Protein Oxidative Modification in Brain Function, Brain Ageing and Neurological Diseases—2nd Edition
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 25 July 2025 | Viewed by 17
Special Issue Editors
Interests: redox biology; oxidative stress; neurodegeneration/neurodegenerative disorders; interactomics; proteomics; signal transductions; mass spectrometry
Special Issues, Collections and Topics in MDPI journals
Interests: mitochondria; mitochondrial dysfunction; oxidative stress; neurodegenerative disease; neurosciences
Special Issues, Collections and Topics in MDPI journals
Interests: neurodegenerative disease; oxidative stress; nitrosative stress; proteomics; metabolomics; stem cell-derived cellular models; neurosciences
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Redox signaling plays an important role in the homeostatic control of several molecular pathways and in cell function, particularly in relation to changes in the redox status of cysteine and other amino acid residues of proteins, which are extremely susceptible to reversible and irreversible oxidation by reactive oxygen and nitrogen species (RONS). These changes can lead to redox post-translational modifications (redox PTMs) in proteins, which can directly affect protein structure, activity and function, ultimately impacting a multitude of biological functions. Mitochondrial dysfunction and excessive RONS levels can give rise to oxidative and nitrosative stresses and aberrant redox PTMs, which are well established contributors to a plethora of diseases. However, the underlying mechanisms are not fully understood. In this Special Issue, we invite original research and review articles related to the role of redox PTM-mediated signaling in modulating protein structure and activity and brain function in health, ageing and neurological conditions.
Dr. Sandra Anjo
Dr. Andreia N. Carvalho
Dr. Mattéa J. Finelli
Guest Editors
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Keywords
- protein oxidative modifications
- post-translational modifications
- S-glutathionylation
- S-nitrosylation/S-nitrosation
- persulfidation
- redox signaling
- oxidative and nitrosative stresses
- cysteine oxidation
- antioxidants
- redox-based pharmacological/therapeutic approaches
- mitochondrial dysfunction
- mitochondria-targeted molecules
- brain function and ageing
- neurological/neurodegenerative diseases
- proteomics
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