Alcohol-Induced Oxidative Stress in Health and Disease, 2nd Edition
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: 20 February 2025 | Viewed by 819
Special Issue Editor
Interests: neurobiology; endocrinology; neurotrophins; oxidative stress; cancer; toxicology; addiction; antioxidants; polyphenols; alcohol use disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Alcohol is one of the oldest and most common recreational substances and is present in various beverages such as wine, beer, and spirits. While moderate alcohol consumption may elicit pleasure, euphoria, increased sociability, and decreased anxiety, it also carries a wide range of short-term and long-term adverse effects. These include neurocognitive impairment, nausea, vomiting, dizziness, and hangover symptoms. Chronic alcohol abuse leads to alcohol use disorder, addiction, and withdrawal, all of which severely impact health, causing liver and brain damage, and significantly increasing the risk of cancer. A key mechanism underlying these detrimental effects is alcohol-induced oxidative stress.
Alcohol metabolism, through both mitochondrial and microsomal pathways, generates reactive oxygen species (ROS) and reactive nitrogen species (RNS), overwhelming the body's endogenous antioxidant defense system. This oxidative stress results in cellular and tissue damage, disrupting biological functions and leading to severe health consequences. Research suggests that antioxidants may mitigate some of these harmful effects, offering a potential therapeutic approach.
Building on the fruitful first edition of this Special Issue, available at https://www.mdpi.com/si/139960, the second edition continues to explore the complexities of alcohol-induced oxidative stress and its implications for health and disease. We invite original research and review articles that delve into clinical and preclinical data, providing insights into this critical area of study and guiding future research directions.
Dr. Marco Fiore
Guest Editor
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
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Keywords
- alcohol
- alcohol use disorder
- reactive oxygen species
- antioxidant defense
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