Innovative Experimental Approaches Targeting Gastrointestinal Tumors with Phytochemicals and Anticancer Drugs
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: closed (30 July 2022) | Viewed by 6020
Special Issue Editors
Interests: cancer prevention; dietary phytochemicals; molecular biology and cell biology of cancer
Special Issues, Collections and Topics in MDPI journals
Interests: nutrition; endocrinology; food science thyroid hormones; vitamins; micronutrients; antioxidant activity of foods
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is focused on the use of molecular biology techniques to increase the efficacy of phytochemicals and anticancer drugs utilized against gastrointestinal tumors, like gastric cancer, liver cancer, colon cancer, and pancreatic cancer. These tumors represent an important health problem, because they cause high rates of mortality in oncological patients.
The main targets of antitumor therapies are represented by the described hallmarks of cancer: self-sufficiency in growth signals, insensitivity to anti-growth signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis, tissue invasion and metastasis, deregulated metabolic pathways, evasion of the immune system, chromosomal instability, pro-inflammatory tumor microenvironment, and resistance to anticancer drugs (exerted through P-glycoprotein 1). Targeting several oncogenes and oncoproteins of these molecular pathways with the same drug or a combination of natural and synthetic molecules can increase the efficacy of antitumor therapies.
The use of high concentrations of anticancer drugs may lead to the development of toxic side effects in oncological patients. On the other hand, the utilization of natural extracts and new molecular techniques can both increase the efficacy of the antitumor drug and reduce its required therapeutic dose, diminishing the harmful side effects. The interdisciplinary teamwork with colleagues of both basic and translational cancer research fields will lead to the development of new experimental approaches against gastrointestinal cancers, based on innovative molecular strategies.
In this Special Issue, we invite your contributions, either in the form of original research manuscripts or reviews, on the theme of “Innovative Experimental Approaches Targeting Gastrointestinal Tumors with Phytochemicals and Anticancer Drugs".
Dr. Emanuele-Salvatore Scarpa
Prof. Dr. Marco Giammanco
Guest Editors
Manuscript Submission Information
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Keywords
- hallmarks of cancer
- gastrointestinal cancers
- oncogenes
- anticancer drugs
- phytochemicals
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