (1B, d, J = 163 Hz), −12.2 (1B, d, J = 167 Hz), −13.6 (1B, d, J = 164 Hz), −14.6 (1B, d, J = 137 Hz), −18.7 (1B, d, J = 126 Hz), −21.5, (1B, d, J = 131 Hz). 31P NMR (acetone-d6, ppm): δ 15.7 (d, JPP = 43.1 Hz), 1.5 (d, JPP = 43.1 Hz). IR (film, cm−1): 3067 (νC-H), 2997 (νC-H), 2935 (νC-H), 2893 (νC-H), 2830 (νC-H), 2553 (br, νB-H), 1487, 1439, 1383, 1320, 1291, 1250. ESI HRMS: m/z for C31H43B9NiOP2S: calcd. m/z 699.3095 [M+NH4]+, obsd. m/z 699.3099 [M+ NH4]+. UV (acetone, nm): λ 345, 445, 589, 738.
3,3-(EtPh2P)2-1-MeO(CH2)2S-closo-3,1,2-NiC2B9H10 (8). The synthesis was carried out using 3 (0.25 g, 0.70 mmol), t-BuOK (0.24 g, 2.10 mmol), and [(EtPh2P)2NiCl2] (0.43 g, 0.77 mmol) in THF (20 mL) to give a green solid of 8 (0.24 g, 48% yield). 1H NMR (CD3CN, ppm): δ 8.11 (2H, br m, PPh), 7.71 (7H, br m, PPh), 7.55 (11H, br m, PPh), 3.24 (2H, m, SCH2CH2OCH3), 3.24 (3H, s, OCH3), 2.13 (2H, m, SCH2CH2OCH3), 2.55–2.25 (4H, br m, PCH2CH3), 1.54 (1H, CHcarb), 1.08 (3H, m, PCH2CH3), 0.96 (3H, m, PCH2CH3), 3.5–0.4 (9H, m, BH). 13C NMR (CD3CN, ppm): δ 134.2 (Ph), 134.1 (Ph), 132.7 (Ph), 131.7 (Ph), 131.1 (Ph), 130.7 (Ph), 130.5 (Ph), 128.8 (Ph), 128.6 (Ph), 128.5 (Ph), 71.2 (SCH2CH2OCH3), 58.1 (OCH3), 38.6 (SCH2CH2OCH3), 21.4 (PCH2CH3), 8.2 (PCH2CH3), 4.9 (PCH2CH3). 11B NMR (CD3CN, ppm): δ −5.1 (1B, d, J = 136 Hz), −8.7 (2B, d, J = 129 Hz), −12.0 (1B, d, J = 188 Hz), −13.5 (2B, d, J = 159 Hz), −15.9 (1B, d, J = 144 Hz), −17.7 (1B, d, J = 179 Hz), −22.8 (1B, d, J = 149 Hz). 31P NMR (acetone-d6, ppm): δ 21.8 (d, JPP = 35.3 Hz), 12.6 (d, JPP = 35.3 Hz). IR (film, cm−1): 2933 (νC-H), 2881 (νC-H), 2853 (νC-H), 2544 (br, νB-H), 1487, 1455, 1439, 1368. ESI HRMS: m/z for C33H47B9NiOP2S: calcd. m/z 732.2962 [M+Na]+, obsd. m/z 732.2958 [M+ Na]+. UV (acetone, nm): λ 345, 481, 601, 701.
3,3-(Bu3P)2-1-MeO(CH2)2S-closo-3,1,2-NiC2B9H10 (9). The synthesis was carried out using 3 (0.25 g, 0.70 mmol), t-BuOK (0.24 g, 2.10 mmol), and [(Bu3P)2NiCl2] (0.41 g, 0.77 mmol) in THF (20 mL) to give a reddish solid of 9 (0.20 g, 42% yield). 1H NMR (acetone-d6, ppm): δ 3.48 (2H, SCH2CH2OCH3), 3.26 (3H, OCH3), 3.00 (2H, SCH2CH2OCH3), 1.83 (12H, PCH2CH2CH2CH3), 1.78 (1H, CHcarb), 1.69 (12H, PCH2CH2CH2CH3), 1.44 (12H, PCH2CH2CH2CH3), 0.94 (18H, PCH2CH2CH2CH3), 3.6–0.5 (9H, m, BH). 13C NMR (acetone-d6, ppm): δ 71.5 (SCH2CH2OCH3), 57.8 (OCH3), 50.7 (CScarb), 41.0 (d, J = 15.0 Hz, CHcarb), 35.9 (SCH2CH2OCH3), 25.9 (d, J = 20.4 Hz, PCH2CH2CH2CH3), 24.3 (d, J = 11.0 Hz, PCH2CH2CH2CH3), 24.2 (d, J = 10.9 Hz, PCH2CH2CH2CH3), 13.3 (PCH2CH2CH2CH3). 11B NMR (acetone-d6, ppm): δ −3.0 (1B), −4.5 (2B, d, J = 129 Hz), −8.5 (2B, d, J = 127 Hz), −14.1 (2B), −15.3 (2B), −21.5 (1B). 31P NMR (acetone-d6, ppm): δ 10.5 (d, JPP = 43.6 Hz), 1.9 (d, JPP = 43.6 Hz). IR (film, cm−1): 2964 (νC-H), 2876 (νC-H), 2821 (νC-H), 2590 (br, νB-H), 2508 (br, νB-H), 1473, 1384, 1247. ESI HRMS: m/z for C29H71B9NiOP2S: calcd. m/z 685.4945 [M]+, obsd. m/z 685.4934 [M]+. UV (acetone, nm): λ 344, 457, 593, 697.

4.7. Single Crystal X-ray Diffraction Study

Crystallographic data for 5∙0.5Me2CO: C31H41B9NiOSP2 0.5(C3H6O) are triclinic, space group P-1: a = 12.3355(7) Å, b = 12.7617(7) Å, c = 23.3086(12) Å, α = 94.623(2)°, β = 95.020(2)°, γ = 94.286(2)°, V = 3630.9(3) Å3, Z = 4, M = 708.67, dcryst = 1.296 g·cm−3. wR2 = 0.0876 calculated on F2hkl for all 14,295 independent reflections with 2θ < 52.1°, (GOF = 1.051, R = 0.0377 calculated on Fhkl for 11,059 reflections with I > 2σ(I)).
The CCDC number 2243695 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge via www.ccdc.cam.ac.uk/data_request/cif.

Supplementary Materials

The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/inorganics11030127/s1, The NMR spectra of compounds 1–9 and crystallographic data on compound 5.

Author Contributions

Conceptualization, M.Y.S.; methodology, M.Y.S. and I.B.S.; validation, D.K.S., M.Y.S. and I.B.S.; formal analysis, D.K.S., K.Y.S. and M.Y.S.; investigation, D.K.S.; data curation, I.B.S.; writing—original draft preparation, M.Y.S.; writing—review and editing, I.B.S.; supervision, I.B.S. All authors have read and agreed to the published version of the manuscript.

Funding

This research was supported by the Russian Science Foundation (21-73-10199).

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Not applicable.

Acknowledgments

The NMR, UV–Vis, and IR spectra as well as the single crystal X-ray diffraction data were obtained using equipment from the Center for Molecular Structure Studies at the A.N. Nesmeyanov Institute of Organoelement Compounds, operating with financial support from the Ministry of Science and Higher Education of the Russian Federation.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Wiesboeck, R.A.; Hawthorne, M.F. Dicarbaundecaborane(13) and derivatives. J. Am. Chem. Soc. 1964, 86, 1642–1643. [Google Scholar] [CrossRef]
  2. Hawthorne, M.F.; Young, D.C.; Garrett, P.M.; Owen, D.A.; Schwerin, S.G.; Tebbe, F.N.; Wegner, P.A. Preparation and characterization of the (3)-1,2- and (3)-1,7-dicarbadodecahydroundecaborate(-1) ions. J. Am. Chem. Soc. 1968, 90, 862–868. [Google Scholar] [CrossRef]
  3. Buchanan, J.; Hamilton, E.J.M.; Reed, D.; Welch, A.J. The structure of [7,8-C2B9H12]–; correction of a popular misconception. J. Chem. Soc. Dalton. Trans. 1990, 2, 677–680. [Google Scholar] [CrossRef]
  4. Harris, C.B. Transition metal nuclear quadrupole resonance. I. Cobalt-59 nuclear quadrupole resonance in Cs(1,2-B9C2H11)2Co(III) and the bonding in ferrocene. Inorg. Chem. 1968, 7, 1517–1521. [Google Scholar] [CrossRef]
  5. Brown, D.A.; Fanning, M.O.; Fitzpatrick, N.J. Bonding in the (.pi.-(3)-1,2-dicarbollyl)tricarbonylmanganese anion. Inorg. Chem. 1980, 19, 1822–1823. [Google Scholar] [CrossRef]
  6. Semin, G.K.; Bryukhova, E.V. On the manifestation of electron-nuclear dynamics in 59Co NQR spectra for the series of π-cyclopentadienyl-π-(3)-1,2-dicarbollylcobalt derivatives. Russ. J. Phys. Chem. 2010, 84, 235–239. [Google Scholar] [CrossRef]
  7. Hawthorne, M.F.; Young, D.C.; Andrews, T.D.; Howe, D.V.; Pilling, R.L.; Pitts, A.D.; Reintjer, M.; Warren, L.F.; Wegner, P.A. π-Dicarbollyl derivatives of the transition metals. Metallocene analogs. J. Am. Chem. Soc. 1968, 90, 879–896. [Google Scholar] [CrossRef]
  8. Grimes, R.N. Transitional metal metallacarbaboranes. In Comprehensive Organometallic Chemistry II; Elsevier: Oxford, UK, 1995; Volume 1, pp. 373–430. [Google Scholar]
  9. Grimes, R.N. Metallacarboranes in the new millennium. Coord. Chem. Rev. 2000, 200, 773–811. [Google Scholar] [CrossRef]
  10. Hosmane, N.S.; Maguire, J.A. Metallacarboranes of d- and f-block metals. In Comprehensive Organometallic Chemistry III; Elsevier: Oxford, UK, 2007; Volume 3, pp. 175–264. [Google Scholar]
  11. Grimes, R.N. Metallacarboranes of the transition and lanthanide elements. In Carboranes, 3rd ed.; Academic Press: London, UK, 2016; pp. 711–903. [Google Scholar] [CrossRef]
  12. Kar, S.; Pradhan, A.N.; Ghosh, S. Polyhedral metallaboranes and metallacarboranes. In Comprehensive Organometallic Chemistry IV; Elsevier: Oxford, UK, 2022; Volume 9, pp. 263–369. [Google Scholar] [CrossRef]
  13. Grishin, I.D.; Turmina, E.S.; D’yachihin, D.I.; Peregudova, S.M.; Chizhevsky, I.T.; Grishin, D.F. Ruthenium carborane complexes: A relationship between the structure, electrochemical properties, and reactivity in catalysis of polymerization processes. Russ. Chem. Bull. 2013, 62, 692–698. [Google Scholar] [CrossRef]
  14. Chan, A.P.Y.; Parkinson, J.A.; Rosair, G.M.; Welch, A.J. Bis(phosphine)hydridorhodacarborane derivatives of 1,1′-bis(ortho-carborane) and their catalysis of alkene isomerization and the hydrosilylation of acetophenone. Inorg. Chem. 2020, 59, 2011–2023. [Google Scholar] [CrossRef]
  15. Zimina, A.M.; Anufriev, S.A.; Derendyaeva, M.A.; Knyazeva, N.A.; Somov, N.V.; Malysheva, Y.B.; Sivaev, I.B.; Grishin, I.D. Ruthenium complexes of 5-MeC2B9-carborane ligand: Synthesis and application in polymerization catalysis. Dokl. Chem. 2021, 498, 97–103. [Google Scholar] [CrossRef]
  16. Grishin, I.D.; Zimina, A.M.; Anufriev, S.A.; Knyazeva, N.A.; Piskunov, A.V.; Dolgushin, F.M.; Sivaev, I.B. Synthesis and catalytic properties of novel ruthenacarboranes based on nido-[5-Me-7,8-C2B9H10]2− and nido-[5,6-Me2-7,8-C2B9H9]2− dicarbollide ligands. Catalysts 2021, 11, 1409. [Google Scholar] [CrossRef]
  17. Causey, P.W.; Besanger, T.R.; Valliant, J.F. Synthesis and screening of mono- and di-aryl technetium and rhenium metallocarboranes. A new class of probes for the estrogen receptor. J. Med. Chem. 2008, 51, 2833–2844. [Google Scholar] [CrossRef] [PubMed]
  18. Cooke, M.; Valliant, J.F. Metallocarborane-based bisphosphonates for tumour imaging and therapy. Nucl. Med. Biol. 2010, 37, 681–682. [Google Scholar] [CrossRef]
  19. Zheng, Y.; Liu, W.; Chen, Y.; Jiang, H.; Yan, H.; Kosenko, I.; Chekulaeva, L.; Sivaev, I.; Bregadze, V.; Wang, X. A Highly potent antibacterial agent targeting methicillin-resistant Staphylococcus aureus based on cobalt bis(1,2-dicarbollide) alkoxy derivative. Organometallics 2017, 36, 3484–3490. [Google Scholar] [CrossRef]
  20. Gozzi, M.; Schwarze, B.; Hey-Hawkins, E. Half- and mixed-sandwich metallacarboranes for potential applications in medicine. Pure Appl. Chem. 2019, 91, 563–573. [Google Scholar] [CrossRef]
  21. Gozzi, M.; Murganic, B.; Drača, D.; Popp, J.; Coburger, P.; Maksimović-Ivanić, D.; Mijatović, S.; Hey-Hawkins, E. Quinoline-conjugated ruthenacarboranes: Toward hybrid drugs with a dual mode of action. ChemMedChem 2019, 14, 2061–2074. [Google Scholar] [CrossRef] [Green Version]
  22. Schwarze, B.; Jelača, S.; Welcke, L.; Maksimović-Ivanić, D.; Mijatović, S.; Hey-Hawkins, E. 2,2′-Bipyridine-modified tamoxifen: A versatile vector for molybdacarboranes. ChemMedChem 2019, 14, 2075–2083. [Google Scholar] [CrossRef] [Green Version]
  23. Grüner, B.; Brynda, J.; Das, V.; Šícha, V.; Štěpánková, J.; Nekvinda, J.; Holub, J.; Pospíšilová, K.; Fábry, M.; Pachl, P.; et al. Metallacarborane sulfamides: Unconventional, specific, and highly selective inhibitors of carbonic anhydrase IX. J. Med. Chem. 2019, 62, 9560–9575. [Google Scholar] [CrossRef]
  24. Kellert, M.; Sárosi, I.; Rajaratnam, R.; Meggers, E.; Lönnecke, P.; Hey-Hawkins, E. Ruthenacarborane-phenanthroline derivatives as potential metallodrugs. Molecules 2020, 25, 2322. [Google Scholar] [CrossRef]
  25. Teixeira, R.G.; Marques, F.; Robalo, M.P.; Fontrodona, X.; Garcia, H.; Geninatti Crich, S.; Viñas, C.; Valente, A. Ruthenium carboranyl complexes with 2,2′-bipyridine derivatives for potential bimodal therapy application. RSC Adv. 2020, 10, 16266–16276. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  26. Drača, D.; Marković, M.; Gozzi, M.; Mijatović, S.; Maksimović-Ivanić, D.; Hey-Hawkins, E. Ruthenacarborane and quinoline: A promising combination for the treatment of brain tumors. Molecules 2021, 26, 3801. [Google Scholar] [CrossRef] [PubMed]
  27. Swietnicki, W.; Goldeman, W.; Psurski, M.; Nasulewicz-Goldeman, A.; Boguszewska-Czubara, A.; Drab, M.; Sycz, J.; Goszczyński, T.M. Metallacarborane derivatives effective against Pseudomonas aeruginosa and Yersinia enterocolitica. Int. J. Mol. Sci. 2021, 22, 6762. [Google Scholar] [CrossRef]
  28. Kubiński, K.; Masłyk, M.; Janeczko, M.; Goldeman, W.; Nasulewicz-Goldeman, A.; Psurski, M.; Martyna, A.; Boguszewska-Czubara, A.; Cebula, J.; Goszczyński, T.M. Metallacarborane derivatives as innovative anti-Candida albicans agents. J. Med. Chem. 2022, 65, 13935–13945. [Google Scholar] [CrossRef]
  29. Sivaev, I.B.; Bregadze, V.I. Chemistry of cobalt bis(dicarbollides). A review. Collect. Czech. Chem. Commun. 1999, 64, 783–805. [Google Scholar] [CrossRef]
  30. Dash, B.P.; Satapathy, R.; Swain, B.R.; Mahanta, C.S.; Jena, B.B.; Hosmane, N.S. Cobalt bis(dicarbollide) anion and its derivatives. J. Organomet. Chem. 2017, 849–850, 170–194. [Google Scholar] [CrossRef]
  31. Druzina, A.A.; Shmalko, A.V.; Sivaev, I.B.; Bregadze, V.I. Cyclic oxonium derivatives of cobalt and iron bis(dicarbollide)s and their use in organic synthesis. Russ. Chem. Rev. 2021, 90, 785–830. [Google Scholar] [CrossRef]
  32. Vinogradov, M.M.; Nelyubina, Y.V.; Pavlov, A.P.; Novikov, V.V.; Shvydkiy, N.V.; Kudinov, A.R. Polyhedral rearrangements in the complexes of rhodium and iridium with isomeric carborane anions [7,8-Me2-X-SMe2-7,8-nido- C2B9H8]− (X = 9 and 10). Organometallics 2017, 36, 791–800. [Google Scholar] [CrossRef]
  33. Timofeev, S.V.; Zhidkova, O.B.; Sivaev, I.B.; Starikova, Z.A.; Suponitsky, K.Y.; Yan, H.; Bregadze, V.I. Synthesis of rhodacarboranes containing σ- and π-carboranyl ligands in one molecule. J. Organomet. Chem. 2018, 867, 342–346. [Google Scholar] [CrossRef]
  34. Vinogradov, M.M.; Nelyubina, Y.V.; Ikonnikov, N.S. Different reactivity of cyclooctadiene complexes 3,3-(cod)- 8-SMe2-closo-3,1,2-RhC2B9H10 and 1,8-Me2-2,2-(cod)-11-SMe2-2,1,8-closo-RhC2B9H8 toward iodine. J. Organomet. Chem. 2018, 867, 224–227. [Google Scholar] [CrossRef]
  35. Vinogradov, M.M.; Loginov, D.A. Rhoda- and iridacarborane halide complexes: Synthesis, structure and application in homogeneous catalysis. J. Organomet. Chem. 2020, 910, 121135. [Google Scholar] [CrossRef]
  36. Timofeev, S.V.; Zhidkova, O.B.; Suponitsky, K.Y.; Anisimov, A.A.; Sivaev, I.B.; Yan, H.; Bregadze, V.I. Rhodacarboranes containing σ- and π-carborane ligands. New aspects. Inorg. Chim. Acta 2021, 518, 120243. [Google Scholar] [CrossRef]
  37. Sivaev, I.B.; Bregadze, V.I. Chemistry of nickel and iron bis(dicarbollides). A review. J. Organomet. Chem. 2002, 614–615, 27–36. [Google Scholar] [CrossRef]
  38. Miller, S.B.; Hawthorne, M.F. Novel ligand rearrangement of closo-nickelacarbaboranes. J. Chem. Soc. Chem. Commun. 1976, 19, 786–787. [Google Scholar] [CrossRef]
  39. King III, R.E.; Miller, S.B.; Knobler, C.B.; Hawthorne, M.F. Simultaneous conversion of NiPR3 and BH to NiH and BPR3 linkages by thermal rearrangement of d8 closo-bis(triarylphosphine)nickelacarboranes. Crystal and molecular structure of [closo-3-(μ-CO)-8-PPh3-3,1,2-NiC2B9H10]2: A dimeric nickelacarborane complex containing a metal-metal bond. Inorg. Chem. 1983, 22, 3548–3554. [Google Scholar] [CrossRef]
  40. Erdman, A.A.; Zubreichuk, Z.P.; Knizhnikov, V.A.; Maier, A.A.; Aleksandrov, G.G.; Nefedov, S.E.; Eremenko, I.L. Synthesis and the structure of the triphenylphosphine complex of o-nickelacarborane, 3,3-(PPh3)2-3,1,2-NiC2B9H11. Russ. Chem. Bull. 2001, 50, 2248–2250. [Google Scholar] [CrossRef]
  41. Hodson, B.E.; McGrath, T.D.; Stone, F.G.A. Supraicosahedral and icosahedral nickelacarbaboranes bearing exopolyhedral metal fragments. Dalton Trans. 2004, 16, 2570–2577. [Google Scholar] [CrossRef] [PubMed]
  42. Hodson, B.E.; McGrath, T.D.; Stone, F.G.A. Synthesis, structure, and dynamics of nickelacarboranes incorporating the [nido-7,9-C2B9H11]2- ligand. Inorg. Chem. 2004, 43, 3090–3097. [Google Scholar] [CrossRef]
  43. Wang, L.; Perveen, S.; Ouyang, Y.; Zhang, S.; Jiao, J.; He, G.; Nie, Y.; Li, P. Well-defined, versatile and recyclable half-sandwich nickelacarborane catalyst for selective carbene-transfer reactions. Chem. Eur. J. 2021, 27, 5754–5760. [Google Scholar] [CrossRef]
  44. Carr, N.; Mullica, D.F.; Sappenfield, E.L.; Stone, F.G.A. Carborane complexes of nickel and platinum: Synthesis and protonation reactions of anionic allyl(carborane) species. Inorg. Chem. 1994, 33, 1666–1673. [Google Scholar] [CrossRef]
  45. Garrioch, R.M.; Kuballa, P.; Low, K.S.; Rosair, G.M.; Welch, A.J. The ‘1,2 to 1,2’ cage carbon isomerisation in bisphosphine carbanickelaboranes: Synthesis and spectroscopic and crystallographic characterisation of 1,2-Ph2- 4,4-(PMe2Ph)2-4,1,2-closo-NiC2B9H9, 1,2-Ph2-4,4-(PEt3)2-4,1,2-closo-NiC2B9H9 and 1,2-Ph2-4-(dppe)-4,1,2-closo-NiC2B9H9. J. Organomet. Chem. 1999, 575, 57–62. [Google Scholar] [CrossRef]
  46. Kudinov, A.R.; Petrovskii, P.V.; Meshcheryakov, V.I.; Rybinskaya, M.I. Synthesis of the first metallacarborane triple-decker complexes with a central cyclopentadienyl ligand. Russ. Chem. Bull. 1999, 48, 1356–1361. [Google Scholar] [CrossRef]
  47. Park, J.-S.; Kim, D.-H.; Kim, S.-J.; Ko, J.; Kim, S.H.; Cho, S.; Lee, C.-H.; Kang, S.O. Preparation and reactions of a half-sandwich dicarbollyl nickel(II) complex containing a dimethylamino pendent group. Organometallics 2001, 20, 4483–4491. [Google Scholar] [CrossRef]
  48. Robertson, S.; Ellis, D.; Rosair, G.M.; Welch, A.J. Nickelation of [3-Et-7,8-Ph2-7,8-nido-C2B9H8]2−: Synthesis and characterization of 1,2 → 1,2 and 1,2 → 1,7 isomerized products. Appl. Organometal. Chem. 2003, 17, 518–524. [Google Scholar] [CrossRef]
  49. Robertson, S.; Garrioch, R.M.; Ellis, D.; McGrath, T.D.; Hodson, B.E.; Rosair, G.M.; Welch, A.J. Towards the mechanism of heteroborane isomerisation: 1,2 → 1,2 and 1,2 → 1,7 low-temperature isomerisations from metallations of [5-I-7,8-Ph2-7,8-nido-C2B9H8]2−. Inorg. Chim. Acta 2005, 358, 1485–1493. [Google Scholar] [CrossRef]
  50. Yinghuai, Z.; Sia, S.L.P.; Carpenter, K.; Kooli, F.; Kemp, R.A. Syntheses and catalytic activities of single-wall carbon nanotubes-supported nickel (II) metallacarboranes for olefin polymerization. J. Phys. Chem. Solids 2006, 67, 1218–1222. [Google Scholar] [CrossRef]
  51. Stogniy, M.Y.; Erokhina, S.A.; Suponitsky, K.Y.; Markov, V.Y.; Sivaev, I.B. Synthesis and crystal structures of nickel(II) and palladium(II) complexes with o-carboranyl amidine ligands. Dalton Trans. 2021, 50, 4967–4975. [Google Scholar] [CrossRef]
  52. Stogniy, M.Y.; Erokhina, S.A.; Suponitsky, K.Y.; Sivaev, I.B.; Bregadze, V.I. Coordination ability of 10-EtC(NHPr)=HN-7,8-C2B9H11 in the reactions with nickel(II) phosphine complexes. Crystals 2021, 11, 306. [Google Scholar] [CrossRef]
  53. Stogniy, M.Y.; Anufriev, S.A.; Sivaev, I.B. Charge-compensated derivatives of nido-carborane. Inorganics 2023, 11, 72. [Google Scholar] [CrossRef]
  54. Timofeev, S.V.; Sivaev, I.B.; Prikaznova, E.A.; Bregadze, V.I. Transition metal complexes with charge-compensated dicarbollide ligands. J. Organomet. Chem. 2014, 751, 221–250. [Google Scholar] [CrossRef]
  55. Zhang, D.; Dou, J.; Li, D.; Wang, D. Synthesis and characterization of three group 10 complexes containing nido-carborane diphosphine: [MCl(PPh3){7,8-(PPh2)2-7,8-C2B9H10}] (M = Ni, Pd, Pt). Inorg. Chim. Acta 2006, 13, 4243–4249. [Google Scholar] [CrossRef]
  56. Axtell, J.C.; Kirlikovali, K.O.; Djurovich, P.I.; Jung, D.; Nguyen, V.T.; Munekiyo, B.; Royappa, A.T.; Rheingold, A.L.; Spokoyny, A.M. Blue phosphorescent zwitterionic iridium(III) complexes featuring weakly coordinating nido-carborane-based ligands. J. Am. Chem. Soc. 2016, 138, 15758–15765. [Google Scholar] [CrossRef]
  57. Uemura, K.; Tanaka, K.; Chujo, Y. Conformation-dependent electron donation of nido-carborane substituents and its influence on phosphorescence of tris(2,2′-bipyridyl)ruthenium(II) complex. Crystals 2022, 12, 688. [Google Scholar] [CrossRef]
  58. Yinghuai, Z.; Yulin, Z.; Carpenter, K.; Maguire, J.A.; Hosmane, N.S. Synthesis and catalytic activities of Group 4 metal complexes derived from C(cage)-appended cyclohexyloxocarborane trianion. J. Organomet. Chem. 2005, 690, 2802–2808. [Google Scholar] [CrossRef]
  59. Yinghuai, Z.; Lo Pei Sia, S.; Kooli, F.; Carpenter, K.; Kemp, R.A. Another example of carborane based trianionic ligand: Syntheses and catalytic activities of cyclohexylamino tailed ortho-carboranyl zirconium and titanium dicarbollides. J. Organomet. Chem. 2005, 690, 6284–6291. [Google Scholar] [CrossRef]
  60. Shen, H.; Chan, H.-S.; Xie, Z. Guanylation of amines catalyzed by a half-sandwich titanacarborane amide complex. Organometallics 2006, 25, 5515–5517. [Google Scholar] [CrossRef]
  61. Gao, M.; Tang, Y.; Xie, M.; Qian, C.; Xie, Z. Synthesis, structure, and olefin polymerization behavior of constrained-geometry Group 4 metallacarboranes incorporating imido-dicarbollyl ligands. Organometallics 2006, 25, 2578–2584. [Google Scholar] [CrossRef]
  62. Shen, H.; Chan, H.-S.; Xie, Z. Synthesis, structure, and reactivity of [σ:η1:η5-(OCH2)(Me2NCH2)C2B9H9]Ti(NR2) (R = Me, Et). Organometallics 2007, 26, 2694–2704. [Google Scholar] [CrossRef]
  63. Lee, J.-D.; Lee, Y.-J.; Son, K.-C.; Han, W.-S.; Cheong, M.; Ko, J.; Kang, S.O. Synthesis, characterization, and reactivity of new types of constrained geometry Group 4 metal complexes derived from picolyl-substituted dicarbollide ligand systems. J. Organomet. Chem. 2007, 692, 5403–5413. [Google Scholar] [CrossRef]
  64. Anufriev, S.A.; Sivaev, I.B.; Nakamura, H. Two possible ways to combine boron and gadolinium for Gd-quided BNCT. A concept. Phosphorus Sulfur Silicon Relat. Elem. 2020, 195, 910–917. [Google Scholar] [CrossRef]
  65. Park, J.-S.; Kim, D.-H.; Ko, J.; Kim, S.H.; Cho, S.; Lee, C.-H.; Kang, S.O. Half-sandwich iron(II) and ruthenium(II) complexes with the dicarbollylamino ligand system. Organometallics 2001, 20, 4632–4640. [Google Scholar] [CrossRef]
  66. Kim, D.-H.; Won, J.H.; Kim, S.-J.; Ko, J.; Kim, S.H.; Cho, S.; Kang, S.O. Dicarbollide analogues of the constrained-geometry polymerization catalyst. Organometallics 2001, 20, 4298–4300. [Google Scholar] [CrossRef]
  67. Lee, J.-D.; Lee, Y.-J.; Son, K.-C.; Cheong, M.; Ko, J.; Kang, S.O. New types of constrained geometry Group 4 metal complexes derived from the aminomethyldicarbollyl ligand system: Synthesis and structural characterization of mono-dicarbollylamino and bis-dicarbollylamino Group 4 metal complexes. Organometallics 2007, 26, 3374–3384. [Google Scholar] [CrossRef]
  68. Mandal, D.; Man, W.Y.; Rosair, G.M.; Welch, A.J. Steric versus electronic factors in metallacarborane isomerisation: Nickelacarboranes with 3,1,2-, 4,1,2- and 2,1,8-NiC2B9 architectures and pendant carborane groups, derived from 1,1′-bis(o-carborane). Dalton Trans. 2016, 45, 15013–15025. [Google Scholar] [CrossRef] [PubMed]
  69. Mandal, D.; Rosair, G.M. Exploration of bis(nickelation) of 1,1′-bis(o-carborane). Crystals 2021, 11, 16. [Google Scholar] [CrossRef]
  70. Viñas, C.; Bertran, J.; Gomez, S.; Teixidor, F.; Dozol, J.-F.; Rouquette, H.; Kivekäs, R.; Sillanpää, R. Aromatic substituted metallacarboranes as extractants of 137Cs and 90Sr from nuclear wastes. J. Chem. Soc. Dalton Trans. 1998, 17, 2849–2854. [Google Scholar] [CrossRef]
  71. Semyonov, D.K.; Slushko, G.K.; Stogniy, M.Y.; Anufriev, S.A.; Godovikov, I.A.; Suponitsky, K.Y.; Bregadze, V.I.; Sivaev, I.B. Interligand interactions in half-sandwich nickelacarboranes with phosphine ligands: Away from skeletal rearrangements. Organometallics 2023, 42. [Google Scholar] [CrossRef]
  72. Stogniy, M.Y.; Sivaev, I.B.; Petrovskii, P.V.; Bregadze, V.I. Synthesis of monosubstituted functional derivatives of carboranes from 1-mercapto-ortho-carborane: 1-HOOC(CH2)nS-1,2-C2B10H11 and [7-HOOC(CH2)nS-7,8-C2B9H11]−(n = 1–4). Dalton Trans. 2010, 39, 1817–1822. [Google Scholar] [CrossRef] [PubMed]
  73. Stogniy, M.Y.; Erokhina, S.A.; Druzina, A.A.; Sivaev, I.B.; Bregadze, V.I. Synthesis of novel carboranyl azides and “click” reactions thereof. J. Organomet. Chem. 2019, 904, 121007. [Google Scholar] [CrossRef]
  74. Standley, E.A.; Smith, S.J.; Müller, P.; Jamison, T.F. A broadly applicable strategy for entry into homogeneous nickel(0) catalysts from air-stable nickel(II) complexes. Organometallics 2014, 33, 2012–2018. [Google Scholar] [CrossRef] [Green Version]
  75. Armarego, W.L.F.; Chai, C.L.L. Purification of Laboratory Chemicals, 6th ed.; Butterworth-Heinemann: Burlington, UK, 2009. [Google Scholar]
Inorganics 11 00127 sch001 550
Scheme 1. Synthesis of closo- and nido-carboranyl thioethers 1–4.
Scheme 1. Synthesis of closo- and nido-carboranyl thioethers 1–4.
Inorganics 11 00127 sch001
Inorganics 11 00127 sch002 550
Scheme 2. Synthesis of 3,3-dppe-1-MeO(CH2)2S-closo-3,1,2-NiC2B9H10 (5).
Scheme 2. Synthesis of 3,3-dppe-1-MeO(CH2)2S-closo-3,1,2-NiC2B9H10 (5).
Inorganics 11 00127 sch002
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Figure 1. The comparison of 11B{1H} NMR spectra of nido-carborane 3 (a) and complex 5 (b).
Figure 1. The comparison of 11B{1H} NMR spectra of nido-carborane 3 (a) and complex 5 (b).
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Inorganics 11 00127 g002 550
Figure 2. General view of the molecule of 3,3-dppe-1-MeO(CH2)2S-closo-3,1,2-NiC2B9H10 (5) showing the numbering scheme. Thermal ellipsoids are given at the 50% probability level.
Figure 2. General view of the molecule of 3,3-dppe-1-MeO(CH2)2S-closo-3,1,2-NiC2B9H10 (5) showing the numbering scheme. Thermal ellipsoids are given at the 50% probability level.
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Inorganics 11 00127 g003 550
Figure 3. Comparison of two symmetrically independent molecules in the structure of complex 5. A (left) and A’ (right) shown as in the projections onto the open face (C1–C2–B7–B8–B4) of the dicarbollide ligand.
Figure 3. Comparison of two symmetrically independent molecules in the structure of complex 5. A (left) and A’ (right) shown as in the projections onto the open face (C1–C2–B7–B8–B4) of the dicarbollide ligand.
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Inorganics 11 00127 g004 550
Figure 4. Intermolecular hydrogen bonding in the crystal structure of 3,3-dppe-1-MeO(CH2)2S- closo-3,1,2-NiC2B9H10∙0.5Me2CO.
Figure 4. Intermolecular hydrogen bonding in the crystal structure of 3,3-dppe-1-MeO(CH2)2S- closo-3,1,2-NiC2B9H10∙0.5Me2CO.
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Inorganics 11 00127 sch003 550
Scheme 3. Syntheses of nickelacarboranes 6–9.
Scheme 3. Syntheses of nickelacarboranes 6–9.
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Figure 5. The 1H NMR spectrum of complex 7.
Figure 5. The 1H NMR spectrum of complex 7.
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MDPI and ACS Style

Semyonov, D.K.; Stogniy, M.Y.; Suponitsky, K.Y.; Sivaev, I.B. Half-Sandwich Nickelacarboranes Derived from [7-(MeO(CH2)2S)-7,8-C2B9H11]−. Inorganics 2023, 11, 127. https://doi.org/10.3390/inorganics11030127

AMA Style

Semyonov DK, Stogniy MY, Suponitsky KY, Sivaev IB. Half-Sandwich Nickelacarboranes Derived from [7-(MeO(CH2)2S)-7,8-C2B9H11]−. Inorganics. 2023; 11(3):127. https://doi.org/10.3390/inorganics11030127

Chicago/Turabian Style

Semyonov, Dmitriy K., Marina Yu. Stogniy, Kyrill Yu. Suponitsky, and Igor B. Sivaev. 2023. "Half-Sandwich Nickelacarboranes Derived from [7-(MeO(CH2)2S)-7,8-C2B9H11]−" Inorganics 11, no. 3: 127. https://doi.org/10.3390/inorganics11030127

APA Style

Semyonov, D. K., Stogniy, M. Y., Suponitsky, K. Y., & Sivaev, I. B. (2023). Half-Sandwich Nickelacarboranes Derived from [7-(MeO(CH2)2S)-7,8-C2B9H11]−. Inorganics, 11(3), 127. https://doi.org/10.3390/inorganics11030127

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