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Antioxidants
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Roles of NADPH Oxidase in Modulation of Signal Transduction and...
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Roles of NADPH Oxidase in Modulation of Signal Transduction and Cellular Metabolism—2nd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Antioxidant Enzyme Systems".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 2586

Special Issue Editors

Prof. Rosario Ammendola

E-Mail Website
Guest Editor
Department of Molecular Medicine and Medical Biotechnologies, School of Medicine, University of Naples “Federico II”, 80131 Naples, Italy
Interests: redox signaling; NOX; GPCRs; TKRs; cellular metabolism
Special Issues, Collections and Topics in MDPI journals
Dr. Fabio Cattaneo

E-Mail Website
Guest Editor
Department of Molecular Medicine and Medical Biotechnologies, School of Medicine, University of Naples “Federico II”, 80131 Naples, Italy
Interests: signal transduction; ROS; formyl peptide receptors; NADPH oxidase; TKR-transactivation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We invite you to submit your latest valuable research outcomes for publication in the Second Volume of the Special Issue entitled "Roles of NADPH Oxidase in Modulation of Signal Transduction and Cellular Metabolism" for the Antioxidants journal (MDPI).

This Special Issue will focus on the emerging role of the NOX family of NADPH oxidases in the regulation of cell metabolism and redox signaling. The NOX family includes seven isoforms with different activation mechanisms, widely expressed in several tissues. The main role of these enzymes is to produce reactive oxygen species (ROS) that can act as second messengers, modulating many biological functions and cellular processes. In particular, a significant correlation of NOX-mediated oxidative stress with redox signaling and cellular metabolism has been observed in several pathological and physiological conditions. Therefore, we encourage you to contribute to this Special Issue with research or review articles, collecting data from both in vitro and in vivo to disclose the functions and role of NADPH oxidase family members in different cellular systems and their contributions to pathological and physiological conditions.

The following topics may be included in this Special Issue: NOX-dependent diseases; aging; signal transduction; cellular metabolism; metabolic reprogramming; tumor microenvironment; Warburg effect; lipid peroxidation; ferroptosis; receptor transactivation; kinase and phosphatase activation; NOX subunits; transcription; angiogenesis; cell proliferation; cell death and apoptosis; stress response; immunoregulation; inflammation; chronic granulomatous disease; NOX activators and inhibitors.

Research or review articles collecting data from both in vitro and in vivo investigations are welcome.

Prof. Rosario Ammendola
Dr. Fabio Cattaneo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • redox signaling
  • inflammation
  • NADPH oxidase
  • ROS
  • cell metabolism
  • redox-state
  • Warburg effect
  • metabolic reprogramming
  • tumor microenvironment
  • cell proliferation

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Published Papers (2 papers)

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Research

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16 pages, 2885 KiB  
Article
Association Between NOX2-Mediated Oxidative Stress, Low-Grade Endotoxemia, Hypoalbuminemia, and Clotting Activation in COVID-19
by Roberto Carnevale, Cristina Nocella, Raffaella Marocco, Paola Zuccalà, Anna Carraro, Vittorio Picchio, Alessandra Oliva, Roberto Cangemi, Maria Claudia Miele, Massimiliano De Angelis, Francesca Cancelli, Giovanni Enrico Casciaro, Luca Cristiano, Pasquale Pignatelli, Giacomo Frati, Mario Venditti, Francesco Pugliese, Claudio Maria Mastroianni, Francesco Violi, Lorenzo Ridola, Cosmo Del Borgo, Silvia Palmerio, Emiliano Valenzi, Rita Carnevale, Domenico Alvaro, Miriam Lichtner and Vincenzo Cardinaleadd Show full author list remove Hide full author list
Antioxidants 2024, 13(10), 1260; https://doi.org/10.3390/antiox13101260 - 17 Oct 2024
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Abstract
Low-grade endotoxemia by lipopolysaccharide (LPS) has been detected in COVID-19 and could favor thrombosis via eliciting a pro-inflammatory and pro-coagulant state. The aim of this study was to analyze the mechanism accounting for low-grade endotoxemia and its relationship with oxidative stress and clotting [...] Read more.
Low-grade endotoxemia by lipopolysaccharide (LPS) has been detected in COVID-19 and could favor thrombosis via eliciting a pro-inflammatory and pro-coagulant state. The aim of this study was to analyze the mechanism accounting for low-grade endotoxemia and its relationship with oxidative stress and clotting activation thrombosis in COVID-19. We measured serum levels of sNOX2-dp, zonulin, LPS, D-dimer, and albumin in 175 patients with COVID-19, classified as having or not acute respiratory distress syndrome (ARDS), and 50 healthy subjects. Baseline levels of sNOX2-dp, LPS, zonulin, D-dimer, albumin, and hs-CRP were significantly higher in COVID-19 compared to controls. In COVID-19 patients with ARDS, sNOX2-dp, LPS, zonulin, D-dimer, and hs-CRP were significantly higher compared to COVID-19 patients without ARDS. Conversely, concentration of albumin was lower in patients with ARDS compared with those without ARDS and inversely associated with LPS. In the COVID-19 cohort, the number of patients with ARDS progressively increased according to sNOX2-dp and LPS quartiles; a significant correlation between LPS and sNOX2-dp and LPS and D-dimer was detected in COVID-19. In a multivariable logistic regression model, LPS/albumin levels and D-dimer predicted thrombotic events. In COVID-19 patients, LPS is significantly associated with a hypercoagulation state and disease severity. In vitro, LPS can increase endothelial oxidative stress and coagulation biomarkers that were reduced by the treatment with albumin. In conclusion, impaired gut barrier permeability, increased NOX2 activation, and low serum albumin may account for low-grade endotoxemia and may be implicated in thrombotic events in COVID-19. Full article
(This article belongs to the Special Issue Roles of NADPH Oxidase in Modulation of Signal Transduction and Cellular Metabolism—2nd Edition)
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Review

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14 pages, 5018 KiB  
Review
Redox Signaling in Endosomes Using the Example of EGF Receptors: A Graphical Review
by Dana Maureen Hebchen and Katrin Schröder
Antioxidants 2024, 13(10), 1215; https://doi.org/10.3390/antiox13101215 - 9 Oct 2024
Cited by 1 | Viewed by 1378
Abstract
Early endosomes represent first-line sorting compartments or even organelles for internalized molecules. They enable the transport of molecules or ligands to other compartments of the cell, such as lysosomes, for degradation or recycle them back to the membrane by various mechanisms. Moreover, early [...] Read more.
Early endosomes represent first-line sorting compartments or even organelles for internalized molecules. They enable the transport of molecules or ligands to other compartments of the cell, such as lysosomes, for degradation or recycle them back to the membrane by various mechanisms. Moreover, early endosomes function as signaling and scaffolding platforms to initiate or prolong distinct signaling pathways. Accordingly, early endosomes have to be recognized as either part of a degradation or recycling pathway. The physical proximity of many ligand-binding receptors with other membrane-bound proteins or complexes such as NADPH oxidases may result in an interaction of second messengers, like reactive oxygen species (ROS) and early endosomes, that promote the correct recognition of individual early endosomes. In fact, redoxosomes comprise an endosomal subsection of signaling endosomes. One example of such potential interaction is epidermal growth factor receptor (EGFR) signaling. Here we summarize recent findings on EGFR signaling as a well-studied example for receptor trafficking and trans-activation and illustrate the interplay between cellular and endosomal ROS. Full article
(This article belongs to the Special Issue Roles of NADPH Oxidase in Modulation of Signal Transduction and Cellular Metabolism—2nd Edition)
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