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COVID, Volume 4, Issue 12 (December 2024) – 3 articles

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10 pages, 233 KiB  
Article
Adverse Childhood Experiences and Vulnerability to Mood and Anxiety Disorders During the COVID-19 Pandemic
by Scott B. Patten
COVID 2024, 4(12), 1863-1872; https://doi.org/10.3390/covid4120131 - 26 Nov 2024
Viewed by 123
Abstract
The COVID-19 pandemic had a global impact on mental health. Identification of individuals at higher or lower risk of mental health problems may assist with targeting prevention, support and treatment efforts during future pandemics. Using a Canadian national mental health survey that collected [...] Read more.
The COVID-19 pandemic had a global impact on mental health. Identification of individuals at higher or lower risk of mental health problems may assist with targeting prevention, support and treatment efforts during future pandemics. Using a Canadian national mental health survey that collected data during the pandemic period (March 2022–December 2022), this study examined the vulnerability of participants reporting abuse during their childhood by examining the annual prevalence of mood, anxiety and substance use disorders. Psychiatric disorders were identified using a version of the Composite International Diagnostic Interview (CIDI). Because childhood adversities are well-known risk factors for mental disorders, the analysis focused on interactions between childhood adversities and pandemic-related stressors by estimating the relative excess risk due to interaction (RERI). RERIs provide evidence of synergy based on the occurrence of greater than additive interactions. Physical and sexual abuse interacted synergistically with pandemic-related stressors in predicting mood and anxiety disorders. No synergies were found for substance use disorders. Childhood adversities increase vulnerability to later stressors and may be useful for the identification of individuals more likely to have mental health needs during this type of public health emergency. Full article
12 pages, 377 KiB  
Article
Assessing the Effects of Unit-Based Pricing on Household Waste Reduction During COVID-19 in Japan
by Michiko Karasawa and Hiroyuki Taguchi
COVID 2024, 4(12), 1851-1862; https://doi.org/10.3390/covid4120130 - 25 Nov 2024
Viewed by 189
Abstract
Focusing on the COVID-19 period in Japan, this study identifies the effectiveness of a municipal unit-based pricing (UBP) system on household waste reduction through a panel data analysis targeting 770 cities for 2013–2022. It focuses on simple unit pricing (SUP) and two-tiered pricing [...] Read more.
Focusing on the COVID-19 period in Japan, this study identifies the effectiveness of a municipal unit-based pricing (UBP) system on household waste reduction through a panel data analysis targeting 770 cities for 2013–2022. It focuses on simple unit pricing (SUP) and two-tiered pricing (TTP) systems as the UBP components. As previous studies have not considered the COVID-19 period when assessing UBP, this study significantly contributes to the literature by providing new evidence. The main findings are as follows: First, SUP effectively reduced household waste even during the COVID-19 period; however, its effectiveness was slightly neutralized owing to the pandemic environment. Second, TTP also restrained household waste efficiently; however, its effect was smaller than that of SUP, and its reduction effect accelerated during the COVID-19 period (in 2020) because people became cautious about excessive waste volumes beyond the TTP criteria. The study implicates the need to expand the municipal adoption of the UBP system for household waste reduction. Full article
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18 pages, 350 KiB  
Review
Klotho Deficiency in Severe COVID-19: A Unifying Hypothesis
by Natalia Campos-Obando, M. Carola Zillikens and Roman F. Macaya
COVID 2024, 4(12), 1833-1850; https://doi.org/10.3390/covid4120129 - 22 Nov 2024
Viewed by 376
Abstract
COVID-19 is characterized by a striking similarity to premature aging. Its clinical manifestations range from asymptomatic to critical illness. No single central agent has been demonstrated so far. We present Klotho, an antiaging protein, as a key factor in COVID-19 pathophysiology. There is [...] Read more.
COVID-19 is characterized by a striking similarity to premature aging. Its clinical manifestations range from asymptomatic to critical illness. No single central agent has been demonstrated so far. We present Klotho, an antiaging protein, as a key factor in COVID-19 pathophysiology. There is epidemiological evidence that both acute and chronic uses of Klotho agonists have a beneficial effect in reducing COVID-19 severity and mortality. A review of the PubMed epidemiological, clinical, and mechanistic evidence supports a role for Klotho deficit as a central determinant of severe COVID-19. Clinical data support the idea that chronic use of Klotho agonists protects against severe COVID-19 and that its acute use may be beneficial. We propose a unifying hypothesis that low Klotho levels play a key role in severe COVID-19, while increasing Klotho levels can have a beneficial effect through the prevention of acute kidney injury (AKI) and potential antiviral effects. Further research is needed. Full article
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