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Antioxidants
Special Issues
Dietary Antioxidants and Cardiovascular Health, 2nd Edition
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Dietary Antioxidants and Cardiovascular Health, 2nd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (20 November 2024) | Viewed by 8323

Special Issue Editors

Prof. Dr. Wojciech Drygas

E-Mail Website
Guest Editor
1. Department of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, National Institute of Cardiology, Alpejska 42, 04-628 Warsaw, Poland
2. Department of Social and Preventive Medicine, Faculty of Health Sciences, Medical University of Lodz, Hallera 1, 90-001 Lodz, Poland
Interests: cardiovascular diseases prevention; health promotion; metabolic diseases; obesity, physical activity; dietary antioxidants; oxidative stress; population studies; public health
Special Issues, Collections and Topics in MDPI journals
Dr. Magdalena Kwasniewska

E-Mail Website
Guest Editor
Department of Social and Preventive Medicine, Faculty of Health Sciences, Medical University of Lodz, Hallera 1, 90-001 Lodz, Poland
Interests: preventive cardiology; metabolic syndrome; health promotion; physical activity; dietary antioxidants; population studies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Dietary antioxidants, such as polyphenols, antioxidant vitamins (C, E, A), and minerals (zinc, iron, copper, manganese, selenium), support the internal antioxidant system in reducing oxidative stress, which is involved in the pathogenesis of chronic diseases. Extensive studies have indicated that dietary antioxidants are important in the prevention and treatment of cardiovascular diseases. A large body of evidence suggests that adequate intake of various antioxidants may contribute to better clinical outcomes, including morbidity, mortality, as well as quality of life.

In this Special Issue, we invite all researchers interested in sharing their latest research findings or review articles in the field of dietary antioxidants and cardiovascular health. Our aim for this Special Issue is to provide a comprehensive discussion of potential epigenetic, metabolic, and physiological mechanisms of antioxidant compounds in modifying cardiovascular risk. Since the bioavailability of nutrients has been shown to be affected by several processes, studies focused on the potential effect of food structure and processing on the bioavailability of dietary antioxidants will be considered as well. Due to inconsistency in findings concerning health benefits of supplements containing antioxidants, new research is of special interest. There is also a need for epidemiological data, preferably from large representative studies or prospective observations, presenting the intake of antioxidants in different sociodemographic groups in the context of cardiovascular health. 

Considering the increased interest in such a vast field of cardiovascular health, we are pleased to invite you to submit your research to this new Special Issue, which is intended to be a continuation of the fruitful first edition (https://www.mdpi.com/journal/antioxidants/special_issues/antioxidant_cardiovascular).

This Special Issue aims to gather research from professionals from different fields, including biochemistry, genetics, physiology, nutrition, epidemiology, public health, and cardiology.

We look forward to your contributions.

Prof. Dr. Wojciech Drygas
Dr. Magdalena Kwasniewska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dietary antioxidants
  • food antioxidants
  • dietary polyphenols
  • flavonoids
  • antioxidant-rich diet
  • cardiovascular health
  • cardiovascular diseases
  • hypertension

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (4 papers)

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Research

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14 pages, 1851 KiB  
Article
Camphene as a Protective Agent in Myocardial Ischemia/Reperfusion Injury
by Rodopi Stamatiou, Maria Anagnostopoulou, Konstantina Ioannidou-Kabouri, Chrysa Rapti and Antigone Lazou
Antioxidants 2024, 13(4), 405; https://doi.org/10.3390/antiox13040405 - 28 Mar 2024
Viewed by 1692
Abstract
Myocardial ischemia/reperfusion injury (I/R) and the resulting heart failure is one of the main causes of mortality and morbidity worldwide. Camphene has been shown to have anti-inflammatory and hypolipidemic properties; however, its role in the protection of the heart from ischemia and reperfusion [...] Read more.
Myocardial ischemia/reperfusion injury (I/R) and the resulting heart failure is one of the main causes of mortality and morbidity worldwide. Camphene has been shown to have anti-inflammatory and hypolipidemic properties; however, its role in the protection of the heart from ischemia and reperfusion has not been investigated. The cardioprotective role of camphene and the mechanism that mediates its action against I/R injury was evaluated in the present study. A single dose of camphene was administered in adult rats prior to ex vivo I/R induction. Infarct size was measured using 2,3,5-triphenyltetrazolium chloride (TTC) staining and cardiomyocyte injury was assessed by determining the release of the enzyme lactate dehydrogenase (LDH). Camphene pretreatment provided significant protection reducing myocardial infarct size and cell death after I/R. The effect was correlated with the reduction in oxidative stress as evidenced by the determination of protein carbonylation, GSH/GSSG ratio, the increase in mitochondrial content as determined by CS activity, and the modulation of antioxidant defense mechanisms (expression of Nrf2 and target genes and activities of CAT, MnSOD, and GR). Furthermore, ferroptosis was decreased, as demonstrated by downregulation of GPx4 expression and reduction in lipid peroxidation. The results suggest that camphene can protect the heart against I/R injury by maintaining redox homeostasis and can hold therapeutic potential for mitigating the detrimental effects of I/R in the heart. Full article
(This article belongs to the Special Issue Dietary Antioxidants and Cardiovascular Health, 2nd Edition)
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14 pages, 1679 KiB  
Article
Protective Role of Taurine on Rat Offspring Hypertension in the Setting of Maternal Chronic Kidney Disease
by You-Lin Tain, Chih-Yao Hou, Guo-Ping Chang-Chien, Sufan Lin and Chien-Ning Hsu
Antioxidants 2023, 12(12), 2059; https://doi.org/10.3390/antiox12122059 - 29 Nov 2023
Cited by 7 | Viewed by 1720
Abstract
Taurine is a natural antioxidant with antihypertensive properties. Maternal chronic kidney disease (CKD) has an impact on renal programming and increases the risk of offspring hypertension in later life. The underlying mechanisms cover oxidative stress, a dysregulated hydrogen sulfide (H2S) system, [...] Read more.
Taurine is a natural antioxidant with antihypertensive properties. Maternal chronic kidney disease (CKD) has an impact on renal programming and increases the risk of offspring hypertension in later life. The underlying mechanisms cover oxidative stress, a dysregulated hydrogen sulfide (H2S) system, dysbiotic gut microbiota, and inappropriate activation of the renin–angiotensin–aldosterone system (RAAS). We investigated whether perinatal taurine administration enables us to prevent high blood pressure (BP) in offspring complicated by maternal CKD. Before mating, CKD was induced through feeding chow containing 0.5% adenine for 3 weeks. Taurine was administered (3% in drinking water) during gestation and lactation. Four groups of male offspring were used (n = 8/group): controls, CKD, taurine-treated control rats, and taurine-treated rats with CKD. Taurine treatment significantly reduced BP in male offspring born to mothers with CKD. The beneficial effects of perinatal taurine treatment were attributed to an augmented H2S pathway, rebalance of aberrant RAAS activation, and gut microbiota alterations. In summary, our results not only deepen our knowledge of the mechanisms underlying maternal CKD-induced offspring hypertension but also afford us the impetus to consider taurine-based intervention as a promising preventive approach for future clinical translation. Full article
(This article belongs to the Special Issue Dietary Antioxidants and Cardiovascular Health, 2nd Edition)
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Review

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23 pages, 2332 KiB  
Review
The Role of Oxidative Stress in Hypertension: The Insight into Antihypertensive Properties of Vitamins A, C and E
by Ewelina Młynarska, Laura Biskup, Maria Możdżan, Olivia Grygorcewicz, Zofia Możdżan, Jan Semeradt, Michał Uramowski, Jacek Rysz and Beata Franczyk
Antioxidants 2024, 13(7), 848; https://doi.org/10.3390/antiox13070848 - 15 Jul 2024
Viewed by 1428
Abstract
Hypertension stands as a pervasive global health challenge, contributing significantly to mortality rates worldwide. Various factors, including lifestyle choices and dietary habits, contribute to the development of hypertension. In recent years, oxidative stress has garnered significant attention as a factor influencing hypertension risk, [...] Read more.
Hypertension stands as a pervasive global health challenge, contributing significantly to mortality rates worldwide. Various factors, including lifestyle choices and dietary habits, contribute to the development of hypertension. In recent years, oxidative stress has garnered significant attention as a factor influencing hypertension risk, prompting a shift in research focus towards exploring it as a potential target for prevention and treatment. Antioxidants found in our diet, such as vitamins C, E and carotenoids exhibit the ability to neutralize reactive oxygen species, thereby mitigating oxidative stress. In addition, Vitamin A has an antioxidant effect despite not being an antioxidant itself. Consequently, supplementation or increased intake of these antioxidants has been hypothesized to potentially lower blood pressure levels and aid in the management of hypertension, thereby potentially prolonging life expectancy. Research findings regarding this effect have been diverse. This paper examines the existing literature demonstrating favorable outcomes associated with antioxidant supplementation. Full article
(This article belongs to the Special Issue Dietary Antioxidants and Cardiovascular Health, 2nd Edition)
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25 pages, 2017 KiB  
Review
Lipid Oxidation Products and the Risk of Cardiovascular Diseases: Role of Lipoprotein Transport
by Markku Ahotupa
Antioxidants 2024, 13(5), 512; https://doi.org/10.3390/antiox13050512 - 24 Apr 2024
Cited by 1 | Viewed by 2675
Abstract
Cholesterol has for decades ruled the history of atherosclerotic cardiovascular diseases (CVDs), and the present view of the etiology of the disease is based on the transport of cholesterol by plasma lipoproteins. The new knowledge of the lipoprotein-specific transport of lipid oxidation products [...] Read more.
Cholesterol has for decades ruled the history of atherosclerotic cardiovascular diseases (CVDs), and the present view of the etiology of the disease is based on the transport of cholesterol by plasma lipoproteins. The new knowledge of the lipoprotein-specific transport of lipid oxidation products (LOPs) has introduced another direction to the research of CVD, revealing strong associations between lipoprotein transport functions, atherogenic LOP, and CVD. The aim of this review is to present the evidence of the lipoprotein-specific transport of LOP and to evaluate the potential consequences of the proposed role of the LOP transport as a risk factor. The associations of cholesterol and lipoprotein LOP with the known risk factors of CVD are mostly parallel, and because of the common transport and cellular intake mechanisms it is difficult to ascertain the independent effects of either cholesterol or LOP. While cholesterol is known to have important physiological functions, LOPs are merely regarded as metabolic residues and able to initiate and boost atherogenic processes. It is therefore likely that with the increased knowledge of the lipoprotein-specific transport of LOP, the role of cholesterol as a risk factor of CVD will be challenged. Full article
(This article belongs to the Special Issue Dietary Antioxidants and Cardiovascular Health, 2nd Edition)
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