Mitophagy and Oxidative Stress

Dear Colleagues,

Over the past few decades, the prevalence of cardiometabolic diseases, including type 2 diabetes mellitus (T2MD), polycystic ovary syndrome (PCOS), obesity, insulin resistance, metabolic syndrome, atherosclerosis, hyperlipidaemia, and hepatic steatosis, has increased dramatically. In this context, reactive oxygen species (ROS) are reactive intermediates of molecular oxygen that act as important secondary messengers within the cells; however, an imbalance between generation of reactive ROS and antioxidant defence systems establishes oxidative stress. Previous studies have found that excessive amounts of ROS being generated could attack the cellular proteins, lipids, and nucleic acids, leading to cellular dysfunction, immune activation, and inflammation that are critical for the pathogenesis of metabolic diseases. Underlying molecular mechanisms that lead to cellular dysfunction include mitochondrial impairment, autophagy, mitophagy, endoplasmic reticulum stress, apoptosis, but there is still much to be learned about their mutual interaction and modifications they undergo during metabolic diseases. Furthermore, although the precise molecular mechanisms of mitophagy in diabetes have yet to be fully clarified, recent findings imply that mitophagy improves cardiac function in the heart of a diabetic. However, excessive mitophagy may exacerbate myocardial damage in patients with diabetes. Given the relevance of this topic, it would seem appropriate to summarize some of the main recent advances in research on the role of oxidative stress and underlying molecular mechanisms, especially mitophagy, in the pathogenesis of metabolic diseases and their impact on health, disease, and ageing.

We invite authors to submit original articles and review articles on this interesting topic.

• Potential topics include, but are not limited, to the following:
• Role of ROS and oxidative stress in metabolic diseases;
• Mitochondrial impairment and metabolic diseases;
• Oxidative stress and autophagy-mitophagy in metabolic diseases;
• Therapeutic strategies to overwhelmed oxidative stress in metabolic diseases;
• Mitophagy and oxidative stress;
• Mitophagy and homeostasis.

Prof. Dr. Victor M. Victor
Dr. Milagros Rocha
Dr. Rovira-Llopis Susana
Guest Editors

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• mitochondria
• mitophagy
• diabetes
• oxidative stress
• ROS
• antioxidants
• autophagy
• human
• cardiometabolic
• endothelium