applsci-logo

Journal Browser

Journal Browser

Cyclodextrin-Based Materials and Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Materials Science and Engineering".

Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 8132

Special Issue Editors


E-Mail Website
Guest Editor
Department of Chemistry, University of Florence, via Schiff 6, Sesto Fiorentino, 50019 Florence, Italy
Interests: cyclodextrins; drug delivery systems; drug-in-cyclodextrins-in-colloidal systems; microparticulate systems
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Chemistry, University of Florence, via Schiff 6, Sesto Fiorentino, 50019 Florence, Italy
Interests: cyclodextrins; drug delivery systems; drug-in-cyclodextrin-in-nanolipid carriers; oral administration; pediatric formulations; topical delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cyclodextrins (CDs) are cyclic oligosaccharides consisting of D-glucose units joined by α-1,4-glucosidic linkages. They present a truncated cone structure with a hydrophilic outer surface and a hydrophobic inner cavity able to partially or entirely accommodate suitably sized lipophilic molecules.

In the pharmaceutical field, CDs have primarily been applied to enhance drug efficacy. In fact, due to their solubilizing and stabilizing power towards drugs, they are able to improve drug bioavailability and/or reduce adverse effects after oral, parenteral or other routes of administration. However, there are many other applications of CDs, and not only in pharmaceutics but also in the food, cosmetics, textiles, biomedical, and analytical fields.

Recently, studies on nanosystems containing CDs have been receiving great attention in academic research due to the versatility of these systems and their significant opportunities in pharmaceuticals. It is well recognized that CDs are able to increase the entrapment capacity of nanoparticles. The peculiar structures of CDs enable the design and synthesis of CD-based polymers with the desired structures and functions, supramolecular assemblies, and hydrogels that are of particular interest in the field of biomedicine, allowing to improve the stabilization of drugs, their contact with biological membranes, and then their permeability and also to gain delivery of genes. Thus, CDs-based nanosponges have recently emerged in the field of nanotechnology and in particular for their pharmaceutical, biomedical, and biotechnological applications, due to their contribution to achieving foremost prerequisites such as solubility, stability, sustained release, enhancement of permeability and bioavailability, improved efficacy, and also their usefulness in enabling proteins and peptides delivery, stimuli-sensitive drug release, and ocular delivery.

We kindly invite you to submit full papers, communications and reviews regarding the above-described topics, dealing with CD-based materials and their applications. 

Prof. Dr. Francesca Maestrelli
Dr. Marzia Cirri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

19 pages, 4493 KiB  
Article
Evaluation of Polyethylene Glycol Crosslinked β-CD Polymers for the Removal of Methylene Blue
by Isabelle Mallard, David Landy and Sophie Fourmentin
Appl. Sci. 2020, 10(13), 4679; https://doi.org/10.3390/app10134679 - 7 Jul 2020
Cited by 14 | Viewed by 4892
Abstract
The environment is at the heart of global worldwide discussion. This study describes the synthesis of ecofriendly polymers by a crosslinking reaction between β-cyclodextrin as the monomer and polyethylene glycol diglycidyl ether (PEDGE) as well as ethylene diglycidyl ether (EDGE) as the crosslinking [...] Read more.
The environment is at the heart of global worldwide discussion. This study describes the synthesis of ecofriendly polymers by a crosslinking reaction between β-cyclodextrin as the monomer and polyethylene glycol diglycidyl ether (PEDGE) as well as ethylene diglycidyl ether (EDGE) as the crosslinking agents. The studied polymers were characterized by several techniques, such as SEM, FTIR, TGA-TDA and XRD. Their adsorption properties for methylene blue under various conditions of pH, contact time and initial concentration of dye were assessed in order to find the optimal conditions. The results indicate that the polymers are good nominates for methylene blue adsorption with adsorption capacities up to 15 mg/g. The adsorption mechanism was demonstrated to follow the Langmuir model. Finally, the regeneration of the polymers was investigated using Soxhlet extraction with ethanol. The absorption capacities of the adsorbent were stable after three cycles. Full article
(This article belongs to the Special Issue Cyclodextrin-Based Materials and Applications)
Show Figures

Graphical abstract

12 pages, 9827 KiB  
Article
Investigating the In Vitro Osteogenic Properties of the Inclusion Nanocarrier of Icariin with Beta-Cyclodextrin-Alginate
by Somang Choi, Yeong Seok Lee, Han-Saem Jo, Woong Kyo Jeong, Hak-Jun Kim, Mi Hyun Song, Kyeongsoon Park and Sung Eun Kim
Appl. Sci. 2020, 10(12), 4137; https://doi.org/10.3390/app10124137 - 16 Jun 2020
Cited by 7 | Viewed by 2588
Abstract
In this study, we created an inclusion nanocarrier of icariin (ICA) and β-cyclodextrin-alginate conjugate (ICA/β-CD-ALG) and determined its in vitro osteogenic ability on MC3T3-E1 cells. The morphological shape of the prepared β-CD-ALG with or without ICA was nano-sized and round. The use of [...] Read more.
In this study, we created an inclusion nanocarrier of icariin (ICA) and β-cyclodextrin-alginate conjugate (ICA/β-CD-ALG) and determined its in vitro osteogenic ability on MC3T3-E1 cells. The morphological shape of the prepared β-CD-ALG with or without ICA was nano-sized and round. The use of β-CD-ALG achieved a sustained ICA release for up to 7 days. In vitro studies found that ICA/β-CD-ALG had a greater potential in osteogenesis on MC3T3-E1 cells compared to β-CD-ALG by exhibiting both higher alkaline phosphatase levels and the amount of calcium deposits. Moreover, ICA/β-CD-ALG greatly increased the levels of osteogenesis markers including osteocalcin (OCN) and osteopontin (OPN). Our results suggest that ICA/β-CD-ALG plays a significant role in cellular osteogenic activity. Full article
(This article belongs to the Special Issue Cyclodextrin-Based Materials and Applications)
Show Figures

Graphical abstract

Back to TopTop