Advancements in Biocompatible Materials for Implantable Medical Devices

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 2210

Special Issue Editors


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Guest Editor
Department of Biomedical, Industrial and Human Factors Engineering, Orthopaedic Surgery, Sports Medicine and Rehabilitation, Wright State University, 3640 Colonel Glenn Hwy, Dayton, OH 45435, USA
Interests: application of biomaterials; biomechanics; wear and fatigue related research in medical devices; mathematical modeling
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Guest Editor
College of Engineering and Computer Science, Wright State University, Dayton, OH 45435, USA
Interests: advanced engineering materials; material property characterization and lifecycle assessment; biomechanics; biomedical engineering; bone biomechanics; mechanical testing; finite element modeling; biomedical devices
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Advancements in biocompatible materials for implantable medical devices have revolutionized modern healthcare, offering innovative solutions for treating a wide range of medical conditions. These materials are designed to be compatible with the body's natural systems, minimizing the risk of rejection and promoting better integration with surrounding tissues. Over the years, researchers have made significant strides in developing new materials with improved biocompatibility, mechanical properties, and functionality. These advancements have led to the development of safer, more durable, and more effective implantable devices, thereby enhancing patient outcomes and quality of life. In this context, this Special Issue on "Advancements in Biocompatible Materials for Implantable Medical Devices" will showcase the latest research and innovations in this rapidly evolving field, highlighting the transformative impact of biocompatible materials on modern healthcare. Topics of interest for this Special Issue include, but are not limited to, the following:

  1. Novel biocompatible materials for implantable medical devices;
  2. Surface modifications that improve the biocompatibility of implant materials;
  3. Nanostructured materials for enhanced biocompatibility and functionality;
  4. Composite materials that improve the mechanical properties of implants;
  5. In vitro and in vivo studies on biocompatible materials for implants;
  6. Regulatory considerations and standards for biocompatible materials in implantable devices;
  7. Clinical applications and case studies of biocompatible materials in implantable medical devices;
  8. Computational modeling and simulations of biocompatible materials for implants;
  9. Emerging trends and future directions concerning biocompatible materials for implantable medical devices.

This Special Issue welcomes all research areas related to innovative experimental and computational approaches in the development and evaluation of biocompatible materials for implantable medical devices.

Prof. Dr. Tarun Goswami
Dr. Farah Hamandi
Guest Editors

PhD student Anmar Salih
Guest Editor Assistant

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Keywords

  • biomaterials
  • clinical engineering
  • biomedical devices
  • cardiovascular engineering
  • biomedical instrumentation
  • biomechanical engineering
  • biomedical modeling
  • biomedical technology

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Published Papers (1 paper)

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25 pages, 7220 KiB  
Article
Advancements in Finite Element Modeling for Cardiac Device Leads and 3D Heart Models
by Anmar Salih, Farah Hamandi and Tarun Goswami
Bioengineering 2024, 11(6), 564; https://doi.org/10.3390/bioengineering11060564 - 3 Jun 2024
Viewed by 1224
Abstract
The human heart’s remarkable vitality necessitates a deep understanding of its mechanics, particularly concerning cardiac device leads. This paper presents advancements in finite element modeling for cardiac leads and 3D heart models, leveraging computational simulations to assess lead behavior over time. Through detailed [...] Read more.
The human heart’s remarkable vitality necessitates a deep understanding of its mechanics, particularly concerning cardiac device leads. This paper presents advancements in finite element modeling for cardiac leads and 3D heart models, leveraging computational simulations to assess lead behavior over time. Through detailed modeling and meshing techniques, we accurately captured the complex interactions between leads and heart tissue. Material properties were assigned based on ASTM (American Society for Testing and Materials) standards and in vivo exposure data, ensuring realistic simulations. Our results demonstrate close agreement between experimental and simulated data for silicone insulation in pacemaker leads, with a mean force tolerance of 19.6 N ± 3.6 N, an ultimate tensile strength (UTS) of 6.3 MPa ± 1.15 MPa, and a percentage elongation of 125% ± 18.8%, highlighting the effectiveness of simulation in predicting lead performance. Similarly, for polyurethane insulation in ICD leads, we found a mean force of 65.87 N ± 7.1 N, a UTS of 10.7 MPa ± 1.15 MPa, and a percentage elongation of 259.3% ± 21.4%. Additionally, for polyurethane insulation in CRT leads, we observed a mean force of 53.3 N ± 2.06 N, a UTS of 22.11 MPa ± 0.85 MPa, and a percentage elongation of 251.6% ± 13.2%. Correlation analysis revealed strong relationships between mechanical properties, further validating the simulation models. Classification models constructed using both experimental and simulated data exhibited high discriminative ability, underscoring the reliability of simulation in analyzing lead behavior. These findings contribute to the ongoing efforts to improve cardiac device lead design and optimize patient outcomes. Full article
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