Epidemiology of Carbapenem Resistance in Clinical Gram-Negative Bacteria
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: closed (1 August 2023) | Viewed by 3246
Special Issue Editors
2. Romanian Academy of Scientists, Spl. Independentei 54, Romanian Academy of Medical Sciences, ulevardul Ion C. Bratianu 1, 030167 Bucuresti, Romania
Interests: infectious diseases; epidemiology; HIV; hepatitis; travel medicine
2. Clinical Infectious Disease Hospital of Constanta, 900178 Constanta, Romania
Interests: infectious diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Carbapenem resistance in Gram-negative bacteria has become a worldwide problem, causing a global epidemic that continues to grow. The 2017 World Health Organization (WHO) global priority list of pathogens ranks carbapenem-resistant Enterobacteriaceae (CRE), carbapenem-resistant Pseudomonas aeruginosa, and carbapenem-resistant Acinetobacter baumannii in the highest-priority category (critical). Defining the molecular mechanisms of resistance and applying insights about pharmacodynamic and pharmacokinetic properties of antibiotics, in order to maximize the impact of old and new therapeutic approaches, should be the new paradigm in treating infections caused by CRE. A concerted effort is needed to establish the superiority of combination therapy vs. monotherapy, confirm the role of novel beta-lactam/beta-lactamase inhibitor combinations as therapy against KPC- and OXA-48 producing Enterobacteriaceae, and evaluate new antibiotics active against CRE as they are introduced into the clinic. Advances in rapid diagnostic tests to improve the detection of carbapenem resistance and the use of large, population-based datasets to capture a greater proportion of carbapenem-resistant organisms can help us gain a better understanding of this urgent threat and enable physicians to select the most appropriate antibiotics. To address this global epidemic, identification and ongoing surveillance of carbapenem-resistant Gram-negative bacteria are needed to continue.
Prof. Dr. Sorin Rugina
Prof. Dr. Irina Magdalena Dumitru
Guest Editors
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Keywords
- Enterobacteriaceae carbapenems
- beta-lactamase inhibitors
- carbapenem-resistant Enterobacteriaceae
- Pseudomonas aeruginosa
- Acinetobacter baumannii
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