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Oral Health and Chronic Non Communicable Diseases (NCDs)

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Dentistry and Oral Sciences".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 6506

Special Issue Editors


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Guest Editor
UOSD Special Care Dentistry, Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, 00100 Rome, Italy
Interests: oral health; systemic disease; oral disease; gum disease; dental materials ; dental technologies; special care dentistry; preventive dentistry
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. UOSD Nephrology and Dialysis, University Hospital Tor Vergata, Rome, Italy
2. Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
Interests: nutrition in chronic kidney disease; hemodialysis; natural active compounds for prevention of chronic non-communicable diseases; body composition assessment; uremic sarcopenia; oxidative stress; microbiome in CKD; endothelial dysfunction in CKD
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chronic degenerative non communicable diseases (NCDs) have high rates of morbidity and mortality. The major NCDs are diabetes mellitus (DM), cardiovascular diseases (CVDs), lung disease, osteoporosis, cancer, neurodegenerative diseases and chronic kidney disease (CKD). Currently, it is believed that approximately 40% of deaths worldwide may be attributable to these pathological conditions. Lifestyle factors such as physical activity, a healthy diet and abstention from smoking seem to play a key role in reducing the onset and the progression of NCDs. Among the NCDs emerging risk factors, the periodontitis is assuming a relevant role. In fact, a correlation between CKD and oral diseases has been recently demonstrated. Specifically, CKD influences the oral health since it induces gingival hyperplasia, xerostomia, calcification of root canals, delayed tooth eruption and periodontal disease (PD). NCDs can influence the development of oral disease via systemic and oral cavity inflammation. Therefore, the treatment of PD could be useful in reducing the systemic inflammation and the NCDs onset. In recent years, among many innovative therapies for their treatment, natural bioactive compounds and adapted physical activity have been validated as effective by numerous authors. The aim of this Special Issue is to explore the possible correlation between oral diseases and NCDs, analyzing new potential treatments.

Dr. Michele Basilicata
Dr. Annalisa Noce
Guest Editors

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Keywords

  • oral health
  • systemic disease
  • oral disease
  • chronic kidney disease
  • special care dentistry
  • oral care
  • oral medicine
  • prevention
  • periodontal disease

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Published Papers (3 papers)

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Research

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11 pages, 213 KiB  
Article
Prevalence of Medical Conditions and Medication Usage: Implications for Oral Health among Older Adults in Rural Victoria
by Rodrigo Mariño, Kristen Glenister, Lisa Bourke and David Simmons
Appl. Sci. 2024, 14(16), 7270; https://doi.org/10.3390/app14167270 - 19 Aug 2024
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Abstract
(1) Background: A study was undertaken to provide a comprehensive profile of the prevalence and distribution, by selected socio-demographic characteristics, of chronic diseases and health conditions including those that impact the oral health and oral health self-care of independently living older adults in [...] Read more.
(1) Background: A study was undertaken to provide a comprehensive profile of the prevalence and distribution, by selected socio-demographic characteristics, of chronic diseases and health conditions including those that impact the oral health and oral health self-care of independently living older adults in rural areas of the state of Victoria; (2) Methods: The study analyzed data from the Crossroads-II project, with a total of 1407 participants aged 55 years and older. Participants responded to questionnaires about their medical health history, health service use, and socio-demographics. In total, 572 attended a 2-h health screening that included an assessment of prescribed medications; (3) Results: Most participants were female (55.3%), with a mean age of 69.1 (SD = 9.2) years. Participants had a high prevalence of medical conditions; the most common were high blood pressure, arthritis, high lipids, hearing loss, and chronic pain. Almost all participants reported taking medications, with an average of 4.3 medications per person. Among those who attended the health screening, 78.1% were taking medications that could cause xerostomia (dry mouth); (4) Conclusions: This study provides initial information on the prevalence of medical conditions, medication usage, and the potential impact on the oral health of older adults living in rural Victoria. This information would be valuable for healthcare and dental workforce planning, policy development, and improving the overall well-being of this population. Full article
(This article belongs to the Special Issue Oral Health and Chronic Non Communicable Diseases (NCDs))

Review

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29 pages, 2917 KiB  
Review
Healthy Effects of Pomegranate (Punica granatum L.) in Internal Medicine and Dentistry
by Giulia Marrone, Michele Basilicata, Manuela Di Lauro, Chiara Vita, Claudia Masci, Francesca Gioia Klinger, Kevin Cornali, Gianluca Maddaloni, Patrizio Bollero, Antonino De Lorenzo and Annalisa Noce
Appl. Sci. 2024, 14(4), 1570; https://doi.org/10.3390/app14041570 - 16 Feb 2024
Cited by 2 | Viewed by 3680
Abstract
Punica granatum L., commonly known as pomegranate, is a typical fruit of Asia, Mediterranean countries, the Middle East and the USA. While in ancient times pomegranate was considered an ornamental plant, nowadays numerous scientific studies have highlighted its antioxidant and anti-radical activities, making [...] Read more.
Punica granatum L., commonly known as pomegranate, is a typical fruit of Asia, Mediterranean countries, the Middle East and the USA. While in ancient times pomegranate was considered an ornamental plant, nowadays numerous scientific studies have highlighted its antioxidant and anti-radical activities, making it a “superfood”. Pomegranate presents a high content of natural bioactive compounds (NBCs), and its consumption appears to exert numerous healthy effects, in particular, in several pathological conditions as metabolic syndrome, cancer, nephrolithiasis, urinary tract infections and neurodegenerative diseases. Moreover, recent studies have pointed out the possible beneficial action of pomegranate on oral health. For these reasons, the utility of pomegranate in internal medicine and dentistry represents a promising field, as it could enable the development of innovative natural adjuvant therapies and empower standard pharmaceutical therapies. Full article
(This article belongs to the Special Issue Oral Health and Chronic Non Communicable Diseases (NCDs))
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Other

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12 pages, 697 KiB  
Systematic Review
Mechanism behind the Upregulation of Proteins Associated with the NLRP3 Inflammasome in Periodontitis and Their Role in the Immune Response in Diabetes—A Systematic Review
by Elisabetta Ferrara, Ilaria Converti, Roberta Scarola, Francesco Carlo Tartaglia, Antonio Gnoni, Gaetano Isola and Biagio Rapone
Appl. Sci. 2023, 13(14), 8278; https://doi.org/10.3390/app13148278 - 18 Jul 2023
Viewed by 1431
Abstract
Background: The molecular crosstalk between periodontitis and diabetes is well established. The role of the NLRP3 inflammasome, a multicomponent inflammatory machinery, is an emerging field of research on the relationship between these two uncommunicable diseases. Recent advances are revealing further molecular details regarding [...] Read more.
Background: The molecular crosstalk between periodontitis and diabetes is well established. The role of the NLRP3 inflammasome, a multicomponent inflammatory machinery, is an emerging field of research on the relationship between these two uncommunicable diseases. Recent advances are revealing further molecular details regarding the biological function and the mechanism behind the NLRP3 inflammasome dysregulation and highlighting an unexpected role for the caspase-1 in immune homeostasis. We aimed to understand which metabolic checkpoints are involved in contributing to and instigating the relationship between periodontitis and diabetes. We tried to explore the involvement of the NLRP3 in regulating the cytokine-chemokines profile and discussed the potential synergism in these mechanisms when these two diseases coexist in the same patient. Methods: A literature search was carried out in the electronic databases (MEDLINE, EMBASE, and Cochrane Library) for relevant studies from inception until January 2022 for trials and cohort studies that investigated the activation and regulation mechanism of the NLRP3 inflammasome in patients with periodontitis and type two diabetes. Two investigators independently extracted data. The data quality assessment was rated by the Joanna Briggs Institute (JBI). Results: from twenty-six references identified, three studies (two case-control and one cross-sectional) met the inclusion criteria. Analysis of periodontal tissue samples in diabetic individuals exhibited significant overexpression of the NLRP3 inflammasome when compared with healthy controls. Conclusions: there is insufficient evidence to sustain the involvement of the upregulation of genes and proteins involved in the activation of NLRP3 inflammasome components in patients with periodontitis and diabetes. Full article
(This article belongs to the Special Issue Oral Health and Chronic Non Communicable Diseases (NCDs))
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