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The Development and Therapeutic Intervention of Non-alcoholic Steatohepatitis (Nash)
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The Development and Therapeutic Intervention of Non-alcoholic Steatohepatitis (Nash)

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Medical Biology".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 6072

Special Issue Editors

Dr. Bin Qiu

E-Mail Website
Guest Editor
Department of Pharmacology, Yale University School of Medicine, Yale University, New Haven, CT 06520, USA
Interests: NAFLD; NASH; liver fibrosis; steatosis; obesity; adipocyte differentiation; autophagy; mitophagy; neointima formation; protein post-translational modification; MKP1; FKBP5
Dr. Yi Luan

E-Mail Website
Guest Editor
Department of Pharmacology, Yale University School of Medicine, Yale University, New Haven, CT 06520, USA
Interests: neutrophil; macrophage; myeloid cells; immune response; tumor immunity; mTOR signaling pathway; protein degradation

Special Issue Information

Dear Colleagues,

Non-alcoholic steatohepatitis (NASH) is a severe type of non-alcoholic fatty liver disease (NAFLD), accompanied by the presence of steatosis, hepatocellular injury, and ballooning. The NASH-induced recruitment of immune cells also contributes to liver inflammation and the activation of hepatic stellate cells (HSCs), leading to progressive liver fibrosis and ultimately to cirrhosis and hepatocellular carcinoma (HCC). There is currently no effective pharmacological therapy approved for NASH, and efforts to control complications arising from the condition are far from satisfactory. Therefore, understanding the underlying mechanisms that govern the development of NASH will play an important role in identifying new modalities for therapeutic intervention.

The goal of this Special Issue is to broaden our understanding of the development and therapy of NASH. We invite the submission of reviews, comments, and original research articles that cover, but are not restricted to, the following areas related to NASH:

-Steatosis and hepatic lipotoxicity;
-Hepatocyte apoptosis;
-Immune cells infiltration and inflammation;
-Hepatic stellate cell (HSC) activation;
-Liver fibrosis;
-Therapeutic intervention to treat NASH.

Dr. Bin Qiu
Dr. Yi Luan
Guest Editors

Manuscript Submission Information

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Keywords

  • non-alcoholic steatohepatitis (NASH)
  • non-alcoholic fatty liver disease (NAFLD)
  • steatosis
  • lipotoxicity
  • hepatocellular apoptosis
  • inflammation
  • hepatic stellate cell (HSC) activation
  • liver fibrosis
  • therapeutic interventions

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Published Papers (2 papers)

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Research

12 pages, 14096 KiB  
Article
Feasibility of Ultrasound Attenuation Imaging for Assessing Pediatric Hepatic Steatosis
by Kyungchul Song, Nak-Hoon Son, Dong Ryul Chang, Hyun Wook Chae and Hyun Joo Shin
Biology 2022, 11(7), 1087; https://doi.org/10.3390/biology11071087 - 20 Jul 2022
Cited by 9 | Viewed by 2208
Abstract
We investigated the feasibility of ultrasound attenuation imaging (ATI) for assessing pediatric hepatic steatosis. A total of 111 children and adolescents who underwent liver ultrasonography with ATI for suspected hepatic steatosis were included. Participants were classified into the normal, mild, or moderate–severe fatty [...] Read more.
We investigated the feasibility of ultrasound attenuation imaging (ATI) for assessing pediatric hepatic steatosis. A total of 111 children and adolescents who underwent liver ultrasonography with ATI for suspected hepatic steatosis were included. Participants were classified into the normal, mild, or moderate–severe fatty liver group according to grayscale US findings. Associations between clinical factors, magnetic resonance imaging proton density fat fraction, steatosis stage and ATI values were evaluated. To determine the cutoff values of ATI for staging hepatic steatosis, areas under the curve (AUCs) were analyzed. Factors that could cause measurement failure with ATI were assessed. Of 111 participants, 88 had successful measurement results. Median ATI values were significantly increased according to steatosis stage (p < 0.001). Body mass index (BMI) was a significant factor for increased ATI values (p = 0.047). To differentiate fatty liver from normal liver, a cutoff value of 0.59 dB/cm/MHz could be used with an AUC value of 0.853. To differentiate moderate to severe fatty liver from mild fatty liver, a cutoff value of 0.69 dB/cm/MHz could be used with an AUC value up to 0.91. ATI can be used in children as an effective ultrasonography technique for quantifying and staging pediatric hepatic steatosis. Full article
(This article belongs to the Special Issue The Development and Therapeutic Intervention of Non-alcoholic Steatohepatitis (Nash))
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13 pages, 1868 KiB  
Article
Comparison of the Modified TyG Indices and Other Parameters to Predict Non-Alcoholic Fatty Liver Disease in Youth
by Kyungchul Song, Hae Won Lee, Han Saem Choi, Goeun Park, Hye Sun Lee, Su Jin Kim, Myeongseob Lee, Junghwan Suh, Ahreum Kwon, Ho-Seong Kim and Hyun Wook Chae
Biology 2022, 11(5), 685; https://doi.org/10.3390/biology11050685 - 29 Apr 2022
Cited by 23 | Viewed by 2859
Abstract
We investigated the modified triglycerides-glucose (TyG) indices and other markers for non-alcoholic fatty liver disease (NAFLD) in 225 participants aged 10–19 years, and the participants were divided into subgroups according to their NAFLD grade. We performed logistic regression analysis and calculated the odds [...] Read more.
We investigated the modified triglycerides-glucose (TyG) indices and other markers for non-alcoholic fatty liver disease (NAFLD) in 225 participants aged 10–19 years, and the participants were divided into subgroups according to their NAFLD grade. We performed logistic regression analysis and calculated the odds ratios (ORs) with 95% confidence intervals (CIs) of tertiles 2 and 3 for each parameter, with those of tertile 1 as a reference. The area under the receiver operating characteristic (ROC) curve was calculated to compare the parameters for identifying NAFLD. TyG and modified indices, aspartate transaminase-to-platelet ratio index (APRI)-body mass index (BMI), APRI-BMI standard deviation score (SDS), APRI waist-to-hip ratio, fibrosis-4 index (FIB)-4, and hepatic steatosis index (HSI) were higher in participants with NAFLD than in those without NAFLD. The ORs and 95% CIs for NAFLD progressively increased across tertiles of each parameter. TyG and modified TyG indices, FIB-4, HSI, and modified APRIs, except APRI waist-to-height ratio, predicted NAFLD significantly through ROC curves. Modified TyG indices, APRI-BMI SDS, and HSI were superior to the other markers for NAFLD prediction. Modified TyG indices, APRI-BMI SDS, and HSI appear to be useful for assessing NAFLD in youths. Full article
(This article belongs to the Special Issue The Development and Therapeutic Intervention of Non-alcoholic Steatohepatitis (Nash))
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