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Bioengineering
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Noble Metal Functionalized Nanoparticles for Biomedical Applications
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Noble Metal Functionalized Nanoparticles for Biomedical Applications

A special issue of Bioengineering (ISSN 2306-5354).

Deadline for manuscript submissions: closed (31 May 2019) | Viewed by 49397

Special Issue Editor

Dr. Ilaria Fratoddi

E-Mail Website
Guest Editor
Department of Chemistry, Sapienza University of Rome, 00185 Rome, Italy
Interests: nanomaterials; metal nanoparticles; metal oxide nanoparticles; polymers; nanostructured polymeric materials; hybrid nanostructures; organometallic complexes; nanomaterials synthesis and characterization; nanomaterial applications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bioengineering promotes new applicative pathways that allow a multidisciplinary interconnection of biochemical and biomedical technologies with engineering principles of design and analysis. In this huge context, nanotechnology provides a powerful tool and allows new approaches in, for example, drug delivery systems, tissue engineered organs, medical imaging technology, diagnostic sensors, and devices.

Thanks to the small size and biocompatibility of noble metal nanoparticles (MNPs), mainly AuNPs, but also AgNPs and PtNPs, they can be easily integrated into new bioengineering technologies, either for therapeutic applications or in clinical applications, with an emphasis on their use as drug delivery vehicles for the selective targeting of cancer cells or for antimicrobial applications. Moreover, the use of MNPs opens new perspectives in bioengineering as diagnostics tools, including the sensing of bioactive molecules and biomolecules, or even for quality control and absorption of chemical and biochemical products present, for example, in the environment and in foods.  With the rapid surge in the field of nanomaterials, new methodologies and targets have been explored and these topics should be taken into consideration when a current scenario is required in the design of new experimental approaches or in a comprehensive data interpretation.

This Special Issue "Noble Metal Functionalized Nanoparticles for Biomedical Applications" is intended to highlight emerging studies on nanomaterials based on noble metals nanoparticles (mainly AuNPs, but also AgNPs, PtNPs, etc.) and their applications in the development of bioengineering technologies, ranging from biomedicine to diagnostics.

For this Special Issue, we invite the submission of review articles, original research, communications/letters to editors covering the following topics (but not limited to them): Preparation of noble metal nanoparticles with different functionalities, preparation of nanoparticles and nanocomposites suitable for drug delivery, tissue engineering, diagnostics tools in the chemical sensing of analytes for environmental or food control, sensing and biosensing, and antimicrobial applications.

We are looking forward to receiving your contribution to this Special Issue.

Dr. Ilaria Fratoddi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • functionalized metal nanoparticles
  • AuNPs
  • AgNPs
  • drug delivery
  • tissue engineering
  • diagnostics tools
  • chemical sensing of analytes for environmental or food control
  • antimicrobial applications

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Published Papers (5 papers)

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Review

18 pages, 3194 KiB  
Review
Advances in Magnetic Noble Metal/Iron-Based Oxide Hybrid Nanoparticles as Biomedical Devices
by Laura M. Sanchez and Vera A. Alvarez
Bioengineering 2019, 6(3), 75; https://doi.org/10.3390/bioengineering6030075 - 28 Aug 2019
Cited by 28 | Viewed by 6743
Abstract
The study of the noble metal magnetic hybrid nanoparticles is a really promising topic from both the scientific and the technological points of views, with applications in several fields. Iron oxide materials which are hybridized with noble metal nanoparticles (NPs) have attracted increasing [...] Read more.
The study of the noble metal magnetic hybrid nanoparticles is a really promising topic from both the scientific and the technological points of views, with applications in several fields. Iron oxide materials which are hybridized with noble metal nanoparticles (NPs) have attracted increasing interest among researchers because of their cooperative effects on combined magnetic, electronic, photonic, and catalytic activities. This review article contains a summary of magnetic noble metal/iron oxide nanoparticle systems potentially useful in practical biomedical applications. Among the applications, engineered devices for both medical diagnosis and treatments were considered. The preparation to produce different structures, as blends or core-shell structures, of several nanometric systems was also considered. Several characterization techniques available to describe the structure, morphology and different kinds of properties of hybrid nanoparticles are also included in this review. Full article
(This article belongs to the Special Issue Noble Metal Functionalized Nanoparticles for Biomedical Applications)
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26 pages, 2752 KiB  
Review
Engineered Gold-Based Nanomaterials: Morphologies and Functionalities in Biomedical Applications. A Mini Review
by Iole Venditti
Bioengineering 2019, 6(2), 53; https://doi.org/10.3390/bioengineering6020053 - 10 Jun 2019
Cited by 68 | Viewed by 9691
Abstract
In the last decade, several engineered gold-based nanomaterials, such as spheres, rods, stars, cubes, hollow particles, and nanocapsules have been widely explored in biomedical fields, in particular in therapy and diagnostics. As well as different shapes and dimensions, these materials may, on their [...] Read more.
In the last decade, several engineered gold-based nanomaterials, such as spheres, rods, stars, cubes, hollow particles, and nanocapsules have been widely explored in biomedical fields, in particular in therapy and diagnostics. As well as different shapes and dimensions, these materials may, on their surfaces, have specific functionalizations to improve their capability as sensors or in drug loading and controlled release, and/or particular cell receptors ligands, in order to get a definite targeting. In this review, the up-to-date progress will be illustrated regarding morphologies, sizes and functionalizations, mostly used to obtain an improved performance of nanomaterials in biomedicine. Many suggestions are presented to organize and compare the numerous and heterogeneous experimental data, such as the most important chemical-physical parameters, which guide and control the interaction between the gold surface and biological environment. The purpose of all this is to offer the readers an overview of the most noteworthy progress and challenges in this research field. Full article
(This article belongs to the Special Issue Noble Metal Functionalized Nanoparticles for Biomedical Applications)
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Graphical abstract

17 pages, 607 KiB  
Review
Nanostructured Materials for Food Applications: Spectroscopy, Microscopy and Physical Properties
by Shubham Sharma, Swarna Jaiswal, Brendan Duffy and Amit K. Jaiswal
Bioengineering 2019, 6(1), 26; https://doi.org/10.3390/bioengineering6010026 - 19 Mar 2019
Cited by 73 | Viewed by 12294
Abstract
Nanotechnology deals with matter of atomic or molecular scale. Other factors that define the character of a nanoparticle are its physical and chemical properties, such as surface area, surface charge, hydrophobicity of the surface, thermal stability of the nanoparticle and its antimicrobial activity. [...] Read more.
Nanotechnology deals with matter of atomic or molecular scale. Other factors that define the character of a nanoparticle are its physical and chemical properties, such as surface area, surface charge, hydrophobicity of the surface, thermal stability of the nanoparticle and its antimicrobial activity. A nanoparticle is usually characterized by using microscopic and spectroscopic techniques. Microscopic techniques are used to characterise the size, shape and location of the nanoparticle by producing an image of the individual nanoparticle. Several techniques, such as scanning electron microscopy (SEM), transmission electron microscopy/high resolution transmission electron microscopy (TEM/HRTEM), atomic force microscopy (AFM) and scanning tunnelling microscopy (STM) have been developed to observe and characterise the surface and structural properties of nanostructured material. Spectroscopic techniques are used to study the interaction of a nanoparticle with electromagnetic radiations as the function of wavelength, such as Raman spectroscopy, UV–Visible spectroscopy, attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR), dynamic light scattering spectroscopy (DLS), Zeta potential spectroscopy, X-ray photoelectron spectroscopy (XPS) and X-ray photon correlation spectroscopy. Nanostructured materials have a wide application in the food industry as nanofood, nano-encapsulated probiotics, edible nano-coatings and in active and smart packaging. Full article
(This article belongs to the Special Issue Noble Metal Functionalized Nanoparticles for Biomedical Applications)
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Figure 1

17 pages, 1607 KiB  
Review
Application of Metal Nanoparticle–Hydrogel Composites in Tissue Regeneration
by Hui-Li Tan, Sin-Yeang Teow and Janarthanan Pushpamalar
Bioengineering 2019, 6(1), 17; https://doi.org/10.3390/bioengineering6010017 - 11 Feb 2019
Cited by 116 | Viewed by 12794
Abstract
Challenges in organ transplantation such as high organ demand and biocompatibility issues have led scientists in the field of tissue engineering and regenerative medicine to work on the use of scaffolds as an alternative to transplantation. Among different types of scaffolds, polymeric hydrogel [...] Read more.
Challenges in organ transplantation such as high organ demand and biocompatibility issues have led scientists in the field of tissue engineering and regenerative medicine to work on the use of scaffolds as an alternative to transplantation. Among different types of scaffolds, polymeric hydrogel scaffolds have received considerable attention because of their biocompatibility and structural similarity to native tissues. However, hydrogel scaffolds have several limitations, such as weak mechanical property and a lack of bioactive property. On the other hand, noble metal particles, particularly gold (Au) and silver (Ag) nanoparticles (NPs), can be incorporated into the hydrogel matrix to form NP–hydrogel composite scaffolds with enhanced physical and biological properties. This review aims to highlight the potential of these hybrid materials in tissue engineering applications. Additionally, the main approaches that have been used for the synthesis of NP–hydrogel composites and the possible limitations and challenges associated with the application of these materials are discussed. Full article
(This article belongs to the Special Issue Noble Metal Functionalized Nanoparticles for Biomedical Applications)
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Figure 1

12 pages, 229 KiB  
Review
Noble Metal Nanoparticles Applications: Recent Trends in Food Control
by Giuliana Vinci and Mattia Rapa
Bioengineering 2019, 6(1), 10; https://doi.org/10.3390/bioengineering6010010 - 21 Jan 2019
Cited by 76 | Viewed by 7059
Abstract
Scientific research in the nanomaterials field is constantly evolving, making it possible to develop new materials and above all to find new applications. Therefore, nanoparticles (NPs) are suitable for different applications: nanomedicine, drug delivery, sensors, optoelectronics and food control. This review explores the [...] Read more.
Scientific research in the nanomaterials field is constantly evolving, making it possible to develop new materials and above all to find new applications. Therefore, nanoparticles (NPs) are suitable for different applications: nanomedicine, drug delivery, sensors, optoelectronics and food control. This review explores the recent trend in food control of using noble metallic nanoparticles as determination tools. Two major uses of NPs in food control have been found: the determination of contaminants and bioactive compounds. Applications were found for the determination of mycotoxins, pesticides, drug residues, allergens, probable carcinogenic compounds, bacteria, amino acids, gluten and antioxidants. The new developed methods are competitive for their use in food control, demonstrated by their validation and application to real samples. Full article
(This article belongs to the Special Issue Noble Metal Functionalized Nanoparticles for Biomedical Applications)
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