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Bioengineering
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MEMS/NEMS Fabricated Tissue Scaffolding Devices
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MEMS/NEMS Fabricated Tissue Scaffolding Devices

A special issue of Bioengineering (ISSN 2306-5354).

Deadline for manuscript submissions: closed (30 June 2015) | Viewed by 11429

Special Issue Editor

Prof. Dr. Gou-Jen Wang

E-Mail Website
Guest Editor
Graduate Institute of Biomedical Engineering, National Chung-Hsing University, Taichung 40227, Taiwan
Interests: chemical sensors; biosensors; immunosensors; nanomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the past decade, tissue engineering in the field of medicine has proven to provide alternative therapies for tissue or organ implants, especially providing a functional implantation and avoiding immune rejection of tissues and organs. Cell, scaffold and growth information are considered to be the basic elements of tissue engineering. Scaffolds are expected to support cell colonization, migration, growth and differentiation, and to guide the development of the required tissue. In cell biology, it has been demonstrated that cell adhesion, proliferation, migration and differentiation can be manipulated using scaffolds of different micro- or nano-structures. Recent progress in MEMS/NEMS fabrication techniques has enabled the production of diverse scaffolds of micro- and nano-structures, on various biomaterials, for tissue regeneration applications. This special issue focuses on the state of the art in scaffold design and fabrication themes based on MEMS/NEMS manufacturing techniques. The topics include the design, fabrication, characterization and cell culture of the tissue scaffolds using MEMS/NEMS approaches.

Prof. Dr. Gou-Jen Wang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


Keywords

  • Tissue engineering
  • Tissue scaffold design
  • MEMS/NEMS fabricated tissue scaffold

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Published Papers (2 papers)

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Editorial

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69 KiB  
Editorial
Special Issue on “MEMS/NEMS Fabricated Tissue Scaffolding Devices”
by Gou-Jen Wang
Bioengineering 2014, 1(2), 113; https://doi.org/10.3390/bioengineering1020113 - 5 Jun 2014
Viewed by 4643
Abstract
Over the past decade, tissue engineering in the field of medicine has proven to provide alternative therapies for tissue or organ implants, especially providing a functional implantation and avoiding immune rejection of tissues and organs. [...] Full article
(This article belongs to the Special Issue MEMS/NEMS Fabricated Tissue Scaffolding Devices)

Research

Jump to: Editorial

1508 KiB  
Article
Ovarian Cancer Cell Adhesion/Migration Dynamics on Micro-Structured Laminin Gradients Fabricated by Multiphoton Excited Photochemistry
by Ruei-Yu He, Visar Ajeti, Shean-Jen Chen, Molly A. Brewer and Paul J. Campagnola
Bioengineering 2015, 2(3), 139-159; https://doi.org/10.3390/bioengineering2030139 - 16 Jul 2015
Cited by 5 | Viewed by 6002
Abstract
Haptotaxis, i.e., cell migration in response to adhesive gradients, has been previously implicated in cancer metastasis. A better understanding of cell migration dynamics and their regulation could ultimately lead to new drug targets, especially for cancers with poor prognoses, such as ovarian [...] Read more.
Haptotaxis, i.e., cell migration in response to adhesive gradients, has been previously implicated in cancer metastasis. A better understanding of cell migration dynamics and their regulation could ultimately lead to new drug targets, especially for cancers with poor prognoses, such as ovarian cancer. Haptotaxis has not been well-studied due to the lack of biomimetic, biocompatible models, where, for example, microcontact printing and microfluidics approaches are primarily limited to 2D surfaces and cannot produce the 3D submicron features to which cells respond. Here we used multiphoton excited (MPE) phototochemistry to fabricate nano/microstructured gradients of laminin (LN) as 2.5D models of the ovarian basal lamina to study the haptotaxis dynamics of a series of ovarian cancer cells. Using these models, we found that increased LN concentration increased migration speed and also alignment of the overall cell morphology and their cytoskeleton along the linear axis of the gradients. Both these metrics were enhanced on LN compared to BSA gradients of the same design, demonstrating the importance of both topographic and ECM cues on the adhesion/migration dynamics. Using two different gradient designs, we addressed the question of the roles of local concentration and slope and found that the specific haptotactic response depends on the cell phenotype and not simply the gradient design. Moreover, small changes in concentration strongly affected the migration properties. This work is a necessary step in studying haptotaxis in more complete 3D models of the tumor microenvironment for ovarian and other cancers. Full article
(This article belongs to the Special Issue MEMS/NEMS Fabricated Tissue Scaffolding Devices)
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