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Bioengineering
Special Issues
Recent Advances in Micro/Nano Robots and Their Applications
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Recent Advances in Micro/Nano Robots and Their Applications

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Nanobiotechnology and Biofabrication".

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 4136

Special Issue Editors

Prof. Dr. Lin Feng

E-Mail Website
Guest Editor
School of Mechanical Engineering and Automation, Institute of Bionic and Micro-Nano Systems, Beihang University, Beijing 100191, China
Interests: micro/nano robotics; targeted drug delivery
Special Issues, Collections and Topics in MDPI journals
Dr. Junjie Xu

E-Mail Website
Guest Editor
School of Mechanical Engineering & Automation, Beihang University, Beijing 100191, China
Interests: biofabrication; biomaterial; fermentation
Dr. Lina Jia

E-Mail Website
Guest Editor
School of Mechanical Engineering & Automation, Beihang University, Beijing 100191, China
Interests: drug delivery; cell robot; biocompatibility
Dr. Xue Bai

E-Mail Website
Guest Editor
School of Biomedical Engineering, Capital Medical University, Beijing 100069, China
Interests: micro/nano robotics; micro- and nanoscale engineering; nano-bio interfaces

Special Issue Information

Dear Colleagues,

Field-controlled micro nano manipulations and micro nano robots have attracted increasing attention in the fields of medicine, environment, engineering, and energy due to their outstanding characteristics, which include small size, strong controllability, cluster action, and strong penetrability; thus, they have gradually become an important research focus in micro nano manufacturing and in vivo detection. However, precise cluster control, targeted drug delivery in vivo, and cellular micro nano operation remain challenges. Considering the current research enthusiasm and application challenges, the micro nano manipulations and micro nano robots driven by physical fields (magnetic field, sound field, and light field) are critical. This Special Issue will focus on micro nano robots control mechanisms, control objectives, supporting technologies, recent research results, advantages and future development trends driven by physic fields, etc.

Hence, in the spirit of sharing ideas and fostering innovation, we sincerely invite you to contribute your research papers and review articles to this Special Issue with a focus on novel methodologies in the fabrication, actuation, control, and application of field controlled micro- and nanorobots, and innovative micro- and nanotechnologies in related areas.

Prof. Dr. Lin Feng
Dr. Junjie Xu
Dr. Lina Jia
Dr. Xue Bai
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • micro-nano robots
  • micro-nano manipulations
  • microfluidics
  • field-controlled micro/nano robotics
  • biomedicine

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Published Papers (1 paper)

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Research

15 pages, 2357 KiB  
Article
Biomanufacturing Biotinylated Magnetic Nanomaterial via Construction and Fermentation of Genetically Engineered Magnetotactic Bacteria
by Junjie Xu, Shijiao Ma, Haolan Zheng, Bo Pang, Shuli Li, Feng Li, Lin Feng and Jiesheng Tian
Bioengineering 2022, 9(8), 356; https://doi.org/10.3390/bioengineering9080356 - 30 Jul 2022
Cited by 3 | Viewed by 2713
Abstract
Biosynthesis provides a critical way to deal with global sustainability issues and has recently drawn increased attention. However, modifying biosynthesized magnetic nanoparticles by extraction is challenging, limiting its applications. Magnetotactic bacteria (MTB) synthesize single-domain magnetite nanocrystals in their organelles, magnetosomes (BMPs), which are [...] Read more.
Biosynthesis provides a critical way to deal with global sustainability issues and has recently drawn increased attention. However, modifying biosynthesized magnetic nanoparticles by extraction is challenging, limiting its applications. Magnetotactic bacteria (MTB) synthesize single-domain magnetite nanocrystals in their organelles, magnetosomes (BMPs), which are excellent biomaterials that can be biologically modified by genetic engineering. Therefore, this study successfully constructed in vivo biotinylated BMPs in the MTB Magnetospirillum gryphiswaldense by fusing biotin carboxyl carrier protein (BCCP) with membrane protein MamF of BMPs. The engineered strain (MSR−∆F−BF) grew well and synthesized small-sized (20 ± 4.5 nm) BMPs and were cultured in a 42 L fermenter; the yield (dry weight) of cells and BMPs reached 8.14 g/L and 134.44 mg/L, respectively, approximately three-fold more than previously reported engineered strains and BMPs. The genetically engineered BMPs (BMP−∆F−BF) were successfully linked with streptavidin or streptavidin-labelled horseradish peroxidase and displayed better storage stability compared with chemically constructed biotinylated BMPs. This study systematically demonstrated the biosynthesis of engineered magnetic nanoparticles, including its construction, characterization, and production and detection based on MTB. Our findings provide insights into biomanufacturing multiple functional magnetic nanomaterials. Full article
(This article belongs to the Special Issue Recent Advances in Micro/Nano Robots and Their Applications)
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