Antioxidant Activity of Polyphenolic Extracts

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1478

Special Issue Editor


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Guest Editor
Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece
Interests: antioxidant activity of plant extracts, plant polyphenols and other natural products; physiological adaptive mechanisms of human organism to oxidative stress conditions; chemopreventive (anticarcinogenic) activity of plant extracts, plant polyphenols and other natural products; anti-angiogenic activity of chemical compounds (natural or synthetic); biochemical and physiological role of human aldehyde dehydrogenases
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Special Issue Information

Dear Colleagues,

Plant polyphenols are secondary metabolites characterized by one or more hydroxyl groups binding to one or more aromatic rings. Several thousand polyphenolic molecules have been identified in higher plants including edible ones. Plant polyphenols are divided into two major groups, flavonoids and non-flavonoids. Flavonoids can be divided into flavanols, flavonols, anthocyanidins, flavones, flavanones, and chalcones. Non-flavonoids include stilbene, phenolic acids, saponin, and tannins. Among the important biological properties exhibited by plant polyphenols, there has been a great interest in their antioxidant activity. A number of studies have shown that plant polyphenols could be used as antioxidants against different oxidative stress-induced diseases. We invite you to submit your latest research findings or a review article to this Special Issue, which will bring together current research concerning and critical thinking on the antioxidant activity of polyphenolic extracts derived from different natural sources such as terrestrial and marine plants and algae. The identification of the polyphenolic composition of the plant extracts is required for the submitted articles. Your contribution can include both in vitro and in vivo studies relating to different aspects of antioxidant activity of polyphenolic extracts such as structure–activity relationship, the regulation of endogenous antioxidant responses and their role in signaling, metabolism, cell cycle, gene regulation, cellular stress, and the prevention of diseases.

Dr. Dimitrios Stagos
Guest Editor

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Keywords

  • antioxidant activity
  • polyphenols
  • plant extracts
  • oxidative stress

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Published Papers (1 paper)

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Research

13 pages, 4903 KiB  
Article
Local Application of a New Chalconic Derivative (Chalcone T4) Reduces Inflammation and Oxidative Stress in a Periodontitis Model in Rats
by Angelo Constantino Camilli, Mariely Araújo de Godoi, Vitória Bonan Costa, Natalie Aparecida Rodrigues Fernandes, Giovani Cirelli, Larissa Kely Faustino da Silva, Letícia Ribeiro Assis, Luis Octavio Regasini and Morgana Rodrigues Guimarães-Stabili
Antioxidants 2024, 13(10), 1192; https://doi.org/10.3390/antiox13101192 - 30 Sep 2024
Viewed by 1007
Abstract
Chalcones are phenolic compounds with biological properties. This study had the aim to evaluate the effects of topical administration of a new synthetic chalcone, Chalcone T4, in an animal model of periodontitis induced by ligature. Forty rats were distributed in the following experimental [...] Read more.
Chalcones are phenolic compounds with biological properties. This study had the aim to evaluate the effects of topical administration of a new synthetic chalcone, Chalcone T4, in an animal model of periodontitis induced by ligature. Forty rats were distributed in the following experimental groups: negative control (without periodontitis and topical application of distilled water), positive control (periodontitis and topical application of distilled water), chalcone I and II (periodontitis and topical application of 0.6 mg/mL and 1.8 mg/mL, respectively). Chalcone or distilled water was administered into the gingival sulcus of the first molars daily for 10 days, starting with the ligature installation. The following outcomes were evaluated: alveolar bone loss (µCT and methylene blue dye staining), quantification of osteoclasts (histomorphometry), cell infiltrate and collagen content (stereometry), gene expression of mediators (Nfact11, Tnf-α, Mmp-13, iNos, Sod and Nrf2) by (RT-qPCR); expression of BCL-2 and Caspase-1 (immunohistochemistry). Chalcone T4 inhibited bone resorption and prevented collagen matrix degradation. Reduction in the expression of inflammatory markers (Nfact11, Tnf-α, Mmp-13, and Caspase-1), attenuation of oxidative stress (iNOS reduction, and increase in Sod), and pro-apoptotic effect of the compound (BCL-2 reduction), were associated its effects on periodontal tissues. Topical application of Chalcone T4 prevented bone resorption and inflammation, demonstrating potential in the adjunctive treatment of periodontitis. Full article
(This article belongs to the Special Issue Antioxidant Activity of Polyphenolic Extracts)
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