The Role of Matrix Metalloproteinases in Ocular Pathologies
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Medical Biology".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 1938
Special Issue Editors
Interests: biomarker; tear film; hydrogel; ocular surface; dry eye; glaucoma
Interests: ocular pathologies; nanomedicine; innovative strategies; monitoring, diagnosis, treatment
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Matrix metalloproteases (MMPs) are a family of more than twenty Zn2+-dependent endopeptidases that share the same structural pattern. Their combined activity is capable of degrading almost all the components of the extracellular matrix (ECM), which points to their essential role in physiological processes that require matrix remodelling, such as embryonic development, the endometrial cycle, tissue repair or angiogenesis.
Similarly, MMPs are also involved in pathological processes in which excessive degradation of the matrix occurs, such as arthritis, cancer, cardiovascular and neurological diseases. The MMPs known to date can be divided into different subgroups based on their structure and specific substrates. These subgroups include collagenases, stromelysins, matrilysins, gelatinases, membrane metalloproteinases (MT-MMPs) and other MMPs that do not fit into the above groups.
I am pleased to invite you to contribute to this Special Issue of Biology entitled: “The Role of Matrix Metalloproteinases in Ocular Pathologies”. Biology publishes reviews, research papers, and communications in all areas of biology and at the interface of related disciplines.
This Special Issue summarizes current knowledge regarding these proteins, their participation in physiological and pathophysiological roles, their involvement in activation and inhibition, and their interactions with other proteins.
In this Special Issue, original research articles and reviews are welcome.
I look forward to receiving your contributions.
Dr. Arantxa Acera
Dr. Elisa Julião Campos
Guest Editors
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Keywords
- biomarkers
- MMPs
- extracellular matrix
- dry eye
- TIMPs
- glaucoma
- ocular surface
- trabecular meshwork
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