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Applied Nano
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Editorial Board Members' Collection Series: Bioactive Nanomaterials for Antimicrobial and...
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Editorial Board Members' Collection Series: Bioactive Nanomaterials for Antimicrobial and Antiviral Applications

A special issue of Applied Nano (ISSN 2673-3501).

Deadline for manuscript submissions: closed (30 March 2024) | Viewed by 8745

Special Issue Editors

Prof. Dr. Anthony William Coleman

E-Mail Website
Guest Editor
LMI CNRS UMR 5615, Université Lyon 1, 69622 Villeurbanne, France
Interests: biomechanics; silver nanoparticle antibiotic action; metal ions in epigenetics; bioactive supramolecular systems; 3D printing and biofilms
Special Issues, Collections and Topics in MDPI journals
Dr. Giacomo Dacarro

E-Mail Website
Guest Editor
Dipartimento di Chimica, Università di Pavia, viale Taramelli, 12, 27100 Pavia, Italy
Interests: coordination chemistry; supramolecular chemistry; inorganic nanoparticles; surface functionalization; antibacterial inorganic materials; photothermal nanoparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce this Special Issue collection titled "Editorial Board Members' Collection Series: Bioactive Nanomaterials for Antimicrobial and Antiviral Applications". This Issue will be a collection of papers from our Editorial Board Members and researchers invited by the Editorial Board Members. The aim is to provide a venue for networking and communication between Applied Nano and scholars in the field of bioactive nanomaterials. All papers will be fully open access upon publication after peer review.

Prof. Dr. Anthony William Coleman
Dr. Giacomo Dacarro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Nano is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • bioactive nanomaterials
  • antimicrobial
  • antiviral
  • nanomedicine
  • functional materials
  • nanoparticles

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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Research

16 pages, 2178 KiB  
Article
Oral Delivery of mRNA by Liposomes Functionalized with Cell-Penetrating Peptides
by Valerie Dürr, Sabrina Wohlfart, Tom Eisenzapf, Walter Mier, Gert Fricker and Philipp Uhl
Appl. Nano 2023, 4(4), 293-308; https://doi.org/10.3390/applnano4040017 - 9 Nov 2023
Viewed by 2724
Abstract
Lipid nanoparticles, including liposomes, have emerged as promising vehicles for the delivery of a variety of therapeutics. Several formulations have been approved and are used in medical practice—the COVID-19 mRNA vaccines represent the most recent milestone. Achieving effective oral delivery would elevate the [...] Read more.
Lipid nanoparticles, including liposomes, have emerged as promising vehicles for the delivery of a variety of therapeutics. Several formulations have been approved and are used in medical practice—the COVID-19 mRNA vaccines represent the most recent milestone. Achieving effective oral delivery would elevate the potential of these formulations. Therefore, this study investigates the oral application of mRNA using liposomes as a nanocarrier system. A cyclic cell-penetrating peptide was coupled to the liposomal surface to allow uptake into the intestinal mucosal cells. The liposomes were loaded with mRNA (up to 112 µg/mL) and characterized in terms of their size (Z-average; 135.4 nm ± 1.1 nm), size distribution (polydispersity index (PDI); 0.213 ± 0.007 nm), surface charge (2.89 ± 0.27 mV), structure, lamellarity (multilamellar liposomes), and cargo capacity (>90%). The impact of freeze-drying and long-term storage of liposomal formulations was examined, and in vitro experiments on Caco-2 cells were conducted to evaluate the cytotoxicity of the liposomal formulations and demonstrate the uptake of the liposomes into cells. The efficiency of the formulations could be proven in vitro. When compared to control liposomes and 1,2-dioleoyl-3-trimethylammonium propane (DOTAP)-liposomes, the new formulations exhibited significantly enhanced uptake in Caco-2 cells, an immortalized epithelial cell line. Moreover, the cytocompatibility of the formulations could be proven by the absence of cytotoxic effects on the viability of Caco-2 cells. Hence, this liposomal drug delivery system holds significant promise for the oral delivery of mRNA. Full article
(This article belongs to the Special Issue Editorial Board Members' Collection Series: Bioactive Nanomaterials for Antimicrobial and Antiviral Applications)
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14 pages, 4547 KiB  
Article
Biosynthesis and Characterization of Copper Nanoparticles Using a Bioflocculant Produced by a Yeast Pichia kudriavzevii Isolated from Kombucha Tea SCOBY
by Phakamani H. Tsilo, Albertus K. Basson, Zuzingcebo G. Ntombela, Nkosinathi G. Dlamini and Rajasekhar V. S. R. Pullabhotla
Appl. Nano 2023, 4(3), 226-239; https://doi.org/10.3390/applnano4030013 - 11 Aug 2023
Cited by 4 | Viewed by 3069
Abstract
Over recent years, the ‘green’ chemistry approach to synthesizing nanoparticles has made significant developments. Because of their unique features, nanoparticles have received a lot of attention. The use of a bioflocculant to promote the environmentally friendly synthesis of copper nanoparticles is described in [...] Read more.
Over recent years, the ‘green’ chemistry approach to synthesizing nanoparticles has made significant developments. Because of their unique features, nanoparticles have received a lot of attention. The use of a bioflocculant to promote the environmentally friendly synthesis of copper nanoparticles is described in this paper. Copper nanoparticles were biosynthesized using bioflocculant which was produced from a yeast, Pichia kudriavzevii. The chemical reduction approach was used to synthesize copper nanoparticles (CuNPs) using a bioflocculant as a capping agent. Characterization of the as-synthesized copper nanoparticles was conducted using Fourier transform infrared (FT-IR) spectroscopy, UV-visible spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and energy dispersive X-ray (EDX). The FT-IR spectra revealed characteristic peaks at 3267, 2956, 1656, 1059, and 511 cm−1 for the bioflocculant, while for the bioflocculant passivated CuNPs, the characteristic peaks were at 3482 (-OH), 3261, 1640, 1059, 580, and 519 cm−1 (Cu-O). These peaks revealed that functional groups such as hydroxyls, amines, and copper oxide bonds were present. The UV-Vis analysis showed surface plasmon resonance (SPR) at an absorbance range of 500–600 nm, with peak maxima at 555 and 575 nm for the as-synthesized CuNPs. The XRD pattern revealed planes such as (200) and (220) at 2θ = 43 and 52°, and the particle size (30 nm) was determined by the Debye–Scherrer equation. The transmission electron microscopy analysis revealed a spherical-shaped particle with an average size of 20 nm. The EDX analysis of the as-synthesized CuNPs revealed the presence of the element Cu, which was not present in the EDX image of the bioflocculant used in the synthesis of the CuNPs; this indicated the success of biosynthesis. Full article
(This article belongs to the Special Issue Editorial Board Members' Collection Series: Bioactive Nanomaterials for Antimicrobial and Antiviral Applications)
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Graphical abstract

13 pages, 5722 KiB  
Article
Effect of the Cross-Section Morphology in the Antimicrobial Properties of α-Ag2WO4 Rods: An Experimental and Theoretical Study
by Nivaldo F. Andrade Neto, Marisa C. Oliveira, José Heriberto O. Nascimento, Elson Longo, Renan A. P. Ribeiro, Mauricio R. D. Bomio and Fabiana V. Motta
Appl. Nano 2023, 4(3), 213-225; https://doi.org/10.3390/applnano4030012 - 31 Jul 2023
Cited by 3 | Viewed by 1793
Abstract
In this work, α-Ag2WO4 particles with different cross-sections were obtained using the co-precipitation method at different synthesis temperatures. The samples were characterized by X-ray diffraction (XRD), field-scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS). The antimicrobial activity was analyzed [...] Read more.
In this work, α-Ag2WO4 particles with different cross-sections were obtained using the co-precipitation method at different synthesis temperatures. The samples were characterized by X-ray diffraction (XRD), field-scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS). The antimicrobial activity was analyzed using the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) methods against the Escherichia coli and Salmonella spp. gram-negative bacteria. The antimicrobial tests against Escherichia coli and Salmonella spp. indicated that concentrations of 2.5–5 mg/mL and 5 mg/mL completely inhibit its growth, respectively. The antimicrobial activity was analyzed employing band-edge positions for ROS generations and the superficial distribution of Ag+ species that contribute to antimicrobial activity. Quantum-chemical calculations were used at the DFT level to investigate the surface-dependent reactivity of α-Ag2WO4, and we demonstrated how the antimicrobial properties could be tailored by the geometry and electronic structure of the exposed surfaces, providing guidelines for the morphology design. Full article
(This article belongs to the Special Issue Editorial Board Members' Collection Series: Bioactive Nanomaterials for Antimicrobial and Antiviral Applications)
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