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Biology
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Physiological and Pathophysiological Responses to Biomaterials 2.0: From Nano- to...
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Physiological and Pathophysiological Responses to Biomaterials 2.0: From Nano- to Microscale Effects and Interactions

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Physiology".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 7347

Special Issue Editors

Dr. Amilcare Barca

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Guest Editor
Department of Biological and Environmental Sciences and Technologies (DeBEST), Università del Salento, Via per Monteroni c/o Ecotekne, 73100 Lecce, Italy
Interests: cell physiology; comparative and applied physiology; cellular homeostasis; transmembrane transport processes/systems; solute carriers (SLC); epithelial physiology; epithelial cell models; oligopeptides; immunity and inflammation; animal models; zebrafish; cytotoxicity; cell–material interactions; biomaterials; tissue engineering; tissue regeneration
Special Issues, Collections and Topics in MDPI journals
Dr. Marta Madaghiele

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Guest Editor
Department of Engineering for Innovation, University of Salento, Via per Monteroni, 73100 Lecce, Italy
Interests: polymeric devices for biomedical applications, including scaffolds for regenerative medicine, micro- and nano-particles for controlled drug delivery, wound dressings, and perm-selective barriers for cell encapsulation
Special Issues, Collections and Topics in MDPI journals
Dr. Stefania Scialla

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Guest Editor
Institute of Polymers, Composites and Biomaterials, Viale J.F. Kennedy 54, Mostra d'Oltremare Pad. 20, 80125 Naples, Italy
Interests: stimuli responsive nanocomposites for controlled drug delivery; magnetic nanocomposites for theranostics; magnetic resonance imaging and hyperthermia; natural polymer and composite scaffolds for tissue engineering; biomaterials functionalization

Special Issue Information

Dear Colleagues,

In recent years, the intertwinement of molecular physiology, biomaterials science and tissue engineering has led to the elucidation and definition of many mechanisms of cell–material and tissue–material interactions. Nevertheless, the increasing investigations on new biomaterial formulations and biomedical devices at the nano-, meso- or microscale levels imply the identification of new types of impact and extremely diverse responses from cells and tissues, which may vary upon the physiological or pathophysiological processes which the biomaterial/device must face.

In this second version of our Special Issue, we invite the submission of original scientific reports, research articles, communications and review articles, on the broad topic of cell–material and tissue–material interactions specifically investigated at nano-, meso- or microscale levels of application, for deepening knowledge on (a) the use of biomaterials in physiological and pathophysiological contexts, and (b) the basic structure–function relationships of biomaterials and biomedical devices (including scaffolds, surfaces and microfluidic devices, for advanced in vitro models) with cells and tissues.

With this Special Issue, we aim at describing a shared overview of the essential framework of physiological responses triggered by biomaterials, pointing out both convergent and divergent pathways on the two-way physiological–pathophysiological route. In this view, we seek giving a useful transdisciplinary contribution to better shape the physiological context at the interface between cells/tissues and biomaterials.

Dr. Amilcare Barca
Dr. Marta Madaghiele
Dr. Stefania Scialla
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extracellular stimuli and physiological responses
  • plasma membrane interface
  • cell–material interactions
  • tissue–material interactions
  • tissue engineering
  • biomaterials
  • biomedical devices
  • in vitro models and on-chip/microfluidic systems
  • bioreactors
  • structure–function relationship

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Published Papers (3 papers)

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Research

15 pages, 6571 KiB  
Article
Development of PVA Electrospun Nanofibers for Fabrication of Bacteriological Swabs
by Rebecca Pellegrino, Stefania Villani, Daniela Spagnolo, Irene Carofalo, Nico Carrino, Matteo Calcagnile, Pietro Alifano, Marta Madaghiele, Christian Demitri and Paola Nitti
Biology 2023, 12(11), 1404; https://doi.org/10.3390/biology12111404 - 6 Nov 2023
Viewed by 1624
Abstract
In recent years, the enormous demand for swabs for clinical use has promoted their relevance and, consequently, brought the environmental issues due to their single use and lack of biodegradability to the attention of the healthcare industry. Swabs consist of a stick that [...] Read more.
In recent years, the enormous demand for swabs for clinical use has promoted their relevance and, consequently, brought the environmental issues due to their single use and lack of biodegradability to the attention of the healthcare industry. Swabs consist of a stick that facilitates their easy handling and manoeuvrability even in complex districts and an absorbent tip designed to uptake and release biological samples. In this study, we focused on the fabrication of an innovative biodegradable poly(vinyl alcohol) (PVA) nanofiber swab tip using the electrospinning technique. The innovative swab tip obtained showed comparable uptake and release capacity of protein and bacterial species (Pseudomonas aeruginosa and Staphylococcus aureus) with those of the commercial foam-type swab. In this way, the obtained swab can be attractive and suitable to fit into this panorama due to its low-cost process, easy scalability, and good uptake and release capabilities. Full article
(This article belongs to the Special Issue Physiological and Pathophysiological Responses to Biomaterials 2.0: From Nano- to Microscale Effects and Interactions)
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15 pages, 3653 KiB  
Article
Physiologic Response Evaluation of Human Foetal Osteoblast Cells within Engineered 3D-Printed Polylactic Acid Scaffolds
by Maria Giovanna Rizzo, Nicoletta Palermo, Paola Alibrandi, Emanuele Luigi Sciuto, Costantino Del Gaudio, Vincenzo Filardi, Barbara Fazio, Antonella Caccamo, Salvatore Oddo, Giovanna Calabrese and Sabrina Conoci
Biology 2023, 12(3), 424; https://doi.org/10.3390/biology12030424 - 10 Mar 2023
Cited by 4 | Viewed by 2101
Abstract
Large bone defect treatments have always been one of the important challenges in clinical practice and created a huge demand for more efficacious regenerative approaches. The bone tissue engineering (BTE) approach offered a new alternative to conventional bone grafts, addressing all clinical needs. [...] Read more.
Large bone defect treatments have always been one of the important challenges in clinical practice and created a huge demand for more efficacious regenerative approaches. The bone tissue engineering (BTE) approach offered a new alternative to conventional bone grafts, addressing all clinical needs. Over the past years, BTE research is focused on the study and realisation of new biomaterials, including 3D-printed supports to improve mechanical, structural and biological properties. Among these, polylactic acid (PLA) scaffolds have been considered the most promising biomaterials due to their good biocompatibility, non-toxic biodegradability and bioresorbability. In this work, we evaluated the physiological response of human foetal osteoblast cells (hFOB), in terms of cell proliferation and osteogenic differentiation, within oxygen plasma treated 3D-printed PLA scaffolds, obtained by fused deposition modelling (FDM). A mechanical simulation to predict their behaviour to traction, flexural or torque solicitations was performed. We found that: 1. hFOB cells adhere and grow on scaffold surfaces; 2. hFOB grown on oxygen plasma treated PLA scaffolds (PLA_PT) show an improvement of cell adhesion and proliferation, compared to not-plasma treated scaffolds (PLA_NT); 3. Over time, hFOB penetrate along strands, differentiate, and form a fibrous matrix, tissue-like; 4. 3D-printed PLA scaffolds have good mechanical behaviour in each analysed configuration. These findings suggest that 3D-printed PLA scaffolds could represent promising biomaterials for medical implantable devices in the orthopaedic field. Full article
(This article belongs to the Special Issue Physiological and Pathophysiological Responses to Biomaterials 2.0: From Nano- to Microscale Effects and Interactions)
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17 pages, 4676 KiB  
Article
Physiotherapeutic Protocol and ZnO Nanoparticles: A Combined Novel Treatment Program against Bacterial Pyomyositis
by Hesham El-Shaer, Bassma H. Elwakil, Basant A. Bakr, Ahmed M. Eldrieny, Mostafa El-Khatib, Khim Phin Chong and Amr A. Abo Gazia
Biology 2022, 11(10), 1393; https://doi.org/10.3390/biology11101393 - 23 Sep 2022
Cited by 4 | Viewed by 2246
Abstract
Myositis tropicans or pyomyositis is a muscle inflammation resulting from a bacterial infection of skeletal muscle (commonly caused by Staphylococcus aureus) that usually leads to hematogenous muscle seeding. The present study was designed to estimate the role of ZnO-NPs and a physiotherapeutic [...] Read more.
Myositis tropicans or pyomyositis is a muscle inflammation resulting from a bacterial infection of skeletal muscle (commonly caused by Staphylococcus aureus) that usually leads to hematogenous muscle seeding. The present study was designed to estimate the role of ZnO-NPs and a physiotherapeutic program in the management of induced biceps femoris atrophy in rats through histological, biochemical, and radiological examinations at different time intervals. At the beginning, several bacterial strains were evaluated through a proteolytic enzyme activity assay and the highest activity was recorded with the Staphylococcus aureus strain. ZnO-NPs were synthesized with the arc discharge method with an average size of 19.4 nm. The antibacterial activity of ZnO-NPs was investigated and it was revealed that the prepared ZnO-NPs showed a minimum inhibitory concentration of 8 µg/mL against the tested bacterium. The cytotoxicity of the prepared ZnO-NPs was tested in C2C12 myoblast cells, and it was elaborated that CC50 was 344.16 µg/mL. Biceps femoris pyomyositis was induced with a potent strain (Staphylococcus aureus); then, a physiotherapeutic program combined with the prepared ZnO-NPs treatment protocol was applied and evaluated. The combined program claimed antibacterial properties, preventing muscle atrophy, and resulted in the most comparable value of muscle mass. Full article
(This article belongs to the Special Issue Physiological and Pathophysiological Responses to Biomaterials 2.0: From Nano- to Microscale Effects and Interactions)
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