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Antibiotics
Special Issues
Rational Use of Antibiotics in Veterinary Medicine
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Rational Use of Antibiotics in Veterinary Medicine

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics in Animal Health".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 3856

Special Issue Editor

Dr. JeongWoo Kang

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Guest Editor
Animal Disease Diagnosis Division, Animal and Plant Quarantine Agency (APQA), Ministry of Agriculture, Food and Rural Affairs, 177, Hyeoksin 8-ro, Gimcheon-si 39660, Republic of Korea
Interests: veterinary forensic analysis; medication misadventure of animal antibiotics; antimicrobial resistance
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are excited to announce a call for manuscripts for a Special Issue entitled “Rational Use of Antibiotics in Veterinary Medicine”. This Special Issue is dedicated to expanding our knowledge and improving practices in the field of antibiotics, addressing several key aspects:

  1. Good manufacturing practice (GMP) in antibiotic production: We are interested in research that explores the application of GMP principles in the manufacturing of antibiotics. This includes innovations in production processes, quality control measures, and compliance with regulatory standards to ensure the production of high-quality antibiotic products;
  2. Research and systems in antibiotic quality control: We are seeking studies that explore innovative approaches in the quality control of antibiotics. This includes advancements in testing methods, regulatory frameworks, and quality assurance protocols that ensure the safety and efficacy of antibiotics;
  3. Consequences of improper antibiotic use: Manuscripts that examine the impact of antibiotic misuse are crucial. This encompasses research on the adverse effects resulting from incorrect dosages, inappropriate prescribing practices, and self-medication, which contribute to the growing problem of antibiotic resistance;
  4. Antibiotic stewardship programs: We encourage submissions that focus on the development, implementation, and evaluation of antibiotic stewardship programs. These programs are essential in promoting the appropriate use of antibiotics, optimizing patient outcomes, and reducing resistance;
  5. Antibiotic resistance management research: Studies that delve into the mechanisms of antibiotic resistance, strategies for its management, and the development of new antibiotics or alternative therapies to combat resistant strains are particularly welcome.

We believe that this Special Issue will serve as an important platform for sharing research findings, insights, and innovations in these crucial areas of antibiotic research and management. Your contributions will help in shaping better practices and policies, ultimately contributing to improved healthcare outcomes.

We look forward to receiving your submissions and to the valuable discussions that they will undoubtedly inspire.

Dr. JeongWoo Kang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • good manufacturing practice (GMP) in antibiotic production
  • research and systems in antibiotic quality control
  • consequences of improper antibiotic use
  • antibiotic stewardship programs
  • antibiotic resistance management

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Published Papers (2 papers)

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Research

12 pages, 2231 KiB  
Article
Pharmacodynamic Profiling of Amoxicillin: Targeting Multidrug-Resistant Gram-Positive Pathogens Staphylococcus aureus and Staphylococcus pseudintermedius in Canine Clinical Isolates
by Syed Al Jawad Sayem, Ga-Yeong Lee, Muhammad Aleem Abbas, Seung-Chun Park and Seung-Jin Lee
Antibiotics 2025, 14(1), 99; https://doi.org/10.3390/antibiotics14010099 - 16 Jan 2025
Viewed by 827
Abstract
The rising threat of antimicrobial resistance (AMR) is a global concern in both human and veterinary medicine, with multidrug-resistant (MDR) pathogens such as Staphylococcus aureus and Staphylococcus pseudintermedius presenting significant challenges. Background/Objectives: This study evaluates the effectiveness of amoxicillin against these MDR [...] Read more.
The rising threat of antimicrobial resistance (AMR) is a global concern in both human and veterinary medicine, with multidrug-resistant (MDR) pathogens such as Staphylococcus aureus and Staphylococcus pseudintermedius presenting significant challenges. Background/Objectives: This study evaluates the effectiveness of amoxicillin against these MDR pathogens in canine isolates using pharmacokinetic and pharmacodynamic parameters. Methods: Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and mutation prevention concentration (MPC) were assessed. Additionally, time-kill assays and post-antibiotic effect (PAE) assessments were performed. Epidemiological cutoff (ECOFF) values were established for both species to guide therapy. Results: S. aureus had a higher resistance rate (35.89%) than S. pseudintermedius (15.27%), with MIC50 values of 0.50 μg/mL and 0.25 μg/mL, respectively. The MPC analysis revealed that S. pseudintermedius required higher antibiotic concentrations (16.11 μg/mL) to prevent mutations compared to S. aureus (2.20 μg/mL). Time-kill assays indicated that higher amoxicillin dosages caused faster bacterial reduction. The PAE analysis showed extended post-treatment bacterial suppression at elevated doses, particularly against S. aureus. Conclusions: Species-specific amoxicillin dosing strategies are necessary due to differing resistance and susceptibility profiles between S. aureus and S. pseudintermedius. High-dose amoxicillin therapy is recommended to achieve optimal therapeutic outcomes for resistant SA, while slightly adjusted dosing can manage S. pseudintermedius infections. These findings provide essential insights for veterinary antimicrobial stewardship, underscoring the need for tailored therapeutic approaches to minimize AMR development while ensuring effective infection control. Full article
(This article belongs to the Special Issue Rational Use of Antibiotics in Veterinary Medicine)
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16 pages, 3404 KiB  
Article
Comparative Pharmacokinetics of Gentamicin C1, C1a and C2 in Healthy and Infected Piglets
by Eun-Young Kim, Tae-Won Kim, Elias Gebru Awji, Eon-Bee Lee and Seung-Chun Park
Antibiotics 2024, 13(4), 372; https://doi.org/10.3390/antibiotics13040372 - 18 Apr 2024
Viewed by 2354
Abstract
Gentamicin, an aminoglycoside antibiotic, is a mixture of therapeutically active C1, C1a, C2 and other minor components. Despite its decades-long use in pigs and other species, its intramuscular (IM) pharmacokinetics/pharmacodynamics (PKs/PDs) are unknown in piglets. Furthermore, the PKs [...] Read more.
Gentamicin, an aminoglycoside antibiotic, is a mixture of therapeutically active C1, C1a, C2 and other minor components. Despite its decades-long use in pigs and other species, its intramuscular (IM) pharmacokinetics/pharmacodynamics (PKs/PDs) are unknown in piglets. Furthermore, the PKs of many drugs differ between healthy and sick animals. Therefore, we investigated the PKs of gentamicin after a single IM dose (10 mg/kg) in healthy piglets and piglets that were intranasally co-infected with Actinobacillus pleuropneumoniae and Pasteurella multocida (PM). The plasma concentrations were measured using validated liquid chromatography/mass spectrometry. The gentamicin exposure was 36% lower based on the area under the plasma concentration–time curve and 16% lower based on the maximum plasma concentration (Cmax) in the infected piglets compared to the healthy piglets, while it was eliminated faster (shorter half-life and larger clearance) in the infected piglets compared to the healthy piglets. The clearance and volume of distribution were the highest for the C1 component. C1, C1a and C2 accounted for 22–25%, 33–37% and 40–42% of the total gentamicin exposure, respectively. The PK/PD target for the efficacy of aminoglycosides (Cmax/minimum inhibitory concentration (MIC) > 10) could be exceeded for PM, with a greater magnitude in the healthy piglets. We suggest integrating this PK information with antibiotic susceptibility data for other bacteria to make informed antibiotic and dosage regimen selections against piglet infections. Full article
(This article belongs to the Special Issue Rational Use of Antibiotics in Veterinary Medicine)
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