Bioenergetic in Mitochondria and Reactive Oxygen Species Production in Domestic Animals

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "ROS, RNS and RSS".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 2494

Special Issue Editor


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Animal Nutrition, Life Sciences, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza-Aoba, Aoba-ku, Sendai 980-8572, Japan
Interests: mitochondria; phytochemicals; intestinal/systemic inflammation; protein metabolism; metabolism
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Special Issue Information

Dear Colleagues,

Mitochondria are the power plants of the cells and have an important role in cell energetic homeostasis. The organelle also generates reactive oxygen species as a byproduct of anerobic metabolism, which affects cell physiology, metabolism, immunity, etc. The study of mitochondria in domestic animals has evolved to understand the influences on phenotypes such as growth performance, stress resistance, and pathology. In this Special Issue, studies of mitochondrial functions, morphology/histochemistry and bioenergetics, but not genetics, in domestic animals’ tissues and cultured cells are welcomed.

Dr. Motoi Kikusato
Guest Editor

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Keywords

  • cell physiology
  • metabolism
  • inflammation
  • stress
  • pathology
  • chicken
  • pig
  • cow/cattle

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Published Papers (1 paper)

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Research

20 pages, 2353 KiB  
Article
Polydatin Attenuates Intra-Uterine Growth Retardation-Induced Liver Injury and Mitochondrial Dysfunction in Weanling Piglets by Improving Energy Metabolism and Redox Balance
by Yanan Chen, Yue Li, Peilu Jia, Shuli Ji, Hao Zhang and Tian Wang
Antioxidants 2022, 11(4), 666; https://doi.org/10.3390/antiox11040666 - 30 Mar 2022
Cited by 2 | Viewed by 1990
Abstract
The present study investigated the potential of polydatin to protect against liver injury and the mitochondrial dysfunction of weanling piglets suffering from intra-uterine growth retardation (IUGR). Thirty-six normal birth weight weanling piglets and an equal number of IUGR littermates were given a basal [...] Read more.
The present study investigated the potential of polydatin to protect against liver injury and the mitochondrial dysfunction of weanling piglets suffering from intra-uterine growth retardation (IUGR). Thirty-six normal birth weight weanling piglets and an equal number of IUGR littermates were given a basal diet with or without polydatin (250 mg/kg) from 21 to 35 d of age. Plasma and liver samples were collected to measure biochemistry parameters at 35 d of age. IUGR caused hepatic apoptosis, mitochondrial dysfunction, and oxidative damage, along with a lower efficiency of energy metabolism and inferior antioxidant ability. Polydatin decreased apoptotic rate, improved the features of mitochondrial damage, inhibited mitochondrial swelling and superoxide anion formation, and preserved mitochondrial membrane potential in the liver. Concurrently, polydatin promoted mitochondrial biogenesis, increased sirtuin 1 activity, and upregulated the expression levels of several genes related to mitochondrial function and fitness. Polydatin also facilitated mitochondrial oxidative metabolism with a beneficial outcome of increased energy production. Furthermore, polydatin mitigated the IUGR-induced reduction in manganese superoxide dismutase activity and prevented the excessive accumulation of oxidative damaging products in the liver. These findings indicate that polydatin confers protection against hepatic injury and mitochondrial dysfunction in the IUGR piglets by improving energy metabolism and redox balance. Full article
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