Redox Proteomics
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "ROS, RNS and RSS".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 9663
Special Issue Editor
Special Issue Information
Dear Colleagues,
Reactive oxygen/nitrogen species (ROS/NOS) are common by-products of the metabolism, which are associated, not only with deleterious effects and disease development, but also with a physiological role as second messengers in the regulation of several pathways. Among several amino acids, cysteine thiol groups are particularly susceptible to oxidation by those reactive species, with the modifications of these residues being related to modulation of protein function and biological processes. The redox state of cysteine residues can be rapidly and reversibly modified, making the cysteinome a good predictor of the overall cellular state and fate. Although low levels of oxidation are required for cellular functions, both the over-reduction and over-oxidation of the cysteines tends to lead to protein dysfunction and damage, which can be associated with a disease state or even cell death. In this sense, the characterization of the cysteinome can be of extreme importance in understanding the tight regulation between physiological and pathophysiological processes and to provide new targets for therapeutic purposes.
In this Special Issue, we invite researchers to provide original research articles and review articles related to will the modulation of proteins by cysteine oxidation, including both large proteomics screenings and studies of a single target. Methodological articles focused on new strategies to study cysteine oxidation and works involving the study of low molecular thiols will also be considered. We want to make this Special Issue a valued overview of the developments in the cysteine oxidation field, highlighting its importance to gain new insight into redox signaling regulation
Dr. Sandra Anjo
Guest Editor
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Keywords
- cysteine oxidation
- redox signaling
- redoxome proteomic screenings
- redox biology
- low molecular thiols
- mass spectrometry methods
- cysteine probes
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