Understanding Ischemia–Reperfusion Signaling: Future Perspectives in Organ Protection with Transplantation
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: closed (30 September 2019) | Viewed by 410
Special Issue Editors
Interests: antioxidants; inflammation; lung fibrosis; oxidative stress; radiotherapy; radiation medical countermeasures; radiation toxicity; space radiation; genomics; metabolomics
Special Issues, Collections and Topics in MDPI journals
Interests: pulmonary endothelial signaling; reactive oxygen species; NLRP3 inflammasome; inflammation–immune signals; danger signals; ischemia-reperfusion injury; graft rejection
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Tissue injury associated with ischemia–reperfusion (I/R) is a major cause of disease and death. Injury occurs as a result of the ischemic event and is often amplified during reperfusion. The multiple cellular pathways that are activated by I/R are driven primarily by reactive oxygen species (ROS), ATP-dependent ion transport, calcium overload and mitochondrial dysfunction. Collectively, these events lead to the recruitment of pro-inflammatory neutrophils, injury and cell death. The resultant oxidative stress is the cause of injury in pathologies such as myocardial infarction and stroke; injury is also pivotal in graft rejection post-transplantation. In this Special Issue, a collection of articles will highlight the signalling pathways that lead to the development of I/R injury and the various approaches that can be undertaken to limit the extent of injury. Our focus will be on transplant biology, where I/R injury has been well-established as a major cause of graft injury and rejection. In this context, recent therapeutic strategies in the form of inhibiting I/R signalling by improved manoeuvres, by reduction of ROS, or by blocking inflammation and innate immune responses will be showcased in various organ transplant models.
Prof. Dr. Melpo Christofidou-Solomidou
Dr. Shampa Chatterjee
Guest Editor
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Keywords
- Ischemia reperfusion
- Redox signaling
- Antioxidants, protection, scavenging
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