The Role of Extracellular Vesicles in Cancer Metastasis

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cancer Biology".

Deadline for manuscript submissions: 9 December 2024 | Viewed by 1401

Special Issue Editor


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Guest Editor
The Medical School, University of Sheffield, Sheffield S10 2TN, UK
Interests: mechanisms that regulate EV release from tumour cells

Special Issue Information

Dear Colleagues,

We are compiling a Special Issue focused on the role of extracellular vesicles (EVs) in cancer metastasis to be published in Biology. EVs are membrane-bound vesicles that transport functional biomolecules between cells for intercellular communication, and their role in pathophysiology is an emerging field. In several cancers, tumor-derived EVs can provide a sequestered environment for cargo destined for specific cells in the local microenvironment or at distant sites to facilitate cancer survival, progression and metastasis.

In this Special Issue of Biology, we welcome research articles or reviews that showcase recent developments in our understanding of how EVs affect cancer progression and metastasis. We are interested in high-quality original submissions that address, but are not limited to, the following topics:

  • EVs and the modulation of the tumour microenvironment
  • EV-mediated immunosuppression
  • EV and cancer progression
  • Premetastatic niche formation and metastasis
  • Liquid biopsies and biomarkers

Dr. Karan Shah
Guest Editor

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Keywords

  • extracellular vesicles
  • exosomes
  • microvesicles
  • cancer
  • tumour microenvironment
  • metastasis

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Published Papers (1 paper)

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Review

16 pages, 2507 KiB  
Review
Prospects and Current Challenges of Extracellular Vesicle-Based Biomarkers in Cancer
by Samuel R. Lawrence and Karan M. Shah
Biology 2024, 13(9), 694; https://doi.org/10.3390/biology13090694 - 4 Sep 2024
Viewed by 1035
Abstract
Cancer continues to impose a substantial global health burden, particularly among the elderly, where the ongoing global demographic shift towards an ageing population underscores the growing need for early cancer detection. This is essential for enabling personalised cancer care and optimised treatment throughout [...] Read more.
Cancer continues to impose a substantial global health burden, particularly among the elderly, where the ongoing global demographic shift towards an ageing population underscores the growing need for early cancer detection. This is essential for enabling personalised cancer care and optimised treatment throughout the disease course to effectively mitigate the increasing societal impact of cancer. Liquid biopsy has emerged as a promising strategy for cancer diagnosis and treatment monitoring, offering a minimally invasive method for the isolation and molecular profiling of circulating tumour-derived components. The expansion of the liquid biopsy approach to include the detection of tumour-derived extracellular vesicles (tdEVs) holds significant therapeutic opportunity. Evidence suggests that tdEVs carry cargo reflecting the contents of their cell-of-origin and are abundant within the blood, exhibiting superior stability compared to non-encapsulated tumour-derived material, such as circulating tumour nucleic acids and proteins. However, despite theoretical promise, several obstacles hinder the translation of extracellular vesicle-based cancer biomarkers into clinical practice. This critical review assesses the current prospects and challenges facing the adoption of tdEV biomarkers in clinical practice, offering insights into future directions and proposing strategies to overcome translational barriers. By addressing these issues, EV-based liquid biopsy approaches could revolutionise cancer diagnostics and management. Full article
(This article belongs to the Special Issue The Role of Extracellular Vesicles in Cancer Metastasis)
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